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Smad7 in nucleus is decreased irt Tgfb1
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  *** xSmad7[tAb] locatedin(nucleus)[IHC] is decreased irt Tgfb1 (2 hr)
    *** cells: MV1LU in BMS
    *** source: 9786930-Fig-6
  *** xSmad7[tAb] locatedin(nucleus)[IHC] is decreased itpo xTgfbR1(T204D)"CA"
    *** cells: COS1 in BMS
    *** source: 9786930-Fig-5
  --- may be due to sensitivity issues --------------------------
  *** Smad7[Ab] infraction(nuclear)[WB] is unchanged irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0+ 2+ 6+ 18+ hr
    *** source: 15684397-Fig-3g
  *** Smad7[Ab] infraction(nuclear)[WB] is unchanged irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 2+ 6+ 18+ hr
    *** source: 15684397-Fig-3g

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Smad7 is recruited to the TgfbR complex irt to Tgfb1
but is the complex still at the cell membrane or in the perinuclear region?
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  *** TgfbR1[125I-Tgfb1-XL] copptby[WB] xSmad7[tAb] is detectable
    *** cells: MV1LU in BMS
    *** source: 9786930-Fig-4
  *** TgfbR2[125I-Tgfb1-XL] copptby[WB] xSmad7[tAb] is detectable
    *** cells: MV1LU in BMS
    *** source: 9786930-Fig-4
  *** xTgfbR2[125I-Tgfb1-XL] copptby[WB] xSmad7[tAb] is detectable
    *** cells: COS1<xTgfbR1> in BMS
    *** reqs: xTgfbR1 [omission]
    *** unaffected by: xTgfbR1(K232R)"KD" [substitution]
    *** inhibited by: xTgfbR2(K277R)"KD" [substitution]
    *** source: 9215638-Fig-5a
  -----------------------------------------------------------------------
  *** Smad7[Ab] locatedin(perinuclear-region)[IHC] is increased irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0 2+ 6 12+ hr
    *** comment: Smad7 is located in the nucleus in untreated cells
    *** source: 15684397-Fig-3e,3f
  *** Smad7[Ab] locatedin(perinuclear-region)[IHC] is increased irt Tgfb1 (times)
    *** cells: mEFs in BMS
    *** times: 0 2++ 6+ 12++ hr
    *** comment: Smad7 is located in the nucleus in untreated wt and P38a-null cells
    *** reqs: P38a [KO]
    *** source: 15684397-Fig-4c
  *** Smad7[Ab] locatedin(perinuclear-region)[IHC] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0 2+ 6 12+ hr
    *** comment: Smad7 is located in the nucleus in untreated cells
    *** source: 15684397-Fig-3a


  *** xSmad7[tAb] locatedin(cytoplasm)[IHC] is increased irt Tgfb1 (tnr)
    *** cells: HEP3B in BMS
    *** inhibited by: xPdpk1 [addition]
    *** unaffected by: xPdpk1(mnr)"KD" [addition]
    *** repressed by: Pdpk1 [RNAi]
    *** source: 17327236-Fig-9e

