===============
Kinase Activity
===============

not Mlk3--

  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5 8+ 10+ 12++ 15++ 30 60 min
    *** does not req: Mlk3 [KO]
    *** source: 15831472(D)

Tpl2--

  *** xErk1[tAb]IP IVKA(Elk1)[32P-ATP] is increased irt Tnf (times)
    *** cells: MCF7 in BMLS
    *** times: 0 10+ 20++ min
    *** reqs: Tpl2 [KO]
    *** source: 16291755-Fig-1c

No extras

  *** Erk2[Ab]IP IVKA(Elk1)[32P-ATP] is increased irt Tnf (times)
    *** cells: HEK293 in BMS
    *** times: 0 10+ 20+ 30 min
    *** source: 16291755-Fig-3c

===========================
Phosphorylation on TEY site
===========================

Cltc--  ???

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (10 min)
    *** cells: HELA in BMS
    *** partially reqs: Cltc [RNAi]
    *** source: 19687304-Fig-5d

not EgfR--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5 10+ min
    *** does not req: EgfR [RNAi]
    *** source: 19687304-Fig-7b

not Ikk1-- and/or Ikk2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30 min
    *** does not req: Ikk1 [KO]
    *** does not req: Ikk2 [KO]
    *** comment: decrease in phos at 30 min is not seen in Ikk-null cells
    *** source: 11733537-Fig-2

not Irak3--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 10++ 20++ 60 min
    *** does not req: Irak3 [KO]
    *** source: 12150927-Fig-4c

Irak4-- ???

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 10+ 15+ 30 min
    *** unaffected by: xIrak4(K213A/K214A)"KD" [addition]
    *** source: 17337443-Fig-3d

Mek1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (15 min)
    *** cells: mEFs in BMS
    *** unaffected by: SB203580 [addition]
    *** bkg inhibited by: PD184352 [addition]
    *** bkg inhibited by: SB203580 + PD184352 [addition]
    *** source: 15304344-Fig-5b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (15 min)
    *** cells: mEFs<Jnk1~null><Jnk2~null> in BMS
    *** bkg inhibited by: PD184352 [addition]
    *** unaffected by: SB203580 [addition]
    *** bkg inhibited by: SB203580 + PD184352 [addition]
    *** source: 15304344-Fig-5d

not Mekk1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mESCs in BMS
    *** times: 0 10++ 30+ 60 min
    *** enhanced by: kMekk1(1-1188)"del-kinase-domain" [addition]
    *** source: 10805784-Fig-2

not Mekk3--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMLS
    *** times: 0 10++ 15++ 30+ min
    *** does not req: Mekk3 [KO]
    *** source: 18021073-Fig-8b

not Mnk1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (30 min)
    *** cells: mEFs in BMLS
    *** does not req: Mnk1 and/or Mnk2 [DKO]
    *** source: 15254222-Fig-3a

not P38a--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (10 min)
    *** cells: HELA in BMS
    *** does not req: P38a [RNAi]
    *** source: 19687304-Fig-4d

not Raf1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMLS
    *** times: 0 5+ 10++ 20++ min
    *** does not req: Raf1 [KO]
    *** source: 11296228-Fig-7b

not Rela--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 10+ 60 min
    *** does not req: Rela [RNAi]
    *** source: 19687304-Fig-7c

Ripk1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 10++ 15++ min
    *** partially reqs: Ripk1 [KO]
    *** source: 12776182-Fig-1a

Syk--

  *** xErk1[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: HEK293 in BMLS
    *** times: 0 10+ 15+ min
    *** enhanced by: xSyk [addition]
    *** source: 16291755-Fig-8
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: JURKAT-H33HJ-JA1 in BMLS
    *** times: 0 10+ 15+ 20+ min
    *** reqs: Syk [null-mut]
    *** source: 16291755-Fig-7b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (tnr)
    *** cells: MCF7 in BMLS
    *** reqs: Syk [RNAi]
    *** source: 16291755-Fig-7e
  ---------------------------------------------------------------
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Tnf (times)
    *** cells: JCam1 in BMS "Syk and Lck deficient"
    *** times: 0 5 10 15 30 min
    *** unaffected by: xLck [addition]
    *** source: 15240695-Fig-3e
  ---------------------------------------------------------------
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (10 min)
    *** cells: mBMMs in BMLS
    *** inhibited by: Piceatannol [addition]
    *** source: 16291755-Fig-4a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (10 min)
    *** cells: mBMMs in BMLS
    *** inhibited by: Piceatannol [addition]
    *** source: 16291755-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (15 min)
    *** cells: HELA in BMLS
    *** inhibited by: Piceatannol [addition]
    *** source: 16291755-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (15 min)
    *** cells: JURKAT-H33HJ-JA1 in BMLS
    *** inhibited by: Piceatannol [addition]
    *** source: 16291755-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 5+ 10++ 15++ 30+ min
    *** inhibited by: Piceatannol [addition]
    *** source: 15240695-Fig-2e
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 5+ 10++ min
    *** inhibited by: Piceatannol [addition]
    *** source: 16291755-Fig-5b

