=====================
Phosphorylation Sites
=====================

Total/Unknown sites

  *** Eif4ebp1[Ab] phos[WBMS] is increased irt Ins (tnr)
    *** cells: CHOK1 in BMS
    *** source: 12194824(D)
  *** Eif4ebp1[Ab] phos[WBMS] is increased irt Ins (30 min)
    *** cells: CHOK1 in BMLS
    *** comment: unaffected by replacing BMLS with BSS+Glucose + AminoAcids for 30 min before Ins
    *** comment: bkg inhibited by replacing BMLS with BSS+Glucose - AminoAcids for 30 min before Ins
    *** comment: unaffected by replacing BMLS with BSS+Glucose + CHX for 30 min before Ins
    *** source: 15024086-Fig-4a
  *** Eif4ebp1[Ab] phos[WBMS] is increased irt Ins (30 min)
    *** cells: KB in BMLS
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** inhibited by: Wortmannin [pretreatment]
    *** unaffected by: U0126 [pretreatment]
    *** source: 15024086-Fig-2b
  *** Eif4ebp1[Ab] phos[WBMS] is increased irt Ins (30 min)
    *** cells: KB in BMLS
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** source: 15024086-Fig-6b
  *** Eif4ebp1[Ab] phos[WBMS] is increased irt Ins (30 min)
    *** cells: KB in BMLS
    *** comment: bkg inhibited by replacing BMLS with BSS+Glucose - AminoAcids for 4 h4 before Ins
    *** comment: unaffected by replacing BMLS with BSS+Glucose + AminoAcids for 4 hr before Ins
    *** source: 15024086-Fig-4b

phos(T36/T37)

  *** Eif4ebp1[phosAb] phos(T36/T37)[phosAb] is increased irt Ins (15 min)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** inhibited by: Rapamycin [addition]
    *** unaffected by: FK506 [addition]
    *** unaffected by: Rapamycin + FK506 [addition]
    *** source: 16541103-Fig-3e
  *** Eif4ebp1[phosAb] phos(T36/T37)[phosAb] is increased irt Ins (times)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** times: 0 1+ 3++ 5++ 15++ 30++ 60++ min
    *** source: 16541103-Fig-7a

phos(T36/T45)

  *** Eif4ebp1[phosAb] phos(T36/T45)[phosAb] is increased irt Ins (10 min)
    *** cells: 3T3L1 in BSS "differentiated into adipocytes"
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** source: 10942774-Fig-4a,5a
  *** xEif4ebp1[phosAb] phos(T36/T45)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS "AminoAcid deprived for 3 hr"
    *** inhibited by: Rapamycin [pretreatment]
    *** unaffected by: AminoAcids [cotreatment]
    *** source: 10942774-Fig-3a

phos(T37)

  *** Eif4ebp1[phosAb] phos(T37)[phosAb] is increased irt Ins (45 min)
    *** cells: HEK293 in BMLS
    *** source: 12777372-Fig-1b
  *** Eif4ebp1[phosAb] phos(T37)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: H89 [pretreatment]
    *** source: 11777913-Fig-5b
  *** Eif4ebp1[phosAb] phos(T37)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD98059 [pretreatment]
    *** source: 11777913-Fig-2c
  *** Eif4ebp1[phosAb] phos(T37)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD169316 [pretreatment]
    *** source: 11777913-Fig-2a
  *** Eif4ebp1[phosAb] phos(T37)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: SB202190 [pretreatment]
    *** source: 11777913-Fig-2b
  *** Eif4ebp1[phosAb] phos(T37)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: U0126 [pretreatment]
    *** source: 11777913-Fig-2d
  *** Eif4ebp1[phosAb] phos(T37)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: Wortmannin [pretreatment]
    *** source: 11777913-Fig-7a
  *** Eif4ebp1[phosAb] phos(T37)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: xErk2(mnr)"DN" [addition]
    *** source: 11777913-Fig-3b
  *** Eif4ebp1[phosAb] phos(T37)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: xJnk1(mnr)"DN" [addition]
    *** source: 11777913-Fig-3c
  *** Eif4ebp1[phosAb] phos(T37)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: xP38a(mnr)"DN" [addition]
    *** source: 11777913-Fig-3a

phos(T37/T46)

