===================
Jnk kinase activity
===================

Smad3-- ???

  *** Jnks[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt Tgfb1 (times)
    *** cells: MV1LU in BMLS
    *** times: 0 15++ 30++ 60+ 120+ 360+ 720++ 1440++ min
    *** comment: inhibited at 720-1440 min by xSmad3(mnr)"DN" [addition]
    *** inhibited by: xTgfbR2(mnr)"DN" [addition]
    *** source: 10601313-Fig-3a

Smad4-- ???

  *** Jnks[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt Tgfb1 (times)
    *** cells: MDAMB468 in BMLS
    *** times: 0+ 15++ 30+ 60+ 120+ 360+ 720+ 1440+ min
    *** enhanced by: xSmad4 [addition]
    *** comment: addition of xSmad4 causes an addition peak at 720 min
    *** source: 10601313-Fig-3b

Rhoa--

  *** xJnk1[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt Tgfb1 (10 min)
    *** cells: MV1LU in BMLS
    *** inhibited by: xRhoa(T19N)"DN" [addition]
    *** source: 10601313-Fig-2a

no extras

  *** xJnk1[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt Tgfb1 (10 min)
    *** cells: MV1LU in BMLS
    *** unaffected by: xRac1(T17N)"DN" [addition]
    *** source: 10601313-Fig-2a
  *** Jnks[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt Tgfb1 (times)
    *** cells: MV1LU in BMLS
    *** times: 0 5++ 10+++ 15++ 30++ 60+ 120+ 240++ 360+ 480+ 720++ 960++ 1440++ min
    *** source: 10601313-Fig-1a
  *** Jnks[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (15 min)
    *** cells: MV1LU in BMLS
    *** source: 10601313-Fig-1b
  *** Jnks[Ab]IP IVKA(Smad3)[32P-ATP] is increased irt Tgfb1 (tnr)
    *** cells: MV1LU in BMLS
    *** source: 10601313-Fig-4a

later times

  *** xJnk1[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt Tgfb1 (12 hr)
    *** cells: MV1LU in BMLS
    *** inhibited by: xRac1(T17N)"DN" [addition]
    *** source: 10601313-Fig-2a
  *** xJnk1[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt Tgfb1 (12 hr)
    *** cells: MV1LU in BMLS
    *** unaffected by: xRhoa(T19N)"DN" [addition]
    *** source: 10601313-Fig-2a

===================
Jnk phosphorylation
===================

Tak1--  ubiq sites

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0 5+ 10++ 15+ 30+ min
    *** inhibited by: xTak1(K158R) [substitution]
    *** partially inhibited by: xTak1(K34R) [substitution]
    *** source: 20837137-Fig-4a

no extras

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: RGM1 in BMLS
    *** times: 0 5++ 15++ 30+ 60 120 min
    *** source: 15326485-Fig-2a
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt Tgfb1 (15 min)
    *** cells: RGM1 in BMLS
    *** source: 15326485-Fig-2g
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: mEFs in BMS
    *** times: 0+ 2++ 5++ 15++ min
    *** source: 18758450-Fig-5a

later times

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: FAO in BMS
    *** times: 0 1 4 8+ 12+ 16++ 20++ 24++ hr
    *** source: 15069087-Fig-7a
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt Tgfb1 (24 hr)
    *** cells: FAO in BMS
    *** enhanced by: xMlk3 [addition]
    *** partially inhibited by: xMlk3(mnr)"DN" [addition]
    *** source: 15069087-Fig-7b
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt Tgfb1 (24 hr)
    *** cells: FAO in BMS
    *** inhibited by: SP600125 [addition]
    *** source: 15069087-Fig-8b


contradictions

  *** Jnk1[phosAb] phos(TPY)[phosAb] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: HEK293 in BMS
    *** times: 0+ 15+ 30+ 60+ min
    *** source: 10085140-Fig-5a
  *** Jnk2[phosAb] phos(TPY)[phosAb] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: HEK293 in BMS
    *** times: 0+ 15+ 30+ 60+ min
    *** source: 10085140-Fig-5a
