*** Cd40--
  *** Cd40[Ab] surface-exp[FACS] is increased irt CpG (24 hr)
    *** cells: mPECs in BMS
    *** inhibited by: Unc93b1(H412R) [fmut]
    *** source: 16415873-Fig-1b
*** Cd80--
  *** Cd80[Ab] surface-exp[FACS] is increased irt CpG-2006 (48 hr)
    *** cells: hPDCs in BMS
    *** source: 12707322-Fig-3
  *** Cd80[Ab] surface-exp[FACS] is increased irt CpG-2006 (48 hr)
    *** cells: hPDCs in BMS
    *** unaffected by: anti-IfnaR [cotreatment]
    *** source: 12707322-Fig-5
  *** Cd80[Ab] surface-exp[FACS] is increased irt CpG-2216 (48 hr)
    *** cells: hPDCs in BMS
    *** source: 12707322-Fig-3
  *** Cd80[Ab] surface-exp[FACS] is increased irt CpG-2216 (48 hr)
    *** cells: hPDCs in BMS
    *** unaffected by: anti-IfnaR [cotreatment]
    *** source: 12707322-Fig-5
*** Cd86--
  *** Cd86[Ab] surface-exp[FACS] is increased irt CpG (24 hr)
    *** cells: mSpBCs in BMLS
    *** does not req: Peli1 [KO]
    *** source: 19734906-Fig-3a
  *** Cd86[Ab] surface-exp[FACS] is increased irt CpG-2006 (48 hr)
    *** cells: hPDCs in BMS
    *** source: 12707322-Fig-3
  *** Cd86[Ab] surface-exp[FACS] is increased irt CpG-2006 (48 hr)
    *** cells: hPDCs in BMS
    *** unaffected by: anti-IfnaR [cotreatment]
    *** source: 12707322-Fig-5
  *** Cd86[Ab] surface-exp[FACS] is increased irt CpG-2216 (48 hr)
    *** cells: hPDCs in BMS
    *** source: 12707322-Fig-3
  *** Cd86[Ab] surface-exp[FACS] is increased irt CpG-2216 (48 hr)
    *** cells: hPDCs in BMS
    *** unaffected by: anti-IfnaR [cotreatment]
    *** source: 12707322-Fig-5
  *** Cd86[Ab] surface-exp[FACS] is unchanged irt CpG (24 hr)
    *** cells: mPECs in BMS
    *** unaffected by: Unc93b1(H412R) [fmut]
    *** source: 16415873-Fig-1b
*** Erks--
*** Ifna4-gene--
*** Ifna--
  *** Ifna[Ab] prot-exp[FACS] is increased irt CpG-D19 (tnr)
    *** cells: mBMcDCs in BMS
    *** reqs: Myd88 [KO]
    *** source: 16039576-Fig-6d
  *** Ifna[Ab] prot-exp[FACS] is increased irt CpG-D19 (tnr)
    *** cells: mBMpDCs in BMS
    *** reqs: Myd88 [KO]
    *** source: 16039576-Fig-6d
  *** Ifna[Ab] prot-exp[FACS] is increased irt CpG-D35 (8 hr)
    *** cells: mBMfDCs in BMS
    *** reqs: Irak1 [KO]
    *** source: 15767370-Fig-3c
  *** Ifna[Ab] secretion[ELISA] is increased irt CpG-2006 (48 hr)
    *** cells: hPDCs in BMS
    *** comment: the Ifna secreted irt CpG-2006 is 60X lower than irt CpG-2216
    *** source: 12707322-Fig-1a
  *** Ifna[Ab] secretion[ELISA] is increased irt CpG-2006 (48 hr)
    *** cells: hPDCs in BMS
    *** inhibited by: anti-Clec4c [pretreatment]
    *** source: 12707322-Fig-8a
  *** Ifna[Ab] secretion[ELISA] is increased irt CpG-2006 (48 hr)
    *** cells: hPDCs in BMS
    *** unaffected by: anti-IfnaR [cotreatment]
    *** enhanced by: Cd40L [cotreatment]
    *** source: 12707322-Fig-11a
  *** Ifna[Ab] secretion[ELISA] is increased irt CpG-2006 (48 hr)
    *** cells: hPDCs in BMS
    *** unaffected by: anti-IfnaR [cotreatment]
    *** source: 12707322-Fig-4a
  *** Ifna[Ab] secretion[ELISA] is increased irt CpG-2006 (times)
    *** cells: hPDCs in BMS
    *** times: 0 12+ 24 48 hr
    *** source: 12707322-Fig-1b
