===============
phos(S423/S425)
===============

Adam17--  ????

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (times)
    *** cells: HACAT in BMLS
    *** times: 0 2++ 8+ 12+ hr
    *** comment: decrease after 2 hr is repressed itao Adam17 [RNAi]
    *** source: 19595713-Fig-5c

not Akt1--

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (120 min)
    *** cells: AKR2B in BMLS
    *** unaffected by: xAkt1 [addition]
    *** source: 16288034-Fig-3

not Csnk1g2--

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0 30+ 60+ min
    *** unaffected by: xCsnk1g2 [addition]
    *** source: 18794808-Fig-4b

not EgfR-- or Erbb2--

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (1 hr)
    *** cells: AKR2B in BMLS
    *** does not req: EgfR [RNAi]
    *** does not req: Erbb2 [RNAi]
    *** does not req: EgfR or Erbb2 [RNAi]
    *** source: 23913859-Fig-2b

Erbin--  ???

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (45 min)
    *** cells: AKR2B in BMLS
    *** unaffected by: xErbin [addition]
    *** source: 19289088-Fig-4a
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (5 min)
    *** cells: AKR2B in BMLS
    *** comment: unaffected by addition Erbin[Ab]IP from MV1LU in BMS to lysate
    *** source: 19289088-Fig-3b

inibited by Hgf--

  *** Smad3[Ab]IP phos(S423/S425)[phosAb] is unchanged irt Tgfb1 (30 min)
    *** cells: RGM1 in BMLS
    *** inhibited by: Hgf (30 min) [pretreatment]
    *** source: 15326485-Fig-1d

not Hras--

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb2
    *** cells: AKR2B in BMLS
    *** unaffected by: Hras(S17N)"DN" [addition]
    *** source: 17440079-Fig-3a

not Merlin--

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (45 min)
    *** cells: AKR2B<xErbin> in BMLS
    *** does not req: Merlin [RNAi]
    *** source: 19289088-Fig-4a

not Pak2--

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (45 min)
    *** cells: AKR2B in BMLS
    *** unaffected by: xPak2 [addition]
    *** unaffected by: xPak2(K278R)"KD" [addition]
    *** source: 14612425-Fig-4

not PdgfRa-- or PdgfRb--

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (3 hr)
    *** cells: AKR2B in BMLS
    *** does not req: PdgfRa [RNAi]
    *** does not req: PdgfRb [RNAi]
    *** does not req: PdgfRa or PdgfRb [RNAi]
    *** source: 23913859-Fig-1b

inhibited by Ppm1a--

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (1 hr)
    *** cells: NIH3T3 in BMS
    *** inhibited by: xPpm1a [addition]
    *** source: 16751101-Fig-S8b
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (tnr)
    *** cells: HACAT in BMS
    *** does not req: Ppm1a [RNAi]
    *** source: 16751101-Fig-4b
  *** xSmad3[tAb]IP phos(S423/S425)[phosAb] is increased itpo xTgfbR1(T202D)
    *** cells: HEK293T in BMS
    *** inhibited by: xPpm1a [addition]
    *** source: 16751101-Fig-2b
  *** xSmad3[tAb]IP phos(S423/S425)[phosAb] is increased itpo xTgfbR1(T202D)
    *** cells: HEK293T in BMS
    *** inhibited by: xPpm1a [addition]
    *** unaffected by: xPpm1a(D239N) [addition]
    *** source: 16751101-Fig-2d

not Rac1--

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (1 hr)
    *** cells: PANC1 in BMS
    *** unaffected by: xRac1(S17N)"DN" [addition]
    *** comment: antibody cited in methods does not exist
    *** source: 21624123-Fig-6

not Smad2--

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (5 min)
    *** cells: AKR2B in BMLS
    *** comment: unaffected by addition Smad2[Ab]IP from MV1LU in BMS to lysate
    *** source: 19289088-Fig-3b
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (45 min)
    *** cells: mEFs<Smad2~null> in BMLS
    *** source: 14612425-Fig-3

