===============
Kinase Activity
===============

Lamtor--  ???

  *** xErk1[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Serum (10 min)
    *** cells: NIH3T3 in BMLS
    *** enhanced by: xLamtor3 [addition]
    *** source: 9733512-Fig-4
  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Serum (10 min)
    *** cells: NIH3T3 in BMLS
    *** unaffected by: xLamtor3 [addition]
    *** source: 9733512-Fig-4

Mek1--

  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Serum (30 min)
    *** cells: NIH3T3 in BMLS
    *** inhibited by: xMek1(mnr)"DN" [addition]
    *** source: 10473620-Fig-7a

not Mek5--

  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Serum (30 min)
    *** cells: COS7 in BMLS
    *** unaffected by: xMek5(S311A/T315A)"DN" [addition]
    *** source: 10473620-Fig-5a
  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Serum (30 min)
    *** cells: NIH3T3 in BMLS
    *** unaffected by: xMek5(S311A/T315A)"DN" [addition]
    *** source: 10473620-Fig-7a

not Mlk3--

  *** xErk1[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Serum (5 min)
    *** cells: HEK293 in BMS
    *** unaffected by: xMlk3 [addition]
    *** unaffected by: xMlk3(K144A)"KD" [addition]
    *** source: 10232608-Fig-4b

Wdr83-- ???

  *** xErk1[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Serum (10 min)
    *** cells: COS1<xErk1> in BMLS
    *** enhanced by: xWdr83 [addition]
    *** comment: inhibition occurs at higher xWdr83 concentrations
    *** source: 15118098-Fig-4a

Chemicals

  *** Erks[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt Serum (15 min)
    *** cells: mEFs<Jnk1~null><Jnk2~null> in BMLS
    *** inhibited by: PP1 [addition]
    *** source: 12110590-Fig-6a
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Serum (times)
    *** cells: CCL39 in BMLS
    *** times: 0 1+++ 3++ 12+ hr
    *** unaffected by: ALLN [pretreatment]
    *** source: 9700154-Fig-5b
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Serum (times)
    *** cells: CCL39 in BMLS
    *** times: 0 7+ 60++ 280+ min
    *** enhanced by: CHX [pretreatment]
    *** unaffected by: ALLN [pretreatment]
    *** source: 9700154-Fig-5a

no extras--

  *** Erk1[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Serum (times)
    *** cells: CCL39 in BMLS
    *** times: 0 30++ 60+ 180+ 360+ 540+ min
    *** source: 8392845-Fig-3
  *** xErk1[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Serum (5 min)
    *** cells: HEK293 in BMS
    *** source: 10232608-Fig-4c
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Serum (15 min)
    *** cells: MV1LU in BMLS
    *** source: 10601313-Fig-1b
  *** Erks[Ab]IP IVKA(Smad3)[32P-ATP] is increased irt Serum (tnr)
    *** cells: MV1LU in BMLS
    *** source: 10601313-Fig-4a
  *** Erks[Ab]IP IVKA(snr)[32P-ATP] is increased irt Serum (times)
    *** cells: HEK293 in BMLS
    *** times: 0+ 5+++ 15++ 30+ 60+ 120+ min
    *** source: 9465032-Fig-2b


==============
Phosphorylaton
==============

Braf--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (times)
    *** cells: mEFs in BMLS
    *** times: 0 5+ 10+ 30+ min
    *** partially reqs: Braf [KO]
    *** source: 15199148-Fig-2b

inhibited by Merlin--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (10 min)
    *** cells: RT4<Merlin~null> in BMLS
    *** inhibited by: xMerlin [addition]
    *** source: 16537381-Fig-3d

Mlk3--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (10 min)
    *** cells: HEI193 in BMLS
    *** reqs: Mlk3 [RNAi]
    *** source: 16537381-Fig-3a

not Mnk1-- or Mnk2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (15 min)
    *** cells: mEFs in BMLS
    *** does not req: Mnk1 and/or Mnk2 [DKO]
    *** source: 15254222-Fig-3a

Parva--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (10 min)
    *** cells: HELA in BMLS
    *** partially reqs: Parva [RNAi]
    *** source: 12654898-Fig-5a

Pea15-- ???

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (times)
    *** cells: NIH3T3 in BMLS
    *** times: 0 10+++ 30+++ 60++ 180+ 420+ min
    *** enhanced by: xPea15 [addition]
    *** source: 11702783-Fig-1d

not Pdpk1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (15 min)
    *** cells: mESCs in BMLS
    *** does not req: Pdpk1 [KO]
    *** source: 16763566-Fig-3a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (30 min)
    *** cells: mESCs in BMLS
    *** bkg inhibited by: kPdpk1(L155E)"PIF" [knockin]
    *** source: 16763566-Fig-3b

not Raf1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (10 min)
    *** cells: mEFs in BMLS
    *** does not req: Raf1 [KO]
    *** source: 11296228-Fig-6d

Rheb-- ???