  *** Eif4ebp1[phosAb] phos(T37/T46)[phosAb] is increased irt Ins (15 min)
    *** cells: mEFs in BMLS
    *** does not req: Sin1 [KO]
    *** source: 16962653-Fig-5a
  *** xEif4ebp1[phosAb] phos(S37/S46)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** comment: this is more of an decrease in mobility than band intensity
    *** unaffected by: xEif4ebp1(S101A) [substitution]
    *** source: 12588975-Fig-2c
  *** xEif4ebp1[phosAb] phos(S37/S46)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** comment: this is more of an decrease in mobility than band intensity
    *** unaffected by: xEif4ebp1(S112A) [substitution]
    *** source: 12588975-Fig-3a

phos(S65) phos(S65/S101)??? see 12588975

  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (30 min)
    *** cells: HELA in BMLS
    *** source: 16049009-Fig-5c
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (times)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** times: 0 1 3+ 5+ 15+ 30+ 60+ min
    *** source: 16541103-Fig-7a
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (15 min)
    *** cells: HC11 in BMLS
    *** times: 0 7+ 15++ min
    *** inhibited by: LY294002 [addition]
    *** partially inhibited by: Rapamycin [addition]
    *** source: 16984645-Fig-5
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293E<xS6k1> in BMLS
    *** unaffected by: xS6k1(T412A) [substitution]
    *** inhibited by: Rapamycin [addition]
    *** source: 16286006-Fig-4d
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (times)
    *** cells: HEK293E in BMLS
    *** times: 0 2 5 10+ 20+ 30+ min
    *** source: 16286006-Fig-5b
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (30 min)
    *** cells: RAT1A in BMLS
    *** bkg inhibited by: 5ThioGlucose [cotreatment]
    *** source: 16027121-Fig-3b
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (45 min)
    *** cells: HEK293 in BMLS
    *** source: 12777372-Fig-1b
  *** xEif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293E<xEif4ebp1> in BMLS
    *** bkg inhibited by: Wortmannin [addition]
    *** source: 12906785-Fig-2a
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (10 min)
    *** cells: 3T3L1 in BSS "differentiated into adipocytes"
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** source: 10942774-Fig-4a,5a
  *** xEif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS "AminoAcid deprived for 3 hr"
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** enhanced by: AminoAcids [cotreatment]
    *** source: 10942774-Fig-3b
  *** Eif4ebp1[phosAb] phos(S65/S101)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1(S65A)> in BMLS
    *** source: 12588975-Fig-2a
  *** xEif4ebp1[phosAb] phos(S65/S101)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** inhibited by: xEif4ebp1(S101A) [substitution]
    *** unaffected by: xEif4ebp1(S101E) [substitution]
    *** unaffected by: xEif4ebp1(S101D) [substitution]
    *** source: 12588975-Fig-2b
  *** xEif4ebp1[phosAb] phos(S65/S101)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** inhibited by: xEif4ebp1(S101A) [substitution]
    *** source: 12588975-Fig-2c
  *** xEif4ebp1[phosAb] phos(S65/S101)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** unaffected by: xEif4ebp1(S101A) [substitution]
    *** source: 12588975-Fig-3a

phos(T70)

  *** Eif4ebp1[phosAb] phos(T70)[phosAb] is detectable-but unchanged irt Ins (30 min)
    *** cells: HEK293 in BMLS "Serum and AminoAcid deprived"
    *** enhanced by: AminoAcids [cotreatment]
    *** source: 16176982-Fig-1b
  *** xEif4ebp1[phosAb] phos(T70)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMS
    *** unaffected by: xRheb [addition]
    *** source: 12820960-Fig-3b
  *** Eif4ebp1[phosAb] phos(T70)[phosAb] is increased irt Ins (10 min)
    *** cells: 3T3L1 in BSS "differentiated into adipocytes"
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** source: 10942774-Fig-4a,5a
  *** xEif4ebp1[phosAb] phos(T70)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS "AminoAcid deprived for 3 hr"
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** unaffected by: AminoAcids [cotreatment]
    *** source: 10942774-Fig-3c
  *** xEif4ebp1[phosAb] phos(T70)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** unaffected by: xEif4ebp1(S112A) [substitution]
    *** source: 12588975-Fig-3a
  *** xEif4ebp1[phosAb] phos(T70)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** unaffected by: xEif4ebp1(S101A) [substitution]
    *** source: 12588975-Fig-2c
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: H89 [pretreatment]
    *** source: 11777913-Fig-5b
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD98059 [pretreatment]
    *** source: 11777913-Fig-2c
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD169316 [pretreatment]
    *** source: 11777913-Fig-2a
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: SB202190 [pretreatment]
    *** source: 11777913-Fig-2b
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: U0126 [pretreatment]
    *** source: 11777913-Fig-2d
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: Wortmannin [pretreatment]
    *** source: 11777913-Fig-7a
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: xErk2(mnr)"DN" [addition]
    *** source: 11777913-Fig-3b
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: xJnk1(mnr)"DN" [addition]
    *** source: 11777913-Fig-3c
  *** Eif4ebp1[phosAb] phos(S65)[phosAb] is increased irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: xP38a(mnr)"DN" [addition]
    *** source: 11777913-Fig-3a


phos(S112)

