============
Ikk1 to TnfR
=============

Nemo--

  *** Ikk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** reqs: Nemo [KO]
    *** source: 16547522-Fig-5a

not Ripk1--

  *** Ikk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** does not req: Ripk1 [KO]
    *** source: 10795740-Fig-4b
  *** Ikk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** does not req: Ripk1 [KO]
    *** source: 10795740-Fig-4a

Traf2--

  *** Ikk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** reqs: Traf2 [KO]
    *** source: 10795740-Fig-4a
  *** Ikk1[Ab] copptby[WB] TnfR1[Ab] is unchanged irt Tnf (5 min)
    *** cells: mEFs<Traf2~null><xTraf2(87-501)> in BMS
    *** source: 10795740-Fig-5

coppt by other members of TnfR1 complex

Traf2--

  *** Ikk1[Ab] copptby[WB] Traf2[Ab] is increased irt Tnf (5 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** does not req: Ripk1 [KO]
    *** source: 10795740-Fig-4c

Tak1--

  *** Ikk1[Ab] copptby[WB] Tak1[Ab] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** source: 12547194-Fig-5b

Tax1bp1--

  *** xIkk1[tAb] copptby[WB] Tax1bp1[Ab] is increased irt Tnf (15 min)
    *** cells: mEFs<Ikk1~null><xIkk1> in BMS
    *** inhibited by: xIkk1(K44M)"KD" [substitution]
    *** source: 21765415-Fig-1g

Ikk1 goes where Nemo goes irt Tnf

  *** Ikk1[Ab] copptby[WB] Nemo[Ab] is unchanged irt Tnf (5 min)
    *** cells: HEK293T in BMS
    *** source: 12867425-Fig-4h

no extras

  *** Ikk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: HELAS3 in BMS
    *** times: 0 2+++ 5+++ 10+++ 15++ 30+ min
    *** source: 10755617(D)
  *** Ikk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** source: 10795740-Fig-5
  *** Ikk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 2+ 5+ 10+ min
    *** source: 10795740-Fig-6b

============
Ikk2 to TnfR
============

Nemo--

  *** Ikk2[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 2+ 5+ min
    *** reqs: Nemo [KO]
    *** source: 16603398-Fig-5c
  *** Ikk2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** reqs: Nemo [KO]
    *** source: 16547522-Fig-5a

Ripk1--  ????

  *** Ikk2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** does not req: Ripk1 [KO]
    *** source: 10795740-Fig-4a

  ---  contradiction possibly due to Tnf also binding to TnfR2 ----

  *** Ikk2[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 2+ 5+ min
    *** reqs: Ripk1 [KO]
    *** source: 16603398-Fig-4a
  *** Ikk2[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null><Ripk1~null><xRipk1> in BMS
    *** times: 0 2+ 5+ min
    *** inhibited by: xRipk1(K377R)"Ubiq-deficient-mut" [substitution]
    *** source: 16603398-Fig-4a

not Tab2-- and/or Tab3--

  *** Ikk2[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: HEK293 in BMS
    *** times: 0 5+ 10+ min
    *** does not req: Tab2 or Tab3 [DRNAi]
    *** source: 16603398-Fig-5d

not Tak1--

  *** Ikk2[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: HEK293 in BMS
    *** times: 0 5+ 10+ min
    *** does not req: Tak1 [RNAi]
    *** source: 16603398-Fig-5d

Traf2--

  *** Ikk2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** reqs: Traf2 [KO]
    *** source: 10795740-Fig-4a

Ikk2 goes where Nemo goes irt Tnf

  *** Ikk2[Ab] copptby[WB] Nemo[Ab] is unchanged irt Tnf (5 min)
    *** cells: HEK293T in BMS
    *** source: 12867425-Fig-4h

coppt by other members of TnfR1 complex

  *** Ikk2[Ab] copptby[WB] Tak1[Ab] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** source: 12547194-Fig-5b
  *** Ikk2[Ab] copptby[WB] Traf2[Ab] is increased irt Tnf (5 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** does not req: Ripk1 [KO]
    *** source: 10795740-Fig-4c

no extras

  *** Ikk2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (10 min)
    *** cells: HELAS3 in BMS
    *** source: 10755617(D)
  *** Ikk2[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** inhibited by: Geldanamycin [addition]
    *** source: 11864612-Fig-6c

