===============
Kinase Activity
===============

InsR attributes

  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** partially inhibited by: xInsR(Y1158F) [substitution]
    *** partially inhibited by: xInsR(Y1162F/T1163F) [substitution]
    *** inhibited by: xInsR(Y1158F/T1162F) [substitution]
    *** source: 7806540-Fig-7

chemicals

  *** Erks[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt Ins (15 min)
    *** cells: NIH3T3<xInsR> in BMLS
    *** partially inhibited by: PD98059 [addition]
    *** source: 12110590-Fig-4b
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0 5+ 30 min
    *** inhibited by: PD98059 [addition]
    *** source: 8626428-Fig-5b

no extras

  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0 5++ 30+ min
    *** source: 8626428-Fig-3a
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ins (times)
    *** cells: NIH3T3L in BMS "differentiated into adipocytes"
    *** times: 0 5++ 30+ min
    *** source: 8626428-Fig-3a

===========================
Phosphorylation on TEY site
===========================

Dok1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** unaffected by: xDok1 [addition]
    *** source: 10202139-Fig-7c

Hras--

  *** Erks[Ab] phos[WBMS] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0 5+ 30 min
    *** partially inhibited by: xHras(S17N)"DN" [addition]
    *** source: 8626428-Fig-6a

Mek1--

  *** Erks[Ab] phos[WBMS] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0 5++ 30 min
    *** inhibited by: xMek1(K97R)"DN" [addition]
    *** source: 7673108-Fig-4a

not Ralb--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (times)
    *** cells: NIH3T3<xInsR> in BMLS
    *** times: 0 5++ 10+ 15+ min
    *** unaffected by: xRalb(S28N)"DN" [addition]
    *** source: 12110590-Fig-1c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (15 min)
    *** cells: NIH3T3<xInsR> in BMLS
    *** unaffected by: xRalb(S28N)"DN" [addition]
    *** source: 11046144-Fig-4b,6a,6b

not RalGds--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (times)
    *** cells: MCF7 in BMLS
    *** times: 0 5+ 10+ 30+ min
    *** does not req: RalGds [RNAi]
    *** source: 18285454-Fig-4
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (times)
    *** cells: MCF10A in BMLS
    *** times: 0 5+ 10+ 30+ min
    *** does not req: RalGds [RNAi]
    *** source: 18285454-Fig-1b

not Rheb--

  *** xErk1[phosAb] phos(TEY)[phosAb] is increased irt Serum (30 min)
    *** cells: HELA<xErk1> in BMLS
    *** unaffected by: xRheb [addition]
    *** source: 12820960-Fig-3a

not Rin1--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (8 min)
    *** cells: HEPG2 in BMS
    *** does not req: Rin1 [RNAi]
    *** does not req: Rin2 [RNAi]
    *** does not req: Rin3 [RNAi]
    *** source: 16457816-Fig-5b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (8 min)
    *** cells: HEPG2 in BMS
    *** inhibited by: xRin1 [addition]
    *** inhibited by: xRin1(mnr)"Nterm" [addition]
    *** inhibited by: xRin1(mnr)"Dterm" [addition]
    *** bkg enhanced by: xRin1(mnr/del(429-490)) [addition]
    *** source: 16457816-Fig-4d

=========
No Extras
=========

  *** xErk?[phosAb] phos(TEY)[phosAb] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** source: 11551902-Fig-7a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (5 min)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** source: 16541103-Fig-8c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (times)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** times: 0 1 3++ 5++ 15++ 30+ 60+ min
    *** source: 16541103-Fig-7a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (tnr)
    *** cells: MEWO in BMLS
    *** source: 19274086-Fig-2a
 --------------------------------------------------------------------
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Ins (tnr)
    *** cells: 3731T in BMLS
    *** source: 19274086-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Ins (15 min)
    *** cells: mEFs in BMLS
    *** source: 16962653-Fig-5b
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Ins (30 min)
    *** cells: HELA in BMLS
    *** source: 16763566-Fig-1a
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Ins (times)
    *** cells: HELA in BMLS
    *** times: 0 3 5 10 15 30 min
    *** source: 16763566-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Ins (tnr)
    *** cells: HELA in BMLS
    *** source: 16763566-Fig-5a



Chemicals

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (15 min)
    *** cells: NIH3T3<xInsR> in BMLS
    *** unaffected by: PP1 [addition]
    *** source: 11046144-Fig-4b,6a,6b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (times)
    *** cells: NIH3T3<xInsR> in BMLS
    *** times: 0 10+ 30+ min
    *** inhibited by: PD98059 [addition]
    *** unaffected by: LY294002 [addition]
    *** source: 11046144-Fig-1d
  *** Erks[Ab] phos[WBMS] is increased irt Ins (5 min)
    *** cells: NIH3T3L in BMS "differentiated into adipocytes"
    *** inhibited by: PD98059 [addition]
    *** source: 7673108-Fig-2a
  *** Erks[Ab] phos[WBMS] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0 3+ 5++ 10+ 15 30 min
    *** inhibited by: PD98059 [addition]
    *** source: 7673108-Fig-1a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (30 min)
    *** cells: NIH3T3<xInsR> in BMLS
    *** unaffected by: Wortmannin [addition]
    *** unaffected by: Rapamycin [addition]
    *** source: 12820960-Fig-2b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (30 min)
    *** cells: KB in BMLS
    *** unaffected by: Rapamycin [pretreatment]
    *** unaffected by: Wortmannin [pretreatment]
    *** inhibited by: U0126 [pretreatment]
    *** source: 15024086-Fig-2b
  *** Erks[Ab] phos[WBMS] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0 2++ 5++ 10++ 30+ 60+ min
    *** source: 8626428-Fig-1a
  *** Erks[Ab] phos[WBMS] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0 5+ 30 min
    *** inhibited by: PD98059 [addition]
    *** source: 8626428-Fig-5a
  *** Erks[Ab] phos[WBMS] is increased irt Ins (times)
    *** cells: NIH3T3L in BMS "differentiated into adipocytes"
    *** times: 0 5++ 30+ min
    *** source: 8626428-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 11777913-Fig-2c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 11777913-Fig-2d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD169316 [pretreatment]
    *** source: 11777913-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: SB202190 [pretreatment]
    *** source: 11777913-Fig-2b
