=========================
Fak2 auto kinase activity
=========================

  *** xFak2[Ab]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** comment: HEK293 do not express detectable Fak2
    *** inhibited by: xFak2(K457A)"KD" [substitution]
    *** unaffected by: xFak2(Y402F) [substitution]
    *** source: 12514172-Fig-1a
  *** xFak2[tAb]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: mBMPOs in BMS
    *** inhibited by: xFak2(K457A)"KD" [substitution]
    *** partially inhibited by: xFak2(Y402F) [substitution]
    *** source: 12514172-Fig-3
  *** xFak2[Ab]IP IVKA(peptide)[32P-ATP] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xFak2(K457A) [substitution]
    *** inhibited by: xFak2(D567N) [substitution]
    *** inhibited by: xFak2(K457A/Y402F) [substitution]
    *** partially inhibited by: xFak2(Y402F) [substitution]
    *** partially inhibited by: xFak2(Y579F/Y580F) [substitution]
    *** partially inhibited by: xFak2(Y402F/Y881F) [substitution]
    *** unaffected by: xFak2(Y881F) [substitution]
    *** source: 10085136-Fig-1a
  *** xFak2[tAb]IP IVKA(peptide)[32P-ATP] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xFak2(Y402F) [substitution]
    *** unaffected by: xFak2(Y881F) [substitution]
    *** inhibited by: xFak2(mnr)"KD" [substitution]
    *** source: 10329689-Fig-1c

  *** Fak2[Ab]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: mBMPOs in BMS
    *** enhanced by: xFak2(WT) [addition]
    *** unaffected by: xFak2(K457A)"KD" [addition]
    *** enhanced by: xFak2(Y402F) [addition]
    *** comment: enhancement probably due to increase in xFak2 protein
    *** source: 12514172-Fig-3

==================================
Fak2 is phosphorylated on tyrosine
==================================

  *** xFak2[Ab]IP Yphos[pYAb] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xFak2(691-1009)"CRNK" [addition]
    *** inhibited by: xFak1(693-1052)"FRNK" [addition]
    *** source: 10085136-Fig-7a
  *** xFak2[Ab]IP Yphos[pYAb] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xFak2(K457A) [substitution]
    *** inhibited by: xFak2(D567N) [substitution]
    *** inhibited by: xFak2(K457A/Y402F) [substitution]
    *** inhibited by: xFak2(Y402F) [substitution]
    *** partially inhibited by: xFak2(Y579F/Y580F) [substitution]
    *** inhibited by: xFak2(Y402F/Y881F) [substitution]
    *** unaffected by: xFak2(Y881F) [substitution]
    *** source: 10085136-Fig-1b

==============================
Fak2 is phosphorylated on Y402
==============================

  *** xFak2[Ab]IP phos(Y402)[phosAb] is detectable
    *** cells: HEK293 in BMS
    *** comment: HEK293 do not express detectable Fak2
    *** partially inhibited by: xFak2(K457A)"KD" [substitution]
    *** inhibited by: xFak2(Y402F) [substitution]
    *** source: 12514172-Fig-1b
  *** Fak2[Ab]IP phos(Y402)[phosAb] is detectable
    *** cells: mBMPOs in BMS
    *** enhanced by: xFak2(WT) [addition]
    *** enhanced by: xFak2(K457A)"KD" [addition]
    *** unaffected by: xFak2(Y402F) [addition]
    *** source: 12514172-Fig-4a
  *** xFak2[tAb]IP phos(Y402)[phosAb] is detectable
    *** cells: mBMPOs in BMS
    *** unaffected by: xFak2(K457A)"KD" [substitution]
    *** inhibited by: xFak2(Y402F) [substitution]
    *** source: 12514172-Fig-4a

===================================
Fak2 is phosphorylated on Y579/Y580
===================================

  *** xFak2[Ab]IP phos(Y579/Y580)[phosAb] is detectable
    *** cells: HEK293 in BMS
    *** comment: HEK293 do not express detectable Fak2
    *** partially inhibited by: xFak2(K457A)"KD" [substitution]
    *** inhibited by: xFak2(Y402F) [substitution]
    *** source: 12514172-Fig-1b
  *** Fak2[Ab]IP phos(Y579/Y580)[phosAb] is detectable
    *** cells: mBMPOs in BMS
    *** unaffected by: xFak2(WT) [addition]
    *** unaffected by: xFak2(K457A)"KD" [addition]
    *** unaffected by: xFak2(Y402F) [addition]
    *** source: 12514172-Fig-4b
  *** xFak2[tAb]IP phos(Y579/Y580)[phosAb] is detectable
    *** cells: mBMPOs in BMS
    *** unaffected by: xFak2(K457A)"KD" [substitution]
    *** inhibited by: xFak2(Y402F) [substitution]
    *** source: 12514172-Fig-4b

==============================
Fak2 is phosphorylated on Y881
==============================

  *** xFak2[Ab]IP phos(Y881)[phosAb] is detectable
    *** cells: HEK293 in BMS
    *** comment: HEK293 do not express detectable Fak2
    *** inhibited by: xFak2(K457A)"KD" [substitution]
    *** inhibited by: xFak2(Y402F) [substitution]
    *** source: 12514172-Fig-1b
  *** Fak2[Ab]IP phos(Y881)[phosAb] is detectable
    *** cells: mBMPOs in BMS
    *** enhanced by: xFak2(WT) [addition]
    *** enhanced by: xFak2(K457A)"KD" [addition]
    *** unaffected by: xFak2(Y402F) [addition]
    *** source: 12514172-Fig-4c
  *** xFak2[tAb]IP phos(Y881)[phosAb] is detectable
    *** cells: mBMPOs in BMS
    *** unaffected by: xFak2(K457A)"KD" [substitution]
    *** inhibited by: xFak2(Y402F) [substitution]
    *** source: 12514172-Fig-4c

================
coprecipitations
================

Bcar--

  *** Fak2[Ab] copptby[WB] Bcar1[Ab] is detectable
    *** cells: hTonsillarBCs in BMS
    *** source: 9020138-Fig-5b

Grb2--  reqs Src-kinase activity

  *** xFak2[Ab] copptby[WB] Grb2[Ab] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xFak2(Y402F) [substitution]
    *** inhibited by: xFak2(Y881F) [substitution]
    *** inhibited by: xFak2(mnr)"KD" [substitution]
    *** source: 10329689-Fig-2b
  *** xFak2[Ab] copptby[WB] Grb2[Ab] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xSrc(mnr)"KD" [addition]
    *** source: 10329689-Fig-2c

Itgb3--

  *** Fak2[Ab] copptby[WB] Itgb3[Ab] is detectable
    *** cells: mOLCs in BMS
    *** source: 16600665-Fig-3a

Nedd9--

  *** Fak2[Ab] copptby[WB] Nedd9[Ab] is detectable
    *** cells: hTonsillarBCs in BMS
    *** source: 9020138-Fig-5b

Pdpk1--

  *** xFak2[tAb] copptby[WB] xPdpk1[tAb] is detectable
    *** cells: HEK293<xPdpk1><xFak2> in BMS
    *** inhibited by: xFak2(K457A) [substitution]
    *** source: 14585963-Fig-6c
  *** xFak2[tAb] copptby[WB] xPdpk1[tAb] is detectable
    *** cells: HEK293<xPdpk1><xFak2> in BMS
    *** inhibited by: xPdpk1(Y9F) [substitution]
    *** source: 14585963-Fig-6c


