=================
Required Proteins
=================

Ampka1--

  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: THP1 in BMS
    *** enhanced by: xAmpka1 [addition]
    *** source: 22833096-Fig-3a


Bcl10--

  *** Nfkb-reporter[Luc] is increased irt Lps (30 min)
    *** cells: RAW2647 in BMS
    *** reqs: Bcl10 [RNAi]
    *** source: 15213237-Fig-4b,5b
  *** Nfkb-reporter[Luc] is increased irt Lps (30 min)
    *** cells: RAW2647 in BMS
    *** reqs: Bcl10 [RNAi]
    *** inhibited by: xBcl10(L41Q/G78R)"oligo-mut" [addition]
    *** source: 16831874-Fig-6b,8b,8d

Btk--

  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xBtk(K430R)"DN" [addition]
    *** source: 15849198-Fig-1a
  *** Nfkb-reporter[Luc] is increased irt Lps (18 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xBtk(K430R)"DN" [addition]
    *** source: 12724322(D)
  *** Nfkb-reporter[Luc] is increased irt Lps (18 hr)
    *** cells: U373 in BMS
    *** inhibited by: xBtk(K430R)"DN" [addition]
    *** source: 12724322(D)

Casp1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 15++ 30++ 45+ 60+ min
    *** reqs: Casp1 [KO]
    *** source: 16585594-Fig-5a
  *** Nfkb-reporter[Luc] is increased irt Lps (tnr)
    *** cells: mPECs in BMS
    *** partially reqs: Casp1 [KO]
    *** source: 16585594-Fig-5b
  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: U373 in BMS
    *** inhibited by: Ac-YVAD-CMK [addition]
    *** source: 17360653-Fig-3a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 15+ 30+ min
    *** reqs: Casp1 [KO]
    *** source: 17360653(D)

Cd14--  ???

  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: HEK293<xTLR2> in BMS
    *** enhanced by: xCd14 [addition]
    *** source: 10364168(D)
  *** Nfkb-reporter[Luc] is increased irt Lps (5 hr)
    *** cells: HEK293<xMd2> in BMS
    *** reqs: xMd2 [omission]
    *** unaffected by: xCd14 [addition]
    *** source: 12324469(D)

Cebpb--

  *** Nfkb-reporter[Luc] is increased irt Lps (times)
    *** cells: mSPImacs in BMS
    *** times: 0 2+ 4++ 8++ hr
    *** partially reqs: Cebpb [KO]
    *** source: 19733238-Fig-1a

Ikba--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (15 min)
    *** cells: 70Z3<xCd14><xIkba> in BMS "pretreated with ZVAD"
    *** inhibited by: xIkba(S32A/S36A) [substitution]
    *** source: 12138192-Fig-1c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: RAW2647 in BMS
    *** inhibited by: xIkba(mnr)"DN" [addition]
    *** source: 12354379-Fig-4a

Ikk1-- and/or Ikk2--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (90 min)
    *** cells: mEFs in BMS
    *** reqs: Ikk1 and/or Ikk2 [DKO]
    *** source: 10898787-Fig-2a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (1 hr)
    *** cells: mEFs in BMS
    *** does not req: Ikk2 [KO]
    *** source: 12736252-Fig-1b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mSpBCs in BMS
    *** times: 0 60+ 90++ min
    *** does not req: Ikk1 [KO]
    *** source: 11520989-Fig-2b
  *** Nfkb-reporter[Luc] is increased irt Lps (5 hr)
    *** cells: THP1 in BMS
    *** unaffected by: xIkk1(K44M)"DN" [addition]
    *** partially inhibited by: xIkk2(K44M)"DN" [addition]
    *** source: 9804806-Fig-4,5

not Ikke--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 30+ 60+ 120+ min
    *** does not req: Ikke [KO]
    *** source: 15210742-Fig-3a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 1++ 2++ 5+ hr
    *** does not req: Ikke [KO]
    *** source: 12736252-Fig-4d

Irak1--  ???

