=================
Required Proteins
=================

not Gnai1-- or Gnai3--

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (times)
    *** cells: mEFs in BMLS
    *** times: 0 10+ 20+ min
    *** does not req: Gnai1 or Gnai3 [KO]
    *** source: 19401591-Fig-2b

not Sin1--

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** does not req: Sin1 [RNAi]
    *** source: 17043309-Fig-2a
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293 in BMS
    *** does not req: Sin1 [RNAi]
    *** source: 17043309-Fig-2b

not Raptor--

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** does not req: Raptor [RNAi]
    *** source: 17043309-Fig-2a
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293 in BMS
    *** does not req: Raptor [RNAi]
    *** source: 17043309-Fig-2b

not Rictor--

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** does not req: Rictor [RNAi]
    *** source: 17043309-Fig-2a
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293 in BMS
    *** does not req: Rictor [RNAi]
    *** source: 17043309-Fig-2b
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (20 min)
    *** cells: mEFs<Rictor~null> in BMLS
    *** source: 21464307-Fig-S4a

Mtor-- ????

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** bkg reqs: Mtor [RNAi]
    *** source: 17043309-Fig-2a
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293 in BMS
    *** bkg reqs: Mtor [RNAi]
    *** source: 17043309-Fig-2b

not S6k1--

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293E<xS6k1> in BMLS
    *** unaffected by: xS6k1(T412A) [substitution]
    *** source: 16286006-Fig-4c

other

  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Ins (10 min)
    *** cells: MC3T3E1 in BMS
    *** unaffected by: Dkk1 [pretreatment]
    *** source: 16959574-Fig-S4a


chemicals

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (times)
    *** cells: HC11 in BMLS
    *** times: 0 7+ 15+ min
    *** bkg inhibited by: LY294002 [addition]
    *** source: 16984645-Fig-5
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293E in BMLS
    *** inhibited by: Rapamycin [addition]
    *** source: 16286006-Fig-1d
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293E<xS6k1> in BMLS
    *** inhibited by: Rapamycin [addition]
    *** source: 16286006-Fig-4c
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (times)
    *** cells: HC11 in BMLS
    *** times: 0 7+ 15+ min
    *** bkg inhibited by: Rapamycin [addition]
    *** source: 16984645-Fig-5
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (30 min)
    *** cells: mEFs in BMLS
    *** inhibited by: 2DOG [posttreatment]
    *** inhibited by: 5ThioGlucose [posttreatment]
    *** source: 16027121-Fig-6a
  *** Rps6[phosAb] phos(S235)[phosAb] is increased irt Ins (30 min)
    *** cells: KB in BMLS
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** inhibited by: Wortmannin [pretreatment]
    *** unaffected by: U0126 [pretreatment]
    *** source: 15024086-Fig-2b
  *** Rps6[phosAb] phos(S235)[phosAb] is increased irt Ins (30 min)
    *** cells: KB in BMLS
    *** comment: bkg inhibited by replacing BMLS with BSS+Glucose - AminoAcids for 4 h4 before Ins
    *** comment: unaffected by replacing BMLS with BSS+Glucose + AminoAcids for 4 hr before Ins
    *** source: 15024086-Fig-4b
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293E in BMLS
    *** inhibited by: Rapamycin [pretreatment]
    *** source: 17360704-Fig-5c
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293E in BMLS
    *** unaffected by: FMK [pretreatment]
    *** source: 17360704-Fig-4b
  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293E in BMLS
    *** inhibited by: Rapamycin [pretreatment]
    *** source: 17360704-Fig-5c
  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293E in BMLS
    *** unaffected by: FMK [pretreatment]
    *** source: 17360704-Fig-4b



No Extras

  *** Rps6[Ab] phos[WBMS] is increased irt Ins (times)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** times: 0 1 3 5 15+ 30+ 60+ min
    *** source: 16541103-Fig-7a
  ---------------  phos(S235)  -------------------------------------
  *** Rps6[phosAb] phos(S235)[phosAb] is unchanged irt Ins (tnr)
    *** cells: CHOK1 in BMS
    *** source: 12194824-Fig-2
  *** Rps6[phosAb] phos(S235)[phosAb] is increased irt Ins (30 min)
    *** cells: mEFs in BMLS
    *** source: 15024086-Fig-5b
  ---------------  phos(S235/S236)  -------------------------------------
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (times)
    *** cells: HEK293E in BMLS
    *** times: 0 2 5+ 10+ 20++ 30++ min
    *** source: 16286006-Fig-5a
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is unchanged irt Ins (30 min)
    *** cells: RAT1A in BMS
    *** source: 16027121-Fig-4a
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (45 min)
    *** cells: HEK293 in BMLS
    *** source: 12777372-Fig-2b
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293T in BMLS
    *** source: 12842888-Fig-4a
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293T<xTsc1><xTsc2> in BMLS
    *** source: 12842888-Fig-4a
  ---------------  phos(S240/S244)  -------------------------------------
  *** Rps6[phosAb] phos(S240/S244)[phosAb] is unchanged irt Ins (30 min)
    *** cells: HEK293 in BMS
    *** source: 12172553-Fig-2b
  *** Rps6[phosAb] phos(S240/S244)[phosAb] is unchanged irt Ins (30 min)
    *** cells: HEK293 in BMLS "Serum and AminoAcid deprived"
    *** source: 16176982-Fig-1b
  *** Rps6[phosAb] phos(S240/S244)[phosAb] is unchanged irt Ins (45 min)
    *** cells: HEK293 in BMLS
    *** source: 12777372-Fig-2b
  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Ins (times)
    *** cells: HELA in BMLS
    *** times: 0 3 5 10+ 15++ 30++ min
    *** source: 16763566-Fig-1b


====================
Other initial states
====================

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (30 min)
    *** cells: mHepatocytes in BMLS "AminoAcid and Glucose deprived"
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** source: 16763566-Fig-2a
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Ins (30 min)
    *** cells: mHepatocytes in BMLS "AminoAcid and Glucose deprived"
    *** reqs: S6k1 or S6k2 [KO]
    *** source: 16763566-Fig-2a
