======================================================
Proteins Required for Tak1-Tab1-Tab2 complex to TnfR1
======================================================

Ripk1--

  *** Tak1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 10++ 20+ min
    *** reqs: Ripk1 [KO]
    *** source: 15175328-Fig-7a
  *** Tak1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (30 min)
    *** cells: MCF10A in BMS
    *** partially reqs: Ripk1 [RNAi]
    *** source: 18037881-Fig-5c
  *** Tak1[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 2+ 5+ min
    *** reqs: Ripk1 [KO]
    *** source: 16603398-Fig-4a
  *** Tab2[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 2+ 5+ min
    *** reqs: Ripk1 [KO]
    *** source: 16603398-Fig-4a

  ---- Ripk1-ubiq ----

  *** Tab2[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null><Ripk1~null><xRipk1> in BMS
    *** times: 0 2+ 5+ min
    *** inhibited by: xRipk1(K377R)"Ubiq-deficient-mut" [substitution]
    *** source: 16603398-Fig-4a
  *** xRipk1[Ab] copptby[WB] Tab2[Ab] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null><Ripk1~null><xRipk1> in BMS
    *** times: 0 2+ 5+ min
    *** inhibited by: xRipk1(K377R)"Ubiq-deficient-mut" [substitution]
    *** source: 16603398-Fig-4a
  *** Tak1[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null><Ripk1~null><xRipk1> in BMS
    *** times: 0 2+ 5+ min
    *** inhibited by: xRipk1(K377R)"Ubiq-deficient-mut" [substitution]
    *** source: 16603398-Fig-4a
  *** Ripk1[Ab] copptby[WB] Tab2[Ab] is increased irt Tnf (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 10+ min
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-S4d
  *** Ripk1[Ab] copptby[WB] Tab2[Ab] is increased irt Tnf (times)
    *** cells: U2OS<Ubiq~null><xUbiq(K63R)> in BMS
    *** times: 0 5+ 10+ min
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-S4d


Muc1--

  *** Tak1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (30 min)
    *** cells: MCF10A in BMS
    *** reqs: Muc1 [RNAi]
    *** source: 18037881-Fig-5c

not Nemo--

  *** Tab2[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 2+ 5+ min
    *** does not req: Nemo [KO]
    *** source: 16603398-Fig-5c

=================================================
Coprecipitation with other TnfR1 binding Proteins
=================================================

Traf2--

  *** Tak1[Ab] copptby[WB] Traf2[Ab] is increased irt Tnf (15 min)
    *** cells: CMT93 in BMS
    *** inhibited by: Tgfb1 (18 hr) [pretreatment]
    *** source: 17384642-Fig-6b
  *** Tak1[Ab] copptby[WB] Traf2[Ab] is increased irt Tnf (15 min)
    *** cells: mBMMs in BMS
    *** inhibited by: Tgfb1 (18 hr) [pretreatment]
    *** source: 17384642-Fig-6a
  *** Tak1[Ab] copptby[WB] Traf2[Ab] is increased irt Tnf (times)
    *** cells: MCF7 in BMS
    *** times: 0 5+ 15++ min
    *** inhibited by: xSmad7 [addition]
    *** source: 17384642-Fig-6c

  *** Tab2[Ab] copptby[WB] Traf2[Ab] is increased irt Tnf (15 min)
    *** cells: CMT93 in BMS
    *** inhibited by: Tgfb1 (18 hr) [pretreatment]
    *** source: 17384642-Fig-6b
  *** Tab2[Ab] copptby[WB] Traf2[Ab] is increased irt Tnf (15 min)
    *** cells: mBMMs in BMS
    *** inhibited by: Tgfb1 (18 hr) [pretreatment]
    *** source: 17384642-Fig-6a

  *** Tab3[Ab] copptby[WB] Traf2[Ab] is increased irt Tnf (15 min)
    *** cells: CMT93 in BMS
    *** inhibited by: Tgfb1 (18 hr) [pretreatment]
    *** source: 17384642-Fig-6b
  *** Tab3[Ab] copptby[WB] Traf2[Ab] is increased irt Tnf (15 min)
    *** cells: mBMMs in BMS
    *** inhibited by: Tgfb1 (18 hr) [pretreatment]
    *** source: 17384642-Fig-6a

Nemo--

  *** xTak1[tAb] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: HELA<xTak1> in BMS
    *** times: 0 2++ 5++ 15+ min
    *** inhibited by: xTak1(K158R) [substitution]
    *** comment: coppt xTak1 is ubiquitinated
    *** source: 20038579-Fig-6b

================================================
Tak1-Tab1-Tab2-Tab3 complex stays intact irt Tnf
================================================

  *** Tak1[Ab] copptby[WB] Tab2[Ab] is unchanged irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0+ 3+ 15++ min
    *** comment: coppt Tak1 phos[WBMS] does not change with time
    *** source: 14633987-Fig-5b
  *** Tak1[Ab] copptby[WB] Tab3[Ab] is unchanged irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0+ 3+ 15++ min
    *** comment: coppt Tak1 phos[WBMS] does not change with time
    *** source: 14633987-Fig-5b
  *** Tak1[Ab] copptby[WB] Tab2[Ab] is unchanged irt Tnf (times)
    *** cells: MCF7 in BMS
    *** times: 0+ 5+ 15+ 30+ min
    *** unaffected by: xSmad7 [addition]
    *** source: 17384642-Fig-6d
  *** Tab2[Ab] copptby[WB] Tak1[Ab] is unchanged irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0+ 3+ 15+ min
    *** comment: coppt Tab2 phos[WBMS] increases with time
    *** source: 14633987-Fig-5b
  *** Tak1[Ab] copptby[WB] Tab2[Ab] is unchanged irt Tnf (times)
    *** cells: KB in BMLS
    *** times: 0+ 5+ min
    *** comment: upshift of Tak1 coppt by Tab2 is increased irt Tnf (5 min)
    *** source: 14670075-Fig-4b
  *** Tak1[Ab] copptby[WB] Tab3[Ab] is unchanged irt Tnf (times)
    *** cells: KB in BMLS
    *** times: 0+ 5+ min
    *** comment: upshift of Tak1 coppt by Tab3 is increased irt Tnf (5 min)
    *** source: 14670075-Fig-4b
  *** Tab2[Ab] copptby[WB] Tab3[Ab] is unchanged irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0+ 3+ 15+ min
    *** comment: coppt Tab2 phos[WBMS] increases with time
    *** source: 14633987-Fig-5b
  *** Tab3[Ab] copptby[WB] Tab2[Ab] is unchanged irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0+ 3+ 15+ min
    *** comment: coppt Tab3 phos[WBMS] increases with time
    *** source: 14633987-Fig-5b
  *** Tab3[Ab] copptby[WB] Tak1[Ab] is unchanged irt Tnf (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0+ 3+ 15+ min
    *** comment: coppt Tab3 phos[WBMS] increases with time
    *** source: 14633987-Fig-5b

============
Tak1-ubiq???
============

  *** Tak1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 10++ 20+ min
    *** comment: coppt Tak1 is ubiq [WBMS]
    *** source: 15175328-Fig-7a


=========
no extras
=========

  *** Tak1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (10 min)
    *** cells: HEK293 in BMS
    *** source: 16115877-Fig-7c
