Azi2--

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** enhanced by: xAzi2 [addition]
    *** reqs: Azi2 [RNAi]
    *** source: 14560022-Fig-5b,7b

Bag4--

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** repressed by: Bag4 [AntiSense]
    *** source: 9915703-Table-1

Bcl3-- ???

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: MCF7 in BMS
    *** bkg reqs: Bcl3 [AntiSense]
    *** source: 16280327-Fig-10

Bcl10-- ???

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: MCF7 in BMS
    *** bkg reqs: Bcl10 [AntiSense]
    *** source: 16280327-Fig-10
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: RAW2647 in BMS
    *** does not req: Bcl10 [RNAi]
    *** source: 15213237-Fig-3b,4a,5b
  *** Nfkb-reporter[Luc] is increased irt Tnf (30 min)
    *** cells: RAW2647 in BMS
    *** unaffected by: xBcl10(L41Q/G78R)"oligo-mut" [addition]
    *** source: 16831874-Fig-6b,8b
  *** Nfkb-reporter[Luc] is increased irt Tnf (60 min)
    *** cells: mEFs in BMS "treated with CHX"
    *** does not req: Bcl10 [KO]
    *** source: 17095601-Fig-1d

Ciap1--

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** unaffected by: xCiap1 [addition]
    *** partially inhibited by: xCiap1(1-570)"del-RING" [addition]
    *** inhibited by: xCiap1(C605A) [addition]
    *** source: 12867425-Fig-4a
  *** Nfkb-reporter[Luc] is increased irt Tnf (3 hr)
    *** cells: mEFs<Ciap2~null> in BMS
    *** partially reqs: Ciap1 [RNAi]
    *** source: 18621737-Fig-S1
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: C2C12 in BMS
    *** partially reqs: Ciap1 [RNAi]
    *** source: 18697935-Fig-2c

not Xiap--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** does not req: Xiap [KO]
    *** source: 20932476-Fig-7b

not Btrc--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (tnr)
    *** cells: HEK293 in BMS "nuclear-extracts"
    *** unaffected by: xBtrc [addition]
    *** source: 10075690-Fig-1b

not Casp9--

  *** Nfkb-reporter[Luc] is increased irt Tnf (2 hr)
    *** cells: HEK293T in BMS
    *** unaffected by: xCasp9(C287S)"Caspase-inactive-mut" [addition]
    *** source: 10880512-Fig-5d

Cbp--  ???

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: mEFs<xRela> in BMS
    *** enhanced by: xCbp [addition]
    *** source: 12881425-Fig-8a

Cebpb--

  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: mSPImacs in BMS
    *** partially reqs: Cebpb [KO]
    *** source: 19733238-Fig-1a

inhibition by Cezanne--

  *** Nfkb-reporter[Luc] is increased irt Tnf (16 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xCezanne [addition]
    *** partially inhibited by: xCezanne(C209S) [addition]
    *** source: 18178551-Fig-3a
  *** Nfkb-reporter[Luc] is increased irt Tnf (16 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xCezanne [addition]
    *** unaffected by: xCezanne(C209S) [addition]
    *** source: 18178551-Fig-3a
  *** Nfkb-reporter[Luc] is increased irt Tnf (16 hr)
    *** cells: HEK293 in BMS
    *** repressed by: Cezanne [RNAi]
    *** source: 18178551-Fig-2d

Csnk1a1--

  *** Nfkb-reporter[Luc] is increased irt Tnf (10 hr)
    *** cells: HELA in BMS
    *** enhanced by: xCsnk1a1 [addition]
    *** partially inhibited by: xCsnk1a1(K46A)"KD" [addition]
    *** source: 18067272-Fig-1

inhibition by Cyld--

  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xCyld [addition]
    *** source: 12917691-Fig-4a
  *** Nfkb-reporter[Luc] is increased irt Tnf (24 hr)
    *** cells: U2OS in BMS
    *** repressed by: Cyld [RNAi]
    *** source: 12917690-Fig-1e
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: HEK293 in BMS
    *** partially inhibited by: xCyld [addition]
    *** unaffected by: xCyld(mnr)"CIA" [addition]
    *** source: 20932476-Fig-5f


Erc1--  ????

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 30+ 60++ min
    *** reqs: Erc1 [RNAi]
    *** source: 15218148-Fig-3a
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: HELA in BMS
    *** reqs: Erc1 [RNAi]
    *** source: 15218148-Fig-3c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** does not req: Erc1 [KO]
    *** source: 20932476-Fig-3e

not Fadd--

  *** Nfkb-reporter[Luc] is increased irt Tnf (3 hr)
    *** cells: HELA in BMS
    *** does not req: Fadd [RNAi]
    *** source: 16940186-Fig-S1a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xFadd(80-205)"DN" [addition]
    *** source: 8565075-Fig-8

not Foxp3--

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xFoxp3 [addition]
    *** source: 15790681-Fig-2a

not Hdac1--

  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: HEK293T in BMS
    *** unaffected by: xHdac1 [addition]
    *** source: 11533489-Fig-1a

not Hdac2--

  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: HEK293T in BMS
    *** unaffected by: xHdac2 [addition]
    *** source: 11533489-Fig-1a

not Hdac3--

  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xHdac3 [addition]
    *** source: 11533489-Fig-1a

not Hdac4--

  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: HEK293T in BMS
    *** unaffected by: xHdac4 [addition]
    *** source: 11533489-Fig-1a

not Hdac5--

  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: HEK293T in BMS
    *** unaffected by: xHdac5 [addition]
    *** source: 11533489-Fig-1a

not Hdac6--

  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: HEK293T in BMS
    *** unaffected by: xHdac6 [addition]
    *** source: 11533489-Fig-1a