  *** Nfkb-reporter[Luc] is increased irt (Lps + Lbp) (6 hr)
    *** cells: HEK293<xTLR2> in BMLS
    *** partially inhibited by: xIrak1(1-96)"DN" [addition]
    *** source: 10395652-Fig-6
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 7+ 15+ 30++ 60++ min
    *** comment: reqs Irak1 [KO] at 7-30 min not 60 min
    *** source: 10754329-Fig-2a
  *** Nfkb-reporter[Luc] is increased irt Lps (5 hr)
    *** cells: mEFs in BMS
    *** bkg reqs: Irak1 [KO]
    *** source: 18347055-Fig-5b

Irak4--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 1++ 2+ 3+ hr
    *** reqs: Irak4 [KO]
    *** source: 14634120-Fig-1d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30++ min
    *** unaffected by: kIrak4(K213M/K214M)"KD" [knockin]
    *** source: 17470642-Fig-6d

not Irak2--

  *** Nfkb-reporter[Luc] is increased irt (Lps + Lbp) (6 hr)
    *** cells: HEK293<xTLR2> in BMLS
    *** unaffected by: xIrak2(1-96)"DN" [addition]
    *** source: 10395652-Fig-6

not Irf8--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mBMfDCs in BMS
    *** times: 0 20+ 60++ min
    *** does not req: Irf8 [KO]
    *** source: 15153500-Fig-2b

Malt1--

  *** Nfkb-reporter[Luc] is increased irt Lps (30 min)
    *** cells: RAW2647 in BMS
    *** reqs: Malt1 [RNAi]
    *** source: 16831874-Fig-6b,8b,8d

not Mavs--

  *** Nfkb-reporter[Luc] is increased irt Lps (8 hr)
    *** cells: HEK293<xTLR4><xMd2><xCd14> in BMS
    *** does not req: Mavs [RNAi]
    *** source: 16153868-Fig-6b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 1+ 2+ hr
    *** does not req: Mavs [KO]
    *** source: 16713980-Fig-2f
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (2 hr)
    *** cells: mEFs in BMS
    *** does not req: Mavs [KO]
    *** source: 16785313-Fig-4a

not Mekk1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mESCs in BMS
    *** times: 0 30+ 60+ 120 min
    *** unaffected by: kMekk1(1-1188)"del-kinase-domain" [addition]
    *** source: 10805784-Fig-3b

Mekk3--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 10 20 40+ 60+ min
    *** reqs: Mekk3 [KO]
    *** source: 14661019(D)

Myd88--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (45 min)
    *** cells: hMDMacs in BMS
    *** inhibited by: xMyd88(F56N/del(1-53))"DN" [addition]
    *** source: 14630816(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (45 min)
    *** cells: hSNFs in BMS
    *** inhibited by: xMyd88(F56N/del(1-53))"DN" [addition]
    *** source: 14630816(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (45 min)
    *** cells: mPECs in BMS
    *** inhibited by: xMyd88(F56N/del(1-53))"DN" [addition]
    *** source: 14630816(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 20+ 60+ min
    *** comment: reqs Myd88 [KO] at 10 min only
    *** source: 12447442(D)
  *** Nfkb-reporter[Luc] is increased irt (Lps + Lbp) (6 hr)
    *** cells: HEK293<xTLR2> in BMLS
    *** inhibited by: xMyd88(152-296)"DN" [addition]
    *** source: 10395652-Fig-6
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mLFs in BMS "nuclear fraction"
    *** times: 0 30+ 60+ 120+ min
    *** partially reqs: Myd88 [KO]
    *** source: 12855817-Fig-3d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 10+ 20+ 60++ min
    *** partially reqs: Myd88 [KO]
    *** source: 11812998-Fig-1b
  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xMyd88(mnr)"TIR-domain" [addition]
    *** source: 11544529-Fig-4c
  --------------------------------------------------------------
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 10+ 20++ 60++ min
    *** does not req: Myd88 [KO]
    *** source: 12447441-Fig-3f
  --------------------------------------------------------------
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mEFs in BMS "nuclear fraction"
    *** times: 0 30+ 60+ 120+ hr
    *** reqs: Trif and/or Myd88 [DKO]
    *** source: 12855817-Fig-3e

