=================
Kinase Activation
=================

Cdc42--

  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Pdgf (30 min)
    *** cells: NIH3T3 in BMLS
    *** inhibited by: xCdc42(T17N)"DN" [addition]
    *** source: 8653792-Fig-1a,3

Rac1--

  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Pdgf (30 min)
    *** cells: NIH3T3 in BMLS
    *** partially inhibited by: xRac1(T17N)"DN" [addition]
    *** source: 8653792-Fig-1a,3

chemicals

  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Pdgfb (tnr)
    *** cells: NIH3T3 in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 10903150-Fig-3a
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Pdgfb (tnr)
    *** cells: NIH3T3 in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 10903150-Fig-3b

no extras

  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Pdgfb (times)
    *** cells: NIH3T3 in BMLS
    *** times: 0+ 5++ 15+++ 60++ 180++ 360++ 600++ 720++ 900+ 1080+ min
    *** source: 10903150-Fig-1a
  *** xErk?[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Pdgf (15 min)
    *** cells: NIH3T3 in BMS
    *** source: 11309380-Fig-1a
  *** Erk1[Ab]IP IVKA(Rsk1)[32P-ATP] is increased irt Pdgf (times)
    *** cells: SWISS3T3 in BMLS
    *** times: 0 45+ 60+ 90++ 120++ 150++ 180++ 210+ min
    *** source: 12134156-Fig-6d
  *** Erk2[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Pdgf (times)
    *** cells: BALB3T3<xKsr1> in BMLS
    *** times: 0 5+ 15+ 60 min
    *** source: 9858547-Fig-4a
  *** Erk1[Ab]IP IVKA(Rsk1)[32P-ATP] is increased irt Pdgf (times)
    *** cells: SWISS3T3 in BMLS
    *** times: 0 5+++ 10++ 60++ 90++ 120+ 240+ 360+ min
    *** source: 12134156-Fig-1b
  *** Erk1[Ab]IP IVKA(Rsk?)[32P-ATP] is increased irt Pdgf (times)
    *** cells: SWISS3T3 in BMLS
    *** times: 0 10++ 60+ 120+ min
    *** source: 14673150-Fig-5c


===========================
Phosphorylation on TEY site
===========================

not Abl1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgfb (times)
    *** cells: mEFs<Abl1~null><Abl2~null><xAbl1> in BMLS
    *** times: 0 3+ 30+ min
    *** does not req: xAbl1 [omission]
    *** source: 15039778-Fig-S2a

Gab1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (times)
    *** cells: mEFs in BMLS
    *** times: 0 5++ 10++ 30+ 90 min
    *** partially reqs: Gab1 [KO]
    *** source: 12629518(D)

not Fos--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (30 min)
    *** cells: NIH3T3<xFos> in BMLS
    *** unaffected by: xFos(T232A/T325A/T331A/S374A) [substitution]
    *** source: 12972619-Fig-6a

not Sin1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (15 min)
    *** cells: mEFs in BMLS
    *** does not req: Sin1 [KO]
    *** source: 16962653-Fig-5b

Mlk3--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (10 min)
    *** cells: hUVECs in BMLS
    *** reqs: Mlk3 [RNAi] no-bkg-control
    *** source: 15258589-Fig-2d

Pak1-- and/or Pak2--

  *** xErk1[tAb]IP phos(TEY)[phosAb] is increased irt Pdgf (5 min)
    *** cells: NIH3T3 in BMLS
    *** inhibited by: xPak1(83-149)"DN" [addition]
    *** source: 16129686-Fig-7
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (5 min)
    *** cells: HELA in BMS
    *** does not req: Pak1 [RNAi]
    *** does not req: Pak2 [RNAi]
    *** reqs: Pak1 and/or Pak2 [DRNAi]
    *** source: 16129686-Fig-3a,3b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (5 min)
    *** cells: NIH3T3 in BMLS
    *** partially inhibited by: xPak1(83-149)"DN" [addition]
    *** source: 16129686-Fig-3a,3b

Shp2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (5 min)
    *** cells: mEFs in BMLS
    *** partially reqs: Shp2 [KO]
    *** source: 14967142-Fig-3c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (times)
    *** cells: NIH3T3 in BMLS
    *** times: 0 2++ 10++ 60+ 240+ min
    *** partially inhibited by: xShp2(C459S) [addition]
    *** comment: decrease after 10 min is reversed itpo xShp2 [addition]
    *** source: 14560030-Fig-4b

not Raf1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (10 min)
    *** cells: mEFs in BMLS
    *** does not req: Raf1 [KO]
    *** unaffected by: kRaf1(Y340F/Y341F) [substitution]
    *** source: 11296227-Fig-5b

not Rictor--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 10+ 30+ min
    *** does not req: Rictor [KO]
    *** source: 16962829-Fig-4e

Src-- ????

