=================
Required Proteins
=================

not Ak1-- or Akt2--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: mEFs<xTax1bp1> in BMS
    *** times: 0+ 15 30+ min
    *** does not req: Akt1 or Akt2 [DKO]
    *** source: 21765415-Fig-S3

Ampka1--

  *** Ikba-gene mRNA[RTPCR] is increased irt Tnf (12 hr)
    *** cells: THP1 in BMS
    *** partially reqs: Ampka1 [RNAi]
    *** source: 22833096-Fig-S6

not Cebpb--

  *** Ikba-gene mRNA[RTPCR] is increased irt Tnf (times)
    *** cells: mSPImacs in BMS
    *** times: 0 10 20++ 40++ 60+ 240 480 min
    *** repressed by: Cebpb [KO]
    *** source: 19733238-Fig-5a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: mSPImacs in BMS
    *** times: 0++ 10+ 30 60+ 120++ min
    *** does not req: Cebpb [KO]
    *** source: 19733238-Fig-3a

Erc1--

  *** Ikba-gene mRNA[RTPCR] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 30+ 60+ 120 min
    *** reqs: Erc1 [RNAi]
    *** source: 15218148-Fig-3b

not Nik--

  *** Ikba-gene mRNA[Northern] is increased irt Tnf (8 hr)
    *** cells: mEFs in BMS
    *** does not req: Nik [KO]
    *** source: 11251123-Fig-3a

not Mekk3--

  *** Ikba-gene mRNA[Northern] is increased irt Tnf (times)
    *** cells: mEFs<Mekk3~null> in BMS
    *** times: 0 15 60++ 120+ min
    *** source: 14636585(D)

Rnf11--

  *** Ikba-gene mRNA[RTPCR] is increased irt Tnf (times)
    *** cells: THP1 in BMS
    *** times: 0 15+ 30+ 60+ 120+ 240+ min
    *** comment: increase at 15-60 min reqs Rnf11 [RNAi]
    *** source: 19131965-Fig-3c
  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: THP1 in BMS
    *** times: 0+ 15 30 60+ 120+ 240+ min
    *** comment: reappearance at 60 min reqs Rnf11 [RNAi]
    *** source: 19131965-Fig-3a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: THP1 in BMS
    *** times: 0++ 15 30+ 120++ 240++ min
    *** comment: reappearance at 30 min reqs Rnf11 [RNAi]
    *** source: 19131965-Fig-6b
  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: THP1<Rnf11~null><xRnf11> in BMS
    *** times: 0+ 15 30 120+ 240+ min
    *** comment: reappearance at 120 min is inhibited by substitution with xRnf1(C99A)
    *** comment: reappearance at 120 min is inhibited by substitution with xRnf1(Y40A)
    *** source: 19131965-Fig-6b

not Tab2--

  *** Ikba-gene mRNA[Northern] is increased irt Tnf (16 hr)
    *** cells: mEFs in BMS
    *** does not req: Tab2 [KO]
    *** source: 12556483-Fig-3c

not Tnfaip3--

  *** Ikba-gene mRNA[Northern] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 30+ 60++ 90+ 120+ 150+ min
    *** does not req: Tnfaip3 [KO]
    *** source: 11009421-Fig-3c

not Pias1--

  *** Ikba-gene mRNA[Northern] is increased irt Tnf (times)
    *** cells: U2OS in BMS
    *** times: 0 1++ 2+ hr
    *** inhibited by: xPias1 [addition]
    *** source: 15657437-Fig-2c
  *** Ikba-gene mRNA[RTPCR] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 30++ 60+ 180+ min
    *** repressed by: Pias1 [KO]
    *** comment: repression occurs at 30 min only
    *** source: 15657437-Fig-3a

not Pias4--

  *** Ikba-gene mRNA[RTPCR] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 30+ 60+ 180+ min
    *** unaffected by: Pias4 [KO]
    *** source: 17606919-Fig-2a
  *** Ikba-gene mRNA[RTPCR] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 30+ 60+ 180+ min
    *** repressed by: Pias4 [KO]
    *** source: 17606919-Fig-3b
  *** Ikba-gene mRNA[RTPCR] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 30+ 60++ 180+ min
    *** unaffected by: Pias4 [KO]
    *** source: 17606919-Fig-2a

not Pkc--

  *** Ikba-gene mRNA[RTPCR] is increased irt Tnf (1 hr)
    *** cells: mEFs in BMS
    *** does not req: Pkcz [KO]
    *** source: 11684013-Fig-2a