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (10 min)
    *** cells: HEK293<xBraf> in BMLS
    *** unaffected by: xRheb [addition]
    *** source: 16803888-Fig-2c

not Rsk1-- or Rsk2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (15 min)
    *** cells: HELA<xEif4b> in BMLS
    *** unaffected by: xRsk1 [addition]
    *** unaffected by: xRsk1(mnr)"KD" [addition]
    *** unaffected by: xRsk1(myr)"CA" [addition]
    *** source: 16763566-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (90 min)
    *** cells: HELA<xEif4b> in BMLS
    *** unaffected by: xRsk1 [addition]
    *** unaffected by: xRsk1(mnr)"KD" [addition]
    *** unaffected by: xRsk1(myr)"CA" [addition]
    *** source: 16763566-Fig-4c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (tnr)
    *** cells: HELA in BMLS
    *** does not req: Rsk1 and/or Rsk2 [RNAi]
    *** source: 16763566-Fig-5a

not Sin1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (15 min)
    *** cells: mEFs in BMLS
    *** does not req: Sin1 [KO]
    *** source: 16962653-Fig-5b

Wdr23--  ???

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (10 min)
    *** cells: HELA in BMLS
    *** enhanced by: xWdr83 [addition]
    *** comment: inhibition occurs at higher xWdr83 concentrations
    *** source: 15118098-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (10 min)
    *** cells: HELA in BMLS
    *** enhanced by: xWdr83 [addition]
    *** comment: inhibition occurs at higher xWdr83 concentrations
    *** source: 15118098-Fig-5e
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (10 min)
    *** cells: HELA in BMLS
    *** partially reqs: Wdr83 [RNAi]
    *** source: 15118098-Fig-6b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (10 min)
    *** cells: HELA in BMLS
    *** partially reqs: Wdr83 [RNAi]
    *** source: 15118098-Fig-6c


Chemicals

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (8 min)
    *** cells: mEFs<Jnk1~null><Jnk2~null> in BMLS
    *** inhibited by: U0126 [addition]
    *** source: 19647037-Fig-2d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (10 min)
    *** cells: HEK293<xBraf> in BMLS
    *** unaffected by: Rapamycin [addition]
    *** source: 16803888-Fig-2c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (15 min)
    *** cells: HELA in BMLS
    *** unaffected by: FMK [pretreatment]
    *** source: 16763566-Fig-4e
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (15 min)
    *** cells: HELA<xEif4b> in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 16763566-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (tnr)
    *** cells: HELA in BMLS
    *** unaffected by: Rapamycin [pretreatment]
    *** inhibited by: U0126 [pretreatment]
    *** inhibited by: Rapamycin + U0126 [pretreatment]
    *** source: 16763566-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (30 min)
    *** cells: HELA in BMLS
    *** unaffected by: Rapamycin [pretreatment]
    *** inhibited by: U0126 [pretreatment]
    *** inhibited by: Rapamycin + U0126 [pretreatment]
    *** source: 16763566-Fig-1a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (90 min)
    *** cells: HELA<xEif4b> in BMLS
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 16763566-Fig-4c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (times)
    *** cells: HEK293E in BMLS
    *** times: 0 5+++ 10++ 30+ 60+ min
    *** inhibited by: U0126 [pretreatment]
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 17360704-Fig-1a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (times)
    *** cells: HELA in BMLS
    *** times: 0 2+++ 5+++ 10++ 30+ 60 min
    *** unaffected by: FMK [pretreatment]
    *** source: 17360704-Fig-4a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (times)
    *** cells: HELA in BMLS
    *** times: 0 3+ 5++ 15++ 60+ 90+ min
    *** unaffected by: Rapamycin [pretreatment]
    *** inhibited by: U0126 [pretreatment]
    *** inhibited by: Rapamycin + U0126 [pretreatment]
    *** source: 16763566-Fig-1c

no extras

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (times)
    *** cells: HELA in BMLS
    *** times: 0 3+ 5++ 10+++ 15++ 30 min
    *** source: 16763566-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (times)
    *** cells: mEFs<Jnk1~null><Jnk2~null> in BMLS
    *** times: 0 2+ 4+ 6+ 8+ min
    *** source: 19647037-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (times)
    *** cells: NIH3T3 in BMLS
    *** times: 0 15+ 30+ 60+ 180 min
    *** source: 12049732-Fig-1a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (60 min)
    *** cells: CHO<xProTgfa> in BMLS
    *** source: 20188673-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Serum (times)
    *** cells: CHO in BMLS
    *** times: 0 15+ 30+ 45+ min
    *** source: 19595713-Fig-1f












