===============
Kinase Activity
===============

Sin1--

  *** xAkt1[tAb]IP IVKA(Gsk3?)(SFAE)[phosAb] is increased irt Ins (times)
    *** cells: mEFs in BMLS
    *** times: 0 5+ 15+ 60+ min
    *** partially reqs: Sin1 [KO]
    *** source: 16962653-Fig-3b


Akt1 features

  *** xAkt1[tAb]IP IVKA(HistH2B)[32P-ATP] is increased irt Ins (2 min)
    *** cells: NIH3T3<xInsR> in BMS
    *** inhibited by: xAkt1(R25C)"PH-domain-mut" [substitution]
    *** source: 8999998-Fig-3b
  *** xAkt1[tAb]IP IVKA(Crosstide)[32P-ATP] is increased irt Ins (8 min)
    *** cells: COS7<xAkt1> in BMLS
    *** partially inhibited by: xAkt1(R144A) [substitution]
    *** inhibited by: xAkt1(R200A) [substitution]
    *** source: 12374740-Fig-8a

chemicals

  *** xAkt1[tAb]IP IVKA(HistH2B)[32P-ATP] is increased irt Ins (2 min)
    *** cells: NIH3T3<xInsR> in BMS
    *** inhibited by: LY294002 [addition]
    *** source: 8999998-Fig-3b
  *** Akt1[Ab]IP IVKA(peptide)[32P-ATP] is increased irt Ins (5 min)
    *** cells: rAPCs in BMS "serum and nutrient starved"
    *** unaffected by: Ro318220 [addition]
    *** unaffected by: myr-SIYRRGARRWRKL [addition]
    *** source: 10464256-Fig-6
  *** Akt1[Ab]IP IVKA(peptide)[32P-ATP] is increased irt Ins (15 min)
    *** cells: HEPG2 in BMLS
    *** unaffected by: IL6 [cotreatment]
    *** source: 12456685-Fig-3a
  *** Akts[Ab]IP IVKA(peptide)[32P-ATP] is increased irt Ins (5 min)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD98059 [pretreatment]
    *** unaffected by: SB202190 [pretreatment]
    *** inhibited by: LY294002 [pretreatment]
    *** source: 11350959-Fig-9b

no extras

  *** xAkt1[tAb]IP IVKA(peptide)[32P-ATP] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** source: 11551902-Fig-7c
  *** Akt1[Ab]IP IVKA(Pras40)[32P-ATP] is increased irt Ins (30 min)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** source: 18372248-Fig-1a
  *** Akt1[Ab]IP IVKA(Pras40)[32P-ATP] is increased irt Ins (30 min)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** comment: unaffected by disruption of Mtor/Raptor complex with Triton X100
    *** source: 18372248-Fig-3a

===============
Phosphorylation
===============

not Atm--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (2 min)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** does not req: Atm [RNAi]
    *** source: 16221682-Fig-6b
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (2 min)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** does not req: Atm [RNAi]
    *** source: 16221682-Fig-6b

Dok1-- ???

  *** xAkt1[phosAb] phos(T308)[phosAb] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** inhibited by: xDok1 [addition]
    *** source: 11551902-Fig-8

not Ddit4--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (2 hr)
    *** cells: U2OS in BMLS
    *** unaffected by: xDdit4 [addition]
    *** unaffected by: xDdit4(mnr)"RPAA" [addition]
    *** source: 18198340-Fig-4c

not Gab1--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (times)
    *** cells: mEFs in BMLS
    *** times: 0 2+ 5+ min
    *** does not req: Gab1 [KO]
    *** source: 19401591-Fig-4a
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (times)
    *** cells: mEFs in BMLS
    *** times: 0 2+ 5+ min
    *** does not req: Gab1 [KO]
    *** source: 19401591-Fig-4a

