============================================
Tak1 coppts with TgfbR1 in unstimulated cells
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unaffected by Tgfb1

  *** Tak1[Ab] copptby[WB] TgfbR1[Ab] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: mMesangialCells in BMLS
    *** times: 0+ 2+ 5+ 10+ min
    *** source: 19556242-Fig-1d
  *** Tak1[Ab] copptby[WB] TgfbR1[Ab] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: mMesangialCells in BMLS
    *** times: 0+ 5+ 15+ 30+ min
    *** source: 19556242-Fig-7b
  *** Tak1[Ab] copptby[WB] TgfbR1[Ab] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: HEK293T in BMS
    *** times: 0+ 15+ 30+ 60+ min
    *** source: 18758450-Fig-2b
  *** TgfbR1[Ab] colocwith[IHC] Tak1[Ab] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 10+ 15+ min
    *** source: 18758450-Fig-S4
  *** Tak1[Ab] copptby[WB] TgfbR1[Ab] is detectable
    *** cells: mMesangialCells in BMS
    *** source: 19556242-Fig-1a

sometimes inhibited by addition of xTgfbR2

  *** xTak1[Ab] copptby[WB] xTgfbR1[Ab] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR1> in BMS
    *** inhibited by: xTgfbR2 [addition]
    *** source: 19556242-Fig-1b
  *** xTak1[tAb] copptby[WB] xTgfbR1[tAb] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR1> in BMS
    *** inhibited by: xTgfbR2 [addition]
    *** source: 19556242-Fig-4b
  *** xTak1[tAb] copptby[WB] xTgfbR1[tAb] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR1> in BMS
    *** unaffected by: xTgfbR2 [addition]
    *** source: 19556242-Fig-5b
  *** xTgfbR1[Ab] copptby[WB] xTak1[Ab] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR1> in BMS
    *** inhibited by: xTgfbR2 [addition]
    *** source: 19556242-Fig-1c

required TgfbR1 attributes

  *** xTak1[Ab] copptby[WB] xTgfbR1[Ab] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR1> in BMS
    *** unaffected by: xTgfbR1(T185V/T186V/S187A/S189A/S191A)"GS" [substitution]
    *** partially inhibited by: xTgfbR1(T198D)"CA" [substitution]
    *** source: 19556242-Fig-2b
  *** xTak1[Ab] copptby[WB] xTgfbR1[Ab] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR1> in BMS
    *** unaffected by: xTgfbR1(T185V/T186V/S187A/S189A/S191A)"GS" [substitution]
    *** unaffected by: xTgfbR1(1-255)"LC" [substitution]
    *** inhibited by: xTgfbR1(1-151)"SC" [substitution]
    *** source: 19556242-Fig-2b

required Tak1 attributes

  *** xTak1[tAb] copptby[WB] xTgfbR1[tAb] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR1> in BMS
    *** inhibited by: xTak1(mnr)"del-Cterm" [substitution]
    *** source: 19556242-Fig-8c
  *** xTak1[tAb] copptby[WB] xTgfbR1[tAb] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR1> in BMS
    *** unaffected by: xTak1(K63W)"KD" [substitution]
    *** source: 19556242-Fig-5b
  *** xTgfbR1[tAb] copptby[WB] xTak1[Ab] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR1> in BMS
    *** unaffected by: xTak1(K34R)"ubiq-site-mut" [substitution]
    *** source: 19556242-Fig-7c
  *** xTgfbR1[tAb] copptby[WB] xTak1[tAb] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR1> in BMS
    *** inhibited by: xTak1(mnr)"del-Cterm" [substitution]
    *** source: 19556242-Fig-8b

requires Traf6--

  *** Tak1[Ab] copptby[WB] TgfbR1[Ab] is detectable
    *** cells: mMesangialCells in BMS
    *** reqs: Traf6 [RNAi]
    *** source: 19556242-Fig-7a
  *** Tak1[Ab] copptby[WB] TgfbR1[Ab] is detectable
    *** cells: mMesangialCells in BMS
    *** reqs: Traf6 [RNAi]
    *** source: 19556242-Fig-7b

does not require Tab1--

  *** xTak1[tAb] copptby[WB] xTgfbR1[Ab] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR1> in BMS
    *** unaffected by: xTab1 [addition]
    *** source: 19556242-Fig-6b
  *** xTgfbR1[tAb] copptby[WB] xTak1[Ab] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR1> in BMS
    *** unaffected by: xTab1 [addition]
    *** source: 19556242-Fig-6a


=========================================
Tak1 coppts with TgfbR2 in untreated cells
=========================================

  *** Tak1[Ab] copptby[WB] TgfbR2[Ab] is detectable
    *** cells: mMesangialCells in BMS
    *** source: 19556242-Fig-1a
  *** xTak1[Ab] copptby[WB] xTgfbR2[Ab] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR2> in BMS
    *** inhibited by: xTgfbR1 [addition]
    *** source: 19556242-Fig-1b

  *** xTak1[tAb] copptby[WB] xTgfbR2[Ab] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR2> in BMS
    *** unaffected by: xTab1 [addition]
    *** source: 19556242-Fig-6c
  *** xTak1[tAb] copptby[WB] xTgfbR2[tAb] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR2> in BMS
    *** unaffected by: xTgfbR2(K227R)"KD" [substitution]
    *** inhibited by: xTgfbR2(mnr)"delCterm" [substitution]
    *** source: 19556242-Fig-4a
  *** xTgfbR2[Ab] copptby[WB] xTak1[Ab] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR2> in BMS
    *** inhibited by: xTgfbR1 [addition]
    *** source: 19556242-Fig-1c
  *** xTgfbR2[tAb] copptby[WB] xTak1[Ab] is detectable
    *** cells: mMesangialCells<xTak1><xTgfbR2> in BMS
    *** unaffected by: xTab1 [addition]
    *** source: 19556242-Fig-6a