  *** Ifna[Ab] secretion[ELISA] is increased irt CpG-2216 (48 hr)
    *** cells: hPDCs in BMS
    *** comment: the Ifna secreted irt CpG-2216 is 60X higher than irt CpG-2006
    *** source: 12707322-Fig-1a
  *** Ifna[Ab] secretion[ELISA] is increased irt CpG-2216 (48 hr)
    *** cells: hPDCs in BMS
    *** inhibited by: anti-Clec4c [pretreatment]
    *** source: 12707322-Fig-7a
  *** Ifna[Ab] secretion[ELISA] is increased irt CpG-2216 (48 hr)
    *** cells: hPDCs in BMS
    *** inhibited by: anti-Clec4c [pretreatment]
    *** source: 12707322-Fig-8a
  *** Ifna[Ab] secretion[ELISA] is increased irt CpG-2216 (48 hr)
    *** cells: hPDCs in BMS
    *** inhibited by: anti-Clec4c [pretreatment]
    *** unaffected by: anti-Cd1c [pretreatment]
    *** source: 12707322-Fig-7b
  *** Ifna[Ab] secretion[ELISA] is increased irt CpG-2216 (48 hr)
    *** cells: hPDCs in BMS
    *** partially inhibited by: anti-IfnaR [cotreatment]
    *** partially inhibited by: anti-Clec4c [cotreatment]
    *** source: 12707322-Fig-9a
  *** Ifna[Ab] secretion[ELISA] is increased irt CpG-2216 (48 hr)
    *** cells: hPDCs in BMS
    *** partially inhibited by: anti-IfnaR [cotreatment]
    *** source: 12707322-Fig-4a
  *** Ifna[Ab] secretion[ELISA] is increased irt CpG-2216 (times)
    *** cells: hPDCs in BMS
    *** times: 0 6+ 10++ 24+++ hr
    *** partially inhibited by: anti-IfnaR [cotreatment]
    *** source: 12707322-Fig-4b
  *** Ifna[Ab] secretion[ELISA] is increased irt CpG-2216 (times)
    *** cells: hPDCs in BMS
    *** times: 0 12++ 24+++ 48+ hr
    *** source: 12707322-Fig-1b
*** Ifnb1-- Ifnb1-gene--
*** IL6--
*** IL12--  IL12-gene--
  *** IL12[Ab] prot-exp[FACS] is increased irt CpG-D35 (8 hr)
    *** cells: mBMfDCs in BMS
    *** does not req: Irak1 [KO]
    *** source: 15767370-Fig-3c
  *** IL12[Ab] secretion[ELISA] is increased irt CpG (4 hr)
    *** cells: mBMMs in BMLS
    *** partially reqs: Peli1 [KO]
    *** source: 19734906-Fig-2c
  *** IL12b-gene mRNA[RTPCR] is increased irt CpG (times)
    *** cells: mBMDCs in BMLS
    *** times: 0 2++ 4+ hr
    *** partially reqs: Peli1 [KO]
    *** source: 19734906-Fig-2d
  *** IL12b-gene mRNA[RTPCR] is increased irt CpG (times)
    *** cells: mBMMs in BMLS
    *** times: 0 2++ 4+ hr
    *** partially reqs: Peli1 [KO]
    *** source: 19734906-Fig-2b
*** Irf3--
  *** Irf3-gene mRNA[RTPCR] is decreased irt CpG-2006 (times)
    *** cells: hPDCs in BMS
    *** times: 0++ 3+ 15+ hr
    *** source: 12707322-Fig-6
  *** Irf3-gene mRNA[RTPCR] is decreased irt CpG-2216 (times)
    *** cells: hPDCs in BMS
    *** times: 0++ 3++ 15+ hr
    *** source: 12707322-Fig-6
  *** Irf3[Ab] infraction(nuclear)[WB] is unchanged irt CpG (times)
    *** cells: mBMMs in BMS
    *** times: 0 15 30 60 90 min
    *** source: 12354379-Fig-3a
  *** xIrf3[XFP] locatedin(nucleus)[IHC] is unchanged irt CpG-D19-transfection (times)
    *** cells: HELA<xMyd88> in BMS
    *** times: 0 30 60 120 min
    *** source: 15492225-Fig-2c
*** Irf7--
  *** Irf7-gene mRNA[RTPCR] is increased irt CpG-2006 (times)
    *** cells: hPDCs in BMS
    *** times: 0+ 3++ 15+ hr
