==========================
Akt1 basal kinase activity
==========================

  *** xAkt1[tAb]IP IVKA(peptide)[32P-ATP] is detectable
    *** cells: CHO<xInsR> in BMLS
    *** inhibited by: xDok1 [addition]
    *** inhibited by: rDok1(Y362F/Y398F) [addition]
    *** source: 11551902-Fig-7c
  *** Akt1[Ab]IP IVKA(Gsk3s)(SFAE)[phosAb] is detectable
    *** cells: mEFs in BMLS
    *** partially reqs: Rictor [KO]
    *** source: 16962829-Fig-4f
  *** Akt1[Ab]IP IVKA(Gsk3?)[32P-ATP] is detectable
    *** cells: HEK293T in BMS
    *** reqs: Pdpk1 [RNAi]
    *** source: 18662999-Fig-3b

==================================
Akt1 basal phosphorylation on S473
==================================

not Braf--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: A427 in BMLS
    *** does not req: Braf [RNAi]
    *** does not req: Raf1 or Braf [DRNAi]
    *** source: 16630891-Fig-7c
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: ASPC1 in BMLS
    *** does not req: Braf [RNAi]
    *** does not req: Raf1 or Braf [DRNAi]
    *** source: 16630891-Fig-7b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HPAF in BMLS
    *** does not req: Braf [RNAi]
    *** does not req: Raf1 or Braf [DRNAi]
    *** source: 16630891-Fig-S1b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: MIAPACA2 in BMLS
    *** does not req: Braf [RNAi]
    *** does not req: Raf1 or Braf [DRNAi]
    *** source: 16630891-Fig-7a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: SW480 in BMLS
    *** does not req: Braf [RNAi]
    *** does not req: Raf1 or Braf [DRNAi]
    *** source: 16630891-Fig-S1a

Dok1--

  *** xAkt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: CHO<xInsR> in BMLS
    *** inhibited by: xDok1 [addition]
    *** inhibited by: rDok1(Y362F/Y398F) [addition]
    *** source: 11551902-Fig-7b

not Freud--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** does not req: Freud1 [RNAi]
    *** source: 18662999-Fig-3a

Gab1--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HEK293 in BMLS
    *** reqs: Gab1 [RNAi]
    *** source: 16687399-Fig-8e

not Hras--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: A427 in BMLS
    *** does not req: Hras [RNAi]
    *** source: 16630891-Fig-7c
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: ASPC1 in BMLS
    *** does not req: Hras [RNAi]
    *** source: 16630891-Fig-7b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HPAF in BMLS
    *** does not req: Hras [RNAi]
    *** source: 16630891-Fig-S1b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: MIAPACA2 in BMLS
    *** does not req: Hras [RNAi]
    *** source: 16630891-Fig-7a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: SW480 in BMLS
    *** does not req: Hras [RNAi]
    *** source: 16630891-Fig-S1a

Kras-- ???

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: A427 in BMLS
    *** partially reqs: Kras [RNAi]
    *** source: 16630891-Fig-7c
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: ASPC1 in BMLS
    *** reqs: Kras [RNAi]
    *** source: 16630891-Fig-7b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HPAF in BMLS
    *** reqs: Kras [RNAi]
    *** source: 16630891-Fig-S1b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: MIAPACA2 in BMLS
    *** reqs: Kras [RNAi]
    *** source: 16630891-Fig-7a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: SW480 in BMLS
    *** does not req: Kras [RNAi]
    *** source: 16630891-Fig-S1a

not Mlst8--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** does not req: Mlst8 [RNAi]
    *** source: 12718876(D)

not Mtor--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** does not req: Mtor [RNAi]
    *** source: 12718876(D)

not Nras--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: A427 in BMLS
    *** does not req: Nras [RNAi]
    *** source: 16630891-Fig-7c
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: ASPC1 in BMLS
    *** does not req: Nras [RNAi]
    *** source: 16630891-Fig-7b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HPAF in BMLS
    *** does not req: Nras [RNAi]
    *** source: 16630891-Fig-S1b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: MIAPACA2 in BMLS
    *** does not req: Nras [RNAi]
    *** source: 16630891-Fig-7a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: SW480 in BMLS
    *** does not req: Nras [RNAi]
    *** source: 16630891-Fig-S1a

