Traf6-- required for K48-ubiq but not K64-ubiq

  *** Traf3[Ab]IP ubiq[K48UbAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 10++ 30++ min
    *** reqs: Traf6 [RNAi]
    *** source: 19898473-Fig-3d
  *** Traf3[Ab]IP ubiq[K63UbAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 10++ 30++ min
    *** does not req: Traf6 [RNAi]
    *** source: 19898473-Fig-3d
  *** Traf3[Ab]IP ubiq[UbAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 10++ 30++ min
    *** partially reqs: Traf6 [RNAi]
    *** source: 19898473-Fig-3d


Traf3 features

  *** xTraf3[tAb]IP ubiq[K48UbAb] is increased irt Lps (10 min)
    *** cells: RAW2647<Traf3~kd><xTraf3> in BMS
    *** unaffected by: xTraf3(C68A/H70A) [substitution]
    *** source: 19898473-Fig-5a
  *** xTraf3[tAb]IP ubiq[K48UbAb] is increased irt Lps (10 min)
    *** cells: RAW2647<Traf3~kd><xTraf3> in BMS
    *** unaffected by: xTraf3(K107R) [substitution]
    *** unaffected by: xTraf3(K156R) [substitution]
    *** partially inhibited by: xTraf3(K107R/K156R) [substitution]
    *** unaffected by: xTraf3(K138R/K156R) [substitution]
    *** source: 19898473-Fig-5d
  *** xTraf3[tAb]IP ubiq[K63UbAb] is increased irt Lps (10 min)
    *** cells: RAW2647<Traf3~kd><xTraf3> in BMS
    *** inhibited by: xTraf3(C68A/H70A) [substitution]
    *** source: 19898473-Fig-5a
  *** xTraf3[tAb]IP ubiq[K63UbAb] is increased irt Lps (10 min)
    *** cells: RAW2647<Traf3~kd><xTraf3> in BMS
    *** unaffected by: xTraf3(K107R) [substitution]
    *** unaffected by: xTraf3(K156R) [substitution]
    *** unaffected by: xTraf3(K107R/K156R) [substitution]
    *** unaffected by: xTraf3(K138R/K156R) [substitution]
    *** source: 19898473-Fig-5d
  *** xTraf3[tAb]IP ubiq[UbAb] is increased irt Lps (10 min)
    *** cells: RAW2647<Traf3~kd><xTraf3> in BMS
    *** partially inhibited by: xTraf3(C68A/H70A) [substitution]
    *** source: 19898473-Fig-5a
  *** xTraf3[tAb]IP ubiq[UbAb] is increased irt Lps (10 min)
    *** cells: RAW2647<Traf3~kd><xTraf3> in BMS
    *** unaffected by: xTraf3(K107R) [substitution]
    *** unaffected by: xTraf3(K156R) [substitution]
    *** partially inhibited by: xTraf3(K107R/K156R) [substitution]
    *** unaffected by: xTraf3(K138R/K156R) [substitution]
    *** source: 19898473-Fig-5d

chemicals

  *** Traf3[Ab]IP ubiq[K48UbAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 10+ 30 min
    *** inhibited by: SmacMimetic [pretreatment]
    *** unaffected by: Dynasore [pretreatment]
    *** source: 19898473-Fig-4a
  *** Traf3[Ab]IP ubiq[K63UbAb] is increased irt Lps (times)
    *** cells: mBMMs<Myd88~null> in BMS
    *** times: 0 10+ 30+ min
    *** unaffected by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-S6b
  *** Traf3[Ab]IP ubiq[K63UbAb] is increased irt Lps (times)
    *** cells: mBMMs<Trif~fmut> in BMS
    *** times: 0 10+ 30+ min
    *** unaffected by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-S6b
  *** Traf3[Ab]IP ubiq[K63UbAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 10+ 30++ min
    *** unaffected by: SmacMimetic [pretreatment]
    *** inhibited by: Dynasore [pretreatment]
    *** source: 19898473-Fig-4a
  *** Traf3[Ab]IP ubiq[UbAb] is increased irt Lps (30 min)
    *** cells: RAW2647 in BMS
    *** source: 19898473-Fig-S6a
  *** Traf3[Ab]IP ubiq[UbAb] is increased irt Lps (times)
    *** cells: mBMMs<Myd88~null> in BMS
    *** times: 0 10+ 30+ min
    *** unaffected by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-S6b
  *** Traf3[Ab]IP ubiq[UbAb] is increased irt Lps (times)
    *** cells: mBMMs<Trif~fmut> in BMS
    *** times: 0 10+ 30+ min
    *** inhibited by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-S6b
  *** Traf3[Ab]IP ubiq[UbAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 10++ 30+ min
    *** partially inhibited by: SmacMimetic [pretreatment]
    *** partially inhibited by: Dynasore [pretreatment]
    *** source: 19898473-Fig-4a
