================
Kinase Activity
================

Mekk4--

  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (1 hr)
    *** cells: COS7 in BMLS
    *** inhibited by: xMekk4(K1371R)"DN" [addition]
    *** source: 9305639-Fig-11a

Mkk3--

  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (1 hr)
    *** cells: COS1 in BMS
    *** inhibited by: xMkk3(S189A/T193A) [addition]
    *** source: 8622669-Fig-1c

not Mkk4-- or Mkk7--

  *** P38s[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt UV (times)
    *** cells: mEFs in BMS
    *** times: 0 15++ 30+ 60+ 120+ 240 min
    *** does not req: Mkk4 [KO]
    *** does not req: Mkk7 [KO]
    *** does not req: Mkk4 or Mkk7 [DKO]
    *** source: 11390361-Fig-5b

Chemicals--

  *** P38s[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt UV (1 hr)
    *** cells: A549 in BMS
    *** partially inhibited by: SB203580 [pretreatment]
    *** partially inhibited by: SB202190 [pretreatment]
    *** source: 10581258-Fig-6a
  *** P38s[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt UV (1 hr)
    *** cells: A549 in BMS
    *** partially inhibited by: SB203580 [pretreatment]
    *** partially inhibited by: SB202190 [pretreatment]
    *** source: 10581258-Fig-7a
  *** P38s[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt UV (1 hr)
    *** cells: H1299<Tp53~null><xTp53> in BMS
    *** partially inhibited by: SB203580 [pretreatment]
    *** partially inhibited by: SB202190 [pretreatment]
    *** source: 10581258-Fig-7a
  *** P38s[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt UV (1 hr)
    *** cells: RKO in BMS
    *** partially inhibited by: SB203580 [pretreatment]
    *** partially inhibited by: SB202190 [pretreatment]
    *** source: 10581258-Fig-7a
  *** P38s[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt UV (1 hr)
    *** cells: RKO<xE6!Hpv16> in BMS
    *** partially inhibited by: SB203580 [pretreatment]
    *** partially inhibited by: SB202190 [pretreatment]
    *** source: 10581258-Fig-7a

no extras

  *** P38a[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt UV (times)
    *** cells: HELA in BMS
    *** times: 0+ 15++ 30++ 60++ 120++ min
    *** source: 7535770-Fig-4
  *** xP38a[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS1 in BMS
    *** source: 7839144-Fig-5
  *** P38a[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS1 in BMS
    *** source: 8622669-Fig-7c
  *** xP38a[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS1 in BMS
    *** source: 8622669-Fig-7c
  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (1 hr)
    *** cells: COS1 in BMS
    *** source: 8622669-Fig-2a
  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (15 min)
    *** cells: HELA in BMS
    *** source: 9430721-Fig-5
  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (20 min)
    *** cells: HELA in BMS
    *** source: 8663524-Fig-5
  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (20 min)
    *** cells: HELA in BMS
    *** source: 9535930-Fig-3b
  *** xP38b[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (20 min)
    *** cells: HELA in BMS
    *** source: 8663524-Fig-5
  *** xP38b[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (times)
    *** cells: HELA in BMS
    *** times: 0 15+ 45++ min
    *** source: 9430721-Fig-5
  *** xP38b[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-2b
  *** xP38b[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-3a
  *** xP38b[tAb]IP IVKA(Elk1)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-3a
  *** xP38b[tAb]IP IVKA(Mapkapk2)[32P-ATP] is unchanged irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-3a
  *** xP38b[tAb]IP IVKA(MBP)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-3a
  *** xP38g[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (15 min)
    *** cells: HELA in BMS
    *** source: 9430721-Fig-5
  *** xP38g[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-2b
  *** xP38g[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-3a
  *** xP38g[tAb]IP IVKA(Elk1)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-3a
  *** xP38g[tAb]IP IVKA(Mapkapk2)[32P-ATP] is unchanged irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-3a
  *** xP38g[tAb]IP IVKA(MBP)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-3a
  *** P38s[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** source: 11777913-Fig-4a

required features

  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (30 min)
    *** cells: COS1 in BMS
    *** bkg inhibited by: xP38a(T180A/Y182F) [substitution]
    *** source: 7535770-Fig-9c
  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-2b
  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-3a
  *** xP38a[tAb]IP IVKA(Elk1)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-3a
  *** xP38a[tAb]IP IVKA(Mapkapk2)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-3a
  *** xP38a[tAb]IP IVKA(MBP)[32P-ATP] is increased irt UV (tnr)
    *** cells: COS7 in BMS
    *** source: 9430721-Fig-3a