not Gnai1-- or Gnai3--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (times)
    *** cells: mEFs in BMLS
    *** times: 0 10+ 20+ min
    *** does not req: Gnai1 or Gnai3 [KO]
    *** source: 19401591-Fig-2b
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (times)
    *** cells: mEFs in BMLS
    *** times: 0 10+ 20+ min
    *** does not req: Gnai1 or Gnai3 [KO]
    *** source: 19401591-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (tnr)
    *** cells: mEFs in BMLS
    *** does not req: Gnai1 or Gnai3 [KO]
    *** source: 19401591-Fig-2c
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (tnr)
    *** cells: mEFs in BMLS
    *** does not req: Gnai1 or Gnai3 [KO]
    *** does not req: Gnai1 or Gnai3 [RNAi]
    *** source: 19401591-Fig-3a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (tnr)
    *** cells: mEFs in BMLS
    *** does not req: Gnai1 or Gnai3 [KO]
    *** source: 19401591-Fig-4c
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (tnr)
    *** cells: mEFs in BMLS
    *** does not req: Gnai1 or Gnai3 [KO]
    *** does not req: Gnai1 or Gnai3 [RNAi]
    *** source: 19401591-Fig-3a
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (tnr)
    *** cells: mEFs in BMLS
    *** does not req: Gnai1 or Gnai3 [KO]
    *** source: 19401591-Fig-4c

not Grb10-- Inhibitory

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (5 min)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** inhibited by: xGrb10 [addition]
    *** source: 12493740-Fig-3b
  *** xAkt1[phosAb] phos(S473)[phosAb] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** inhibited by: xGrb10 [addition]
    *** source: 12493740-Fig-1a
  *** xAkt1[phosAb] phos(S473)[phosAb] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMLS
    *** times: 0 1+ 3++ 5++ 10++ 30++ 60++ min
    *** partially inhibited by: xGrb10 [addition]
    *** source: 12493740-Fig-1c
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (5 min)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** inhibited by: xGrb10 [addition]
    *** source: 12493740-Fig-3b
  *** xAkt1[phosAb] phos(T308)[phosAb] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** inhibited by: xGrb10 [addition]
    *** source: 12493740-Fig-1a
  *** xAkt1[phosAb] phos(T308)[phosAb] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMLS
    *** times: 0 1+ 3++ 5++ 10++ 30++ 60++ min
    *** partially inhibited by: xGrb10 [addition]
    *** source: 12493740-Fig-1c

not Ilk--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (2 min)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** does not req: Ilk [RNAi]
    *** source: 16221682-Fig-6b
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (2 min)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** does not req: Ilk [RNAi]
    *** source: 16221682-Fig-6b

not Mlst8--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** does not req: Mlst8 [RNAi]
    *** source: 17043309-Fig-S3
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** does not req: Mlst8 [RNAi]
    *** source: 17043309-Fig-S3

Mtor-- assumption from common rules

Pld1-- and/or Pld2--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (2 hr)
    *** cells: MDAMB231 in BMLS
    *** inhibited by: xPld1(K898R)"CIA" + xPld2(K758R)"CIA" [addition]
    *** source: 19114562-Fig-6b

not Rab5a--

  *** xAkt1[tAb]IP phos(T308)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293E<xAkt1> in BMLS
    *** unaffected by: xRab5a [addition]
    *** unaffected by: xRab5a(S34N)"DN" [addition]
    *** unaffected by: xRab5a(Q79L)"CA" [addition]
    *** source: 20053679-Fig-1c

not S6k1--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293E<xS6k1> in BMLS
    *** unaffected by: xS6k1(mnr)"F5adCT" [substitution]
    *** source: 12906785-Fig-4

Sin1-- for kinase activity and phos(S473) but not phos(T308)

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: mEFs in BMLS
    *** reqs: Sin1 [KO]
    *** source: 16962653-Fig-3a,4a,5b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293 in BMS
    *** reqs: Sin1 [RNAi]
    *** source: 17043309-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** reqs: Sin1 [RNAi]
    *** source: 17043309-Fig-2a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** reqs: Sin1 [RNAi] no-bkg-control
    *** source: 17043309-Fig-S3