Tak1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** reqs: Tak1 [RNAi]
    *** source: 19393267-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (10 min)
    *** cells: HELA in BMS
    *** reqs: Tak1 [RNAi]
    *** source: 19687304-Fig-4a

TnfR1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 5 15+++ 30++ 45+ min
    *** reqs: TnfR1 [KO]
    *** source: 18641654-Fig-1b

Tpl2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mBMMs in BMLS
    *** times: 0 10+ 20+ 30+ 45 min
    *** partially reqs: Tpl2 [KO]
    *** source: 16291755-Fig-1a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMLS
    *** times: 0 10+ 20++ min
    *** reqs: Tpl2 [KO]
    *** source: 16291755-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 5+ 10++ 20+ min
    *** reqs: Tpl2 [KO]
    *** source: 15833743-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 20+ 30+ 40 60 min
    *** reqs: Tpl2 [KO]
    *** source: 15833743-Fig-1a

Tradd--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 5 15+++ 30++ 45+ min
    *** partially reqs: Tradd [KO]
    *** source: 18641654-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5 15+++ 30++ 45 min
    *** reqs: Tradd [KO]
    *** source: 18641654-Fig-1a


Traf2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMLS
    *** times: 0 10+ 20+ 30 min
    *** partially reqs: Traf2 [KO]
    *** source: 16291755-Fig-2e
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 10++ 15++ min
    *** partially reqs: Traf2 [KO]
    *** source: 12776182-Fig-1a

Chemicals

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (10 min)
    *** cells: mBMMs in BMLS
    *** inhibited by: HerbimycinA [addition]
    *** unaffected by: Bisindolylmaleimide-I [addition]
    *** unaffected by: LY294002 [addition]
    *** unaffected by: PP2 [addition]
    *** unaffected by: PP3 [addition]
    *** source: 16291755-Fig-4a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (10 min)
    *** cells: hUVECs in BMS
    *** unaffected by: Ebselen [pretreatment]
    *** source: 14720501-Fig-2
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 15+ 60 min
    *** unaffected by: SB203580 [pretreatment]
    *** source: 19687304-Fig-5e,5f
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (15 min)
    *** cells: mBMMs in BMS
    *** inhibited by: PS1145 [pretreatment]
    *** source: 15199157-Fig-2b

No extras

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: HEK293 in BMS
    *** times: 0 7++ 15+ 30 min
    *** source: 14532121(D)
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: HEK293<xSphk1> in BMS
    *** times: 0 7++ 15+ 30 min
    *** source: 14532121(D)
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Tnf (10 min)
    *** cells: CCD18CO in BMLS
    *** source: 15258589-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Tnf (10 min)
    *** cells: JURKAT<Pten~null> in BMLS
    *** source: 15258589-Fig-2e
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Tnf (5 min)
    *** cells: KB in BMS
    *** source: 14592977-Fig-10
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (tnr)
    *** cells: B16F1 in BMLS
    *** source: 19274086-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (tnr)
    *** cells: MEWO in BMLS
    *** source: 19274086-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Tnf (tnr)
    *** cells: 3731T in BMLS
    *** source: 19274086-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (10 min)
    *** cells: hUVECs in BMS
    *** source: 14720501-Fig-1c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: hUVECs in BMS
    *** times: 0 5+ 10++ 15++ 30+ 60 min
    *** source: 14720501-Fig-1a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 2 4 6 8+ 10+ min
    *** source: 19687304-Fig-4e
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 10+ 30 60 min
    *** source: 19687304-Fig-3a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 2 5+ 10++ 15+ 30 min
    *** source: 15199157-Fig-4

Controdictions

  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Tnf (30 min)
    *** cells: MCF7 in BMLS
    *** source: 17693255-Fig-S1b
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Tnf (times)
    *** cells: MDAMB453 in BMLS
    *** times: 0 5 10 20 30 min
    *** source: 17693255-Fig-S1c

