===============================
Expressed Jak3 is kinase active
===============================

  *** xJak3[Ab]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: COS in BMS
    *** inhibited by: xJak3(mnr)"del-kinase-domain" [substitution]
    *** source: 7568005-Fig-1b
  *** xJak3[Ab]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: COS7 in BMS
    *** inhibited by: xJak3(K855A)"KD" [substitution]
    *** partially inhibited by: xJak3(Y980F) [substitution]
    *** enhanced by: xJak3(Y981F) [substitution]
    *** unaffected by: xJak3(Y980F/Y981F) [substitution]
    *** source: 9391116-Fig-2a
  *** xJak3[Ab]IP IVKA(IL2Rg)[32P-ATP] is detectable
    *** cells: COS7 in BMS
    *** inhibited by: xJak3(K855A)"KD" [substitution]
    *** partially inhibited by: xJak3(Y980F) [substitution]
    *** enhanced by: xJak3(Y981F) [substitution]
    *** partially inhibited by: xJak3(Y980F/Y981F) [substitution]
    *** source: 9391116-Fig-2b

=========================
Expressed Jak3 is Yphosed
=========================

  *** xJak3[Ab]IP Yphos[pYAb] is detectable
    *** cells: COS in BMS
    *** inhibited by: xJak3(mnr)"del-kinase-domain" [substitution]
    *** source: 7568005-Fig-1b
  *** xJak3[Ab]IP Yphos[pYAb] is detectable
    *** cells: COS in BMS
    *** unaffected by: IL2 (5 min) [stim]
    *** source: 7568005-Fig-2b
  *** xJak3[Ab]IP Yphos[pYAb] is detectable
    *** cells: COS7 in BMS
    *** inhibited by: xJak3(K815A)"KD" [substitution]
    *** unaffected by: xJak3(Y975F/Y976F)"FF" [substitution]
    *** unaffected by: xJak3(Y975F)"FY" [substitution]
    *** unaffected by: xJak3(Y976F)"YF" [substitution]
    *** source: 9382798-Fig-3d
  *** xJak3[Ab]IP Yphos[pYAb] is detectable
    *** cells: COS7 in BMS
    *** inhibited by: xJak3(K855A)"KD" [substitution]
    *** inhibited by: xJak3(Y980F) [substitution]
    *** enhanced by: xJak3(Y981F) [substitution]
    *** unaffected by: xJak3(Y980F/Y981F) [substitution]
    *** source: 9391116-Fig-3a
  *** xJak3[Ab]IP Yphos[pYAb] is detectable
    *** cells: U4A in BMS
    *** source: 10825200-Fig-6b
  *** xJak3[pYAb] Yphos[pYAb] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xSocs1 [addition]
    *** source: 9202126-Fig-3f

===========================
Jak3 is not Yphosed by Jak1
===========================

  *** xJak3(mnr)"KD"[Ab]IP Yphos[pYAb] is unchanged itpo xJak1
    *** cells: U4A in BMS
    *** source: 10825200-Fig-6b

================
Coprecipitations
================

Fak2--

  *** Jak3[Ab] copptby[WB] Fak2[Ab] is detectable
    *** cells: BAFB03<xIL2Rb> in BMS "IL2-deprived"
    *** unaffected by: IL2 (60 min) [stim]
    *** source: 9512511-Fig-3d
  *** xJak3[Ab] copptby[WB] xFak2[Ab] is detectable
    *** cells: COS in BMS
    *** source: 9512511-Fig-3c

not IL2Rb--

  *** Jak3[Ab] copptby[WB] IL2Rb[Ab] is undetectable
    *** cells: YT in BMS
    *** source: 7973658-Fig-2
  *** xJak3[Ab] copptby[WB] xIL2Rb[Ab] is undetectable
    *** cells: COS7 in BMS
    *** source: 7973658-Fig-4c
  *** xJak3[Ab] copptby[WB] xIL2Rb[Ab] is undetectable
    *** cells: COS7 in BMS
    *** source: 9382798-Fig-5a

IL2Rg--

  *** Jak3[Ab] copptby[WB] IL2Rg[Ab] is detectable
    *** cells: hIL2RTCs in BMLS "IL2-deprived"
    *** source: 7973657-Fig-3a
  *** Jak3[Ab] copptby[WB] IL2Rg[Ab] is detectable
    *** cells: hIL2RTCs in BMLS "IL2-deprived"
    *** source: 7973657-Fig-3c
  *** Jak3[Ab] copptby[WB] IL2Rg[Ab] is detectable
    *** cells: YT in BMS
    *** source: 7973658-Fig-2
  *** xJak3[Ab] copptby[WB] xIL2Rg[Ab] is detectable
    *** cells: COS in BMS
    *** inhibited by: xIL2Rg(1-290)"M1" [substitution]
    *** inhibited by: xIL2Rg(1-321)"M2" [substitution]
    *** source: 10962026-Fig-1b
  *** xJak3[Ab] copptby[WB] xIL2Rg[Ab] is detectable
    *** cells: COS7 in BMS
    *** source: 7973658-Fig-4a
  *** xJak3[Ab] copptby[WB] xIL2Rg[Ab] is detectable
    *** cells: COS7 in BMS
    *** source: 7973658-Fig-4b

Stam--

  *** Jak3[Ab] copptby[WB] Stam[Ab] is detectable
    *** cells: ILTMAT in BMS
    *** source: 9133424-Fig-4

Stam2--

  *** Jak3[Ab] copptby[WB] Stam2[Ab] is detectable
    *** cells: ILTMAT in BMS
    *** source: 10899310-Fig-2a
  *** xJak3[Ab] copptby[WB] xStam[Ab] is detectable
    *** cells: COS7 in BMS
    *** unaffected by: xStam(del(216-267))"DSH3" [substitution]
    *** inhibited by: xStam(del(355-388))"DIT" [substitution]
    *** inhibited by: xStam(1-370)"DY2" [substitution]
    *** source: 9133424-Fig-5a
  *** xJak3[Ab] copptby[WB] xStam2[tAb] is detectable
    *** cells: COS7 in BMS
    *** inhibited by: Jak3(122-813)"delJH7" [substitution]
    *** inhibited by: Jak3(283-813)"delJH7-5" [substitution]
    *** source: 10899310-Fig-3c
  *** xJak3[Ab] copptby[WB] xStam2[tAb] is detectable
    *** cells: COS7 in BMS
    *** unaffected by: Jak3(1-109)"Mun1" [substitution]
    *** source: 10899310-Fig-3b
  *** xJak3[Ab] copptby[WB] xStam2[tAb] is detectable
    *** cells: COS7 in BMS
    *** unaffected by: xStam2(del(209-256))"2DSH3" [substitution]
    *** inhibited by: xStam2(del(349-377))"2DIT" [substitution]
    *** inhibited by: xStam2(1-343)"2DY2" [substitution]
    *** source: 10899310-Fig-3d
  *** xJak3[Ab] copptby[WB] xStam2[tAb] is detectable
    *** cells: COS7 in BMS
    *** unaffected by: Jak3(1-813)"delJH1" [substitution]
    *** unaffected by: Jak3(1-813)"delJH1" [substitution]
    *** unaffected by: Jak3(1-299)"Acc1" [substitution]
    *** unaffected by: Jak3(1-192)"Stu1" [substitution]
    *** source: 10899310-Fig-3b