Ikba--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS "on gelatin"
    *** times: 0 15++ 60++ 120++ min
    *** partially reqs: Ikba [KO]
    *** comment: Ikba is required at 15 min only
    *** source: 14636585-Fig-1a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: mEFs in BMS
    *** partially reqs: Ikba [KO]
    *** source: 11416149-Fig-1b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10++ 25++ 40++ 55+ 70+ min
    *** comment: Tnf was removed after the first 10 min
    *** comment: the decrease at 55-70 min does not occur in Ikba-null mEFS
    *** source: 11416149-Fig-3a
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xIkba(S32A/S36A) [addition]
    *** source: 11087742-Fig-5a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xIkba(mnr)"DN" [addition]
    *** source: 10692572-Fig-4

Ikk1--  ???

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 2 5 10+ 20++ 60+++ min
    *** bkg reqs: Ikk1 [RNAi]
    *** source: 12547194-Fig-1b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (20 min)
    *** cells: mEFs in BMS
    *** does not req: Ikk1 [KO]
    *** source: 11733537-Fig-3b
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xIkk1(K44A)"KD" [addition]
    *** source: 11087742-Fig-5a
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: HELA in BMS
    *** unaffected by: xIkk1 [addition]
    *** bkg inhibited by: xIkk1(mnr)"KD" [addition]
    *** source: 11864612-Fig-1a
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: mEFs in BMS
    *** bkg reqs: Ikk1 [KO]
    *** source: 11733537-Fig-1b
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: mEFs in BMS
    *** does not req: Ikk1 [KO]
    *** source: 10783893-Fig-3d

Ikk2--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (20 min)
    *** cells: mEFs in BMS
    *** reqs: Ikk2 [KO]
    *** source: 11733537-Fig-3b
  *** Nfkb-reporter[Luc] is increased irt Tnf (15 min)
    *** cells: mEFs in BMS
    *** reqs: Ikk1 and/or Ikk2 [DKO]
    *** source: 15073170-Fig-3a
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xIkk2(K44A)"KD" [addition]
    *** source: 11087742-Fig-5a
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: HELA in BMS
    *** enhanced by: xIkk2 [addition]
    *** bkg inhibited by: xIkk2(mnr)"KD" [addition]
    *** source: 11864612-Fig-1a
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: mEFs in BMS
    *** bkg reqs: Ikk2 [KO]
    *** source: 11733537-Fig-1b
  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: THP1 in BMS
    *** partially inhibited by: xIkk2(K44M)"KD" [addition]
    *** source: 9804806-Fig-6
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xIkk2(K44M)"DN" [addition]
    *** source: 15213237-Fig-3b,4a,5b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 2 5 10+ 20++ 60+++ min
    *** partially reqs: Ikk2 [RNAi]
    *** source: 12547194-Fig-1d
  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xIkk2(K44M)"KD" [addition]
    *** source: 15590691-Fig-5c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: HEK293 in BMS
    *** partially inhibited by: xIkk2(mnr)"KM" [substitution]
    *** partially inhibited by: xIkk2(S177A/S181A) [substitution]
    *** source: 12138192-Fig-2b
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: mEFs in BMS
    *** partially reqs: Ikk2 [KO]
    *** source: 10783893-Fig-3d
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xIkk2(mnr)"KD" [addition]
    *** source: 10783893-Fig-3e


Ikks--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5 20+ min
    *** reqs: Ikk1 and/or Ikk2 [DRNAi]
    *** source: 12547194-Fig-3b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15++ 60+ 120+ min
    *** reqs: Ikk1 and/or Ikk2 [DKO]
    *** source: 10898787-Fig-2a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: mEFs in BMS
    *** reqs: Ikk1 and/or Ikk2 [KO]
    *** comment: Rela is highly upregulated in Ikk1/Ikk2 DKO cells
    *** source: 12138192-Fig-2c
  *** Nfkb-reporter[Luc] is increased irt Tnf (tnr)
    *** cells: mEFs in BMS
    *** reqs: Ikk1 and/or Ikk2 [KO]
    *** source: 12138192-Fig-2d

not Ipaf--

  *** Nfkb-reporter[Luc] is increased irt Tnf (24 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xIpaf [addition]
    *** source: 15107016(D)

not Irak1--  ???

