degradation requires Traf6 so ubiq must be K48

  *** Traf3[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0++ 5++ 10+ 30 min
    *** reqs: Traf6 [RNAi]
    *** source: 19898473-Fig-3a

Traf3 in endosome is K63-ubiq

  *** Traf3[Ab] infraction(endosomal)[WB] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 30+ 60++ min
    *** unaffected by: SmacMimetic [pretreatment]
    *** inhibited by: Dynasore [pretreatment]
    *** comment: Traf3 in endosomal fraction is K63-ubiquitinated
    *** source: 19898473-Fig-4b

chemical evidence that degradation requires Ciap12s

  *** Traf3[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0++ 2++ 5++ 10+ 30 min
    *** inhibited by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-2b

Traf3 does not relocated to cyto with Tak1 complex

  *** Traf3[Ab] copptby[WB] Tak1[Ab] is unchanged irt Lps (times)
    *** cells: mBMMs in BMS "cytosolic fraction"
    *** times: 0 10 30 min
    *** unaffected by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-2a
