=======================
Coppt with TgfbR1:Tgfb1
=======================

  *** xTgfbR1[125I-Tgfb1-XL] copptby[WB] xSmurf2(C716A)"CIA"[tAb] is detectable
    *** cells: COS1<xSmad7> in BMS
    *** inhibited by: xSmurf2(WT) [substitution]
    *** source: 11163210-Fig-2
  *** xTgfbR1[125I-Tgfb1-XL] copptby[WB] xSmurf2[Ab] is detectable
    *** cells: COS1 in BMS
    *** inhibited by: xSmad7(Y211A) [substitution]
    *** source: 11163210-Fig-6a

reqs Smad7--

  *** xTgfbR1[125I-Tgfb1-XL] copptby[WB] xSmurf2(C716A)"CIA"[tAb] is detectable
    *** cells: COS1<xSmad7> in BMS
    *** reqs: xSmad7 [omission]
    *** source: 11163210-Fig-2

===========================
Relocation to cellmembrane
===========================

  *** xSmurf2(C716A)[tAb] locatedin(cellmembrane)[IHC] is increased irt Tgfb1 (1 hr)
    *** cells: MV1LU<xSmad7> in BMS
    *** inhibited by: xSmad7(Y211A)"PY-motif" [substitution]
    *** source: 11163210(D)


================
Coppt with Smad7
================

  *** xTgfbR1[125I-Tgfb1-XL] copptby[WB] xSmad7[Ab] is detectable
    *** cells: COS1 in BMS
    *** unaffected by: xSmad7(Y211A) [substitution]
    *** source: 11163210-Fig-6a
  *** xTgfbR1[125I-Tgfb1-XL] copptby[WB] xSmad7[tAb] is detectable
    *** cells: COS1 in BMS
    *** inhibited by: xSmurf2 [addition]
    *** unaffected by: xSmurf2(C716A)"CIA" [addition]
    *** comment: inhibition by xSmurf2 may be due to decrease in Smad7 prot-exp itpo xSmurf2
    *** source: 11163210-Fig-2


  *** xTgfbR2[125I-Tgfb1-XL] copptby[WB] xSmurf2(C716A)"CIA"[tAb] is detectable
    *** cells: COS1<xSmad7> in BMS
    *** inhibited by: xSmurf2(WT) [substitution]
    *** source: 11163210-Fig-2
  *** xTgfbR2[125I-Tgfb1-XL] copptby[WB] xSmurf2(C716A)"CIA"[tAb] is detectable
    *** cells: COS1<xSmad7> in BMS
    *** reqs: xSmad7 [omission]
    *** source: 11163210-Fig-2

  *** Smurf2[Ab] copptby[WB] Smad23s[Ab] is increased irt Tgfb1 (tnr)
    *** cells: MV1LU in BMS
    *** source: 11389444-Fig-1c