  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: HEK293 in BMS
    *** does not req: Irak1 [null-mut]
    *** source: 10373513-Fig-3b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: HEK293 in BMS
    *** partially reqs: Irak1 [null-mut]
    *** source: 10373513-Fig-3a
  *** Nfkb-reporter[Luc] is increased irt Tnf (20 hr)
    *** cells: EL4 in BMS
    *** unaffected by: xIrak1 [addition]
    *** unaffected by: xIrak1(K239S)"KD" [addition]
    *** source: 10217414-Fig-2

not Irka4--

  *** Nfkb-reporter[Luc] is increased irt Tnf (8 hr)
    *** cells: mEFs in BMS
    *** unaffected by: xIrak4(K213A/K214A) [addition]
    *** source: 17337443-Fig-4a

not Lyk--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: JCam1 in BMS "Syk and Lck deficient"
    *** times: 0 5 10+ 15++ 30+++ 60+++ min
    *** unaffected by: xLck [addition]
    *** source: 15240695-Fig-4b

not Malt1--

  *** Nfkb-reporter[Luc] is increased irt Tnf (30 min)
    *** cells: RAW2647 in BMS
    *** does not req: Malt1 [RNAi]
    *** source: 16831874-Fig-6b,8b
  *** Nfkb-reporter[Luc] is increased irt Tnf (60 min)
    *** cells: mEFs in BMS "treated with CHX"
    *** does not req: Malt1 [KO]
    *** source: 17095601-Fig-1d

not Map4k5--

  *** Nfkb-reporter[CAT] is increased irt Tnf (12 hr)
    *** cells: HEK293T in BMS
    *** partially inhibited by: xMap4k5 [addition]
    *** unaffected by: xMap4k5(T178A)"DN" [addition]
    *** source: 9405407-Fig-5

not Mavs--

  *** Nfkb-reporter[Luc] is increased irt Tnf (8 hr)
    *** cells: HEK293 in BMS
    *** does not req: Mavs [RNAi]
    *** source: 16153868-Fig-6c

not Mekk1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mESCs in BMS
    *** times: 0 10 30+ 60+ min
    *** unaffected by: kMekk1(1-1188)"del-kinase-domain" [addition]
    *** source: 10805784-Fig-3b

Mekk2--  at later times

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS "on gelatin"
    *** times: 0 15++ 60++ 120++ min
    *** comment: reqs Mekk2 [RNAi] at 60,120 min not 15 min
    *** source: 14636585-Fig-6a

Mekk3-- but not kinase activity

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS "on gelatin"
    *** times: 0 15++ 60++ 120++ min
    *** comment: partially reqs Mekk3 [KO] at 15 and 60 min
    *** source: 14636585-Fig-1a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 2 10+ 30+ min
    *** reqs: Mekk3 [KO]
    *** source: 11429546-Fig-1b
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** unaffected by: xMekk3(S526A/K391M)"KD" [addition]
    *** source: 18206350-Fig-3a
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: HELA<xMekk3> in BMS
    *** enhanced by: xMekk3(T294A) [substitution]
    *** source: 18308725-Fig-7b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs<Mekk3~null><xMekk3> in BMS
    *** times: 0 10+ 30+ min
    *** reqs: xMekk3 [omission]
    *** source: 11429546-Fig-2b
  *** Nfkb-reporter[Luc] is increased irt Tnf (12 hr)
    *** cells: mEFs in BMS
    *** reqs: Mekk3 [KO]
    *** source: 11429546-Fig-1d
  *** Nfkb-reporter[Luc] is increased irt Tnf (12 hr)
    *** cells: mEFs<Mekk3~null><xMekk3> in BMS
    *** inhibited by: xMekk3(mnr)"KD" [substitution]
    *** source: 11429546-Fig-2c
  *** Nfkb-reporter[Luc] is increased irt Tnf (12 hr)
    *** cells: mEFs<Mekk3~null><xMekk3> in BMS
    *** reqs: xMekk3 [omission]
    *** source: 11429546-Fig-2c

  --- Mekk2 can substitute for Mekk3 at earlier times

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs<Mekk3~null> in BMS
    *** times: 0 15+ 60+ 120++ min
    *** reqs: Mekk2 [RNAi]
    *** source: 14636585-Fig-1a,6a

not Msk1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 30+ 60+ min
    *** does not req: Msk1 or Msk2 [DKO]
    *** source: 12628924-Fig-8b

not Msk2--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 30+ 60+ min
    *** does not req: Msk1 or Msk2 [DKO]
    *** source: 12628924-Fig-8b

not Myd88--  ???

  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: HEK293 in BMS
    *** does not req: Myd88 [null-mut]
    *** source: 10373513-Fig-3b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (45 min)
    *** cells: hMDMacs in BMS
    *** inhibited by: xMyd88(del(1-53)/F56N)"DN" [addition]
    *** source: 14630816(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS "nuclear fraction"
    *** times: 0 12+ 18+ 60+ min
    *** does not req: Trif or Myd88 [DKO]
    *** source: 12855817-Fig-3e
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xMyd88(F56N)"DN" [addition]
    *** source: 9575168(D)
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293<xTLR4> in BMS
    *** unaffected by: xMyd88(mnr)"TIR-domain" [addition]
    *** source: 11544529-Fig-4c
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: RAW2647 in BMS
    *** unaffected by: xMyd88(mnr)"TIR-domain" [addition]
    *** source: 11544529-Fig-4c
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293<xIL1R1> in BMS
    *** unaffected by: xMyd88(mnr)"TIR" [addition]
    *** source: 10854325-Fig-5a
  ------------------------------------------------------------
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: HEK293 in BMS
    *** partially reqs: Myd88 [null-mut]
    *** source: 10373513-Fig-3a

