===============
Kinase Activity
===============

not Mekk4--

  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt PMA (20 min)
    *** cells: COS7 in BMLS
    *** unaffected by: xMekk4(K1371R)"DN" [addition]
    *** source: 9305639-Fig-10c

not Mlk3--

  *** xErk1[tAb]IP IVKA(MBP)[32P-ATP] is increased irt PMA (10 min)
    *** cells: COS7 in BMLS
    *** unaffected by: xMlk3(WT) [addition]
    *** source: 12738796-Fig-1a

not Tpl2--

  *** Erks[Ab]IP IVKA(Elk1)[32P-ATP] is increased irt PMA (30 min)
    *** cells: mPECs in BMLS
    *** does not req: Tpl2 [KO]
    *** source: 11163183-Fig-5a

Wdr83--  ???

  *** xErk1[phosAb] phos(TEY)[phosAb] is increased irt PMA (10 min)
    *** cells: COS1<xErk1> in BMLS
    *** enhanced by: xWdr83 [addition]
    *** source: 15118098-Fig-5c

Chemicals

  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt PMA (times)
    *** cells: CCL39 in BMLS
    *** times: 0 1+ 3 12 hr
    *** unaffected by: ALLN [pretreatment]
    *** source: 9700154-Fig-5b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (3 min)
    *** cells: C3H10T12 in BMLS
    *** inhibited by: Bisindolylmaleimide-I [addition]
    *** unaffected by: Go6976 [addition]
    *** source: 11358964-Fig-3b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (3 min)
    *** cells: C3H10T12 in BMLS
    *** unaffected by: BaptaAM [addition]
    *** source: 11358964-Fig-3a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (3 min)
    *** cells: C3H10T12 in BMLS
    *** unaffected by: Rottlerin [addition]
    *** source: 11358964-Fig-3c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (5 min)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** source: 16541103-Fig-8c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (5 min)
    *** cells: HELA in BMLS
    *** inhibited by: Forskolin + IBMX [addition]
    *** source: 16581779(D)
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (60 min)
    *** cells: CHO<xProTgfa><xAdam17> in BMS
    *** inhibited by: U0126 [pretreatment]
    *** source: 22550340-Fig-4c

no extras

  *** Erk1[Ab]IP IVKA(Elk1)[32P-ATP] is increased irt PMA (5 min)
    *** cells: bLUCs in BMLS
    *** source: 12644307-Fig-5a
  *** xErk1[Ab]IP IVKA(MBP)[32P-ATP] is increased irt PMA (10 min)
    *** cells: NIH3T3<xErk1> in BMLS
    *** source: 8548291-Fig-1b
  *** Erk2[Ab]IP IVKA(Elk1)[32P-ATP] is increased irt PMA (5 min)
    *** cells: bLUCs in BMLS
    *** source: 12644307-Fig-5a
  *** xErk2[Ab]IP IVKA(MBP)[32P-ATP] is increased irt PMA (10 min)
    *** cells: NIH3T3<xErk1> in BMLS
    *** source: 8548291-Fig-1b
  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt PMA (20 min)
    *** cells: HEK293T<xErk2> in BMS
    *** source: 10575011-Fig-1a
  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt PMA (tnr)
    *** cells: COS1 in BMS
    *** source: 8622669-Fig-2a
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt PMA (5 min)
    *** cells: NIH3T3 in BMS
    *** source: 8289830-Fig-6
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt PMA (15 min)
    *** cells: HELA in BMLS
    *** source: 8846788-Fig-1
  *** Erks[Ab]IP IVKA(snr)[32P-ATP] is increased irt PMA (10 min)
    *** cells: CTLL20 in BMS "IL2-deprived"
    *** source: 7528328-Fig-1a
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt PMA (15 min)
    *** cells: mESCs in BMLS
    *** source: 10801415-Fig-5c

===========================
Phosphorylation on TEY site
===========================

Braf--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (times)
    *** cells: mEFs in BMLS
    *** times: 0 5+ 10+ 30+ min
    *** partially reqs: Braf [KO]
    *** source: 15199148-Fig-2d

Cbl--  ???

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (15 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** unaffected by: xCbl [addition]
    *** source: 11024037-Fig-6a

Dok2--  ???