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (times)
    *** cells: mEFs<Src~null><Yes1~null><Fyn~null><xSrc> in BMLS
    *** times: 0 5++ 15+ 30+ 60+ min
    *** comment: Erk-phos pattern is unusual when xSrc is omitted
    *** source: 14967142-Fig-5c


===================
Inhibitory Proteins
===================

  *** Erks[Ab]IP phos(TEY)[phosAb] is increased irt Pdgf (times)
    *** cells: NIH3T3<xSocs3> in BMS
    *** times: 0 30++ 60++ 120+ 240 hr
    *** inhibited by: xSocs3(Y204F/Y221F) [substitution]
    *** source: 11331873-Fig-4c
  *** Erks[Ab]IP phos(TEY)[phosAb] is increased irt Pdgf (tnr)
    *** cells: NIH3T3<xSocs3> in BMS
    *** unaffected by: xSocs3(Y204F) [substitution]
    *** inhibited by: xSocs3(Y221F) [substitution]
    *** source: 11331873-Fig-4d

Location clues

  *** Erks{phos(TEY)}[phosAb] locatedin(nucleus)[IHC] is increased irt Pdgf (times)
    *** cells: SWISS3T3 in BMLS
    *** times: 0 5+++ 10++ 30+ 45+ 90+ min
    *** comment: the location of total Erks was not determined
    *** source: 12134156-Fig-1c

Chemicals

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (10 min)
    *** cells: NIH3T3 in BMLS
    *** comment: cells are transfected with xFos(TAD)[Gal4-DBD]
    *** unaffected by: SP600125 [addition]
    *** source: 12972619-Fig-3c
  *** Erk1[Ab] copptby[WB] xKsr1[tAb] is increased irt Pdgf (5 min)
    *** cells: NIH3T3 in BMLS
    *** inhibited by: Okadaic-acid [addition]
    *** source: 12932319-Fig-3c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (30 min)
    *** cells: NIH3T3 in BMLS
    *** inhibited by: U0126 [addition]
    *** unaffected by: SP600125 [addition]
    *** unaffected by: SB203580 [addition]
    *** source: 12972619-Fig-2d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (30 min)
    *** cells: NIH3T3<xFos> in BMLS
    *** inhibited by: U0126 [addition]
    *** source: 12972619-Fig-6a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgfa + Pdgfb (15 min)
    *** cells: AKR2B in BMLS
    *** inhibited by: U0126 [cotreatment]
    *** source: 23913859-Fig-3b

no extras

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (tnr)
    *** cells: B16F1 in BMLS
    *** source: 19274086-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (2 min)
    *** cells: A7R5 in BMLS
    *** source: 11907028(D)
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (5 min)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** source: 16541103-Fig-8c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (times)
    *** cells: SWISS3T3 in BMLS
    *** times: 0 5++ 45++ 60+ 90+ 120+ 300+ min
    *** source: 12134156-Fig-6b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (tnr)
    *** cells: 3731T in BMLS
    *** source: 19274086-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgf (tnr)
    *** cells: MEWO in BMLS
    *** source: 19274086-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgfb (times)
    *** cells: SWISS3T3 in BMLS
    *** times: 0 10++ 60+ 180+ 240+ min
    *** source: 14673150-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgfb (times)
    *** cells: SWISS3T3 in BMLS
    *** times: 0 10++ 60++ 90+ 120+ 240+ 360+ min
    *** source: 14673150-Fig-3c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgfa + Pdgfb (15 min)
    *** cells: AKR2B in BMLS
    *** source: 23913859-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Pdgfb (15 min)
    *** cells: AKR2B in BMLS
    *** source: 23913859-Fig-4b