    *** source: 12707322-Fig-6
  *** Irf7-gene mRNA[RTPCR] is increased irt CpG-2216 (times)
    *** cells: hPDCs in BMS
    *** times: 0+ 3++ 15+ hr
    *** source: 12707322-Fig-6
*** Jnks--
*** xMekk2--
  *** xMekk2[tAb]IP phos(S520)[phosAb] is increased irt CpG (times)
    *** cells: mEFs<Mekk2~null> in BMS
    *** times: 0 20++ 40+ min
    *** source: 16362041(D)
*** Mekk3--
  *** Mekk3[Ab] copptby[WB] Traf6[Ab] is unchanged irt CpG (times)
    *** cells: mEFs in BMS
    *** times: 0 5 10 20 40 min
    *** source: 14661019(D)
*** Mhc2s--
  *** Mhc2s[Ab] surface-exp[FACS] is increased irt CpG (24 hr)
    *** cells: mSpBCs in BMLS
    *** does not req: Peli1 [KO]
    *** source: 19734906-Fig-3a
  *** Mhc2s[Ab] surface-exp[FACS] is increased irt CpG-2006 (48 hr)
    *** cells: hPDCs in BMS
    *** source: 12707322-Fig-3
  *** Mhc2s[Ab] surface-exp[FACS] is increased irt CpG-2006 (48 hr)
    *** cells: hPDCs in BMS
    *** unaffected by: anti-IfnaR [cotreatment]
    *** source: 12707322-Fig-5
  *** Mhc2s[Ab] surface-exp[FACS] is increased irt CpG-2216 (48 hr)
    *** cells: hPDCs in BMS
    *** source: 12707322-Fig-3
  *** Mhc2s[Ab] surface-exp[FACS] is increased irt CpG-2216 (48 hr)
    *** cells: hPDCs in BMS
    *** unaffected by: anti-IfnaR [cotreatment]
    *** source: 12707322-Fig-5
*** Nemo--
*** Nfkb--
*** Nfkb-reporter--
  *** Nfkb-reporter[Luc] is increased irt CpG (5 hr)
    *** cells: RAW2647 in BMS
    *** unaffected by: Tirap-Peptide-Inhibitor [addition]
    *** source: 11526399(D)
  *** Nfkb-reporter[Luc] is increased irt CpG (14 hr)
    *** cells: HEK293T<xTLR9> in BMS
    *** unaffected by: xTirap(P125H)"DN" [addition]
    *** inhibited by: xMyd88(mnr)"DN" [addition]
    *** source: 11526399(D)
  *** Nfkb-reporter[Luc] is increased irt CpG (times)
    *** cells: mBMDCs in BMS
    *** times: 0 1+ 2+ 4++ hr
    *** reqs: Myd88 [KO]
    *** source: 12356687-Fig-4
  *** Nfkb-reporter[Luc] is increased irt CpG-1668 (8 hr)
    *** cells: HEK293<xTLR9> in BMS
    *** reqs: xTLR9 [omission]
    *** source: 14976262-Fig-4
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt CpG (times)
    *** cells: mBMMs in BMS
    *** times: 0 10 20 60+ min
    *** does not req: Tirap [KO]
    *** reqs: Myd88 [KO]
    *** source: 12447442(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt CpG (times)
    *** cells: mBMMs in BMS
    *** times: 0 30 60+ 90+ min
    *** does not req: Traf3 [KO]
    *** source: 16306936-Fig-S2d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt CpG (times)
    *** cells: mPECs in BMS
    *** times: 0 10+ 20+ min
    *** does not req: TLR7 [KO]
    *** source: 11812998-Fig-4a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt CpG-1668 (times)
    *** cells: mBMfDCs in BMS
    *** times: 0 20+ 60++ min
    *** partially reqs: Irf8 [KO]
    *** source: 15153500-Fig-2b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt CpG-1668 (times)
    *** cells: mPECs in BMS
    *** times: 0 10+ 60++ min
    *** reqs: TLR9 [KO]
    *** source: 11130078-Fig-3e
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt CpG-1668 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 10+ 20+ 60+ min
