======================================================
Components required for increase in Ikba phos irt Tnf
======================================================

not Azi2--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 10+ 30+ min
    *** does not req: Azi2 [RNAi]
    *** source: 14560022-Fig-7c

Ciap1-- and/or Ciap2--

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (5 min)
    *** cells: C2C12 in BMS
    *** does not req: Ciap2 [RNAi]
    *** partially reqs: Ciap1 [RNAi]
    *** partially reqs: Ciap1 and/or Ciap2 [RNAi]
    *** source: 18697935-Fig-S3b
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** does not req: Ciap1 [RNAi]
    *** does not req: Ciap2 [RNAi]
    *** partially reqs: Ciap1 and/or Ciap2 [RNAi]
    *** source: 18697935-Fig-3a
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (5 min)
    *** cells: mEFs<Ciap1~null> in BMS
    *** reqs: Ciap2 [RNAi]
    *** source: 18697935-Fig-S3a
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (times)
    *** cells: HEK293T in BMS
    *** times: 0 2+ 5++ min
    *** partially reqs: Ciap1 [RNAi]
    *** source: 12867425-Fig-4j

inhibited by: Cezanne--

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** partially inhibited by: xCezanne [addition]
    *** unaffected by: xCezanne(C209S) [addition]
    *** source: 18178551-Fig-4d

Erc1--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 7+ 15+ min
    *** reqs: Erc1 [RNAi]
    *** source: 15218148-Fig-2b

Ikk1-- and/or Ikk2--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** does not req: Ikk1 [KO]
    *** source: 12759443(D)
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** reqs: Ikk2 [KO]
    *** source: 12759443(D)
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 2 5++ 10++ 20+ 60+ min
    *** partially reqs: Ikk1 [RNAi]
    *** source: 12547194-Fig-1a
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 2 5++ 10++ 20+ 60+ min
    *** partially reqs: Ikk2 [RNAi]
    *** source: 12547194-Fig-1c
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** reqs: Ikk1 and/or Ikk2 [DRNAi]
    *** source: 12547194-Fig-3a
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 10 30 min
    *** does not req: Ikk1 [KO]
    *** partially reqs: Ikk2 [KO]
    *** source: 12759443-Fig-2b

not Irak3--

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 20 60+ min
    *** does not req: Irak3 [KO]
    *** source: 12150927-Fig-4c

not Mekk2--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS "on gelatin"
    *** times: 0 15+ 60 120 min
    *** does not req: Mekk2 [RNAi]
    *** source: 14636585(D)

Mekk3--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS "on gelatin"
    *** times: 0 15+ 60 120 min
    *** reqs: Mekk3 [KO]
    *** source: 14636585(D)

Muc1--

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (30 min)
    *** cells: MCF10A in BMS "cytoplasmic fraction"
    *** reqs: Muc1 [RNAi]
    *** source: 18037881-Fig-4b
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (30 min)
    *** cells: mMECs in BMS "cytoplasmic fraction"
    *** reqs: Muc1 [RNAi]
    *** source: 18037881-Fig-4c

Nemo--     Nemo-Ubiq-binding domain

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null><xNemo> in BMS
    *** times: 0 5+ 10+ min
    *** inhibited by: xNemo(Y308S)"Ubiq-binding-mut" [substitution]
    *** source: 16603398-Fig-7g
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (times)
    *** cells: JM452<Nemo~null><xNemo> in BMS
    *** times: 0 2+ 5++ 10++ min
    *** inhibited by: xNemo(C417R) [substitution]
    *** source: 12867425-Fig-5c
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (5 min)
    *** cells: JM452<Nemo~null><xNemo> in BMS
    *** times: 0 2+ 5++ 10++ min
    *** reqs: xNemo [omission]
    *** source: 12867425-Fig-5c

not Nik--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (tbg)
    *** cells: mEFs in BMS
    *** does not req: Nik [KO]
    *** source: 11238593(D)

Ripk1--

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 2+ 5++ min
    *** reqs: Ripk1 [KO]
    *** source: 16260783-Fig-3e
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 2+ 5++ min
    *** reqs: Ripk1 [KO]
    *** source: 16603398-Fig-4a

