==========================================
Tak1 Kinase Activation or Phoshphorylation
==========================================

not Atm--

  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** does not req: Atm [KO]
    *** source: 20932476-Fig-2b
  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Tnf (30 min)
    *** cells: HEK293 in BMS
    *** does not req: Atm [RNAi]
    *** source: 20932476-Fig-2a

not Xiap--

  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** does not req: Xiap [KO]
    *** source: 20932476-Fig-7c

not EgfR--

  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5+ 10 min
    *** does not req: EgfR [RNAi]
    *** source: 19687304-Fig-7b

not Erc1--

  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** does not req: Erc1 [KO]
    *** source: 20932476-Fig-3f
  *** Tab2[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Tnf (30 min)
    *** cells: HEK293 in BMS
    *** does not req: Erc1 [RNAi]
    *** source: 20932476-Fig-S3

not P38s--

  *** Tab1[Ab]IP IVKA(Mkk6,P38a)[32P-ATP] is increased irt Tnf (10 min)
    *** cells: mEFs in BMS
    *** enhanced by: SB203580 [addition] no-bkg-control
    *** source: 14592977-Fig-9a
  *** Tab1[Ab]IP IVKA(Mkk6,P38a)[32P-ATP] is increased irt Tnf (10 min)
    *** cells: mEFs in BMS
    *** repressed by: P38a [KO]
    *** source: 14592977-Fig-9a
  *** Tab1[Ab]IP IVKA(Mkk6,P38a)[32P-ATP] is increased irt Tnf (times)
    *** cells: KB in BMS
    *** times: 0 5++ 10++ 20+ 30+ min
    *** enhanced by: SB203580 [addition] no-bkg-control
    *** source: 14592977-Fig-8a
  *** Tab2[Ab]IP IVKA(Mkk6,P38a,MBP)[32P-ATP] is increased irt Tnf (5 min)
    *** cells: KB in BMLS
    *** unaffected by: SB203580 [addition]
    *** source: 14670075-Fig-4b
  *** Tab3[Ab]IP IVKA(Mkk6,P38a,MBP)[32P-ATP] is increased irt Tnf (5 min)
    *** cells: KB in BMLS
    *** unaffected by: SB203580 [addition]
    *** source: 14670075-Fig-4b
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5++ 10+ min
    *** does not req: P38a [RNAi]
    *** source: 15590691-Fig-7c
  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5++ 10+ min
    *** does not req: P38a [RNAi]
    *** source: 15590691-Fig-7c
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** repressed by: P38a [RNAi]
    *** source: 19393267-Fig-5c

Smad7-- ???

  *** Tak1[Ab] IVKA(Mkk6)[32P-ATP] is increased irt Tnf (10 min)
    *** cells: MCF7 in BMS
    *** bkg inhibited by: xSmad7 [addition]
    *** source: 17384642-Fig-5a

Tab1--

  *** Tak1[Ab]IP IVKA(Mkk6,P38a,MBP)[32P-ATP] is increased irt Tnf (times)
    *** cells: mEFs in BMLS
    *** times: 0 5++ 10+ min
    *** bkg reqs: Tab1 [KO]
    *** source: 18021073-Fig-7a
  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** reqs: Tab1 [RNAi]
    *** source: 15590691-Fig-6a
  *** xTak1[tAb]IP IVKA(Mkk6)[32P-ATP] is increased irt Tnf (times)
    *** cells: HELA<xTak1><xTab1> in BMS
    *** times: 0 5+ 10 min
    *** unaffected by: xTab1(S423A/T431A) [substitution]
    *** source: 15590691-Fig-8c
  *** Tak1[Ab]IP phos(T187)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMLS
    *** times: 0 5++ 10+ min
    *** partially reqs: Tab1 [KO]
    *** source: 18021073-Fig-7b
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** partially reqs: Tab1 [RNAi]
    *** source: 15590691-Fig-6a