Ppp2r1a--


Ppp2r5b--


Rac1--

  *** xAkt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: bAECs in BMS
    *** enhanced by: xRac1(G12V)"CA" [addition]
    *** inhibited by: xRac1(T17N)"DN" [addition]
    *** source: 16339142-Fig-3

not Raf1--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: A427 in BMLS
    *** does not req: Raf1 [RNAi]
    *** does not req: Raf1 or Braf [DRNAi]
    *** source: 16630891-Fig-7c
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: ASPC1 in BMLS
    *** does not req: Braf [RNAi]
    *** does not req: Raf1 or Braf [DRNAi]
    *** source: 16630891-Fig-7b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HPAF in BMLS
    *** does not req: Raf1 [RNAi]
    *** does not req: Raf1 or Braf [DRNAi]
    *** source: 16630891-Fig-S1b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: MIAPACA2 in BMLS
    *** does not req: Raf1 [RNAi]
    *** does not req: Raf1 or Braf [DRNAi]
    *** source: 16630891-Fig-7a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: SW480 in BMLS
    *** does not req: Raf1 [RNAi]
    *** source: 16630891-Fig-S1a

not Raptor--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: A549 in BMS
    *** does not req: Raptor [RNAi]
    *** source: 15718470-Fig-2a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HEK293 in BMS "Leucine deprived"
    *** does not req: Raptor [RNAi]
    *** source: 12150925-Fig-5a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** does not req: Raptor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HELA in BMS
    *** does not req: Raptor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HT29 in BMS
    *** does not req: Raptor [RNAi]
    *** source: 15718470-Fig-2a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: M059J in BMLS
    *** does not req: Raptor [RNAi]
    *** source: 15718470-Fig-S2
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: PC3 in BMS
    *** does not req: Raptor [RNAi]
    *** source: 15718470-Fig-2b

not Shoc2--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: A427 in BMLS
    *** does not req: Shoc2 [RNAi]
    *** source: 16630891-Fig-7c
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: ASPC1 in BMLS
    *** does not req: Shoc2 [RNAi]
    *** source: 16630891-Fig-7b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HPAF in BMLS
    *** does not req: Shoc2 [RNAi]
    *** source: 16630891-Fig-S1b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: MIAPACA2 in BMLS
    *** does not req: Shoc2 [RNAi]
    *** source: 16630891-Fig-7a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: SW480 in BMLS
    *** does not req: Shoc2 [RNAi]
    *** source: 16630891-Fig-S1a

Traf2--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: mEFs in BMS
    *** reqs: Traf2 [KO]
    *** source: 16260598-Fig-4c

Traf6--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: mEFs in BMS
    *** reqs: Traf6 [KO]
    *** source: 16260598-Fig-6e

Chemicals

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: hESKs<xEgfR> in BMLS "Egf and BPE starved"
    *** unaffected by: AG490 [addition]
    *** inhibited by: Fludara [addition]
    *** inhibited by: Wortmannin [addition]
    *** inhibited by: LY294002 [addition]
    *** source: 15284024-Fig-2
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: PC3 in BMLS
    *** inhibited by: KPSD1 [addition]
    *** source: 11313365-Fig-6b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: RAW2647 in BMS
    *** inhibited by: Wortmannin [addition]
    *** source: 12881422-Fig-4b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: SHSY5Y in BMS
    *** unaffected by: Compound-C [addition]
    *** source: 16620785(D)

==================================
Akt1 basal phosphorylation on T308
==================================

Dok1--

  *** xAkt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: CHO<xInsR> in BMLS
    *** inhibited by: xDok1 [addition]
    *** inhibited by: rDok1(Y362F/Y398F) [addition]
    *** source: 11551902-Fig-7b

not Raptor--

  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** does not req: Raptor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: HELA in BMS
    *** does not req: Raptor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: PC3 in BMS
    *** does not req: Raptor [RNAi]
    *** source: 15718470-Fig-2b

Smad3--

  *** xAkt1[GST]IP phos(T308)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** reqs: Smad3 [RNAi]
    *** source: 17327236-Fig-4b

Smad7--

  *** xAkt1[GST]IP phos(T308)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** reqs: Smad7 [RNAi]
    *** source: 17327236-Fig-4b

chemicals

contradictions


==================================
Akt1 basal phosphorylation on snr
==================================

