  *** Mekk3[Ab]IP phos(T294)[phosAb] is decreased irt Tnf (30 min)
    *** cells: RAW2647 in BMS
    *** source: 18308725-Fig-5c
  *** Mekk3[Ab]IP phos(T294)[phosAb] is decreased irt Tnf (times)
    *** cells: RAW2647 in BMS
    *** times: 0+++ 5++ 20+ 60+++ min
    *** source: 18308725-Fig-5c

Hypothesis:
Mekk3 phos on T294 increases binding with Ywhas
release of Mekk3 from Ywhas could allow Mekk3 to join TnfR1 complex
a coppt experiment between Mekk3-TnfR1 would be helpful here

================
Coprecipitations
================

Ikba--  reqs Mekk3 kinase activity, Ikk2, Nemo  not Ikk1

  *** Ikba[Ab] copptby[WB] xMekk3[tAb] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** inhibited by: xMekk3(K391M)"KD" [substitution]
    *** source: 14636585(D)
  *** Ikba[Ab] copptby[WB] Mekk3[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** reqs: Ikk2 [KO]
    *** reqs: Nemo [KO]
    *** does not req: Ikk1 [KO]
    *** source: 14636585-Fig-2c

Ikk1--  reqs Ikba,Ikk2

  *** Mekk3[Ab] copptby[WB] Ikk1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** reqs: Ikba [KO]
    *** source: 14636585-Fig-2f
  *** Mekk3[Ab] copptby[WB] Ikk1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** reqs: Ikk2 [KO]
    *** source: 14636585-Fig-2f

Ikk2--  reqs Ikba, Nemo, not Ikk1
        does not req Ikk2-phos-sites (S177/S181)
        does not req Ikk2-kinase activity

  *** Mekk3[Ab] copptby[WB] Ikk2[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** reqs: Nemo [KO]
    *** source: 14636585-Fig-2d
  *** Mekk3[Ab] copptby[WB] Ikk2[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** does not req: Ikk1 [KO]
    *** source: 14636585-Fig-2d
  *** Mekk3[Ab] copptby[WB] xIkk2[tAb] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** reqs: Ikba [KO]
    *** source: 14636585-Fig-2e
  *** Mekk3[Ab] copptby[WB] xIkk2[tAb] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** unaffected by: xIkk2(K44M)"KD" [substitution]
    *** source: 14636585-Fig-4b
  *** Mekk3[Ab] copptby[WB] xIkk2[tAb] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** unaffected by: xIkk2(K44M)"KD" [substitution]
    *** unaffected by: xIkk2(K44M/S177A/S181A) [substitution]
    *** unaffected by: xIkk2(K44M/S177E/S181E) [substitution]
    *** source: 14636585-Fig-4c
  *** Mekk3[Ab] copptby[WB] Ikk2[Ab] is increased irt Tnf (times)
    *** cells: mEFs in BMS "on gelatin"
    *** times: 0 5+ 15 min
    *** source: 14636585-Fig-3a
  *** Mekk3[Ab] copptby[WB] Ikk2[Ab] is increased irt Tnf (times)
    *** cells: mEFs in BMS "on gelatin"
    *** times: 0 2+ 5+ 15 min
    *** source: 14636585-Fig-3c

Rela--  reqs Mekk3 kinase-activity and Ikba

  *** Mekk3[Ab] copptby[WB] Rela[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** reqs: Ikba [KO]
    *** source: 14636585(D)
  *** Rela[Ab] copptby[WB] xMekk3[tAb] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** inhibited by: xMekk3(K391M)"KD" [substitution]
    *** source: 14636585(D)

Ripk1--

  *** Ripk1[Ab] copptby[WB] Mekk3[Ab] is increased irt Tnf (times)
    *** cells: HEK293T in BMS
    *** times: 0 10+ 30+ 60+ min
    *** source: 14585994-Fig-4e

Tak1--

  *** Tak1[Ab] copptby[WB] xMekk3[tAb] is unchanged irt Tnf (15 min)
    *** cells: HEK293T in BMS
    *** source: 18206350-Fig-1c
  *** xMekk3[tAb] copptby[WB] xTak1[Ab] is unchanged irt Tnf (10 min)
    *** cells: HEK293T in BMS
    *** source: 18206350-Fig-6a