Nemo--

  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: RAT1 in BMS
    *** reqs: Nemo [null-mut]
    *** source: 11087742-Fig-5b
  *** Nfkb-reporter[Luc] is increased irt Tnf (8 hr)
    *** cells: JM452<Nemo~null><xNemo> in BMS
    *** inhibited by: xNemo(del(393-419))"delZF" [substitution]
    *** inhibited by: xNemo(C417R) [substitution]
    *** source: 12867425-Fig-5a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: mEFs in BMS
    *** reqs: Nemo [KO]
    *** source: 16547522-Fig-3e
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: mEFs<Nemo~null><xNemo> in BMS
    *** reqs: xNemo [omission]
    *** inhibited by: xNemo(L320P) [substitution]
    *** source: 16547522-Fig-3e

not Nik--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5 15+ 30+ 60+ min
    *** does not req: Nik [KO]
    *** source: 11251123-Fig-1a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: mEFs in BMS "immortalized"
    *** does not req: Nik [KO]
    *** source: 11251123-Fig-3c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (8 hr)
    *** cells: T98G in BMS
    *** partially inhibited by: xNik(K429A/K430A)"KD" [addition]
    *** source: 10648614-Fig-9

not Peli2--

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: RAW2647 in BMS
    *** does not req: Peli2 [KO]
    *** does not req: Peli2 [RNAi]
    *** unaffected by: xPeli2(del(1-168))"DN" [addition]
    *** source: 15213237-Fig-3b,4a,5b
  *** Nfkb-reporter[Luc] is increased irt Tnf (30 min)
    *** cells: RAW2647 in BMS
    *** does not req: Peli2 [KO]
    *** unaffected by: xPeli2(del(1-168))"DN" [addition]
    *** source: 15213237-Fig-4b

not Pias1--  inhibitory

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: A549 in BMS
    *** inhibited by: xPias1 [addition]
    *** source: 15657437-Fig-2a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xPias1 [addition]
    *** source: 15657437-Fig-2a

not Pias4--  inhibitory

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xPias4 [addition]
    *** source: 17606919-Fig-1c

not Peli1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (2 hr)
    *** cells: HEK293 in BMS
    *** does not req: Peli1 [RNAi]
    *** source: 12496252-Fig-3b

Pin1--

  *** Nfkb-reporter[Luc] is increased irt Tnf (3 hr)
    *** cells: HELA in BMS
    *** enhanced by: xPin1 [addition]
    *** source: 14690596-Fig-2a
  *** Nfkb-reporter[Luc] is increased irt Tnf (tnr)
    *** cells: mEFs in BMS
    *** partially reqs: Pin1 [KO]
    *** source: 14690596-Fig-5b

Pkcz--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** partially reqs: Pkcz [KO]
    *** source: 11684013-Fig-3c
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: mEFs in BMS
    *** reqs: Pkcz [KO]
    *** source: 11684013-Fig-2b

Pkr--  ???

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30+ 60+ 120+ 240+ min
    *** comment: reqs Pkr [KO] for sustained response at 120 and 240 min
    *** source: 10648614-Fig-3
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (20 min)
    *** cells: mEFs in BMLS "nuclear-extracts"
    *** does not req: Pkr [KO]
    *** source: 11113181-Fig-6a

not Ppp2cb--

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xPpp2cb [addition]
    *** source: 14585847-Fig-5a

Rela--  phos-site requirements

  --- not S276
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (tnr)
    *** cells: mEFs<Rela~null><xRela> in BMS
    *** unaffected by: xRela(S276A) [substitution]
    *** source: 15833743-Fig-6d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (10 min)
    *** cells: mEFs<Rela~null><xRela> in BMS
    *** unaffected by: xRela(S276A) [substitution]
    *** source: 12559944-Fig-3b
  --- S311 for Nfkb-reporter activity but not CBS binding
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (1 hr)
    *** cells: mEFs<Rela~null><xRela> in BMS
    *** unaffected by: xRela(S311A) [substitution]
    *** source: 12881425-Fig-4a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: mEFs<xRela> in BMS
    *** inhibited by: xRela(S311A) [substitution]
    *** source: 12881425-Fig-3b
  --- S529 for reporter activity but not CBS binding
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs<Rela~null><xRela> in BMS
    *** times: 0 5+ 15++ 30++ 60+ 120+ 240+ min
    *** unaffected by: xRela(S529A) [substitution]
    *** source: 9792644-Fig-6a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: mEFs<Rela~null><xRela> in BMS
    *** inhibited by: xRela(S529A) [substitution]
    *** source: 9792644-Fig-6c
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: mEFs<Rela~null><xRela> in BMS
    *** reqs: xRela [omission]
    *** enhanced by: xRela(S468A) [substitution]
    *** source: 16046471-Fig-5b