============
Nemo to TnfR
============

Tradd--

  *** Nemo[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 30++ 60++ min
    *** partially reqs: Tradd [KO]
    *** source: 18641654-Fig-1e

Nemo to TnfR1 requires Nemo capable of binding to K48Ubiq chains

  *** xNemo[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 5+ 10+ min
    *** inhibited by: xNemo(Y308S)"Ubiq-binding-mut" [substitution]
    *** source: 16603398-Fig-7g

Nemo and Ciap1 probably relocate to TnfR1 together

  *** Nemo[Ab] copptby[WB] Ciap1[Ab] is unchanged irt Tnf (10 min)
    *** cells: HEK293T in BMS
    *** source: 12867425-Fig-4d

coppt by other members of TnfR1 complex

Ripk1--  K63-ubiquitinated

  *** Nemo[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 2+ 5+ min
    *** reqs: Ripk1 [KO]
    *** source: 16603398-Fig-4a
  *** Nemo[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null><Ripk1~null><xRipk1> in BMS
    *** times: 0 2+ 5+ min
    *** inhibited by: xRipk1(K377R)"Ubiq-deficient-mut" [substitution]
    *** source: 16603398-Fig-4a

  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (10 min)
    *** cells: HELAS3 in BMS
    *** source: 10755617(D)
  *** Ripk1[Ab] copptby[WB] xNemo[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs<Nemo~null> in BMS
    *** comment: coppt Ripk is ubiq [WBMS]
    *** inhibited by: xNemo(L320P) [substitution]
    *** source: 16547522-Fig-4g
  *** Ripk1[Ab] snaggedby[WB] rNemo[GST] is increased irt Tnf (5 min)
    *** cells: mEFs<Nemo~null> in BMS
    *** inhibited by: rNemo(L320P) [substitution]
    *** comment: coppt Ripk is ubiq [WBMS]
    *** source: 16547522-Fig-4a
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: HEK293T in BMS
    *** times: 0 5+ 10+ min
    *** does not req: Rnf31 [RNAi]
    *** source: 19854138-Fig-S8
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: HEK293T in BMS
    *** times: 0 5+ 10++ min
    *** partially reqs: Ube2ds [RNAi]
    *** source: 19854138-Fig-S4c
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 10+ 15+ min
    *** reqs: Ube2ds [RNAi]
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-5a
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 10+ 15+ min
    *** reqs: Ubiq [RNAi]
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-6a,6c
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 10+ min
    *** partially inhibited by: SmacMimetic [addition]
    *** source: 19854138-Fig-7a
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 10++ 15+ min
    *** does not req: Ubc13 [RNAi]
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-5d
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: U2OS<Ube2ds~null><xUbe2d3> in BMS
    *** times: 0 5+ 10+ min
    *** inhibited by: xUbe2d3(C85A) [substitution]
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-5c
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: U2OS<Ubiq~null><xUbiq(K6R/K63R)> in BMS
    *** times: 0 5+ 10+ min
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-S7
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: U2OS<Ubiq~null><xUbiq(K11R)> in BMS
    *** times: 0 5+ 10+ min
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-S6
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: U2OS<Ubiq~null><xUbiq(K11R/K63R)> in BMS
    *** times: 0 5+ 10+ min
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-S7
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: U2OS<Ubiq~null><xUbiq(K27R)> in BMS
    *** times: 0 5+ 10+ min
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-S6
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: U2OS<Ubiq~null><xUbiq(K29R)> in BMS
    *** times: 0 5+ 10+ min
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-S6
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: U2OS<Ubiq~null><xUbiq(K33R)> in BMS
    *** times: 0 5+ 10+ min
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-S6
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: U2OS<Ubiq~null><xUbiq(K63R)> in BMS
    *** times: 0 5+ 10+ min
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** comment: coppt Ripk1 can be ubiquitinated by non-K63-linked Ubiq (Fig-6e,6f)
    *** source: 19854138-Fig-6c
  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: U2OS<Ubiq~null><xUbiq(K63R)> in BMS
    *** times: 0 5+ 10+ min
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-S6

no extras

  *** Nemo[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** source: 10795740-Fig-4d
  *** Nemo[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (10 min)
    *** cells: HELAS3 in BMS
    *** source: 10755617(D)

