=================
Cdc42 association
=================

inhibition by Erbin

  *** Cdc42[Ab] copptby[WB] Pak2[Ab] is increased irt Tgfb1 (45 min)
    *** cells: AKR2B in BMLS
    *** inhibited by: xErbin [addition]
    *** source: 19289088-Fig-5c
  *** Cdc42[Ab] copptby[WB] Pak2[Ab] is increased irt Tgfb1 (45 min)
    *** cells: AKR2B in BMLS
    *** inhibited by: xErbin [addition]
    *** source: 19289088-Fig-5d
  *** Cdc42[Ab] copptby[WB] Pak2[Ab] is increased irt Tgfb1 (45 min)
    *** cells: NMUMG in BMLS
    *** does not req: Erbin [RNAi]
    *** does not req: Merlin [RNAi]
    *** source: 19289088-Fig-6c

Pak2 features

  *** Cdc42[Ab] copptby[WB] Pak2[Ab] is increased irt Tgfb1 (45 min)
    *** cells: NMUMG in BMLS
    *** unaffected by: xPak2(mnr)"CA" [addition]
    *** unaffected by: xPak2(mnr)"DN" [addition]
    *** source: 19289088-Fig-6c
  *** Cdc42[Ab] copptby[WB] xPak2[tAb] is increased irt Tgfb1 (45 min)
    *** cells: AKR2B<xPak2> in BMLS
    *** unaffected by: xPak2(K278R) [substitution]
    *** unaffected by: xPak2(K278R/L106F) [substitution]
    *** source: 19289088-Fig-S2

Requirement for Cdc42-GTP binding
Pak2 only coppts with Cdc42 bound to GTP irt Tgfb1

  *** Cdc42[Ab] copptby[WB] Pak2[Ab] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 5 15+ 30++ min
    *** source: 14612425-Fig-5a
  *** Cdc42[Ab] GTP-association[BDPD] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 5 15+ 30++ min
    *** source: 14612425-Fig-5a
  -----------------------------------------------------------------
  *** Cdc42[Ab] copptby[WB] Pak2[Ab] is unchanged irt Tgfb1 (times)
    *** cells: MV1LU in BMLS
    *** times: 0 5 15 30 min
    *** source: 14612425-Fig-5a
  *** Cdc42[Ab] GTP-association[BDPD] is unchanged irt Tgfb1 (times)
    *** cells: MV1LU in BMLS
    *** times: 0 5 15+ 30++ min
    *** source: 14612425-Fig-5a
  -----------------------------------------------------------------
  *** Cdc42[Ab] copptby[WB] Pak2[Ab] is unchanged irt Tgfb1 (45 min)
    *** cells: A549 in BMLS
    *** source: 19289088-Fig-6a
  *** Cdc42[Ab] GTP-association[BDPD] is unchanged irt Tgfb1 (45 min)
    *** cells: A549 in BMLS
    *** source: 19289088-Fig-6a

================
Rac1 association
================

  *** Rac1[Ab] copptby[WB] Pak2[Ab] is increased irt Tgfb1 (45 min)
    *** cells: AKR2B in BMLS
    *** inhibited by: xErbin [addition]
    *** source: 19289088-Fig-5c
  *** Rac1[Ab] copptby[WB] Pak2[Ab] is increased irt Tgfb1 (45 min)
    *** cells: AKR2B in BMLS
    *** inhibited by: xErbin [addition]
    *** source: 19289088-Fig-5d

Requirement for Rac1-GTP binding
Pak2 only coppts with Rac1 bound to GTP irt Tgfb1

  *** Rac1[Ab] copptby[WB] Pak2[Ab] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 5 15+ 30++ min
    *** source: 14612425-Fig-5a
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 5 15+ 30++ min
    *** source: 14612425-Fig-5a
  ----------------------------------------------------------------
  *** Rac1[Ab] copptby[WB] Pak2[Ab] is unchanged irt Tgfb1 (times)
    *** cells: MV1LU in BMLS
    *** times: 0 5 15 30 min
    *** source: 14612425-Fig-5a