Ripk1--  ubiq

  *** Nfkb-reporter[Luc] is increased irt Tnf (3 hr)
    *** cells: HELA in BMS
    *** reqs: Ripk1 [RNAi]
    *** source: 16940186-Fig-S1a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** reqs: Ripk1 [KO]
    *** source: 16260783-Fig-3d
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: HEK293T in BMS
    *** partially inhibited by: xRipk1(558-671)"DN" [addition]
    *** source: 11087742-Fig-5a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: NIH3T3 in BMS
    *** inhibited by: xRipk1(559-671)"DN" [addition]
    *** source: 14585990-Fig-5a
  *** Nfkb-reporter[Luc] is increased irt Tnf (12 hr)
    *** cells: mEFs in BMS
    *** reqs: Ripk1 [KO]
    *** source: 12654725-Fig-7a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (tnr)
    *** cells: JURKAT<Pten~null><Ripk1~null><xRipk1> in BMS
    *** reqs: xRipk1 [omission]
    *** partially inhibited by: xRipk1(K305R/K306R) [substitution]
    *** source: 16543241-Fig-3b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: JURKAT<Pten~null> in BMS "nuclear-extracts"
    *** reqs: Ripk1 [KO]
    *** source: 15572679-Fig-2c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: JURKAT<Pten~null> in BMS "nuclear-extracts"
    *** reqs: Ripk1 [KO]
    *** source: 15572679-Fig-3a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: JURKAT<Pten~null> in BMS "nuclear-extracts"
    *** reqs: Ripk1 [KO]
    *** source: 15572679-Fig-5c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS "nuclear-extracts"
    *** times: 0 30+ 60+ 120+ min
    *** reqs: Ripk1 [KO]
    *** source: 15572679-Fig-4a

not Ripk2--

  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: HEK293T in BMS
    *** unaffected by: xRipk2(406-540)"DN" [addition]
    *** source: 11087742-Fig-5a

not Smad7--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: MCF7 in BMS
    *** partially inhibited by: xSmad7 [addition]
    *** source: 17384642-Fig-S2c
  *** Nfkb-reporter[Luc] is increased irt Tnf (18 hr)
    *** cells: HEPG2 in BMS
    *** unaffected by: xSmad7(259-287) [addition]
    *** unaffected by: xSmad7(259-325) [addition]
    *** partially inhibited by: xSmad7(259-355) [addition]
    *** partially inhibited by: xSmad7(259-395) [addition]
    *** partially inhibited by: xSmad7(259-426) [addition]
    *** source: 17384642-Fig-S1b
  *** Nfkb-reporter[Luc] is increased irt Tnf (18 hr)
    *** cells: HEPG2 in BMS
    *** unaffected by: xSmad7(259-287) [substitution]
    *** unaffected by: xSmad7(259-325) [substitution]
    *** partially inhibited by: xSmad7(259-355) [substitution]
    *** partially inhibited by: xSmad7(259-395) [substitution]
    *** partially inhibited by: xSmad7(259-426) [substitution]
    *** source: 17384642-Fig-2e
  *** Nfkb-reporter[Luc] is increased irt Tnf (18 hr)
    *** cells: HEPG2 in BMS
    *** unaffected by: xSmad7(259-325) [substitution]
    *** partially inhibited by: xSmad7(259-426) [substitution]
    *** partially inhibited by: xSmad7((259-426)/S336G/S337G/Y338H) [substitution]
    *** unaffected by: xSmad7((259-426)/N349A/D351G/S352A/T354A) [substitution]
    *** source: 17384642-Fig-2f
  *** Nfkb-reporter[Luc] is increased irt Tnf (18 hr)
    *** cells: MCF7 in BMS
    *** inhibited by: xSmad7 [addition]
    *** source: 17384642-Fig-S2a
  *** Nfkb-reporter[Luc] is increased irt Tnf (18 hr)
    *** cells: MCF7 in BMS
    *** inhibited by: xSmad7 [addition]
    *** source: 17384642-Fig-S2b

not Socs1--

  *** Nfkb-reporter[Luc] is increased irt Tnf (12 hr)
    *** cells: RAW2647 in BMS
    *** unaffected by: xSocs1 [addition]
    *** source: 12433365-Fig-6a

not Stat1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (tnr)
    *** cells: mEFs in BMS
    *** repressed by: Stat1 [KO]
    *** source: 10848577-Fig-5b
  *** Nfkb-reporter[Luc] is increased irt Tnf (tnr)
    *** cells: HEK293 in BMS
    *** inhibited by: xStat1 [addition]
    *** source: 10848577-Fig-5d

Syk--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** enhanced by: xSyk [addition]
    *** source: 15240695-Fig-5b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** partially reqs: Syk [RNAi]
    *** source: 15240695-Fig-5d

Tabs-- ???

not Tab2--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30+ min
    *** does not req: Tab2 [KO]
    *** source: 12556483-Fig-4a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: HEK293 in BMS
    *** does not req: Tab2 [RNAi]
    *** source: 20932476-Fig-S1a

Tab3-- ???

  *** Nfkb-reporter[Luc] is increased irt Tnf (21 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTab3(1-392)"Nterm" [substitution]
    *** inhibited by: xTab3(393-712)"Cterm" [substitution]
    *** source: 14633987-Fig-3b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: HEK293 in BMS
    *** does not req: Tab3 [RNAi]
    *** source: 20932476-Fig-S1a

Tank--

  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: HEK293 in BMS
    *** partially reqs: Tank [RNAi]
    *** source: 16336209-Fig-7a
  *** Nfkb-reporter[Luc] is increased itpo xTank
    *** cells: HEK293<xNemo> in BMS
    *** partially inhibited by: xTank(mnr)"Ikke-binding-mutant" [substitution]
    *** inhibited by: xTank(mnr)"Nterm-Nemo-interaction-site-mutant" [substitution]
    *** inhibited by: xTank(mnr)"Cterm-Nemo-interaction-site-mutant" [substitution]
    *** source: 16336209-Fig-7b

Tak1--

  protein expression

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5 10+ 20+ 60++ 90+ min
    *** reqs: Tak1 [RNAi]
    *** source: 12547194-Fig-4b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 20+ 40+ min
    *** reqs: Tak1 [KO]
    *** does not req: Tab1 [KO]
    *** does not req: Tab2 [KO]
    *** source: 16260493(D)
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** unaffected by: xTak1 [addition]
    *** unaffected by: xTab1 [addition]
    *** source: 18206350-Fig-4c
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** partially reqs: Tak1 [RNAi]
    *** source: 16260783-Fig-1b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: HEK293 in BMS
    *** partially reqs: Tak1 [RNAi]
    *** source: 20932476-Fig-1d

  kinase activity ???