chemicals

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (3 hr)
    *** cells: AKR2B in BMLS
    *** unaffected by: AG1295 [cotreatment]
    *** source: 23913859-Fig-1a
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (3 hr)
    *** cells: AKR2B in BMLS
    *** unaffected by: Imatinib [cotreatment]
    *** source: 23913859-Fig-S1a
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (3 hr)
    *** cells: AKR2B in BMLS
    *** unaffected by: Lapatinib [cotreatment]
    *** source: 23913859-Fig-2b
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (3 hr)
    *** cells: AKR2B in BMLS
    *** unaffected by: U0126 [cotreatment]
    *** source: 23913859-Fig-3a
  *** Smad3[Ab]IP phos(S423/S425)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: RGM1 in BMLS "treated with PD169316"
    *** source: 15326485-Fig-4b
  *** Smad3[Ab]IP phos(S423/S425)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: RGM1 in BMLS "treated with SP600125"
    *** source: 15326485-Fig-4a
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: CHO in BMLS
    *** inhibited by: PMA [cotreatment]
    *** comment: inhibition by PMA reqs Adam17 [RNAi]
    *** source: 19595713-Fig-4b
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: CHO in BMLS
    *** inhibited by: PMA [cotreatment]
    *** comment: inhibition by PMA was reversed by pretreatment with TAPI1
    *** source: 19595713-Fig-4a
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: CHO in BMLS
    *** inhibited by: PMA [pretreatment]
    *** comment: inhibition by PMA was reversed by pretreatment with U0126
    *** comment: inhibition by PMA was reversed by pretreatment with Bisindolylmaleimide-I
    *** comment: inhibition by PMA was unaffected by pretreatment with LY294002
    *** source: 19595713-Fig-1b
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: CHO in BMLS
    *** inhibited by: PMA [pretreatment]
    *** source: 19595713-Fig-1a
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (18 hr)
    *** cells: AKR2B in BMLS
    *** unaffected by: AG1295 [cotreatment]
    *** unaffected by: Lapatinib [cotreatment]
    *** source: 23913859-Fig-S2c
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 15++ 30+++ 60+++ 180++ 360+ 540+ 720+ 900+ 1080+ 1260 1440 min
    *** source: 23913859-Fig-S1a
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 15+ 30+  min
    *** unaffected by: LY294002 [pretreatment]
    *** source: 16288034-Fig-2a
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 20+ 40++ 60++ 120++ min
    *** unaffected by: LY294002 [pretreatment]
    *** source: 16288034-Fig-5a

contradictions

  *** Smad3[phosAb] phos(S423/S425)[phosAb] is unchanged irt Tgfb1 (30 min)
    *** cells: hTECs in BMLS "plated on PLL for 4 hr"
    *** source: 18032789-Fig-5b


no extras

  *** Smad3[Ab]IP phos(S423/S425)[phosAb] is increased irt Tgfb1 (times)
    *** cells: RGM1 in BMLS
    *** times: 0 5+ 15++ 30++ 60+ 120+ min
    *** source: 15326485-Fig-1b
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0 1+++ 2++ 4++ 8+ 16+ 24+ hr
    *** source: 16751101-Fig-1a
  *** xSmad3[tAb]IP phos(S423/S425)[phosAb] is increased irt Tgfb1 (tnr)
    *** cells: HEK293T in BMS
    *** source: 16751101-Fig-2i
  *** xSmad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (times)
    *** cells: mEFs<xSmad3> in BMS
    *** times: 0 1++ 4+ hr
    *** source: 18794808-Fig-6a
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: hMesangialCells in BMLS "plated on gelatin for 4 hr"
    *** source: 18032789-Fig-4a
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: hTECs in BMLS "plated on gelatin for 4 hr"
    *** source: 18032789-Fig-5b
  *** Smad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: hTECs<xFak1> in BMLS
    *** unaffected by: xFak1(Y397F) [substitution]
    *** source: 18032789-Fig-8a
  *** xSmad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: hTECs<xSmad3> in BMLS
    *** source: 18032789-Fig-8b
  *** Smad3[phosAb] phos(S425/S425)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: hMesangialCells in BMLS "plated on PLL for 4 hr"
    *** source: 18032789-Fig-4a


