Assume that this is happening via TLR4

not Ikke--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS "immortalized"
    *** times: 0 20+ 40+ min
    *** does not req: Tbk1 or Ikke [DKO]
    *** source: 15210742-Fig-6c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 20++ 40+ min
    *** does not req: Ikke [KO]
    *** source: 15210742-Fig-3b

Irak1--

  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 7+ 15+ 30 60 90 min
    *** partially reqs: Irak1 [KO]
    *** source: 10754329-Fig-3c

not Irak3--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10++ 20++ 60+ min
    *** source: 12150927-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs<Irak3~null> in BMS
    *** times: 0 10++ 20++ 60+ min
    *** source: 12150927-Fig-4b

Irak4--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10++ 30+ min
    *** reqs: Irak4 [KO]
    *** unaffected by: kIrak4(K213M/K214M)"KD" [substitution]
    *** source: 17470642-Fig-6b

Mek1--  Mek2-- chemicals only

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (1 hr)
    *** cells: RAW2647 in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 16537926-Fig-2b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (1 hr)
    *** cells: RAW2647 in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 16537926-Fig-2c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (15 min)
    *** cells: J774 in BMS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 10913190-Fig-5b

not Mekk1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mESCs in BMS
    *** times: 0 30++ 60+ 120 min
    *** enhanced by: kMekk1(1-1188)"del-kinase-domain" [addition]
    *** source: 10805784-Fig-2

not Mekk3--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 20+ 40+ 60+ min
    *** does not req: Mekk3 [KO]
    *** source: 14661019(D)

Myd88-- or Trif-- or Tradd--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10++ 20+ 60 min
    *** comment: reqs Myd88 [KO] at 10 min only
    *** source: 12447442(D)
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 10 30+ 60+ min
    *** does not req: Trif [KO]
    *** does not req: Myd88 [KO]
    *** reqs: Trif and/or Myd88 [DKO]
    *** source: 12872135-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 10++ 30+ 60 min
    *** does not req: Trif [KO]
    *** source: 12872135-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 30++ 60+ min
    *** partially reqs: Myd88 [KO]
    *** reqs: Myd88 and/or Tradd [DKO]
    *** source: 18641654-Fig-5d

Nfkb1--  is required for stabilization of Tpl2 only

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 15++ 30+ min
    *** reqs: Nfkb1 [KO]
    *** source: 17709378-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (30 min)
    *** cells: mBMMs<Nfkb1~null><xNfkb1> in BMS
    *** reqs: xNfkb1 [omission]
    *** source: 12667451-Fig-2e
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 15+ 30+ 60 120 min
    *** reqs: Nfkb1 [KO]
    *** source: 12667451-Fig-1f
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 15+ 30+ min
    *** reqs: Nfkb1 [KO]
    *** source: 12667451-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 15++ 30+ 120 min
    *** reqs: Nfkb1 [KO]
    *** source: 12667451-Fig-5d

  requires Ikk phos sites S921/S923/S927 S927/S932

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (15 min)
    *** cells: mBMMs<Nfkb1~null><xNfkb1> in BMS
    *** inhibited by: xNfkb1(S921A/S923A/S927A) [substitution]
    *** source: 15199157-Fig-9c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (15 min)
    *** cells: mBMMs<Nfkb1~null><xNfkb> in BMS
    *** reqs: xNfkb1 [omission]
    *** inhibited by: xNfkb1(S927A/S932A) [substitution]
    *** source: 15485931-Fig-4e
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647<xNfkb1> in BMS
    *** times: 0 7+ 15++ 30++ min
    *** partially inhibited by: xNfkb1(S927A/S932A) [substitution]
    *** source: 15485931-Fig-4a

not Nfkb2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 15+ 30+ min
    *** does not req: Nfkb2 [KO]
    *** source: 12667451-Fig-2f

not Nlrp3--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 20++ 60++ min
    *** does not req: Nod2 [KO]
    *** source: 16407890(D)

not Nod2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 20++ 60++ min
    *** does not req: Nlrp3 [KO]
    *** source: 16407890(D)