  Ripk1-ubiq

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null><Ripk1~null><xRipk1> in BMS
    *** times: 0 2+ 5+ min
    *** inhibited by: xRipk1(K377R)"Ubiq-deficient-mut" [substitution]
    *** source: 16603398-Fig-4a
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null><Ripk1~null><xRipk1> in BMS
    *** times: 0 5+++ 10++ 20+ min
    *** comment: no total protein controls for Ikba
    *** reqs: xRipk1 [omission]
    *** inhibited by: xRipk1(K377R)"Ubiq-deficient-mut" [substitution]
    *** unaffected by: xRipk1(K396R) [substitution]
    *** partially inhibited by: xRipk1(K396R/K530R) [substitution]
    *** inhibited by: xRipk1(K377R/K306R) [substitution]
    *** source: 16543241-Fig-3b

Rsk2--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (10 min)
    *** cells: HELA in BMLS "cytoplasmic fraction"
    *** partially reqs: Rsk2 [RNAi]
    *** source: 20385620-Fig-4b
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (10 min)
    *** cells: mEFs in BMLS "cytoplasmic fraction"
    *** partially reqs: Rsk2 [KO]
    *** source: 20385620-Fig-4e
  *** xRsk2[tAb] copptby[WB] Ikba[Ab] is increased irt Tnf (times)
    *** cells: HELA<xRsk2> in BMLS "treated with MG132"
    *** times: 0+ 10++ 30++ min
    *** source: 20385620-Fig-2c

inhibited by Smad7--

  *** Ikba[Ab] phos[WBMS] is increased irt Tnf (10 min)
    *** cells: MCF7 in BMS
    *** inhibited by: xSmad7 [addition]
    *** source: 17384642-Fig-5a

Syk--

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 5++ 10+ min
    *** inhibited by: Piceatannol [addition]
    *** source: 16291755-Fig-5b

not Tab1--

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (30 min)
    *** cells: MCF10A in BMS "cytoplasmic fraction"
    *** does not req: Tab1 [RNAi]
    *** source: 18037881-Fig-S5

Tab2--  ???

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (30 min)
    *** cells: MCF10A in BMS "cytoplasmic fraction"
    *** reqs: Tab2 [RNAi]
    *** source: 18037881-Fig-5b
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 2+ 6+ min
    *** does not req: Tab2 [RNAi]
    *** does not req: Tab3 [RNAi]
    *** partially reqs: Tab2 and/or Tab3 [DRNAi]
    *** source: 14633987-Fig-7b

Tak1--

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (30 min)
    *** cells: MCF10A in BMS "cytoplasmic fraction"
    *** reqs: Tak1 [RNAi]
    *** source: 18037881-Fig-5a
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** reqs: Tak1 [RNAi]
    *** source: 12547194(D)
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Tnf (5 min)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** reqs: xTak1 [omission]
    *** unaffected by: xTak1(K34R) [substitution]
    *** source: 19843958-Fig-2f
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0 5+ 15 30 min
    *** inhibited by: xTak1(K209R) [substitution]
    *** source: 19843958-Fig-2d
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (5 min)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** reqs: xTak1 [omission]
    *** partially inhibited by: xTak1(K158R) [addition]
    *** source: 20038579-Fig-7a


not Tbk1--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 1+ 3+ 9 27+ 90+ min
    *** does not req: Tbk1 [KO]
    *** source: 10990461-Fig-5a

not Tpl2--

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (10 min)
    *** cells: mEFs in BMS "treated with MG132"
    *** does not req: Tpl2 [KO]
    *** source: 15833743-Fig-5a
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (2 min)
    *** cells: JURKATT<xNfkb1> in BMS
    *** unaffected by: xTpl2(D270A)"KD" [addition]
    *** source: 9950430-Fig-7b

Tradd--

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 5+ 15+ 30+ 45 min
    *** reqs: Tradd [KO]
    *** source: 18641654-Fig-1b
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15+ 30+ 45+ min
    *** reqs: Tradd [KO]
    *** source: 18641654-Fig-1a

not Traf6--

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Tnf (10 min)
    *** cells: mEFs in BMS
    *** does not req: Traf6 [KO]
    *** source: 16115877-Fig-6a

not Ube1--

  *** Ikba[Ab] phos[WBMS] is increased irt Tnf (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 10+ min
    *** does not req: Ube1 [RNAi]
    *** source: 19854138-Fig-S3d