  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (15 min)
    *** cells: mEFs in BMLS
    *** does not req: Sin1 [KO]
    *** source: 16962653-Fig-3a
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (15 min)
    *** cells: mEFs in BMLS
    *** does not req: Sin1 [KO]
    *** source: 16962653-Fig-4a
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (15 min)
    *** cells: mEFs in BMLS
    *** does not req: Sin1 [KO]
    *** source: 16962653-Fig-5b
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** partially reqs: Sin1 [RNAi] no-bkg-control
    *** source: 17043309-Fig-S3
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** reqs: Sin1 [RNAi]
    *** source: 17043309-Fig-2a

not Mek12s--

  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (times)
    *** cells: NIH3T3<xInsR> in BMLS
    *** times: 0 10+ 30+ min
    *** unaffected by: PD98059 [addition]
    *** source: 11046144-Fig-1d

not Mtor--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293 in BMS
    *** does not req: Mtor [RNAi]
    *** source: 17043309-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** does not req: Mtor [RNAi]
    *** source: 17043309-Fig-2a
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** does not req: Mtor [RNAi]
    *** source: 17043309-Fig-2a

not Pdpk1--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** repressed by: Pdpk1 [RNAi] no-bkg-control
    *** source: 17043309-Fig-S3
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** does not req: Pdpk1 [RNAi]
    *** source: 17043309-Fig-S3

Pi3k--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HELA in BMLS "Serum deprived"
    *** partially reqs: Pik3ca [RNAi]
    *** source: 16176982-Fig-2e

Pras40--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (10 min)
    *** cells: 3T3L1 in BMLS "Serum deprived"
    *** partially reqs: Pras40 [RNAi]
    *** source: 17277771-Fig-3d
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (10 min)
    *** cells: 3T3L1<xPras40> in BMLS "Serum deprived"
    *** unaffected by: xPras40(T246A) [substitution]
    *** source: 17277771-Fig-3d
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (20 min)
    *** cells: 3T3L1 in BMLS "Serum deprived"
    *** reqs: Pras40 [RNAi]
    *** source: 17277771-Fig-3a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (20 min)
    *** cells: HEPG2 in BMS
    *** partially reqs: Pras40 [RNAi]
    *** source: 17277771-Fig-3a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (times)
    *** cells: 3T3L1 in BMLS "Serum deprived"
    *** times: 0 10++ 120+ min
    *** partially reqs: Pras40 [RNAi]
    *** source: 17277771-Fig-3b

not Prkdc--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (2 min)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** does not req: Prkdc [RNAi]
    *** source: 16221682-Fig-6b
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (2 min)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** does not req: Prkdc [RNAi]
    *** source: 16221682-Fig-6b

RalGds--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (times)
    *** cells: MCF7 in BMLS
    *** times: 0 5+ 10+ 30+ min
    *** partially reqs: RalGds [RNAi]
    *** source: 18285454-Fig-4
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (times)
    *** cells: MCF10A in BMLS
    *** times: 0 5+ 10+ 30+ min
    *** partially reqs: RalGds [RNAi]
    *** source: 18285454-Fig-1b
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (times)
    *** cells: MCF7 in BMLS
    *** times: 0 5++ 10+ 30+ min
    *** partially reqs: RalGds [RNAi]
    *** source: 18285454-Fig-4
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (times)
    *** cells: MCF10A in BMLS
    *** times: 0 5+ 10+ 30+ min
    *** reqs: RalGds [RNAi]
    *** source: 18285454-Fig-2
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (times)
    *** cells: MCF10A in BMLS
    *** times: 0 5++ 10+ 30+ min
    *** partially reqs: RalGds [RNAi]
    *** source: 18285454-Fig-1b

not Raptor--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293 in BMS
    *** does not req: Raptor [RNAi]
    *** source: 17043309-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** does not req: Raptor [RNAi]
    *** source: 17043309-Fig-2a

not Rheb--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HELA in BMLS "Serum deprived"
    *** does not req: Rheb [RNAi]
    *** source: 16176982-Fig-2a

Rictor--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (2 min)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** partially reqs: Rictor [RNAi]
    *** source: 16221682-Fig-9b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293 in BMS
    *** reqs: Rictor [RNAi]
    *** source: 17043309-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** reqs: Rictor [RNAi]
    *** source: 17043309-Fig-2a
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (2 min)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** partially reqs: Rictor [RNAi]
    *** source: 16221682-Fig-9b
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** reqs: Rictor [RNAi]
    *** source: 17043309-Fig-2a
  *** Akt1[phosAb] phos(S473)[phosAb] is unchanged irt Ins (20 min)
    *** cells: mEFs<Rictor~null> in BMLS
    *** source: 21464307-Fig-S4a
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (20 min)
    *** cells: mEFs<Rictor~null> in BMLS
    *** source: 21464307-Fig-S4a

