=======================================
Activation or Phosphorylation via Trka
=======================================

reqs Trka phos(Y496/Y791F)

  *** Erk1[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ngf (5 min)
    *** cells: PC12NNR5<xTrka> in BMS
    *** unaffected by: xTrka(Y496F) [substitution]
    *** unaffected by: xTrka(Y791F) [substitution]
    *** inhibited by: xTrka(Y496F/Y791F) [substitution]
    *** source: 8155326-Fig-8a
  *** Erk1[Ab]IP Yphos[pYAb] is increased irt Ngf (5 min)
    *** cells: PC12NNR5<xTrka> in BMS
    *** unaffected by: xTrka(Y496F) [substitution]
    *** unaffected by: xTrka(Y791F) [substitution]
    *** inhibited by: xTrka(Y496F/Y791F) [substitution]
    *** source: 8155326-Fig-8a

Aps-- ???

  *** xErk1[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Ngf (10 min)
    *** cells: HEK293<xTrka> in BMS
    *** enhanced by: xAps [addition]
    *** source: 9856458-Fig-4a


Sh2b1--

  *** xErk1[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Ngf (10 min)
    *** cells: HEK293<xTrka> in BMS
    *** enhanced by: xSh2b1 [addition]
    *** source: 9856458-Fig-4a
  *** xErk1[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Ngf (10 min)
    *** cells: HEK293<xTrka> in BMS
    *** unaffected by: xSh2b1(500-756)"M5" [substitution]
    *** source: 9856458-Fig-5e

Rgs19ip1-- ???

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (5 min)
    *** cells: PC12<xTrka> in BMS
    *** partially inhibited by: xRgs19ip1 [addition]
    *** source: 11251075-Fig-8a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (5 min)
    *** cells: PC12<xTrka> in BMS
    *** partially inhibited by: xRgs19ip1 [addition]
    *** source: 11251075-Fig-8b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (5 min)
    *** cells: PC12<xTrka> in BMS
    *** partially inhibited by: xRgs19ip1 [addition]
    *** source: 11251075-Fig-8c

=======================================
Activation or Phosphorylation via ???
=======================================

not Arms--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (times)   
    *** cells: PC12 in BMS
    *** times: 0 5++ 40+ min
    *** does not req: Arms [RNAi]
    *** comment: decrease at 40 min is enhanced itap Arms [RNAi]
    *** source: 15167895-Fig-7b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (times)   
    *** cells: PC12 in BMS
    *** times: 0 5++ 40+ min
    *** unaffected by: xArms [addition]
    *** partially inhibited by: xArms(del(1110-1131))"PPRPP" [addition]
    *** source: 15167895-Fig-6e

reqs Hras at early times

  *** xErk2[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ngf (times)
    *** cells: PC12 in BMLS
    *** times: 0+ 5+ 10+++ 20+++ 30+ 40++ 60+ min
    *** comment: inhibited by xHras(S17N)"DN" [addition] at 0-10 min only
    *** source: 9560161-Fig-1a
  *** xErk2[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ngf (times)
    *** cells: PC12<xCrkL><xRapGef1> in BMLS
    *** times: 0 5+ 10++ 20++ 30++ 40++ 60+ min
    *** comment: inhibited by xHras(S17N)"DN" [addition] at 5-10 min only
    *** source: 9560161-Fig-4c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC12 in BMS
    *** inhibited by: Hras(S17N)"DN" [addition]
    *** source: 11953455-Fig-4
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC6 in BMLS
    *** partially inhibited by: xHras(S17N)"DN" [addition]
    *** source: 15632082-Fig-8a

reqs Rap1a at later times

  *** xErk2[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ngf (times)
    *** cells: PC12 in BMLS
    *** times: 0+ 5+ 10+++ 20+++ 30+ 40++ 60+ min
    *** comment: inhibited by xRap1a(T17N)"DN" [addition] at 20-60 min only
    *** source: 9560161-Fig-1a
  *** xErk2[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ngf (times)
    *** cells: PC12<xCrkL><xRapGef1> in BMLS
    *** times: 0 5+ 10++ 20++ 30++ 40++ 60+ min
    *** comment: inhibited by xRap1a(T17N)"DN" [addition] at 20-60 min only
    *** source: 9560161-Fig-4c