=========================
phos(S416/S418) SPS site
=========================

  *** xSmad3[phosAb] phos(S416/S418)[phosAb] is increased irt Tgfb1 (15 min)
    *** cells: COS7<xSmad3> in BMLS
    *** source: 18760948-Fig-7a
  *** Smad3[Ab] locatedin(nucleus)[IHC] is increased irt Tgfb1 (20 min)
    *** cells: HELA in BMLS
    *** reqs: Ipo7 [RNAi]
    *** source: 18760948-Fig-S11a


===============
phos(S208/S213)
===============

  *** Smad3[Ab]IP phos(S208/S213)[phosAb] is increased irt Tgfb1 (times)
    *** cells: RGM1 in BMLS
    *** times: 0 5+ 15++ 30+++ 60++ 120+ min
    *** source: 15326485-Fig-1b
  *** Smad3[Ab]IP phos(S208/S213)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: RGM1 in BMLS
    *** source: 15326485-Fig-1d
  *** Smad3[Ab]IP phos(S208/S213)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: RGM1 in BMLS "treated with PD169316"
    *** source: 15326485-Fig-4b
  *** Smad3[Ab]IP phos(S208/S213)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: RGM1 in BMLS "treated with SP600125"
    *** source: 15326485-Fig-4a
  *** Smad3[phosAb] phos(S208/S213)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: hMesangialCells in BMLS "plated on gelatin for 4 hr"
    *** source: 18032789-Fig-4a
  *** Smad3[phosAb] phos(S208/S213)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: hMesangialCells in BMLS "plated on PLL for 4 hr"
    *** source: 18032789-Fig-4a
  *** Smad3[phosAb] phos(S208/S213)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: hTECs in BMLS "plated on gelatin for 4 hr"
    *** source: 18032789-Fig-5b
  *** Smad3[phosAb] phos(S208/S213)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: hTECs<xFak1> in BMLS
    *** inhibited by: xFak1(Y397F) [substitution]
    *** source: 18032789-Fig-8a
  *** xSmad3[phosAb] phos(S208/S213)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: hTECs<xSmad3> in BMLS
    *** source: 18032789-Fig-8b
  --------------------------------------------------------------------
  *** xSmad3[tAb]IP phos(S208)[phosAb] is increased irt Tgfb1 (20 hr)
    *** cells: HACAT in BMS
    *** unaffected by: xCtdsp1 [addition]
    *** source: 17035229-Fig-7d
  --------------------------------------------------------------------
  *** Smad3[phosAb] phos(S213)[phosAb] is decreased irt Tgfb1 (24 hr)
    *** cells: MV1LU in BMLS
    *** source: 15241418-Fig-S5e
  *** Smad3[phosAb] phos(S208/S213)[phosAb] is unchanged irt Tgfb1 (30 min)
    *** cells: hTECs in BMLS "plated on PLL for 4 hr"
    *** source: 18032789-Fig-5b

==========
phos(T179)
==========

  *** Smad3[phosAb] phos(T179)[phosAb] is decreased irt Tgfb1 (24 hr)
    *** cells: MV1LU in BMLS
    *** source: 15241418-Fig-S5e

==========
phos(T8)
==========

  *** Smad3[phosAb] phos(T8)[phosAb] is decreased irt Tgfb1 (24 hr)
    *** cells: MV1LU in BMLS
    *** source: 15241418-Fig-S5e
  *** xSmad3[tAb]IP phos(T8)[phosAb] is unchanged irt Tgfb1 (20 hr)
    *** cells: HACAT in BMS
    *** source: 17035229-Fig-7d