not Rin1-- Rin2-- Rin3--

  *** Akt1[phosAb] phos(sitenr)[phosAb] is increased irt Ins (8 min)
    *** cells: HEPG2 in BMS
    *** does not req: Rin1 [RNAi]
    *** does not req: Rin2 [RNAi]
    *** does not req: Rin3 [RNAi]
    *** source: 16457816-Fig-5c
  *** Akt1[phosAb] phos(sitenr)[phosAb] is increased irt Ins (8 min)
    *** cells: HEPG2 in BMS
    *** inhibited by: xRin1 [addition]
    *** inhibited by: xRin1(mnr)"Nterm" [addition]
    *** inhibited by: xRin1(mnr)"Dterm" [addition]
    *** bkg enhanced by: xRin1(mnr/del(429-490)) [addition]
    *** source: 16457816-Fig-4e

Tbk1--  can be substituted by Ikke or Rictor

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: mEFs in BMLS
    *** partially reqs: Ikke and/or Tbk1 [KO]
    *** source: 21464307-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: mEFs<Rictor~null><xTbk1> in BMLS
    *** reqs: xTbk1 [omission]
    *** source: 21464307-Fig-5a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (times)
    *** cells: mEFs in BMLS
    *** times: 0 15+ 30+ min
    *** partially reqs: Ikke and/or Tbk1 [KO]
    *** source: 21464307-Fig-2a
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (30 min)
    *** cells: mEFs in BMLS
    *** partially reqs: Ikke and/or Tbk1 [KO]
    *** source: 21464307-Fig-2b
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (30 min)
    *** cells: mEFs<Rictor~null><xTbk1> in BMLS
    *** partially reqs: xTbk1 [omission]
    *** source: 21464307-Fig-5a
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (times)
    *** cells: mEFs in BMLS
    *** times: 0 15+ 30+ min
    *** partially reqs: Ikke or Tbk1 [KO]
    *** source: 21464307-Fig-2a

Tsc2--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: mEFs in BMLS "Serum deprived"
    *** reqs: Tsc2 [KO]
    *** source: 17386266-Fig-1e
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HELA in BMLS "Serum deprived"
    *** reqs: Tsc2 [RNAi]
    *** source: 16176982-Fig-1c
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (30 min)
    *** cells: mEFs in BMLS
    *** reqs: Tsc2 [KO]
    *** source: 15024086-Fig-5b
  ------------------------------------------------------------------
  *** xAkt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293 in BMS
    *** unaffected by: xTsc1 + xTsc2 [addition]
    *** source: 12172553-Fig-1d
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293 in BMS
    *** unaffected by: xTsc1 + xTsc2 [addition]
    *** source: 12172553-Fig-2b
  *** xAkt1[phosAb] phos(T308)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293 in BMS
    *** unaffected by: xTsc1 + xTsc2 [addition]
    *** source: 12172553-Fig-1d
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293<xTsc1><xTsc2> in BMS
    *** unaffected by: xTsc2(S939A/T1462A) [substitution]
    *** unaffected by: xTsc2(S1798A) [substitution]
    *** unaffected by: xTsc2(S939A/T1462A/S1798A) [substitution]
    *** source: 15342917-Fig-5b

not Vps34--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HELA in BMLS
    *** does not req: Vps34 [RNAi]
    *** source: 16049009-Fig-2c
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HELA in BMLS "Serum deprived"
    *** does not req: Vps34 [RNAi]
    *** source: 16176982-Fig-4c

Akt1 features

  *** xAkt1[tAb]IP phos(T308)[phosAb] is increased irt Ins (8 min)
    *** cells: COS7<xAkt1> in BMLS
    *** unaffected by: xAkt1(R144A) [substitution]
    *** unaffected by: xAkt1(R200A) [substitution]
    *** source: 12374740-Fig-8b
  *** xAkt1[tAb]IP phos(T473)[phosAb] is increased irt Ins (8 min)
    *** cells: COS7<xAkt1> in BMLS
    *** unaffected by: xAkt1(R144A) [substitution]
    *** unaffected by: xAkt1(R200A) [substitution]
    *** source: 12374740-Fig-8b