  *** xErk2[tAb]IP phos(TEY)[phosAb] is increased irt PMA (times)
    *** cells: COS1 in BMS
    *** times: 0 2+ 5++ 10++ min
    *** unaffected by: xDok2 [addition]
    *** source: 15831486-Fig-4b

not Erbb2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (times)
    *** cells: HELA in BMLS
    *** times: 0 2+ 10+ min
    *** does not req: Erbb2 [RNAi]
    *** source: 16041367-Fig-3e

not Mnk1-- or Mnk2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (15 min)
    *** cells: mEFs in BMLS
    *** does not req: Mnk1 and/or Mnk2 [DKO]
    *** source: 15254222-Fig-3a

not Msk1-- or Msk2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (10 min)
    *** cells: mEFs in BMLS
    *** does not req: Msk2 [KO]
    *** does not req: Msk1 [KO]
    *** does not req: Msk1 or Msk2 [DKO]
    *** source: 11909979-Fig-4a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (10 min)
    *** cells: mESCs in BMS
    *** does not req: Msk1 [KO]
    *** source: 11297520-Fig-8a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (times)
    *** cells: mESCs in BMLS
    *** times: 0 10+ 20+ 30+ min
    *** does not req: Msk1 [KO]
    *** source: 11018520-Fig-3b

not Pdpk1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (10 min)
    *** cells: mESCs in BMS
    *** does not req: Pdpk1 [KO]
    *** source: 11297520-Fig-8a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (15 min)
    *** cells: mESCs in BMLS
    *** does not req: Pdpk1 [KO]
    *** unaffected by: kPdpk1(L155E) [substitution]
    *** source: 12912918-Fig-5

not Phb--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (times)
    *** cells: HELA in BMLS
    *** times: 0 2+ 10+ min
    *** does not req: Phb [RNAi]
    *** source: 16041367-Fig-3e

not Raf1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (10 min)
    *** cells: mEFs in BMLS
    *** does not req: Raf1 [KO]
    *** source: 11296228-Fig-6d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (10 min)
    *** cells: mEFs in BMLS
    *** does not req: Raf1 [KO]
    *** unaffected by: kRaf1(Y340F/Y341F) [substitution]
    *** source: 11296227-Fig-5b

not Rin1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (times)
    *** cells: PC6 in BMLS
    *** times: 0 30+ 240+ min
    *** does not req: Rin1 [RNAi]
    *** source: 16157584-Fig-3a

not Rsk1-- or Rsk2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (20 min)
    *** cells: HEK293E<xRps6> in BMLS
    *** unaffected by: xRps6(S235A/S236A) [substitution]
    *** unaffected by: xRps6(S235D/S236D) [substitution]
    *** source: 17360704-Fig-6a

not Tpl2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (20 min)
    *** cells: HELA in BMS
    *** does not req: Tpl2 [RNAi]
    *** source: 16371247-Fig-2c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (30 min)
    *** cells: mPECs in BMLS
    *** does not req: Tpl2 [KO]
    *** source: 11163183-Fig-5a

Erk features  SPS phos happens first??

  *** xErk2[phosAb] phos(TEY)[phosAb] is increased irt PMA (15 min)
    *** cells: CHO<xErk2> in BMLS
    *** partially inhibited by: xErk2(S246A/P247A/S248A) [substitution]
    *** partially inhibited by: xErk2(del(246-278)) [substitution]
    *** source: 18760948-Fig-1d

