==================================================================
Smad2 DNA binding is increased itpo Tgfb1, activated TgfbR1, Ep300
==================================================================

  *** xSmad2(del(79-108))[tAb] oligo-binding[EMSA] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: COS1 in BMS
    *** enhanced by: xEp300 [addition]
    *** source: 17074756-Fig-5a
  *** CAGA-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: HEPG2<xSmad2(del(79-108))> in BMLS
    *** enhanced by: xEp300 [addition]
    *** source: 17074756-Fig-4a
  *** Smad2[Ab] snaggedby[WB] oligo[biotin] is increased irt Tgfb1 (5 hr)
    *** cells: COS1<xFoxh1> in BMS
    *** oligo: ARE sequence-not-reported
    *** enhanced by: Lactacystin [addition]
    *** source: 10587642-Fig-3b

==================================================================
Smad2 DNA binding is increased itpo Tgfb1, activated TgfbR1, Pcaf
==================================================================

  *** xSmad2(del(79-108))[tAb] oligo-binding[EMSA] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: COS1 in BMS
    *** enhanced by: xPcaf [addition]
    *** source: 17074756-Fig-5b
  *** CAGA-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: HEPG2<xSmad2(del(79-108))> in BMLS
    *** enhanced by: xPcaf [addition]
    *** source: 17074756-Fig-4b

========================================
Smad2 bound to DNA is acetylated on K19
========================================

  *** Smad2[Ab] boundto(Pai1-gene)[ChIP] is increased irt Tgfb1 (times)
    *** cells: HELA in BMS
    *** times: 0 30+ 60++ min
    *** source: 17074756-Fig-3f
  *** Smad2{acetyl(K19)}[AcAb] boundto(Pai1-gene)[ChIP] is increased irt Tgfb1 (times)
    *** cells: HELA in BMS
    *** times: 0 30+ 60++ min
    *** source: 17074756-Fig-3f

  *** xSmad2(del(79-108))[tAb] boundto(Pai1-gene)[ChIP] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: COS1 in BMS
    *** enhanced by: xEp300 [addition]
    *** inhibited by: rSmad2(del(79-108)/K19R) [substitution]
    *** source: 17074756-Fig-6b

  *** Smad2{acetyl(K19)}[AcAb] boundto(Cdkn1a-gene)[ChIP] is increased irt Tgfb1 (1 hr)
    *** cells: HELA in BMS
    *** source: 17074756-Fig-3e
  *** Smad2{acetyl(K19)}[AcAb] boundto(Pai1-gene)[ChIP] is increased irt Tgfb1 (1 hr)
    *** cells: HELA in BMS
    *** source: 17074756-Fig-3e

=============
Gal4 reporter
=============

  *** xSmad2[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb2 (16 hr)
    *** cells: ATDC5 in BMLS
    *** inhibited by: U0126 [addition]
    *** inhibited by: SB203580 [addition]
    *** inhibited by: SKF86002 [addition]
    *** source: 11278290-Fig-6a
  *** xSmad2[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb1 (18 hr)
    *** cells: HEPG2 in BMS
    *** inhibited by: xSmad7 [addition]
    *** source: 9215638-Fig-2b
  *** xSmad2(1-467)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: HEPG2<xSmad2> in BMS
    *** bkg inhibited by: xSmad2(S464A) [substitution]
    *** bkg inhibited by: xSmad2(S465A) [substitution]
    *** bkg inhibited by: xSmad2(S467A) [substitution]
    *** bkg inhibited by: xSmad2(S464A/S465A/S467A) [substitution]
    *** source: 9346908-Fig-7
  *** xSmad2[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: HEPG2 in BMS
    *** inhibited by: xSmurf2 [addition]
    *** unaffected by: xSmurf2(C716A)"CIA" [addition]
    *** source: 11016919-Fig-5

===========
DNA-binding
===========

  *** xSmad2[tAb] oligo-binding[EMSA] is increased irt Tgfb1 (1 hr)
    *** cells: NIH3T3<xFast3!Xenla><xSmad4> in BMS "nuclear-extracts"
    *** oligo: "activin-responsive Xenopus Mix.2 promoter" sequence-not-reported
    *** source: 12374795-Fig-3
  *** xSmad2[tAb] oligo-binding[EMSA] is increased irt Tgfb1 (1 hr)
    *** cells: NIH3T3<xFoxh1!Xenla><xSmad4> in BMS "nuclear-extr sequence-not-reportedacts"
    *** oligo: "activin-responsive Xenopus Mix.2 promoter" sequence-not-reported
    *** source: 12374795-Fig-2
