=================================
Recruitment to Eif4e-mRNA complex
=================================

  *** Eif4b[Ab] snaggedby[WB] capped-mRNA[m7GTP] is increased irt Ins (times)
    *** cells: HEK293E in BMLS
    *** times: 0 2 5 10 20 30++ min
    *** source: 16286006-Fig-5b
  *** Eif4b[Ab] snaggedby[WB] capped-mRNA[m7GTP] is increased irt Ins (30 min)
    *** cells: HEK293E<xS6k1> in BMLS
    *** inhibited by: Rapamycin [addition]
    *** inhibited by: xS6k1(T412A) [substitution]
    *** source: 16286006-Fig-4d

========================
Phosphorylation on S1147  which comes first??
========================

reqs Mtor-- ??? Rapamycin only

  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293E in BMLS
    *** bkg inhibited by: Rapamycin [addition]
    *** source: 16286006-Fig-4a
  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Ins (tnr)
    *** cells: HELA in BMLS
    *** partially inhibited by: Rapamycin [pretreatment]
    *** source: 16763566-Fig-5a
  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Ins (30 min)
    *** cells: HELA in BMLS
    *** inhibited by: Rapamycin [pretreatment]
    *** unaffected by: U0126 [pretreatment]
    *** inhibited by: Rapamycin + U0126 [pretreatment]
    *** source: 16763566-Fig-1a

not Rsk1-- or Rsk2

  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Ins (tnr)
    *** cells: HELA in BMLS
    *** does not req: Rsk1 and/or Rsk2 [RNAi]
    *** source: 16763566-Fig-5a

no extras

  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Ins (times)
    *** cells: HEK293E in BMLS
    *** times: 0+ 2+ 5+ 10++ 20++ 30++ min
    *** source: 16286006-Fig-5a
  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Ins (times)
    *** cells: HELA in BMLS
    *** times: 0 3 5 10 15 30+ min
    *** source: 16763566-Fig-1b


===================
Additional Stresses
===================

  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Ins (30 min)
    *** cells: mHepatocytes in BMLS "AminoAcid and Glucose deprived"
    *** does not req: S6k1 or S6k2 [KO]
    *** source: 16763566-Fig-2a
  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Ins (30 min)
    *** cells: mHepatocytes in BMLS "AminoAcid and Glucose deprived"
    *** inhibited by: Rapamycin [pretreatment]
    *** source: 16763566-Fig-2a