Tak1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mSpBCs in BMS
    *** times: 0 15 30+ 60+ min
    *** reqs: Tak1 [KO]
    *** source: 16186825(D)

not Tbk1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS "immortalized"
    *** times: 0 20+ 40+ min
    *** does not req: Tbk1 or Ikke [DKO]
    *** source: 15210742-Fig-6c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 20++ 40+ min
    *** does not req: Ikke [KO]
    *** does not req: Tbk1 [KO]
    *** source: 15210742-Fig-3b

Tirap--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 10+ 20+ min
    *** comment: reqs Tirap [KO] at 10 min not 20 min
    *** source: 12447441-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10++ 20+ 60 min
    *** comment: reqs Tirap [KO] at 10 min only
    *** source: 12447442(D)

not Tollip--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 20++ 40 75+ min
    *** does not req: Tollip [KO]
    *** source: 16428431(D)
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 10+ 30+ min
    *** does not req: Tollip [KO]
    *** source: 16428431(D)

Tpl2--

  *** Erks[Ab]IP IVKA(Elk1)[32P-ATP] is increased irt Lps (30 min)
    *** cells: mPECs in BMLS
    *** reqs: Tpl2 [KO]
    *** source: 11163183-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (30 min)
    *** cells: mPECs in BMLS
    *** reqs: Tpl2 [KO]
    *** source: 11163183-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (tnr)
    *** cells: mBMMs in BMS
    *** reqs: Tpl2 [KO]
    *** source: 15778223-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 15+ 30+++ 60+ 180+ min
    *** reqs: Tpl2 [KO]
    *** source: 12234923-Fig-4a

  Tpl2 phos(T290)

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (tnr)
    *** cells: mBMMs<Tpl2~null><xTpl2> in BMS
    *** inhibited by: xTpl2(T290A) [substitution]
    *** partially inhibited by: xTpl2(T290D) [substitution]
    *** source: 15778223-Fig-3

  Tpl2 phos(S400) not phos(S413)

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs<Nfkb1~null><xTpl2> in BMS
    *** times: 0 15+ 30+ min
    *** reqs: xTpl2 [omission]
    *** inhibited by: xTpl2(S400A) [substitution]
    *** unaffected by: xTpl2(S413A) [substitution]
    *** source: 17709378-Fig-2b

  Tpl2 kinase activity

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs<Nfkb1~null><xTpl2> in BMS
    *** times: 0 15++ 30+ min
    *** reqs: xTpl2 [omission]
    *** inhibited by: xTpl2(D270A)"KD" [substitution]
    *** source: 17709378-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs<Tpl2~null><xTpl2> in BMS
    *** times: 0 15++ 30+ min
    *** reqs: xTpl2 [omission]
    *** inhibited by: xTpl2(S400A) [substitution]
    *** unaffected by: xTpl2(S413A) [substitution]
    *** inhibited by: xTpl2(D270A)"KD" [substitution]
    *** source: 17709378-Fig-4a

not Traf3--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30++ 60++ min
    *** does not req: Traf3 [KO]
    *** source: 16306937-Fig-S3a

Traf6 ???

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mSMacs in BMS
    *** times: 0 10++ 20++ 30+ 60+ 90 min
    *** partially reqs: Traf6 [KO]
    *** source: 15322147-Fig-3a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30++ 60++ min
    *** does not req: Traf6 [KO]
    *** source: 16306937-Fig-4a