Tab2--

  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** reqs: Tab2 [RNAi]
    *** source: 15590691-Fig-6b
  *** Tak1[Ab] phos[WBMS] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 3+ 10++ min
    *** partially reqs: Tab2 [RNAi]
    *** reqs: Tab2 and/or Tab3 [DRNAi]
    *** source: 14633987-Fig-7b
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** reqs: Tab2 [RNAi]
    *** source: 15590691-Fig-6b

not Tab3--

  *** Tak1[Ab] phos[WBMS] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 3+ 10++ min
    *** does not req: Tab3 [RNAi]
    *** source: 14633987-Fig-7b

chemicals

  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5++ 10+ min
    *** enhanced by: SB203580 [pretreatment]
    *** source: 15590691-Fig-7a
  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Tnf (30 min)
    *** cells: HEK293 in BMS
    *** unaffected by: KU55933 [pretreatment]
    *** source: 20932476-Fig-2c
  ------------------------------------------------------------------
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5++ 10+ min
    *** enhanced by: SB203580 [pretreatment]
    *** source: 15590691-Fig-7a
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** enhanced by: SB203580 [pretreatment]
    *** source: 19393267-Fig-5d

no extras

  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** source: 15590691-Fig-5d
  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 2+ 5+ 10 20 min
    *** source: 15590691-Fig-5a
  ------------------------------------------------------------------
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** source: 15590691-Fig-5d
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 2++ 5+++ 10+ 20 min
    *** source: 15590691-Fig-5a
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** source: 19393267-Fig-1a

=====
Other 
=====




  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 3+ 5++ 10+ 30 min
    *** comment: partially inhibited by prestim with Egf for 10 min
    *** source: 19393267-Fig-5b
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (2 min)
    *** cells: HELA<xTab1> in BMS
    *** comment: partially inhibited by prestim with Egf for 10 min
    *** source: 19393267-Fig-5e
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (2 min)
    *** cells: HELA<xTab1> in BMS
    *** partially inhibited by: xTab1(T431A/S432A) [substitution]
    *** source: 19393267-Fig-5e
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** comment: partially inhibited by prestim with Anisomycin for 10 min
    *** source: 19393267-Fig-5g
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** comment: partially inhibited by prestim with Egf for 2-30 min
    *** source: 19393267-Fig-5a


=========
no extras
=========

  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 2++ 5+ 10+ 20 min
    *** source: 15327770(D)
  *** xTak1[tAb]IP phos(T187)[phosAb] is increased irt Tnf (times)
    *** cells: HELA<xTak1> in BMS
    *** times: 0 2+ 5++ 15+ min
    *** source: 20038579-Fig-6b

  ---------- contradiction -----------------------------------------
  *** Tak1[Ab]IP phos[WBMS] is unchanged irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3 15 min
    *** source: 14633987-Fig-5b
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0 5+ 10++ 15++ 30++ min
    *** inhibited by: xTak1(K158R) [addition]
    *** source: 20038579-Fig-7a


======================
Tak1 K63ubiquitination
======================

  *** xTak1[tAb]IP ubiq[UbAb] is increased irt Tnf (times)
    *** cells: HEK293T<xTak1><xUbiq(K63only)> in BMS
    *** times: 0 2+ 5++ 10+ 30 min
    *** inhibited by: Ubiq(K48only) [substitution]
    *** source: 20038579-Fig-1c
  *** xTak1[tAb]IP ubiq[UbAb] is increased irt Tnf (times)
    *** cells: HELA<xTak1> in BMS
    *** times: 0+ 2++ 5++ 10+ 30+ min
    *** source: 20038579-Fig-1a
  *** xTak1[tAb]IP ubiq[UbAb] is increased irt Tnf (times)
    *** cells: HELA<xTak1> in BMS
    *** times: 0+ 2++ 5++ min
    *** source: 20038579-Fig-4a
  *** xTak1[tAb]IP ubiq[tUbAb] is increased irt Tnf (times)
    *** cells: HEK293<xTak1><xUbiq> in BMLS
    *** times: 0 5+ 10+ 20+ min
    *** source: 22069318-Fig-1a
  *** xTak1[tAb]IP ubiq[tUbAb] is increased irt Tnf (times)
    *** cells: HEK293<xTak1><xUbiq> in BMLS
    *** times: 0+ 5+ 10++ 20+ min
    *** inhibited by: xTak1(K34R) [substitution]
    *** source: 22069318-Fig-3c
  *** Tak1[Ab]IP ubiq[UbAb] is increased irt Tnf (times)
    *** cells: mEFs<xUbiq(K63only)> in BMS
    *** times: 0 10+ 20+ min
    *** source: 19843958-Fig-2c