Pkcd--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC12 in BMS
    *** reqs: Pkcd [AntiSense]
    *** source: 10330161-Fig-7c

not Pkce--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC12 in BMS
    *** does not req: Pkce [AntiSense]
    *** source: 10330161-Fig-7d

does not req Frs2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (times)
    *** cells: PC12<xFrs2> in BMLS
    *** times: 0 5++ 20+ 50+ min
    *** unaffected by: xFrs2(Y436F) [substitution]
    *** unaffected by: xFrs2(Y192F/Y306F/Y349F/Y392F) [substitution]
    *** source: 11278445-Fig-10

reqs Rit1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC6 in BMLS
    *** times: 0 10++ 15++ 60+ min
    *** partially reqs: Rit1 [RNAi]
    *** source: 15632082-Fig-8c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC6 in BMLS
    *** partially inhibited by: xRit1(S35N) [addition]
    *** source: 15632082-Fig-8a


  *** xErk2[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ngf (times)
    *** cells: PC12 in BMLS
    *** times: 0 5+ 10+ 20+ 30+ 40+ 60+ min
    *** inhibited by: xRapGef1(mnr)"Crk-binding-mut" [addition]
    *** source: 9560161-Fig-5b
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ngf (times)
    *** cells: PC12 in BMLS
    *** times: 0+ 10++ 60+ min
    *** comment: decrease at 60 min is reversed itpo xMatk [addition]
    *** source: 10329710-Fig-6a







===================
Effect of Chemicals
===================

  *** Erk1[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ngf (10 min)
    *** cells: PC12 in BMLS
    *** unaffected by: Forskolin [addition]
    *** source: 9094716-Fig-2a
  *** Erk2[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ngf (10 min)
    *** cells: PC12 in BMLS
    *** unaffected by: Forskolin [addition]
    *** source: 9094716-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (2 hr)
    *** cells: PC12 in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 16537926-Fig-4d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (2 hr)
    *** cells: PC12 in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 16537926-Fig-5d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (2 hr)
    *** cells: PC12 in BMLS
    *** unaffected by: LiCl [pretreatment]
    *** source: 16537926-Fig-5d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (times)
    *** cells: PC12 in BMLS
    *** times: 0 5++ 30+ min
    *** partially inhibited by: Brefeldin-A [pretreatment]
    *** source: 11466412-Fig-9
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (times)
    *** cells: PC12 in BMLS
    *** times: 0 5+ 30++ min
    *** inhibited by: U0126 [addition]
    *** source: 16508002-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC6 in BMLS
    *** times: 0 10++ 15++ 60+ min
    *** inhibited by: PD98059 [addition]
    *** source: 15632082-Fig-8c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC6 in BMLS
    *** inhibited by: PD98059 [addition]
    *** unaffected by: SB203580 [addition]
    *** source: 15632082-Fig-8a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC12 in BMS
    *** unaffected by: Wortmannin [pretreatment]
    *** partially inhibited by: PD98059 [pretreatment]
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 11953455-Fig-6
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC12 in BMS
    *** inhibited by: Rottlerin [pretreatment]
    *** source: 10330161-Fig-5b

=========
No extras
=========

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (times)
    *** cells: PC12 in BMLS
    *** times: 0 5++ 20+ 50+ min
    *** source: 11278445-Fig-10
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (times)
    *** cells: PC12 in BMLS
    *** times: 0 2+ 5++ 10+ 30+ 60+ min
    *** source: 11466412-Fig-1a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (times)
    *** cells: PC12 in BMLS
    *** times: 0 2++ 5++ 15+ 30+ 60+ min
    *** source: 11278445-Fig-3c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC6 in BMLS
    *** source: 15632082-Fig-1c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (15 min)
    *** cells: PC12 in BMLS
    *** source: 11733534-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (times)
    *** cells: PC12 in BMLS
    *** times: 0+ 10++ 60+ min
    *** comment: decrease at 60 min is reversed itpo xMatk [addition]
    *** source: 10329710-Fig-6b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (times)
    *** cells: PC12<xGab1> in BMLS
    *** times: 0+ 1+ 5++ 10++ 20++ min
    *** source: 10601297-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (times)
    *** cells: PC12 in BMLS
    *** times: 0 1 5++ 1++ 20 min
    *** source: 10601297-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (tnr)
    *** cells: PC12<xGab1> in BMLS
    *** source: 10601297-Fig-4a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ngf (times)   
    *** cells: PC12 in BMS
    *** times: 0 1 3++ 10+ min
    *** source: 15167895-Fig-1a