Chemicals

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (1 hr)
    *** cells: RAW2647 in BMLS
    *** unaffected by: GSK3inhibitorI [pretreatment]
    *** source: 16537926-Fig-5c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (1 hr)
    *** cells: RAW2647 in BMLS
    *** unaffected by: GSK3inhibitorIX [pretreatment]
    *** source: 16537926-Fig-5b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (1 hr)
    *** cells: RAW2647 in BMLS
    *** unaffected by: LiCl [pretreatment]
    *** source: 16537926-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (1 hr)
    *** cells: RAW2647 in BMLS
    *** unaffected by: PP2 [pretreatment]
    *** source: 16537926-Fig-2c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (15 min)
    *** cells: RAW2647 in BMS
    *** unaffected by: SB203580 [addition] no-bkg-control
    *** inhibited by: PD184352 [addition] no-bkg-control
    *** source: 14592977-Fig-10
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5 15+ 30++ 60+ 120+ min
    *** unaffected by: DMOG [pretreatment]
    *** source: 19762779-Fig-S6b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (20 min)
    *** cells: HMEC1 in BMS
    *** bkg inhibited by: PP1 [addition]
    *** source: 16371247-Fig-4e
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (30 min)
    *** cells: RAW2647 in BMS
    *** unaffected by: Wortmannin [addition]
    *** source: 12881422-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 7+ 15++ 30+ min
    *** unaffected by: LY294002 [pretreatment]
    *** unaffected by: Wortmannin [pretreatment]
    *** source: 17709378-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (15 min)
    *** cells: mBMMs in BMS
    *** inhibited by: 15dPGJ2 [pretreatment]
    *** source: 15199157-Fig-2c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (15 min)
    *** cells: mBMMs in BMS
    *** inhibited by: MG132 [pretreatment]
    *** source: 15199157-Fig-8b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (15 min)
    *** cells: mBMMs in BMS
    *** inhibited by: PS1145 [pretreatment]
    *** source: 15199157-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 7++ 15++ 30+ min
    *** partially inhibited by: Bay117082 [pretreatment]
    *** source: 15485931-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 7++ 15++ 30+ min
    *** partially inhibited by: MG132 [pretreatment]
    *** source: 15485931-Fig-2c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (45 min)
    *** cells: RAW2647 in BMS
    *** inhibited by: PD184352 [pretreatment]
    *** inhibited by: U0126 [pretreatment]
    *** source: 18187448-Fig-6b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (tnr)
    *** cells: mBMMs in BMS
    *** inhibited by: PD98059 [pretreatment]
    *** unaffected by: Ro318220 [pretreatment]
    *** source: 12234923-Fig-6a

No extras--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 15++ 30+ min
    *** source: 12096038-Fig-2c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 40++ 120 min
    *** source: 16574669(D)
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (10 min)
    *** cells: hPBMCs in BMLS
    *** source: 15040785(D)
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (30 min)
    *** cells: mPECs in BMS
    *** source: 11896392-Fig-2
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (1 hr)
    *** cells: RAW2647 in BMLS
    *** source: 16537926-Fig-4c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMLS
    *** times: 0 20 40+ 60+ min
    *** source: 16537926-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (3 hr)
    *** cells: THP1 in BMS
    *** source: 16533170-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (3 hr)
    *** cells: THP1 in BMS "treated for 5 days with PMA"
    *** source: 16533170-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0+ 2+ 5+ 15++ 30+++ 45++ 60++ 90+ min
    *** source: 12881422-Fig-2c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 15 30+ 45+ min
    *** source: 15778223-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647<xTpl2> in BMS "pretreated with MG132"
    *** times: 0 15+ 30+ 45+ 60+ min
    *** source: 15699325-Fig-3
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 2 5 10+ 15++ 30+ min
    *** source: 15199157-Fig-4
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 7+ 15++ 30++ min
    *** source: 15485931-Fig-4a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Lps (20 min)
    *** cells: hMDDCs in BMS
    *** source: 16858407-Fig-2a
  -----------------------------------------------------------------
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Lps (times)
    *** cells: mSpBCs in BMS
    *** times: 0 10 30 60 min
    *** source: 17143273-Fig-3