Nemo--

  Total Protein

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** reqs: xNemo [omission]
    *** inhibited by: xNemo(120-419) [substitution]
    *** source: 12138192-Fig-3d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** reqs: xNemo [omission]
    *** source: 12138192-Fig-3a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** reqs: xNemo [omission]
    *** source: 16497931-Fig-1a

  Ubiquitination: K285R/K399R
  does not req Ubiquitination: S85A or Q86N or Q86A

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(S8A) [substitution]
    *** unaffected by: xNemo(S85A) [substitution]
    *** partially inhibited by: xNemo(S156A) [substitution]
    *** partially inhibited by: xNemo(S364A) [substitution]
    *** partially inhibited by: xNemo(S383A) [substitution]
    *** source: 16497931-Fig-S1c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(S85A) [substitution]
    *** source: 16497931-Fig-1b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(sumo/S85A) [substitution]
    *** source: 16497931-Fig-S3b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: HEK293<xNemo> in BMS
    *** unaffected by: xNemo(S85A) [substitution]
    *** source: 16497931-Fig-3b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(S85A) [substitution]
    *** source: 20932476-Fig-S5b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(S85A) [substitution]
    *** source: 20932476-Fig-S5c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: Nemo(Q86N) [substitution]
    *** unaffected by: Nemo(Q86A) [substitution]
    *** source: 16497931-Fig-1f

  requires Ubiquitin Binding:  Y308A F312A L329P

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** inhibited by: xNemo(F312A) [substitution]
    *** partially inhibited by: xNemo(Y308S) [substitution]
    *** source: 20932476-Fig-5g
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** inhibited by: xNemo(L329P) [substitution]
    *** source: 20932476-Fig-S5a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** inhibited by: xNemo(F312A) [substitution]
    *** source: 20932476-Fig-S5b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** inhibited by: xNemo(Y308A) [substitution]
    *** source: 20932476-Fig-S5c

  does not require Sumoylation: K277A/K309A

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (1 hr)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(K277A) [substitution]
    *** unaffected by: xNemo(K309A) [substitution]
    *** source: 14651848-Fig-2d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (1 hr)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(K277A/K309A) [substitution]
    *** source: 14651848-Fig-2e
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(sumo) [substitution]
    *** source: 14651848-Fig-4d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(K277A/K309A) [substitution]
    *** unaffected by: xNemo(sumo/K277A/K309A) [substitution]
    *** source: 14651848-Fig-4e

  does not require Zinc Finger: C417R

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(C417R) [substitution]
    *** unaffected by: xNemo(sumo/C417R) [substitution]
    *** source: 14651848-Fig-4c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3 in BMS
    *** partially inhibited by: xNemo(1-394)"delC" [addition]
    *** source: 12138192-Fig-5a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo(1-394)"delC"> in BMS
    *** source: 12138192-Fig-5a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** partially inhibited by: xNemo(C417R) [substitution]
    *** partially inhibited by: xNemo(C417A) [substitution]
    *** unaffected by: xNemo(D406V) [substitution]
    *** source: 12138192-Fig-6b

Nik--

  *** Nfkb-reporter[Luc] is increased irt (Lps + Lbp) (6 hr)
    *** cells: HEK293<xTLR2> in BMLS
    *** inhibited by: xNik(K429A/K430A)"DN" [addition]
    *** source: 10395652-Fig-6

Peli2--

  *** Nfkb-reporter[Luc] is increased irt Lps (30 min)
    *** cells: RAW2647 in BMS
    *** partially reqs: Peli2 [KO]
    *** partially inhibited by: xPeli2(del(252-168)) [addition]
    *** source: 15213237-Fig-4b,5b

Pin1--

  *** Nfkb-reporter[Luc] is increased irt Lps (tnr)
    *** cells: mEFs in BMS
    *** reqs: Pin1 [KO]
    *** source: 14690596-Fig-5b