Chemicals

  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (30 min)
    *** cells: KB in BMLS
    *** enhanced by: Rapamycin [pretreatment]
    *** inhibited by: Wortmannin [pretreatment]
    *** unaffected by: U0126 [pretreatment]
    *** source: 15024086-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (times)
    *** cells: HC11 in BMLS
    *** times: 0 7+ 15+ min
    *** inhibited by: LY294002 [addition]
    *** source: 16984645-Fig-5
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (10 min)
    *** cells: rAPCs in BMS "serum and nutrient starved"
    *** inhibited by: Wortmannin [addition]
    *** source: 10464256-Fig-7
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (times)
    *** cells: HC11 in BMLS
    *** times: 0 7+ 15+ min
    *** unaffected by: Rapamycin [addition]
    *** source: 16984645-Fig-5
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** unaffected by: Rapamycin [addition]
    *** unaffected by: FK506 [addition]
    *** unaffected by: Rapamycin + FK506 [addition]
    *** source: 16541103-Fig-3e
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (5 min)
    *** cells: rHepatocytes in BSS "containing glucose" "in suspension"
    *** inhibited by: Aicar [addition]
    *** unaffected by: AminoAcids (30 min) [stim]
    *** source: 16990266(D)
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (10 min)
    *** cells: rAPCs in BMS "serum and nutrient starved"
    *** unaffected by: Ro318220 [addition]
    *** unaffected by: myr-SIYRRGARRWRKL [addition]
    *** source: 10464256-Fig-7
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (30 min)
    *** cells: L17<xTgfbR1> in BMS
    *** inhibited by: Wortmannin [addition]
    *** source: 12034739(D)
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (times)
    *** cells: NIH3T3<xInsR> in BMLS
    *** times: 0 10+ 30+ min
    *** inhibited by: LY294002 [addition]
    *** source: 11046144-Fig-1d
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (times)
    *** cells: HC11 in BMLS
    *** times: 0 7+ 15 min
    *** inhibited by: Rapamycin [addition]
    *** source: 16984645-Fig-5
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** does not req: Raptor [RNAi]
    *** source: 17043309-Fig-2a
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (times)
    *** cells: HC11 in BMLS
    *** times: 0 7+ 15 min
    *** inhibited by: LY294002 [addition]
    *** source: 16984645-Fig-5
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (30 min)
    *** cells: mEFs<Rictor~null><xTbk1> in BMLS
    *** inhibited by: LY294002 [pretreatment]
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 21464307-Fig-5a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: mEFs<Rictor~null><xTbk1> in BMLS
    *** inhibited by: LY294002 [pretreatment]
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 21464307-Fig-5a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (2 hr)
    *** cells: MDAMB231 in BMLS
    *** inhibited by: 1Butanol [cotreatment]
    *** source: 19114562-Fig-6a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (2 hr)
    *** cells: MDAMB231 in BMLS
    *** unaffected by: PA [cotreatment]
    *** source: 19114562-Fig-6a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (2 hr)
    *** cells: MDAMB231 in BMLS
    *** unaffected by: Rapamycin [cotreatment]
    *** inhibited by: Rapamycin + 1Butanol [cotreatment]
    *** source: 19114562-Fig-6c
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (90 min)
    *** cells: mEFs in BMLS
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 18198340-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (10 min)
    *** cells: HEK293T in BMLS
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 17277771-Fig-4b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: mEFs in BMLS
    *** unaffected by: 2DOG [posttreatment]
    *** unaffected by: 5ThioGlucose [posttreatment]
    *** source: 16027121-Fig-6a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: mEFs<Tsc2~null> in BMLS
    *** inhibited by: 2DOG [posttreatment]
    *** inhibited by: 5ThioGlucose [posttreatment]
    *** source: 16027121-Fig-6a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: RAT1A in BMLS
    *** enhanced by: Aicar [cotreatment]
    *** source: 16027121-Fig-4a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: RAT1A in BMLS
    *** unaffected by: 5ThioGlucose [cotreatment]
    *** source: 16027121-Fig-3b
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (15 min)
    *** cells: HEK293<xS6k1> in BMLS
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 15342917-Fig-1a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: NIH3T3<xInsR> in BMLS
    *** inhibited by: Wortmannin [addition]
    *** unaffected by: Rapamycin [addition]
    *** source: 12820960-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293E<xEif4ebp1> in BMLS
    *** inhibited by: Wortmannin [addition]
    *** source: 12906785-Fig-2a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293E<xS6k1> in BMLS
    *** unaffected by: Rapamycin [pretreatment]
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 12906785-Fig-3
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293E<xS6k1> in BMLS
    *** unaffected by: Rapamycin [pretreatment]
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 12906785-Fig-4
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293E<xS6k1> in BSS "containing Glucose and AminoAcids"
    *** unaffected by: Rapamycin [pretreatment]
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 12906785-Fig-3
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293E<xS6k1> in BSS "containing Glucose"
    *** unaffected by: Rapamycin [pretreatment]
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 12906785-Fig-3
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (4 hr)
    *** cells: ARPE19 in BMLS
    *** enhanced by: Aicar [cotreatment]
    *** source: 16516166-Fig-3
  *** Akts[phosAb] phos(FSY)[phosAb] is increased irt Ins (5 min)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD98059 [pretreatment]
    *** unaffected by: SB202190 [pretreatment]
    *** inhibited by: LY294002 [pretreatment]
    *** source: 11350959-Fig-8a
  *** Akts[phosAb] phos(KTF)[phosAb] is increased irt Ins (5 min)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD98059 [pretreatment]
    *** unaffected by: SB202190 [pretreatment]
    *** inhibited by: LY294002 [pretreatment]
    *** source: 11350959-Fig-8a

