====================================
Phosphorylation on S939 and/or T1492
====================================

not Ddit4--

  *** Tsc2[phosAb] phos(S939)[phosAb] is increased irt Ins (90 min)
    *** cells: U2OS in BMLS
    *** unaffected by: xDdit4 [addition]
    *** source: 18198340-Fig-4d
  *** Tsc2[phosAb] phos(T1492)[phosAb] is increased irt Ins (90 min)
    *** cells: U2OS in BMLS
    *** unaffected by: xDdit4 [addition]
    *** source: 18198340-Fig-4d

not Sin1--

  *** Tsc2[phosAb] phos(T1462)[phosAb] is increased irt Ins (15 min)
    *** cells: mEFs in BMLS
    *** does not req: Sin1 [KO]
    *** source: 16962653-Fig-3c
  *** Tsc2[phosAb] phos(S939)[phosAb] is increased irt Ins (15 min)
    *** cells: mEFs in BMLS
    *** does not req: Sin1 [KO]
    *** source: 16962653-Fig-3c

not Vps34--

  *** Tsc2[phosAb] phos(S939)[phosAb] is increased irt Ins (30 min)
    *** cells: HELA in BMLS
    *** does not req: Vps34 [RNAi]
    *** source: 16049009-Fig-2d

Chemicals

  *** Tsc2[phosAb] phos(S939)[phosAb] is increased irt Ins (90 min)
    *** cells: mEFs in BMLS
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 18198340-Fig-2e
  *** Tsc2[phosAb] phos(T1492)[phosAb] is increased irt Ins (90 min)
    *** cells: mEFs in BMLS
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 18198340-Fig-2e
  *** Tsc2[Ab]IP phos[WBMS] is increased irt Ins (15 min)
    *** cells: HELA in BMLS
    *** inhibited by: LY294002 [pretreatment]
    *** inhibited by: Wortmannin [pretreatment]
    *** unaffected by: PD98059 [pretreatment]
    *** source: 12167664-Fig-1e
  *** Tsc2[phosAb] phos(T1462)[phosAb] is increased irt Ins (4 hr)
    *** cells: ARPE19 in BMLS
    *** unaffected by: Aicar [cotreatment]
    *** source: 16516166-Fig-3

Stresses

  *** Tsc2[phosAb] phos(S939)[phosAb] is increased irt Ins (5 hr)
    *** cells: mEFs in BMLS
    *** unaffected by: Hypoxia [pretreatment]
    *** source: 18198340-Fig-2e
  *** Tsc2[phosAb] phos(T1492)[phosAb] is increased irt Ins (5 hr)
    *** cells: mEFs in BMLS
    *** unaffected by: Hypoxia [pretreatment]
    *** source: 18198340-Fig-2e
  *** Tsc2[phosAb] phos(S939)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293 in BMLS "Serum and AminoAcid deprived"
    *** unaffected by: AminoAcids [cotreatment]
    *** source: 16176982-Fig-1b

Tsc2 phos Sites

  *** xTsc2[tAb]IP phos(RXRXXS-T)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293<xTsc1><xTsc2> in BMS
    *** inhibited by: xTsc2(S939A/T1462A) [substitution]
    *** unaffected by: xTsc2(S1798A) [substitution]
    *** bkg inhibited by: xTsc2(S939A/T1462A/S1798A) [substitution]
    *** source: 15342917-Fig-5b


no extras

  *** Tsc2[Ab]IP phos[WBMS-PPase] is increased irt Ins (15 min)
    *** cells: HELA in BMLS
    *** source: 12167664-Fig-1d

Protein expression ???

  *** Tsc2[Ab] prot-exp[WB] is decreased irt Ins (30 min)
    *** cells: HEK293 in BMLS "Serum and AminoAcid deprived"
    *** unaffected by: AminoAcids [cotreatment]
    *** source: 16176982-Fig-1b
  *** Tsc2[Ab] prot-exp[WB] is unchanged irt Ins (30 min)
    *** cells: HELA in BMLS "Serum deprived"
    *** source: 16176982-Fig-1c