Pkce--

  *** Nfkb-reporter[Luc] is increased irt Lps (7 hr)
    *** cells: mEFs<Pkce~null> in BMS
    *** enhanced by: xPkce [addition]
    *** unaffected by: xPkce(S346A/S368A) [addition]
    *** source: 18458086-Fig-6a,6b

not Pycard--

  *** Nfkb-reporter[Luc] is increased irt Lps (times)
    *** cells: THP1 in BMHIS
    *** times: 0 20++ 45+ min
    *** enhanced by: xCasp1 [addition]
    *** enhanced by: xCasp1(C285A)"CIA" [addition]
    *** does not req: Pycard [RNAi]
    *** source: 16585594-Fig-5c
  *** Nfkb-reporter[Luc] is increased irt Lps (times)
    *** cells: THP1 in BMHIS
    *** times: 0 30+ 60++ 120+ min
    *** does not req: Pycard [RNAi]
    *** source: 16585594-Fig-6c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: THP1 in BMHIS
    *** times: 0 30+ 60++ 120++ min
    *** does not req: Pycard [RNAi]
    *** source: 16585594-Fig-6b

Rela--

  *** Nfkb-reporter[Luc] is increased irt Lps (16 hr)
    *** cells: mEFs<Rela~null><xRela> in BMS
    *** reqs: xRela [omission]
    *** source: 12759443-Fig-7

not Rig1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 30+ 60+ min
    *** does not req: Rig1 [KO]
    *** source: 16039576-Fig-4d

not Ripk1--

  *** Nfkb-reporter[Luc] is increased irt (Lps + Lbp) (6 hr)
    *** cells: HEK293<xTLR2> in BMLS
    *** unaffected by: Ripk1(559-671)"DN" [addition]
    *** source: 10395652-Fig-6

not Socs1--

  *** Nfkb-reporter[Luc] is increased irt Lps (12 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xSocs1 [addition]
    *** source: 12433365-Fig-6a
  *** Nfkb-reporter[Luc] is increased irt Lps (12 hr)
    *** cells: HEK293<xTLR4><xMd2> in BMS
    *** inhibited by: xSocs1 [addition]
    *** source: 12433365-Fig-6b


Tab1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 20+ 40+ min
    *** does not req: Tab1 [KO]
    *** source: 16260493(D)

Tab2--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 20+ 40+ min
    *** does not req: Tab2 [KO]
    *** source: 16260493(D)

Tak1-- ???

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 20+ 40+ min
    *** partially reqs: Tak1 [KO]
    *** source: 16260493(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: mEFs in BMS
    *** does not req: Tak1 [KO]
    *** source: 20932476-Fig-1f
  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** partially inhibited by: xTak1(K158R) [substitution]
    *** source: 20038579-Fig-S4b
  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: RAW2647<xTak1> in BMLS
    *** inhibited by: xTak1(K34R) [substitution]
    *** source: 22069318-Fig-9d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS "nuclear-extracts"
    *** times: 0 15++ 30++ 60+ min
    *** bkg inhibited by: xTak1(K209R) [substitution]
    *** source: 19843958-Fig-2e

not Tpl2--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (tnr)
    *** cells: mPECs in BMLS
    *** does not req: Tpl2 [KO]
    *** source: 11163183-Fig-5c

not Tbk1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 30+ 60+ min
    *** does not req: Tbk1 or TnfR1 [DKO]
    *** source: 15210743-Fig-3b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 30+ 60+ 240+ min
    *** does not req: Tbk1 [KO]
    *** source: 15210742-Fig-3a

not Trif--

  *** Nfkb-reporter[Luc] is increased irt Lps (12 hr)
    *** cells: HEK293<xTLR4><xMd2> in BMS
    *** inhibited by: xTrif(mnr)"TIR-domain" [addition]
    *** source: 12471095-Fig-3b
  --------------------------------------------------------------
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mEFs in BMS "nuclear fraction"
    *** times: 0 30+ 60+ 120+ min
    *** reqs: Trif and/or Myd88 [DKO]
    *** source: 12855817-Fig-3e
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mLFs in BMS "nuclear fraction"
    *** times: 0 30+ 60+ 120+ min
    *** does not req: Trif [KO]
    *** source: 12855817-Fig-3d
  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: HEK293<xTLR4><xMd2><xCd14> in BMS
    *** unaffected by: xTrif(P434H)"DN" [addition]
    *** source: 14519765(D)

Ticam2-- ???