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xTak1(K63W) [addition]
    *** source: 15213237-Fig-3b,4a,5b
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMLS
    *** unaffected by: xTak1(K63W) [addition]
    *** source: 22069318-Fig-4a
  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xTak1(K63W)"KD" [addition]
    *** source: 15590691-Fig-5c

  ubiq site K34 ???

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS "nuclear-extracts"
    *** times: 0 15+ 30++ 60 min
    *** unaffected by: xTak1(K34R) [substitution]
    *** source: 19843958-Fig-2g
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMLS
    *** inhibited by: xTak1(K34R) [addition]
    *** source: 22069318-Fig-4b
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMLS
    *** inhibited by: xTak1(K34R) [addition]
    *** source: 22069318-Fig-4a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: PC3U in BMLS
    *** unaffected by: xTak1 [addition]
    *** inhibited by: xTak1(K34R) [addition]
    *** source: 22069318-Fig-8a

  site K209R

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS "nuclear-extracts"
    *** times: 0 15++ 30++ 60+ min
    *** inhibited by: xTak1(K209R) [substitution]
    *** source: 19843958-Fig-2e

not Tbk1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 1+ 3+ 9+ 27+ 90+ min
    *** does not req: Tbk1 [KO]
    *** source: 10990461-Fig-5b
  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTbk1(K38A) [addition]
    *** source: 10581243-Fig-9a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** unaffected by: xTbk1(K38M)"KD" [addition]
    *** source: 10783893-Fig-3e

not Trif--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS "nuclear fraction"
    *** times: 0 12+ 18+ 60+ min
    *** does not req: Trif or Myd88 [DKO]
    *** source: 12855817-Fig-3e

Ticam2--  ???

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xTicam2(78-171)"DN" [addition]
    *** source: 12721283-Fig-5b
  *** Nfkb-reporter[Luc] is increased irt Tnf (8 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTicam2(C113H)"DN" [addition]
    *** source: 14517278-Fig-5b

not Tifa--

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** unaffected by: xTifa(G50E/S66A) [addition]
    *** source: 12566447-Fig-6a

not Tirap--

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293<xTLR4> in BMS
    *** unaffected by: xTirap(mnr)"TIR-domain" [addition]
    *** source: 11544529-Fig-4c
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: RAW2647 in BMS
    *** unaffected by: xTirap(mnr)"TIR-domain" [addition]
    *** source: 11544529-Fig-4c
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTirap(D198A)"DN" [addition]
    *** source: 17360653(D)

not TLR3--

  *** Nfkb-reporter[Luc] is increased irt Tnf (2 hr)
    *** cells: HEK293<xTLR3> in BMS
    *** does not req: xTLR3 [omission]
    *** unaffected by: xTLR3(346-904) [substitution]
    *** source: 22611194-Fig-5e

inhibition by Tnfaip3--

  *** Nfkb-reporter[Luc] is increased irt Tnf (tnr)
    *** cells: mEFs<Tnfaip3~null> in BMS
    *** source: 15258597-Fig-2f
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xTnfaip3 [addition]
    *** source: 8692885-Fig-4,5
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xTnfaip3 [addition]
    *** source: 15474016-Fig-1d
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HELA in BMS
    *** repressed by: Tnfaip3 [RNAi]
    *** source: 19910467-Fig-S1f
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 20+ 30++ 60+ 90 120 180 min
    *** comment: decrease after 60 min reqs: Tnfaip3 [KO]
    *** source: 11009421-Fig-3a
  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: HEK293<xTLR4><xMd2> in BMS
    *** inhibited by: xTnfaip3 [addition]
    *** source: 21220427-Fig-7b

not Tollip--

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: mEFs in BMS
    *** does not req: Tollip [KO]
    *** source: 16428431(D)
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293<xIL1R1> in BMS
    *** unaffected by: xTollip [addition]
    *** source: 10854325-Fig-5a

Tpl2--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 15+ 20+ min
    *** partially reqs: Tpl2 [KO]
    *** source: 15833743-Fig-1b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 20+ 30++ 40+ 60+ min
    *** partially reqs: Tpl2 [KO]
    *** source: 15833743-Fig-2a
  *** Nfkb-reporter[Luc] is increased irt Tnf (36 hr)
    *** cells: mEFs in BMS
    *** partially reqs: Tpl2 [KO]
    *** source: 15833743-Fig-2c
  *** Nfkb-reporter[Luc] is increased irt Tnf (36 hr)
    *** cells: mEFs in BMS
    *** does not req: Tpl2 [KO]
    *** source: 15670770-Fig-1f
  *** Nfkb-reporter[Luc] is increased itpo xTnfR1
    *** cells: HEK293 in BMS
    *** unaffected by: xTpl2(K167M) [addition]
    *** source: 15670770-Fig-1d

Tradd--

  *** Nfkb-reporter[Luc] is increased irt Tnf (3 hr)
    *** cells: HELA in BMS
    *** partially reqs: Tradd [RNAi]
    *** source: 16940186-Fig-S1a

Traf1-- ???