Chemicals

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (10 min)
    *** cells: mEFs in BMLS
    *** inhibited by: PD184352 [addition] no-bkg-control
    *** unaffected by: SB203580 [addition] no-bkg-control
    *** source: 11909979-Fig-3a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (10 min)
    *** cells: mESCs in BMS
    *** bkg inhibited by: PD184352 [addition]
    *** unaffected by: Ro318220 [addition]
    *** source: 11297520-Fig-8b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (15 min)
    *** cells: HEK293 in BMS
    *** inhibited by: U0126 [pretreatment]
    *** inhibited by: Bisindolylmaleimide-I [pretreatment]
    *** unaffected by: Wortmannin [pretreatment]
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 15342917-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (15 min)
    *** cells: HEK293<xTsc1><xTsc2> in BMS
    *** inhibited by: U0126 [pretreatment]
    *** source: 15342917-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (15 min)
    *** cells: mESCs in BMLS
    *** inhibited by: PD184352 [addition] no-bkg-control
    *** source: 12912918-Fig-5
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (15 min)
    *** cells: NIH3T3<xInsR> in BMLS
    *** inhibited by: U0126 [addition]
    *** source: 12110590-Fig-3b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (20 min)
    *** cells: HEK293E in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 17360704-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (30 min)
    *** cells: mEFs in BMS
    *** bkg inhibited by: PD184352 [addition]
    *** source: 15304344-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (30 min)
    *** cells: mEFs<Jnk1~null><Jnk2~null> in BMS
    *** bkg inhibited by: PD184352 [addition]
    *** source: 15304344-Fig-4d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (30 min)
    *** cells: mPECs in BMLS
    *** inhibited by: PD98059 [addition]
    *** source: 11163183-Fig-5c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (times)
    *** cells: HEK293 in BMLS
    *** times: 0 10+ 20+ 30+ min
    *** inhibited by: PD184352 [addition]
    *** unaffected by: Rapamycin [addition]
    *** source: 11500364-Fig-7a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (60 min)
    *** cells: CHO<xProTgfa> in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** unaffected by: SB203580 [pretreatment]
    *** unaffected by: JNK-Inhibitor-II [pretreatment]
    *** unaffected by: Bisindolylmaleimide-I [pretreatment]
    *** source: 20188673-Fig-1d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (75 min)
    *** cells: CHO in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** partially inhibited by: Bisindolylmaleimide-I [pretreatment]
    *** unaffected by: LY294002 [pretreatment]
    *** source: 19595713-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (10 min)
    *** cells: mESCs in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 11018520-Fig-2c

no extras

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (1 hr)
    *** cells: RAW2647 in BMLS
    *** source: 16537926-Fig-4b
  *** Erk2[Ab] phos[WBMS] is increased irt PMA (10 min)
    *** cells: BAF3<IL2Rb~null><xIL2Ra><xIL2Rb> in BMS
    *** source: 8376945-Fig-4a
  *** Erk2[Ab]IP Yphos[pYAb] is increased irt PMA (tnr)
    *** cells: HEPG2 in BMS
    *** source: 10446219-Fig-5c
  *** xErk2[tAb]IP phos(TEY)[phosAb] is increased irt PMA (10 min)
    *** cells: HEK293 in BMLS
    *** source: 11278335-Fig-6c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (30 min)
    *** cells: HEK293 in BMLS
    *** source: 17617058-Fig-6
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (30 min)
    *** cells: HEK293<xMnk1> in BMLS
    *** source: 12897141-Fig-3e
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (30 min)
    *** cells: HEK293<xMnk2> in BMLS
    *** source: 12897141-Fig-3e
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (30 min)
    *** cells: HEK293<xMnk2b> in BMLS
    *** source: 12897141-Fig-3e
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (times)
    *** cells: HEK293 in BMS
    *** times: 0 7+ 15+ 30+ min
    *** source: 14532121(D)
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (times)
    *** cells: HEK293<xSphk1> in BMS
    *** times: 0 7+ 15+ 30+ min
    *** source: 14532121(D)
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (tnr)
    *** cells: MEWO in BMLS
    *** source: 19274086-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (60 min)
    *** cells: CHO<xProTgfa> in BMLS
    *** source: 20188673-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (75 min)
    *** cells: CHO in BMLS
    *** source: 19595713-Fig-1a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (times)
    *** cells: CHO in BMLS
    *** times: 0 15+ 30+ 45+ 60+ min
    *** source: 19595713-Fig-1c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt PMA (15 min)
    *** cells: mESCs in BMLS
    *** unaffected by: LY294002 [pretreatment]
    *** does not req: Pdpk1 [KO]
    *** source: 10801415-Fig-5c

contradictions

  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt PMA (3 min)
    *** cells: C3H10T12 in BMLS "pretreated overnight with PMA"
    *** source: 11358964-Fig-3a
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt PMA (tnr)
    *** cells: 3731T in BMLS
    *** source: 19274086-Fig-2a

===========================
Phosphorylation on SPS site
===========================

  *** xErk2[phosAb] phos(SPS)[phosAb] is increased irt PMA (15 min)
    *** cells: COS7<xErk2> in BMLS
    *** source: 18760948-Fig-2a




