============
phos(sitenr)
============

  *** Smad3[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1
    *** cells: HACAT in BMS
    *** times: 0 5 15+ 30++ 45+++ 60+++ min
    *** source: 11359933-Fig-1b
  *** xSmad3[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1
    *** cells: HEP3B in BMLS
    *** times: 0 5+ 15+++ 30+++ 60+++ 90+++ 180++ 360+ min
    *** unaffected by: xVps39 [addition]
    *** source: 12941698-Fig-7a,7b
  *** Smad3[Ab]IP phos(sitenr)[phosAb] is increased irt Tgfb1 (1 hr)
    *** cells: mEFs in BMS
    *** partially reqs: Pml [KO]
    *** source: 15356634-Fig-S2d
  *** Smad3[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1 (1 hr)
    *** cells: HEPG2 in BMS
    *** enhanced by: xPmlc [addition]
    *** source: 15356634-Fig-S2e
  *** Smad3[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1 (times)
    *** cells: mMesangialCells in BMLS
    *** times: 0 5 15+ min
    *** does not req: Tab1 [RNAi]
    *** source: 19556242-Fig-5c
  *** Smad3[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1 (times)
    *** cells: mMesangialCells in BMLS
    *** times: 0+ 2+ 5+ 15++ min
    *** source: 19556242-Fig-3b
  *** Smad3[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1 (30 min)
    *** cells: mTECs in BMS
    *** repressed by: Smad2 [RNAi]
    *** source: 20595680-Fig-7c
  *** Smad3[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1 (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30++ 60+++ 180++ 720+ 1440 min
    *** source: 20595680-Fig-7d
  *** Smad3[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1 (times)
    *** cells: mEFs<Smad2~null> in BMS
    *** times: 0 15+ 30++ 60+++ 180+ 720 1440 min
    *** source: 20595680-Fig-7d
  *** Smad3[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1 (tnr)
    *** cells: mTECs in BMS
    *** unaffected by: xSmad2 [addition]
    *** source: 20595680-Fig-10b
  *** Smad3[Ab]IP phos(sitenr)[phosAb] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-S5b

==========
total phos
==========

  *** Smad3[Ab]IP phos[32Pi] is increased irt Tgfb1 (tnr)
    *** cells: MV1LU in BMS
    *** source: 9311995-Fig-3a

=============================================
Smad3 phos irt Tgfb1 is inhibited itpo xSmad7
=============================================

  *** xSmad3[Ab]IP phos[32Pi] is increased irt Tgfb1 (tnr)
    *** cells: COS1<xTgfbR1><xTgfbR2> in BMS
    *** inhibited by: xSmad7 [addition]
    *** source: 9335507-Fig-4d

==================================================
Smad3 phos by Jnks irt Tgfb1 occurs at early times
==================================================

  *** xSmad3(S422A/S423A/S425A)[tAb]IP phos[32Pi] is increased irt Tgfb1 (13 min)
    *** cells: MV1LU in BMS
    *** source: 10601313-Fig-5a
  *** xSmad3[tAb]IP phos[32Pi] is increased irt Tgfb1 (18 min)
    *** cells: MV1LU in BMLS
    *** bkg inhibited by: xJnk?(mnr)"DN" [addition]
    *** bkg inhibited by: xTgfbR2(mnr)"DN" [addition]
    *** source: 10601313-Fig-4b
  *** rSmad3[phosAb] phos(S208/S213)[phosAb] is increased by Jnks{phos(TPY)}[phosAb]IP
    *** cells: none
    *** IPfrom: RGM1 in BMS "treated with Tgfb1 for 15 min"
    *** source: 15326485-Fig-3b

======
other
======

  *** xSmad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (times)
    *** cells: mEFs<xSmad3> in BMS
    *** times: 0 30++ 150+ min
    *** comment: decrease at 150 min is reversed by xSmad3(S418A) [substitution]
    *** source: 18794808-Fig-6b
  *** xSmad3[phosAb] phos(S423/S425)[phosAb] is increased irt Tgfb1 (times)
    *** cells: mEFs<xSmad3><xCsnk1g2> in BMS
    *** times: 0 30+ 150 min
    *** comment: decrease at 150 min is reversed by xSmad3(S418A) [substitution]
    *** source: 18794808-Fig-6b