=========
no extras
=========

  *** Ikba-gene mRNA[Northern] is increased irt Tnf (2 hr)
    *** cells: mLFs in BMS
    *** source: 15241416-Fig-1a
  *** Ikba-gene mRNA[Northern] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15++ 60+++ 120+ min
    *** source: 14636585(D)
  *** Ikba-gene mRNA[RTPCR] is increased irt Tnf (times)
    *** cells: mBMDCs in BMS
    *** times: 0 1+++ 2++ 4+ 6+ hr
    *** comment: unaffected by Ifng pretreatment (4 hr)
    *** source: 17018642-Fig-6
  *** Ikba-gene mRNA[RTPCR] is increased irt Tnf (times)
    *** cells: MCF7 in BMS
    *** times: 0+ 15+ 30++ 60++ min
    *** source: 16280327-Fig-3e
  *** Ikba-gene mRNA[RTPCR] is increased irt Tnf (times)
    *** cells: mEFs in BMLS
    *** times: 0+ 15+ 30++ 60++ min
    *** source: 15155743-Fig-1d

=================
Promoter-reporter
=================

  *** Ikba-gene promo-reporter[Luc] is increased irt Tnf (5 hr)
    *** cells: HELA in BMS
    *** inhibited by: xCebpb [addition]
    *** source: 19733238-Fig-5c

==============================================
Reappearance of Protein after Ikba degradation
==============================================

Ikk1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0+ 15 30+ 120+ min
    *** comment: reappearance after 15 min reqs Ikk1 [RNAi]
    *** source: 21765415-Fig-6e
  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0+ 15 30+ 120+ min
    *** comment: reappearance after 15 min reqs Ikk1 [RNAi] or xTax1bp1(S593E/S624E) [substitution]
    *** source: 21765415-Fig-7a


Tax1bp1-- reqs phos

  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0+ 30 60+ min
    *** comment: reappearance of Ikba after 30 min reqs Tax1bp1 [KO]
    *** source: 20185725-Fig-S1e
  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0++ 15 30 45+ 60++ 90++ 120++ 240++ min
    *** comment: reappearance of Ikba after 30 min reqs Tax1bp1 [KO]
    *** source: 20185725-Fig-S1b
  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0++ 15 30 45+ 60++ 90++ 120++ 240++ min
    *** comment: reappearance of Ikba after 30 min reqs Tax1bp1 [KO]
    *** source: 20185725-Fig-S1c
  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0+ 15 30+ 60+ 120+ min
    *** comment: reappearance after 15 min reqs xTax1bp1 [omission]
    *** comment: reappearance after 15 min inhibited by xTax1bp1(S593A/S666A) [substitution]
    *** source: 21765415-Fig-3a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0+ 15 30+ 120+ min
    *** comment: reappearance after 15 min reqs xTax1bp1 [omission]
    *** comment: reappearance after 15 min inhibited by xTax1bp1(S593A/S666A) [substitution]
    *** comment: reappearance after 15 min unaffected by xTax1bp1(S593E/S624E) [substitution]
    *** source: 21765415-Fig-7a

Tnfaip3--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0++ 15 30 45+ 60++ 90++ 120++ 240++ min
    *** comment: reappearance of Ikba after 30 min reqs Tnfaip3 [KO]
    *** source: 20185725-Fig-2b
  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0++ 15 30 45+ 60++ 90++ 120++ 240++ min
    *** comment: reappearance of Ikba after 45 min reqs Tnfaip3 [KO]
    *** source: 20185725-Fig-1c
  *** Ikba[Ab] prot-exp[WB] is decreased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0++ 30 60+ min
    *** comment: reappearance of Ikba after 60 min reqs Tnfaip3 [KO]
    *** source: 20185725-Fig-1d

