  *** Akt1[phosAb] phos(sitenr)[phosAb] is detectable
    *** cells: mEFs in BMS
    *** reqs: Rac1 [KO]
    *** source: 16698790-Fig-6a

================
Coprecipitations
================

Bag1--

  *** Akt1[Ab] copptby[WB] Bag1[Ab] is detectable
    *** cells: PC12 in BMS
    *** source: 16116448-Fig-7d

Bcl10--

  *** Akt1[Ab] copptby[WB] Bcl10[Ab] is detectable
    *** cells: MCF7 in BMS
    *** unaffected by: Tnf (15,30,60 min) [stim]
    *** source: 16280327-Fig-5b

Braf--

  *** Akt1[Ab] copptby[WB] Braf[Ab] is detectable
    *** cells: PC12 in BMS
    *** source: 16116448-Fig-7
  *** xAkt1[tAb] copptby[WB] xBraf[GST] is detectable
    *** cells: HEK293 in BMS
    *** source: 11410590-Fig-4a
  *** xAkt1[tAb] copptby[WB] xBraf[GST] is detectable
    *** cells: HEK293<xBraf> in BMLS
    *** source: 10869359-Fig-2b

not Erk2--

  *** rAkt1[Ab] boundby[WB] rErk2[tAb] is undetectable
    *** cells: none
    *** source: 18662999-Fig-4b

Freud1--

  *** rAkt1[Ab] boundby[WB] rFreud1[tAb] is detectable
    *** cells: none
    *** source: 18662999-Fig-4b
  *** xAkt1[tAb] copptby[WB] xFreud1[tAb] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: LY294002 [addition]
    *** source: 18662999-Fig-5f

Jip1--

  *** xAkt1[tAb] copptby[WB] xJip1[tAb] is detectable
    *** cells: COS7 in BMS
    *** source: 18285454-Fig-6a
  *** xAkt1[tAb] copptby[WB] xJip1[tAb] is detectable
    *** cells: COS7<xMlk3> in BMS
    *** source: 12194869(D)
  *** xAkt1[tAb] copptby[WB] xJip1[tAb] is detectable
    *** cells: COS7<xMlk3><xJnk1> in BMS
    *** source: 12194869(D)
  *** xAkt1[tAb] copptby[WB] xJip1[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 12194869(D)

Sin1--

  *** Akt1[Ab] copptby[WB] Sin1[Ab] is detectable
    *** cells: HEK293T in BMLS
    *** source: 16962653-Fig-5f
  *** xAkt1[tAb] copptby[WB] Sin1[Ab] is detectable
    *** cells: HEK293 in BMS
    *** source: 16962653-Fig-5e
  *** xAkt1[tAb] copptby[WB] Sin1[Ab] is detectable
    *** cells: HEK293T in BMLS
    *** source: 16962653-Fig-5e

Nos3--

  *** Akt1[Ab] copptby[WB] Nos3[Ab] is detectable
    *** cells: bAECs in BMLS
    *** source: 10469573(D)
  *** Akt1[Ab] copptby[WB] Nos3[Ab] is detectable
    *** cells: bAECs in BMS
    *** source: 10469573(D)

Raf1--

  *** xAkt1[tAb] copptby[WB] xRaf1[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 10576742-Fig-5

RalGds--

  *** xAkt1[tAb] copptby[WB] xRalGds[tAb] is detectable
    *** cells: COS7 in BMS
    *** enhanced by: xJip1 [addition]
    *** source: 18285454-Fig-7b
  *** xAkt1[tAb] copptby[WB] xRalGds[tAb] is detectable
    *** cells: COS7 in BMS
    *** unaffected by: Egf (5 min) [stim]
    *** source: 18285454-Fig-7e
  *** xAkt1[tAb] copptby[WB] xRalGds[tAb] is detectable
    *** cells: COS7 in BMS
    *** unaffected by: xRalGds(mnr)"del-Nterm" [substitution]
    *** source: 18285454-Fig-7a

Rictor--

  *** Akt1[Ab] copptby[WB] Rictor[Ab] is undetectable
    *** cells: HEK293 in BMLS
    *** unaffected by: Serum (20 min) [stim]
    *** source: 16962653-Fig-S3

========
Location
========

  *** Akt1[Ab] infraction(membrane)[WB] is detectable
    *** cells: HELA in BMLS
    *** reqs: Parva [RNAi]
    *** source: 12654898-Fig-4a