Other stuff

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HEPG2 in BMLS
    *** unaffected by: IL6 [cotreatment]
    *** source: 12456685-Fig-3b
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (15 min)
    *** cells: HEPG2 in BMLS
    *** unaffected by: IL6 [cotreatment]
    *** source: 12456685-Fig-3b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (5 hr)
    *** cells: HEK293T in BMLS
    *** unaffected by: Hypoxia [pretreatment]
    *** source: 18198340-Fig-2d
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293 in BMLS "Serum and AminoAcid deprived"
    *** unaffected by: AminoAcids [cotreatment]
    *** source: 16176982-Fig-1b


No extras

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (times)
    *** cells: rCMCs in BSS "containing Calcium and BSA"
    *** times: 0 2+ 30+ min
    *** source: 15557332(D)
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (20 min)
    *** cells: HELA in BMLS
    *** source: 16919458-Fig-4a
  *** xAkt1[phosAb] phos(S473)[phosAb] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** source: 11551902-Fig-7b
  *** xAkt1[phosAb] phos(T308)[phosAb] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** source: 11551902-Fig-7b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: MIN6 in BMLS "Glucose and AminoAcid deprived"
    *** source: 17287212(D)
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (times)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** times: 0 1+ 3+ 5+ 15+ 30+ 60+ min
    *** source: 16541103-Fig-7a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (times)
    *** cells: FAO in BMLS
    *** times: 0 10+ 15+ 30+ min
    *** source: 10688912(D)
  *** Akt1[phosAb] phos(T308)[phosAb] is increased irt Ins (times)
    *** cells: rCMCs in BSS "containing Calcium and BSA"
    *** times: 0 2+ 30+ min
    *** source: 15557332(D)
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (times)
    *** cells: mEFs in BMLS
    *** times: 0 5++ 15++ 30++ 60++ 120+ min
    *** source: 16959574-Fig-1b
  *** xAkt1[phosAb] phos(S473)[phosAb] is increased irt Ins (30 min)
    *** cells: HEK293<xAkt1> in BMS
    *** source: 12820960-Fig-3c
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ins (45 min)
    *** cells: HEK293 in BMLS
    *** source: 12777372-Fig-1e
  *** Akts[phosAb] phos(FSY)[phosAb] is increased irt Ins (times)
    *** cells: JB6CL41 in BMLS
    *** times: 0 5++ 15+ 30+ 60+ min
    *** source: 11350959-Fig-8a
  *** Akts[phosAb] phos(KTF)[phosAb] is increased irt Ins (times)
    *** cells: JB6CL41 in BMLS
    *** times: 0 5++ 15+ 30+ 60+ min
    *** source: 11350959-Fig-8a



