not Ciap1-- or Ciap2--

  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** comment: coppt Traf2 is ubiquitinated [WBMS]
    *** does not req: Ciap1 [RNAi]
    *** does not req: Ciap2 [RNAi]
    *** does not req: Ciap1 and/or Ciap2 [RNAi]
    *** comment: slight changes in ubiq pattern was obsevered
    *** source: 18697935-Fig-4a
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mSkMFibros in BMS
    *** does not req: Ciap1 [RNAi]
    *** does not req: Ciap2 [RNAi]
    *** source: 18697935-Fig-4b

repressed by Ripk1--

  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** repressed by: Ripk1 [KO]
    *** source: 10795740-Fig-3a
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** repressed by: Ripk1 [KO]
    *** source: 10795740-Fig-3c
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 10++ 20++ min
    *** repressed by: Ripk1 [KO]
    *** source: 15175328-Fig-7b
  *** Traf2[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: H460 in BMS
    *** times: 0 1+ 5+ min
    *** repressed by: Ripk1 [RNAi]
    *** source: 16940186-Fig-1d
  *** Traf2[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 1+ 5+ min
    *** repressed by: Ripk1 [RNAi]
    *** source: 16940186-Fig-1c
  *** Traf2[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 2+ 5+ min
    *** repressed by: Ripk1 [KO]
    *** source: 16603398-Fig-4a
  *** Traf2[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null><Ripk1~null><xRipk1> in BMS
    *** times: 0 2+ 5+ min
    *** enhanced by: xRipk1(K377R)"Ubiq-deficient-mut" [substitution]
    *** source: 16603398-Fig-4a
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (10 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** repressed by: Ripk1 [RNAi]
    *** source: 16611992-Fig-5c

Tradd--

  *** Traf2[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: H460 in BMS
    *** times: 0 1+ 5+ min
    *** partially reqs: Tradd [RNAi]
    *** source: 16940186-Fig-1d
  *** Traf2[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 1+ 5+ min
    *** reqs: Tradd [RNAi]
    *** source: 16940186-Fig-1c
  *** Traf2[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 30+ 60 min
    *** reqs: Tradd [KO]
    *** source: 18641654-Fig-1d


============================================
coppt with other components of TnfR1 complex
============================================

Tab2--

  *** Traf2[Ab] copptby[WB] Tab2[Ab] is increased irt Tnf (times)
    *** cells: MCF7 in BMS
    *** times: 0 5+ 15++ min
    *** bkg inhibited by: xSmad7 [addition]
    *** source: 17384642-Fig-6d
  *** Traf2[Ab] copptby[WB] Tab2[Ab] is increased irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3++ 15+ min
    *** source: 14633987-Fig-5b
  *** Traf2[Ab] copptby[WB] Tab2[Ab] is increased irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3++ 15+ min
    *** source: 14633987-Fig-6b

Tab3--

  *** Traf2[Ab] copptby[WB] Tab3[Ab] is increased irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3++ 15+ min
    *** source: 14633987-Fig-5b
  *** Traf2[Ab] copptby[WB] Tab3[Ab] is increased irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3++ 15+ min
    *** source: 14633987-Fig-6b

Tak1--

  *** Traf2[Ab] copptby[WB] Tak1[Ab] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** source: 12547194-Fig-5b
  *** Traf2[Ab] copptby[WB] Tak1[Ab] is increased irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3++ 15+ min
    *** source: 14633987-Fig-5b
  *** Traf2[Ab] copptby[WB] xTak1[His] is increased irt Tnf (times)
    *** cells: HEK293T<xTak1> in BMS
    *** times: 0+ 5+ 10++ 15+ min
    *** unaffected by: xTak1(K158R) [substitution]
    *** source: 20038579-Fig-S3a

Tradd--

  *** Traf2[Ab] snaggedby[WB] rTradd[GST] is detectable
    *** cells: HELA in BMS "treated with Tnf (30 min)"
    *** inhibited by: rStat1 [addition]
    *** source: 10848577-Fig-4b
  *** Traf2[Ab] copptby[WB] Tradd[Ab] is increased irt Tnf (30 min)
    *** cells: 2FTGH in BMS
    *** repressed by: Stat1 [null-mut]
    *** source: 10848577-Fig-4a

============================================
Traf2 features required for coppt with TnfR1
============================================

  *** xTraf2(87-501)[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs<Traf2~null> in BMS
    *** source: 10795740-Fig-5

=========
no extras
=========

  *** Traf2[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: HT1080 in BMS
    *** times: 0 5+++ 30+++ 60++ 240+ min
    *** unaffected by: xIkba(mnr)"degradation-deficient-mut" [addition]
    *** source: 12887920(D)
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** unaffected by: Geldanamycin [addition]
    *** source: 11864612-Fig-6c
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** source: 9915703-Fig-4a
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: U937 in BMS
    *** source: 9915703-Fig-4a
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 2++ 5++ 10+ min
    *** source: 9915703-Fig-4b
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: U937 in BMS
    *** times: 0 2++ 5++ 10+ min
    *** source: 9915703-Fig-4b
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** source: 8943045-Fig-2b
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: U937 in BMS
    *** source: 8943045-Fig-2b
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: U937 in BMS
    *** times: 0 2++ 5++ 10++ 20+ 40 min
    *** source: 8943045-Fig-1b
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** source: 10795740-Fig-5
  *** Traf2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 2+ 5+ 10+ min
    *** source: 10795740-Fig-6b