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xTraf1(162-416)"cleavage-product" [addition]
    *** source: 10692572-Fig-4
  *** Nfkb-reporter[Luc] is increased irt Tnf (8 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTraf1 [addition]
    *** source: 7544915-Fig-2a
  *** Nfkb-reporter[Luc] is increased irt Tnf (16 hr)
    *** cells: CT6 in BMS
    *** unaffected by: xTraf1 [addition]
    *** source: 7544915-Fig-2b

Traf2-- can be substituted by Traf5--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30+ min
    *** does not req: Traf2 [KO]
    *** does not req: Traf5 [KO]
    *** reqs: Traf2 and/or Traf5 [DKO]
    *** source: 11479302-Fig-1a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: HEK293 in BMS
    *** does not req: Traf2 [RNAi]
    *** source: 20932476-Fig-S5d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: HEK293 in BMS
    *** does not req: Traf5 [RNAi]
    *** source: 20932476-Fig-S5d
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xTraf2(mnr)"DN" [addition]
    *** source: 10692572-Fig-4
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HELA in BMS
    *** unaffected by: xTraf2 [addition]
    *** source: 14713952-Fig-3d
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HELA in BMS
    *** unaffected by: xTraf2(C49A/H51A/C54A/C57A) [substitution]
    *** unaffected by: xTraf2(C49A/H51A/C209A/C212A) [substitution]
    *** source: 14713952-Fig-2d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 3 10+ 30+ 90+ min
    *** does not req: Traf2 [KO]
    *** source: 9390694-Fig-6a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: NIH3T3 in BMS
    *** inhibited by: xTraf2(87-501)"DN" [addition]
    *** source: 14585990-Fig-5b
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xTraf2(87-501)"DN" [addition]
    *** source: 8565075-Fig-6a,6b
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xTraf2(87-502)"DN" [addition]
    *** source: 8837778-Fig-3a



Traf3-- ???

  *** Nfkb-reporter[Luc] is increased irt Tnf (8 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTraf3 [addition]
    *** source: 7544915-Fig-2a
  *** Nfkb-reporter[Luc] is increased irt Tnf (16 hr)
    *** cells: CT6 in BMS
    *** unaffected by: xTraf3 [addition]
    *** source: 7544915-Fig-2b

not Traf6--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30+ 90 hr
    *** does not req: Traf6 [KO]
    *** source: 10215628-Fig-5a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** unaffected by: xTraf6(mnr)"DN" [addition]
    *** source: 10692572-Fig-4
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTraf6(289-522)"DN" [addition]
    *** source: 8837778-Fig-3a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (20 min)
    *** cells: mEFs in BMS
    *** times: 0 30++ 60+ min
    *** does not req: Traf6 [KO]
    *** source: 16260598-Fig-6d

Trpc4ap-- ???

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: NIH3T3 in BMS
    *** enhanced by: xTrpc4ap [addition]
    *** source: 14585990-Fig-4a

Ubc13-- ???

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xUbc13(C87A)"DN" [addition]
    *** source: 11057907(D)
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HELA in BMS
    *** unaffected by: xUbc13 [addition]
    *** unaffected by: xUbc13(C87A) [addition]
    *** source: 14713952-Fig-3d

Usps--

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xUsp21 [addition]
    *** unaffected by: xUsp21(C221A)"CIA" [addition]
    *** source: 19910467-Fig-1b
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** partially inhibited by: xUsp1 [addition]
    *** unaffected by: xUsp2 [addition]
    *** partially inhibited by: xUsp3 [addition]
    *** unaffected by: xUsp8 [addition]
    *** unaffected by: xUsp12 [addition]
    *** partially inhibited by: xUsp13 [addition]
    *** partially inhibited by: xUsp15 [addition]
    *** unaffected by: xUsp16 [addition]
    *** enhanced by: xUsp18 [addition]
    *** enhanced by: xUsp20 [addition]
    *** partially inhibited by: xUsp21 [addition]
    *** unaffected by: xUsp22 [addition]
    *** partially inhibited by: xUsp25 [addition]
    *** unaffected by: xUsp26 [addition]
    *** partially inhibited by: xUsp28 [addition]
    *** unaffected by: xUsp30 [addition]
    *** unaffected by: xUsp33 [addition]
    *** partially inhibited by: xUsp36 [addition]
    *** partially inhibited by: xUsp37 [addition]
    *** partially inhibited by: xUsp39 [addition]
    *** unaffected by: xUsp40 [addition]
    *** partially inhibited by: xUsp42 [addition]
    *** unaffected by: xUsp44 [addition]
    *** unaffected by: xUsp46 [addition]
    *** unaffected by: xUsp47 [addition]
    *** unaffected by: xUsp48 [addition]
    *** unaffected by: xUsp49 [addition]
    *** unaffected by: xPan2 [addition]
    *** unaffected by: xUsp54 [addition]
    *** unaffected by: xUspl1 [addition]
    *** source: 19910467-Fig-1a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293T in BMS
    *** partially inhibited by: xUsp21 [addition]
    *** source: 19910467-Fig-1a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HELA in BMS
    *** partially repressed by: Usp21 [RNAi]
    *** source: 19910467-Fig-4c
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HELA in BMS
    *** repressed by: Usp21 [RNAi]
    *** source: 19910467-Fig-S1f


not Zfand5--

  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xZfand5 [addition]
    *** source: 14754897-Fig-4a