  *** Nfkb-reporter[Luc] is increased irt Lps (8 hr)
    *** cells: HEK293<xTLR4><xMd2> in BMS
    *** partially inhibited by: xTicam2(C113H)"DN" [addition]
    *** source: 14517278-Fig-5b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 10+ 20++ 60++ 120++ min
    *** comment: reqs Ticam2 [KO] at 60 and 120 min only
    *** source: 14556004(D)
  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: HEK293<xTLR4><xMd2><xCd14> in BMS
    *** inhibited by: xTicam2(C117H)"DN" [addition]
    *** source: 14519765(D)


Tirap-- ???

  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: HEK293<xTLR4> in BMS
    *** inhibited by: xTirap(D198A)"cleavage-site-mut" [addition]
    *** source: 17360653(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (45 min)
    *** cells: hSNFs in BMS
    *** inhibited by: xTirap(P125H)"DN" [addition]
    *** source: 14630816(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 20+ 60+ min
    *** comment: reqs Tirap [KO] at 10 min only
    *** source: 12447442(D)
  *** Nfkb-reporter[Luc] is increased irt Lps (tnr)
    *** cells: HEK293<xTLR4><xCd14><xMd2> in BMS
    *** inhibited by: xTirap(P125H)"DN" [addition]
    *** source: 12539043-Fig-1a
  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: THP1 in BMS
    *** bkg inhibited by: xTirap(mnr)"TIR-domain" [addition]
    *** source: 11544529-Fig-4c
  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xTirap(mnr)"TIR-domain" [addition]
    *** source: 11544529-Fig-4c
  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: HEK293<xTLR4> in BMS
    *** inhibited by: xTirap(P125H)"DN" [addition]
    *** inhibited by: xTirap(Y86F)"DN" [addition]
    *** inhibited by: xTirap(Y187F)"DN" [addition]
    *** source: 16439361(D)
  *** Nfkb-reporter[Luc] is increased irt Lps (5 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: Tirap-Peptide-Inhibitor [addition]
    *** source: 11526399(D)
  -----------------------------------------------------------------
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 10+ 20++ 60++ min
    *** does not req: Tirap [KO]
    *** source: 12447441-Fig-3f

TLR2--  ???

  *** Nfkb-reporter[Luc] is increased irt (Lps + Lbp) (6 hr)
    *** cells: HEK293<xTLR2> in BMLS
    *** reqs: xTLR2 [omission]
    *** source: 10395652-Fig-6
  *** Nfkb-reporter[Luc] is increased irt Lps (5 hr)
    *** cells: HEK293<xTLR2> in BMS "containing Md2 conditioned medium"
    *** does not req: xTLR2 [omission]
    *** source: 12324469(D)

not TLR3--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 20+ 60+ 120++ min
    *** does not req: TLR3 [KO]
    *** source: 11607032-Fig-3d

TLR4--

  *** Nfkb-reporter[Luc] is increased irt Lps (tnr)
    *** cells: HEK293<xTLR4><xCd14><xMd2> in BMS
    *** reqs: xTLR4 and/or xCd14 and/or xMd2 [omission]
    *** source: 12539043-Fig-1a
  *** Nfkb-reporter[Luc] is increased irt Lps (5 hr)
    *** cells: HEK293<xTLR4> in BMS "containing Md2 conditioned medium"
    *** reqs: xTLR4 [omission]
    *** source: 12324469(D)

not TLR9--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (60 min)
    *** cells: mPECs in BMS
    *** does not req: TLR9 [KO]
    *** source: 11130078-Fig-3e

not TnfR1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 30+ 60+ min
    *** does not req: Tbk1 or TnfR1 [DKO]
    *** source: 15210743-Fig-3b

not Traf2--

  *** Nfkb-reporter[Luc] is increased irt (Lps + Lbp) (6 hr)
    *** cells: HEK293<xTLR2> in BMLS
    *** unaffected by: xTraf2(87-501)"DN" [addition]
    *** source: 10395652-Fig-6

not Traf3--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 30++ 60++ 90+ min
    *** repressed by: Traf3 [KO]
    *** source: 16306936-Fig-S2d