    *** does not req: Irf5 [KO]
    *** reqs: Myd88 [KO]
    *** source: 15665823-Fig-4d
*** P38s--
*** xPkce--
  *** xPkce[tAb]IP phos(S346)[phosAb] is increased irt CpG-1826 (tnr)
    *** cells: RAW2647 in BMS
    *** source: 18458086-Fig-3b
*** Pkr--
  *** Pkr[phosAb] phos(sitenr)[phosAb] is increased irt CpG (times)
    *** cells: mPECs in BMS
    *** times: 0 10 30+ 60+ min
    *** reqs: Myd88 [KO]
    *** source: 11526399(D)
  *** Pkr[phosAb] phos(sitenr)[phosAb] is increased irt CpG (times)
    *** cells: RAW2647 in BMS
    *** times: 0 15 25+ 45 min
    *** enhanced by: Tirap-Peptide-Inhibitor [addition]
    *** source: 11526399(D)
*** ProTnf-gene--
*** Spp1--
  *** Spp1[Ab] colocwith[IHC] TLR9[Ab] is increased irt CpG-1668 (10 min)
    *** cells: mSpDCs in BMS
    *** source: 16604075-Fig-5a
*** Stat1--
  *** Stat1-gene mRNA[RTPCR] is increased irt CpG-2006 (times)
    *** cells: hPDCs in BMS
    *** times: 0+ 3++ 15+++ hr
    *** source: 12707322-Fig-6
  *** Stat1-gene mRNA[RTPCR] is increased irt CpG-2216 (times)
    *** cells: hPDCs in BMS
    *** times: 0+ 3++ 15+++ hr
    *** source: 12707322-Fig-6
  *** Stat1[phosAb] phos(sitenr)[phosAb] is unchanged irt CpG (times)
    *** cells: mBMMs in BMS
    *** times: 0 30 120 min
    *** source: 12646618-Fig-6a
  *** Stat1[phosAb] phos(Y701)[phosAb] is unchanged irt CpG (times)
    *** cells: mBMMs in BMS
    *** times: 0 1 2 4 hr
    *** source: 12354379-Fig-6b
*** DNA-synthesis--
  *** DNA-synthesis[3H-Thymidine] is increased irt CpG (48 hr)
    *** cells: mSpBCs in BMLS
    *** partially reqs: Peli1 [KO]
    *** source: 19734906-Fig-3b
*** TLR9--
  *** TLR9-gene mRNA[RTPCR] is decreased irt CpG-K3 (times)
    *** cells: RPMI8226 in BMS
    *** times: 0++ 4++ 8++ 16+ hr
    *** source: 15294971-Fig-2
  *** TLR9-gene promo-reporter[Luc] is decreased irt CpG-K3 (34 hr)
    *** cells: RPMI8226 in BMS
    *** reversed by: Chloroquine [cotreatment]
    *** source: 15294971-Fig-5
  *** TLR9-gene promo-reporter[Luc] is unchanged irt CpG-1471 (34 hr)
    *** cells: RPMI8226 in BMS
    *** source: 15294971-Fig-5
  *** TLR9-gene promo-reporter[Luc] is unchanged irt CpG-A151 (34 hr)
    *** cells: RPMI8226 in BMS
    *** source: 15294971-Fig-5
  *** TLR9-gene promo-reporter[Luc] is unchanged irt CpG-D19 (34 hr)
    *** cells: RPMI8226 in BMS
    *** source: 15294971-Fig-5
  *** TLR9-gene promo-reporter[Luc] is unchanged irt CpG-H154 (34 hr)
    *** cells: RPMI8226 in BMS
    *** source: 15294971-Fig-5
*** TLR9-gene--
*** TLR9-gene--
*** Traf6--
*** Trif--
  *** Trif[Ab] copptby[WB] Traf3[Ab] is unchanged irt CpG-1668 (times)
    *** cells: RAW2647 in BMS
    *** times: 0 30 120 min
    *** source: 16306937-Fig-2d
*** Usf2--
  *** Usf2[Ab] infraction(nuclear)[WB] is unchanged irt CpG (times)
    *** cells: mBMMs in BMS
    *** times: 0+ 15+ 30+ 60+ 90+ min
    *** source: 12354379-Fig-3a
  *** Usf2[Ab] infraction(nuclear)[WB] is unchanged irt CpG-1668 (times)
    *** cells: mEFs in BMS
    *** times: 0+ 1+ 2+ 6+ hr
    *** does not req: Myd88 [KO]
    *** source: 15665823-Fig-4b
