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Requirement for TLR4 Lbp Md2 Cd14 from review articles - need data
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Ikk1--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 10+ 30++ 60++ min
    *** partially reqs: Ikk1 [KO]
    *** source: 12759443-Fig-2b

Ikk2--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 10+ 30++ 60++ min
    *** reqs: Ikk2 [KO]
    *** source: 12759443-Fig-2b

not Irak3--

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10 20 60+ min
    *** does not req: Irak3 [KO]
    *** source: 12150927-Fig-4b

Irak4--  ???

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Lps (30 min)
    *** cells: mBMMs in BMS
    *** unaffected by: kIrak4(K213M/K214M)"KD" [substitution]
    *** source: 17470642-Fig-6a

Myd88--

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 20+ 30+ 60+ min
    *** does not req: Myd88 [KO]
    *** partially reqs: Myd88 and/or Tradd [DKO]
    *** source: 18641654-Fig-5e
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 30+ 60++ min
    *** comment: reqs Myd88 [KO] at 30 min not 60 min
    *** comment: reqs Myd88 and/or Tradd [DKO] at both 30 and 60 min
    *** source: 18641654-Fig-5d

not Nlrp3--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10++ 20+ 60 min
    *** does not req: Nlrp3 [KO]
    *** source: 16407890(D)

not Nod2--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10++ 20+ 60 min
    *** does not req: Nod2 [KO]
    *** source: 16407890(D)

not Ripk1--

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 10 30+ 60++ min
    *** does not req: Ripk1 [KO]
    *** source: 16115877-Fig-1b

not Socs1

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Lps (times)
    *** cells: mPECs<Ifng~null> in BMS
    *** times: 0 1+ 8++ hr
    *** repressed by: Socs1 [KO]
    *** source: 12433365-Fig-3
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 15 30+ 60++ 360+ hr
    *** inhibited by: xSocs1 [addition]
    *** source: 12433365-Fig-5d

Tak1--

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Lps (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0 15+ 30+ 60 min
    *** bkg inhibited by: xTak1(K209R) [substitution]
    *** source: 19843958-Fig-2d
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0++ 5++ 15++ 30+ min
    *** inhibited by: xTak1(K209R) [substitution]
    *** source: 19843958-Fig-2d


Traf6--

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30+ 60 min
    *** reqs: Traf6 [KO]
    *** source: 16115877-Fig-6a

=========
Chemicals
=========

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 10+ 30++ 60++ min
    *** unaffected by: LY294002 [addition]
    *** source: 12759443-Fig-2b
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: HEK293<xTLR4> in BMS
    *** times: 0+ 5+ 15+ 30+ 60 90 min
    *** unaffected by: LFMA13 [pretreatment]
    *** source: 15849198-Fig-1c

=========
No Extras
=========

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Lps (10 min)
    *** cells: hPBMCs in BMLS
    *** source: 15040785(D)
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Lps (times)
    *** cells: hPBMCs in BMS
    *** times: 0 30+ 60+ 120+ 300+ min
    *** source: 15925273(D)
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Lps (times)
    *** cells: J774A1 in BMS
    *** times: 0 30 60+ 120+ 300+ min
    *** source: 15925273(D)
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 30+ 60+ 120 300 min
    *** source: 15925273(D)
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 10+ 30++ 60++ 120++ min
    *** source: 12759443-Fig-1b
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 10+ 30+ 60++ 120++ 240+ min
    *** source: 12759443-Fig-1e
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt Lps (times)
    *** cells: THP1 in BMS "treated with PMA (2 days)"
    *** times: 0 30 60++ 120++ 300+ min
    *** source: 15925273(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0++ 5++ 15 30 45+ 60++ min
    *** source: 15849198-Fig-1d
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0+ 15 45+ min
    *** source: 15849198-Fig-1e
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS "immortalized with v-myc and v-raf"
    *** times: 0 15+ 30++ 60++ min
    *** source: 22476513-Fig-1a
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt Lps (times)
    *** cells: hPBMCs in BMS
    *** times: 0 30+ 60+ min
    *** source: 22476513-Fig-1c