  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Tnf (times)
    *** cells: PC3U in BMS
    *** times: 0+ 15++ 30+++ min
    *** source: 18758450-Fig-S1e
  *** Tak1[Ab]IP phos(T187/S192)[phosAb] is increased irt Tnf (times)
    *** cells: PC3U in BMS
    *** times: 0+ 15++ 30++ min
    *** source: 18758450-Fig-S1d


=================
Tab1 phos irt Tnf
=================

  *** Tab1[Ab]IP phos(S423)[phosAb] is increased irt Tnf (5 min)
    *** cells: KB in BMS
    *** inhibited by: SB203580 [addition] no-bkg-control
    *** unaffected by: PD184352 [addition] no-bkg-control
    *** source: 14592977-Fig-7
  *** Tab1[Ab]IP phos(S423)[phosAb] is increased irt Tnf (10 min)
    *** cells: mEFs in BMS
    *** source: 14592977-Fig-9c
  *** Tab1[Ab]IP phos(T431)[phosAb] is increased irt Tnf (5 min)
    *** cells: KB in BMS
    *** inhibited by: SB203580 [addition] no-bkg-control
    *** unaffected by: PD184352 [addition] no-bkg-control
    *** source: 14592977-Fig-7
  *** Tab1[Ab]IP phos(T431)[phosAb] is increased irt Tnf (10 min)
    *** cells: mEFs in BMS
    *** source: 14592977-Fig-9c
  *** Tab1[phosAb] phos(S438)[phosAb] is unchanged irt Tnf (5 min)
    *** cells: KB in BMS
    *** source: 14592977-Fig-7
  *** Tab1[Ab]IP phos(S438)[phosAb] is unchanged irt Tnf (10 min)
    *** cells: mEFs in BMS
    *** source: 14592977-Fig-9c

=====================
Tab1 upshift irt Tnf
=====================

  *** Tab1[Ab] phos[WBMS] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** source: 15590691-Fig-5d
  *** Tab1[Ab] phos[WBMS] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5+ 10++ min
    *** inhibited by: SB203580 [pretreatment]
    *** source: 15590691-Fig-7a
  *** Tab1[Ab] phos[WBMS] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5+ 10++ min
    *** reqs: P38a [RNAi]
    *** source: 15590691-Fig-7c
  *** xTab1[tAb]IP phos[WBMS] is increased irt Tnf (times)
    *** cells: HELA<xTak1><xTab1> in BMS
    *** times: 0 5+ 10++ min
    *** unaffected by: xTab1(S423A/T431A) [substitution]
    *** source: 15590691-Fig-8c

=====================
Tab2 upshift irt Tnf
=====================

  *** Tab2[Ab]IP phos[WBMS] is increased irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3++ 15+ min
    *** source: 14633987-Fig-5b
  *** Tab2[Ab]IP phos[WBMS] is unchanged irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3 10 min
    *** source: 14633987-Fig-6b
  *** Tab2[Ab] phos[WBMS] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5+ 10++ min
    *** does not req: P38a [RNAi]
    *** source: 15590691-Fig-7c
  *** Tab2[Ab] phos[WBMS] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5+ 10++ min
    *** partially inhibited by: SB203580 [pretreatment]
    *** source: 15590691-Fig-7a
  *** Tab2[Ab] phos[WBMS] is unchanged irt Tnf (5 min)
    *** cells: HELA in BMS
    *** source: 15590691-Fig-5d


  *** Tab3[Ab]IP phos[WBMS] is increased irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3 10+ min
    *** source: 14633987-Fig-6b
  *** Tab3[Ab]IP phos[WBMS] is increased irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3++ 15+ min
    *** source: 14633987-Fig-5b

  not ubiq

  *** Tab3[Ab]IP ubiq[UbAb] is unchanged irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3 10 min
    *** source: 14633987-Fig-6b
  *** Tab2[Ab]IP ubiq[UbAb] is unchanged irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3 10 min
    *** source: 14633987-Fig-6b


