Traf6--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: mSpBCs in BMS "Abelson transformed"
    *** times: 0 30 60+ 120+ 180+ hr
    *** partially reqs: Traf6 [KO]
    *** source: 10215628-Fig-5c
  *** Nfkb-reporter[Luc] is increased irt (Lps + Lbp) (6 hr)
    *** cells: HEK293<xTLR2> in BMLS
    *** partially inhibited by: xTraf6(289-522)"DN" [addition]
    *** source: 10395652-Fig-6

====================
Inhibiting Proteins
====================

Tnfaip3--

  *** Nfkb-reporter[Luc] is increased irt Lps (5 hr)
    *** cells: HEK293<xTLR4><xMd2> in BMS
    *** inhibited by: xTnfaip3 [addition]
    *** source: 21220427-Fig-7b

Tollip--

  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: mEFs in BMS
    *** does not req: Tollip [KO]
    *** source: 16428431(D)
  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xTollip [addition]
    *** source: 11751856(D)

Socs--

  *** Nfkb-reporter[Luc] is increased irt Lps (3 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xSocs1 [addition]
    *** source: 12433373-Fig-7a

=========
Chemicals
=========

  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: U373 in BMS
    *** inhibited by: Ac-YVAD-CMK [addition]
    *** source: 17360653(D)
  *** Nfkb-reporter[Luc] is increased irt Lps (5 hr)
    *** cells: HEK293<xMd2> in BMS
    *** reqs: xMd2 [omission]
    *** inhibited by: Brefeldin-A [addition]
    *** source: 12324469(D)
  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: LFMA13 [pretreatment]
    *** source: 15849198-Fig-1b
  *** Nfkb-reporter[Luc] is increased irt Lps (8 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: DMOG [pretreatment]
    *** source: 19762779-Fig-5a
  *** Nfkb-reporter[Luc] is unchanged irt Lps (4 hr)
    *** cells: HEK293<xTLR2><xTLR1><xTLR6><xCd14><xCd36> in BMS
    *** unaffected by: Brefeldin-A [addition]
    *** source: 16880211(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (1 hr)
    *** cells: rCMCs in BMS
    *** inhibited by: WY14643 [addition]
    *** inhibited by: Rosiglitazone [addition]
    *** source: 11009565-Fig-4b,4c
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3 in BMS
    *** inhibited by: Bay117082 [pretreatment]
    *** source: 12138192-Fig-2a
  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: THP1 in BMS
    *** inhibited by: Compound-C [cotreatment]
    *** source: 22833096-Fig-1a

=========
no extras
=========

  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: HEK293<xTLR4> in BMS
    *** source: 15849198-Fig-2b
  *** Nfkb-reporter[Luc] is increased irt Lps (tnr)
    *** cells: HEK293<xTLR4> in BMS
    *** source: 16751103(D)
  *** Nfkb-reporter[Luc] is increased irt Lps (5 hr)
    *** cells: CHO<xTLR2> in BMS
    *** source: 11323673-Fig-1a
  *** Nfkb-reporter[Luc] is unchanged irt Lps (5 hr)
    *** cells: CHO<xTLR5> in BMS
    *** source: 11323673-Fig-1a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (30 min)
    *** cells: 70Z3 in BMS
    *** source: 12138192-Fig-3a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: 70Z3 in BMS
    *** times: 0 30 60+ 120++ min
    *** source: 9150141-Fig-4a
  *** Nfkb-reporter[Luc] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 1+ 2+ 4++ hr
    *** source: 12356687-Fig-4
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: rCMCs in BMS
    *** times: 0 15+ 30++ 45++ 60+++ 120++ min
    *** source: 11009565-Fig-4a
  *** Nfkb-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: HEK293<xTLR4><xMd2> in BMS
    *** source: 16603631-Fig-4d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 10+ 20++ 30++ 60++ 120++ min
    *** source: 10477696-Fig-6b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 15+ 30++ 60++ 90++ 120++ 180++ min
    *** source: 9804806-Fig-3
  *** Nfkb-reporter[Luc] is increased irt Lps (5 hr)
    *** cells: HEK293T<xTLR4><xCd14><xMd2> in BMS
    *** source: 16709849(D)