Ube2ds--

  *** Ikba[Ab] phos[WBMS] is increased irt Tnf (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 15+ min
    *** partially reqs: Ube2ds [RNAi]
    *** source: 19854138-Fig-4a

not Ube2d3--

  *** Ikba[Ab] phos[WBMS] is increased irt Tnf (times)
    *** cells: U2OS<Ube2ds~null><xUbe2d3> in BMS
    *** times: 0 5+ 15+ min
    *** unaffected by: xUbe2d3(C85A) [substitution]
    *** source: 19854138-Fig-4b


not Ubc13--

  *** Ikba[Ab] phos[WBMS] is increased irt Tnf (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 15+ min
    *** does not req: Ubc13 [RNAi]
    *** source: 19854138-Fig-3a,3c
  *** Ikba[Ab] phos[WBMS] is increased irt Tnf (times)
    *** cells: U2OS<Ubc13~null><xUbc13(C87A)> in BMS
    *** times: 0 5+ 15+ min
    *** source: 19854138-Fig-3c


Ubiq--

  *** Ikba[Ab] phos[WBMS] is increased irt Tnf (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 15+ min
    *** reqs: Ubiq [RNAi]
    *** source: 19854138-Fig-2a,2c

  not K63 Ubiq

  *** Ikba[Ab] phos[WBMS] is increased irt Tnf (10 min)
    *** cells: U2OS<Ubiq~null><xUbiq(K63R)> in BMS
    *** source: 19854138-Fig-S5a
  *** Ikba[Ab] phos[WBMS] is increased irt Tnf (times)
    *** cells: U2OS<Ubiq~null><xUbiq> in BMS
    *** times: 0 5+ 15+ min
    *** unaffected by: xUbiq(K63R) [substitution]
    *** source: 19854138-Fig-2c
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (5 min)
    *** cells: U2OS<Ubiq~null><xUbiq(K6R/K63R)> in BMS
    *** source: 19854138-Fig-S7
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (5 min)
    *** cells: U2OS<Ubiq~null><xUbiq(K11R/K63R)> in BMS
    *** source: 19854138-Fig-S7

not Usp21--

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** does not req: Usp21 [RNAi]
    *** source: 19910467-Fig-4b

======
other--
======

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: HEK293 in BMS
    *** times: 0 5++ 15+ 30 60 120 min
    *** comment: prolonged by xPpp2cb [addition]
    *** source: 14585847-Fig-5a
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5++ 15+ 30 60 120 min
    *** comment: reqs Ppp2bc [RNAi] for the decrease at later times
    *** source: 14585847-Fig-4c
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (times)
    *** cells: MCF10A in BMS "cytoplasmic fraction"
    *** times: 0 30+ 120+ min
    *** source: 18037881-Fig-4a
  *** Ikba[Ab] phos(S32)[phosAb] is increased irt Tnf (15 min)
    *** cells: HELA in BMS "cytoplasmic-extracts"
    *** source: 10075690-Fig-2c
  *** Ikba[Ab] phos(S32)[phosAb] is unchanged irt Tnf (times)
    *** cells: HEK293 in BMS "cytoplasmic-extracts from cells treated with CHX"
    *** times: 0 15 30 min
    *** source: 10075690-Fig-2a
  *** xIkba[Ab] phos[WBMS] is increased irt Tnf (times) 
    *** cells: EL4<xIkba> in BMS "pretreated with ALLN"
    *** times: 0 5++ 15++ 60+ min
    *** inhibited by: xIkba(S32G) [substitution]
    *** source: 7878466-Fig-2d
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS "cytoplasmic fraction"
    *** comment: partially inhibited by prestim with Egf for 10 min
    *** source: 19393267-Fig-6a

=========
no extras
=========

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Tnf (15 min)
    *** cells: SAOS2 in BMS
    *** source: 15073170-Fig-2d
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Tnf (30 min)
    *** cells: C2 in BMS
    *** source: 16806820-Fig-5e
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 2+ 5++ min
    *** source: 16603398-Fig-1a
  *** Ikba[Ab] phos[WBMS] is increased irt Tnf (10 min)
    *** cells: U2OS in BMS
    *** source: 19854138-Fig-S5a
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 2+ 5+ 10 20 30 min
    *** source: 12867425-Fig-1a
  *** Ikba[Ab]IP phos(S32)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS "pretreated with MG132"
    *** times: 0 5++ 15++ 30+ 60+ 120+ min
    *** source: 11297557-Fig-5b