=========
chemicals
=========

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (20 min)
    *** cells: HEK293 in BMS
    *** inhibited by: Bay117082 [pretreatment]
    *** source: 12138192-Fig-2a
  *** Nfkb-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: HEK293T in BMS
    *** enhanced by: TrichostatinA [addition]
    *** source: 11533489-Fig-1a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** partially inhibited by: BD-FMK [addition]
    *** source: 10753878-Fig-4b
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HELA in BMS
    *** partially inhibited by: BD-FMK [addition]
    *** source: 10753878-Fig-4b
  *** Nfkb-reporter[Luc] is increased irt Tnf (tnr)
    *** cells: HELA in BMS
    *** inhibited by: Geldanamycin [addition]
    *** source: 11864612-Fig-5b
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: U937 in BMS
    *** unaffected by: Z-FA-FMK [pretreatment]
    *** source: 23255358-Fig-2g
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 5 10 15+ 30++ 60++ min
    *** bkg inhibited by: Piceatannol [addition]
    *** source: 15240695-Fig-4a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30+ min
    *** unaffected by: Ro318220 [addition]
    *** unaffected by: Bisindolylmaleimide-V [addition]
    *** source: 15833743-Fig-6d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: L929SA in BMS
    *** unaffected by: SB203580 [addition]
    *** unaffected by: PD98059 [addition]
    *** unaffected by: H89 [addition]
    *** source: 12628924-Fig-2a
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: hUVECs in BMS
    *** inhibited by: Ebselen [pretreatment]
    *** source: 14720501-Fig-6b
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMLS
    *** inhibited by: Cl-Radicicol-A [pretreatment]
    *** source: 22069318-Fig-4b
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: LMB [cotreatment]
    *** source: 10655476-Fig-1c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: HELA in BMS "nuclear-extracts"
    *** inhibited by: ALLN [pretreatment]
    *** inhibited by: LMB [pretreatment]
    *** source: 10655476-Fig-1b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: HELA in BMS "nuclear-extracts"
    *** inhibited by: LMB [pretreatment]
    *** inhibited by: SN50 [pretreatment]
    *** source: 10655476-Fig-6b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: PC3 in BMS "nuclear-extracts"
    *** inhibited by: LMB [pretreatment]
    *** comment: inhibition by LMB does not work if added after cell lysis
    *** source: 10655476-Fig-1a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: mEFs in BMS
    *** partially inhibited by: LMB [pretreatment]
    *** partially inhibited by: MG132 [pretreatment]
    *** source: 11416149-Fig-1b


=====
Other
=====

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: HELA in BMS "nuclear-extras"
    *** times: 0 3+ 5++ 10++ min
    *** comment: partially inhibited by prestim with Egf for 10 min
    *** comment: inhibition corelates with inhibition of Rela in nuclear extract
    *** source: 19393267-Fig-6c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: HELA in BMS "enucleated before treatment"
    *** unaffected by: LMB [pretreatment]
    *** source: 10655476-Fig-2a


=========
no extras
=========

  *** Nfkb-reporter[Luc] is increased irt Tnf (7 hr)
    *** cells: NIH3T3 in BMLS
    *** source: 9006902-Fig-5
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** source: 10022904-Fig-8
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** source: 10346818-Fig-2d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (tnr)
    *** cells: HEK293 in BMS
    *** source: 8837778-Fig-2a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HEK293 in BMS
    *** source: 10075690-Fig-1b
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: HELA in BMS
    *** source: 9819420-Fig-1b
  *** Nfkb-reporter[Luc] is increased irt Tnf (8 hr)
    *** cells: HEK293 in BMS
    *** source: 7544915-Fig-3a
  *** Nfkb-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: MCF7 in BMS
    *** source: 16280327-Fig-10
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (1 hr)
    *** cells: HEK293 in BMS "nuclear-extracts"
    *** source: 7544915-Fig-1
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 10+ 30+ 90+ min
    *** source: 11533489-Fig-3c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30+ min
    *** source: 16186825(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: THP1 in BMS
    *** times: 0 3 5+ 10++ 30++ min
    *** source: 10477696-Fig-6b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: hUVECs in BMS
    *** times: 0 3+ 8+ hr
    *** source: 7520526-Fig-3a
  *** Nfkb-reporter[Luc] is increased irt Tnf (4 hr)
    *** cells: HELA in BMS
    *** source: 18308725-Fig-7b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: SAOS2 in BMS
    *** source: 15073170-Fig-2b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: HELA in BMS
    *** source: 12138192-Fig-1a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: T98G in BMS
    *** times: 0 12 30+ 60+ 120+ 240+ min
    *** source: 10648614-Fig-1b