  *** xEif4ebp1[phosAb] phos(S112)[phosAb] is detectable-but unchanged irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** unaffected by: Ins (30 min) [stim]
    *** unaffected by: Rapamycin (30 min) [stim]
    *** unaffected by: Wortmannin (30 min) [stim]
    *** source: 12588975-Fig-4b

========================
Release from capped mRNA Is this a release or a prevention of binding??
========================

  *** Eif4ebp1[Ab] snaggedby[WB] capped-mRNA[m7GTP] is decreased irt Ins (30 min)
    *** cells: HEK293E<xS6k1> in BMLS
    *** unaffected by: xS6k1(T412A) [substitution]
    *** inhibited by: Rapamycin [addition] no-bkg-control
    *** source: 16286006-Fig-4d
  *** Eif4ebp1[Ab] snaggedby[WB] capped-mRNA[m7GTP] is decreased irt Ins (times)
    *** cells: HEK293E in BMLS
    *** times: 0++ 2++ 5+ 10 20 30 min
    *** source: 16286006-Fig-5b
  *** Eif4ebp1[Ab] snaggedby[WB] capped-mRNA[m7GTP] is decreased irt Ins (10 min)
    *** cells: CHO<xInsR><xRaptor> in BMLS
    *** comment: cells were lysed without detergent
    *** source: 12150926-Fig-5a
  *** Eif4ebp1[Ab] snaggedby[WB] capped-mRNA[m7GTP] is decreased irt Ins (10 min)
    *** cells: H4IIE in BMLS
    *** comment: cells were lysed without detergent
    *** source: 12150926-Fig-5b
  *** Eif4ebp1[Ab] snaggedby[WB] capped-mRNA[m7GTP] is decreased irt Ins (45 min)
    *** cells: HEK293 in BMLS
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 12777372-Fig-2a
  *** xEif4ebp1[tAb] snaggedby[WB] capped-mRNA[m7GTP] is decreased irt Ins (30 min)
    *** cells: HEK293E<xEif4ebp1> in BMLS
    *** reversed by: Wortmannin [addition]
    *** source: 12906785-Fig-2b
  *** Eif4ebp1[Ab] snaggedby[WB] capped-mRNA[m7GTP] is decreased irt Ins (60 min)
    *** cells: HELA in BMLS
    *** partially reqs: Slc3a2 [RNAi]
    *** source: 19203585-Fig-S3
  *** Eif4ebp1[Ab] snaggedby[WB] capped-mRNA[m7GTP] is decreased irt Ins (60 min)
    *** cells: HELA in BMLS
    *** partially reqs: Slc7a1 [RNAi]
    *** source: 19203585-Fig-S3
  *** Eif4ebp1[Ab] snaggedby[WB] capped-mRNA[m7GTP] is decreased irt Ins (10 min)
    *** cells: 3T3L1 in BSS "differentiated into adipocytes"
    *** reversed by: Rapamycin [pretreatment]
    *** source: 10942774-Fig-5b
  *** xEif4ebp1[Ab] snaggedby[WB] capped-mRNA[m7GTP] is decreased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** comment: substitution with xEif4ebp1(S101A) decreases bkg but does not reverse inhibition
    *** source: 12588975-Fig-2d
  *** xEif4ebp1[Ab] snaggedby[WB] capped-mRNA[m7GTP] is decreased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** reversed by: xEif4ebp1(S112A) [substitution]
    *** source: 12588975-Fig-3b
  *** xEif4ebp1[Ab] snaggedby[WB] capped-mRNA[m7GTP] is decreased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** reversed by: xEif4ebp1(1-112) [substitution]
    *** source: 12588975-Fig-5b
  *** xEif4ebp1{phos(S65/S101)}[phosAb] snaggedby[WB] capped-mRNA[m7GTP] is decreased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** reversed by: xEif4ebp1(S112A) [substitution]
    *** source: 12588975-Fig-3b
  *** xEif4ebp1{phos(T70)}[phosAb] snaggedby[WB] capped-mRNA[m7GTP] is increased irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** unaffected by: xEif4ebp1(S112A) [substitution]
    *** source: 12588975-Fig-3b


===================
Protein Association
===================

  *** Mtor[Ab] snaggedby[WB] rEif4ebp1[GST] is increased irt Ins (30 min)
    *** cells: CHO<xInsR> in BMLS
    *** source: 17510057-Fig-6a
  *** Raptor[Ab] snaggedby[WB] rEif4ebp1[GST] is increased irt Ins (30 min)
    *** cells: CHO<xInsR> in BMLS
    *** source: 17510057-Fig-6a
