Consensus (ie reviews: 20229235 19623618 18339531) is that binding of
Wnts to Fzds and Lrp6 causes the recruitment of Dvls to the receptor complex.
This somehow causes Axin1 and Gsk3s to be recruited causing phosphorylation
of Lrp6(S1490) by Gsk3b and Lrp6(S1479) by Csnk1g.
But evidence is scarse...


Other Wnts?

  *** xAxin1[tAb] copptby[WB] xLrp6[tAb] is increased itpo xWnt1
    *** cells: HEK293T<xAxin1><xLrp6> in BMS
    *** source: 12897152-Fig-1d


Requirement for Csnk1g1 kinase-activity for Axin1/Lrp6 coppt

  *** xAxin1[tAb] copptby[WB] xLrp6[tAb] is detectable
    *** cells: HEK293T<xAxin1><xLrp6> in BMS
    *** inhibited by: xCsnk1g1(K73R) [addition]
    *** source: 16341016-Fig-4a


Lrp5?

Is Lrp6-phos(1490) required?

  *** xAxin1[tAb] copptby[WB] xLrp6[tAb] is detectable 
    *** cells: HEK293T<xAxin1><xLrp6> in BMS
    *** enhanced by: xLrp6(S1420A) [substitution]
    *** enhanced by: xLrp6(S1420A/S1430A) [substitution]
    *** source: 16513652-Fig-7b
  *** xAxin1[tAb] copptby[WB] xLrp6[tAb] is detectable 
    *** cells: HEK293T<xAxin1><xLrp6> in BMS
    *** unaffected by: xCsnk1e [addition]
    *** source: 16513652-Fig-7b
  *** xAxin1[tAb] copptby[WB] xLrp6((1394-1613)/S1420A/S1430A)"delN"[tAb] is detectable 
    *** cells: HEK293T<xAxin1><xLrp6(1394-1613)> in BMS
    *** partially inhibited by: xCsnk1e [addition]
    *** source: 16513652-Fig-7a
  *** xAxin1[tAb] copptby[WB] xLrp6(1394-1613)"delN"[tAb] is detectable 
    *** cells: HEK293T<xAxin1><xLrp6(1394-1613)> in BMS
    *** enhanced by: xLrp6((1394-1613)/S1420A)"delN" [substitution]
    *** enhanced by: xLrp6((1394-1613)/S1430A)"delN" [substitution]
    *** enhanced by: xLrp6((1394-1613)/S1420A/S1430A)"delN" [substitution]
    *** source: 16513652-Fig-7a
  *** xAxin1[tAb] copptby[WB] xLrp6(1394-1613)"delN"[tAb] is detectable 
    *** cells: HEK293T<xAxin1><xLrp6(1394-1613)> in BMS
    *** unaffected by: xCsnk1e [addition]
    *** source: 16513652-Fig-7a
  *** xAxin1[tAb] copptby[WB] xLrp6(S1420A/S1430A)[tAb] is detectable 
    *** cells: HEK293T<xAxin1><xLrp6> in BMS
    *** partially inhibited by: xCsnk1e [addition]
    *** source: 16513652-Fig-7b
  *** xAxin1[tAb] snaggedby[WB] rLrp6(1397-1613){phos}[GST] is detectable
    *** cells: HEK293T<xAxin1> in BMS
    *** inhibited by: rLrp6(1397-1613) [substitution]
    *** comment: rLrp6(1397-1613) was phosed by both rGsk3b and rCsnk1e
    *** comment: phosphorylation by both kinases was required
    *** source: 16341017-Fig-3c