===========================
Phosphorylation on Tyrosine
===========================

  *** xP38a[tAb]IP Yphos[pYAb] is increased irt UV (30 min)
    *** cells: COS1 in BMS
    *** inhibited by: xP38a(T180A/Y182F) [substitution]
    *** source: 7535770-Fig-9a

===========================
Phosphorylation on TGY site
===========================

does not req Mlk3--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15+ 30+ 45+ 60+ 90+ 120+ min
    *** does not req: Mlk3 [KO]
    *** source: 15831472(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15++ 30++ 45++ 60++ 90+ 120+ min
    *** does not req: Mlk3 [KO]
    *** source: 15831472(D)

does not req Msk1 or Msk2

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (15 min)
    *** cells: mEFs in BMLS
    *** does not req: Msk2 [KO]
    *** does not req: Msk1 [KO]
    *** does not req: Msk1 or Msk2 [DKO]
    *** source: 11909979-Fig-4a

does not req Adam17--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (60 min)
    *** cells: CHO<xProTgfa> in BMLS
    *** does not req: Adam17 [RNAi]
    *** source: 20188673-Fig-3a

Chemicals--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (15 min)
    *** cells: mEFs in BMLS
    *** unaffected by: SB203580 [addition] no-bkg-control
    *** unaffected by: PD184352 [addition] no-bkg-control
    *** source: 11909979-Fig-3a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (15 min)
    *** cells: mEFs<Jnk1~null><Jnk2~null> in BMLS
    *** unaffected by: SB203580 [addition]
    *** source: 12110590-Fig-3c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (tnr)
    *** cells: HEK293T in BMS
    *** inhibited by: SB203580 [addition]
    *** source: 11598209-Fig-7a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (tnr)
    *** cells: U373<xCd14> in BMS
    *** source: 12062447-Fig-4a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (60 min)
    *** cells: CHO<xProTgfa> in BMLS
    *** inhibited by: SB203580 [pretreatment]
    *** source: 20188673-Fig-2a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (60 min)
    *** cells: CHO<xProTgfa> in BMLS
    *** unaffected by: U0126 [pretreatment]
    *** inhibited by: SB203580 [pretreatment]
    *** unaffected by: JNK-Inhibitor-II [pretreatment]
    *** unaffected by: Bisindolylmaleimide-I [pretreatment]
    *** source: 20188673-Fig-1d
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** inhibited by: SB202190 [pretreatment]
    *** source: 11896587-Fig-3a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: LY294002 [pretreatment]
    *** unaffected by: xPik3c?(mnr)"DN" [addition]
    *** source: 11350959-Fig-4
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMS
    *** unaffected by: H89 [pretreatment]
    *** unaffected by: PD98059 [pretreatment]
    *** inhibited by: SB202190 [pretreatment]
    *** source: 11441012-Fig-5c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (times)
    *** cells: JB6CL41 in BMS
    *** times: 0 15++ 30++ 60+ 120 min
    *** unaffected by: H89 [pretreatment]
    *** source: 11441012-Fig-4b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (1 hr)
    *** cells: JB6CL41 in BMLS
    *** inhibited by: PD169316 [pretreatment]
    *** source: 11777913-Fig-2a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (1 hr)
    *** cells: JB6CL41 in BMLS
    *** inhibited by: SB202190 [pretreatment]
    *** source: 11777913-Fig-2b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD98059 [pretreatment]
    *** source: 11777913-Fig-2c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 11777913-Fig-8a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: U0126 [pretreatment]
    *** source: 11777913-Fig-2d
  *** P38s[phosAb] phos(TEY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD98059 [pretreatment]
    *** inhibited by: SB202190 [pretreatment]
    *** source: 11983683-Fig-2b

no extras

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (60 min)
    *** cells: CHO<xProTgfa> in BMLS
    *** source: 20188673-Fig-1b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** source: 11896587-Fig-2a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (times)
    *** cells: JB6CL41 in BMS
    *** times: 0 15+ 30+ 60+ min
    *** source: 11441012-Fig-3b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt UV (2 min)
    *** cells: MCF7 in BMLS
    *** source: 17693255-Fig-S1b

