===============================
Lamtor1-Lamtor2-Lamtor3 Complex
===============================

  *** xLamtor1[tAb] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: HEK293T<xLamtor2><xLamtor3><xLamtor1> in BMS
    *** source: 20381137-Fig-2d
  *** xLamtor1[tAb] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: HEK293T<xLamtor2><xLamtor3><xLamtor1><xMetap2> in BMS
    *** source: 20381137-Fig-2b
  *** xLamtor3[tAb] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: HEK293T<xLamtor2><xLamtor3><xLamtor1> in BMS
    *** source: 20381137-Fig-2d
  *** xLamtor3[tAb] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: HEK293T<xLamtor2><xLamtor3><xLamtor1><xMetap2> in BMS
    *** source: 20381137-Fig-2b
  *** Lamtor1[Ab] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: mEFs<xLamtor2> in BMS
    *** source: 19177150-Fig-4c
  *** Lamtor3[Ab] copptby[WB] Lamtor1[Ab] is detectable
    *** cells: mEFs in BMS
    *** source: 19177150-Fig-4c

colocalization

  *** xLamtor1[XFP] colocwith[IHC] xLamtor2[XFP] is detectable
    *** cells: mEFs<xLamtor1><xLamtor2> in BMS
    *** source: 19177150-Fig-5a
  *** xLamtor1[XFP] colocwith[IHC] xLamtor3[XFP] is detectable
    *** cells: mEFs<xLamtor1><xLamtor3> in BMS
    *** source: 19177150-Fig-5a

direct binding

  *** rLamtor2[Ab] boundby[WB] rLamtor1[GST] is detectable
    *** cells: none
    *** unaffected by: rLamtor3 [addition]
    *** source: 19177150-Fig-4d
  *** rLamtor3[Ab] boundby[WB] rLamtor1[GST] is detectable
    *** cells: none
    *** unaffected by: rLamtor2 [addition]
    *** source: 19177150-Fig-4d
  *** rLamtor3[Ab] boundby[WB] rLamtor2[GST] is detectable
    *** cells: none
    *** source: 19177150-Fig-4d

does not req RagB-- or RagD--

  *** xLamtor1[tAb] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: HEK293T<xLamtor2><xLamtor3><xLamtor1><xMtor><xRaptor> in BMS
    *** unaffected by: xRagB(Q99L)"GTP" and xRagD(S77L)"GDP" [addition]
    *** source: 20381137-Fig-2c
  *** xLamtor3[tAb] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: HEK293T<xLamtor2><xLamtor3><xLamtor1><xMtor><xRaptor> in BMS
    *** unaffected by: xRagB(Q99L)"GTP" and xRagD(S77L)"GDP" [addition]
    *** source: 20381137-Fig-2c

unaffected by AminoAcids

  *** Lamtor2[Ab] copptby[WB] xLamtor1[tAb] is detectable-but unchanged irt AminoAcids (10 min)
    *** cells: mEFs<Lamtor1~null><xLamtor1> in BMS "AminoAcid-deprived"
    *** source: 20381137-Fig-2g
  *** Lamtor3[Ab] copptby[WB] xLamtor1[tAb] is detectable-but unchanged irt AminoAcids (10 min)
    *** cells: mEFs<Lamtor1~null><xLamtor1> in BMS "AminoAcid-deprived"
    *** source: 20381137-Fig-2g

========
Location
========

in DRM fraction

  *** Lamtor1[Ab] infraction(DRM)[WB] is detectable
    *** cells: mEFs in BMS
    *** source: 19177150-Fig-1c
  *** Lamtor2[Ab] infraction(DRM)[WB] is detectable
    *** cells: mEFs<Lamtor1~null><xLamtor1> in BMLS
    *** reqs: xLamtor1 [omission]
    *** source: 19177150-Fig-6e
  *** Lamtor3[Ab] infraction(DRM)[WB] is detectable
    *** cells: mEFs<Lamtor1~null><xLamtor1> in BMLS
    *** reqs: xLamtor1 [omission]
    *** source: 19177150-Fig-6e

in cytoplasmic vesicles

  *** xLamtor1[XFP] locatedin(vesicles)[IHC] is detectable
    *** cells: mEFs<Lamtor1~null><xLamtor1> in BMS
    *** inhibited by: xLamtor1(6-161) [substitution]
    *** inhibited by: xLamtor1(41-161) [substitution]
    *** source: 19177150-Fig-5
  *** xLamtor1[XFP] locatedin(vesicles)[IHC] is detectable
    *** cells: mEFs<Lamtor1~null><xLamtor1> in BMS
    *** inhibited by: xLamtor1(G2A) [substitution]
    *** partially inhibited by: xLamtor1(C3A/C4A) [substitution]
    *** partially inhibited by: xLamtor1(1-10) [substitution]
    *** partially inhibited by: xLamtor1(1-20) [substitution]
    *** partially inhibited by: xLamtor1(1-39) [substitution]
    *** source: 19177150-Fig-1f
  *** xLamtor1[XFP] locatedin(vesicles)[IHC] is detectable
    *** cells: mEFs<Lamtor1~null><xLamtor1> in BMS
    *** unaffected by: xLamtor1(1-39) [substitution]
    *** unaffected by: xLamtor1(1-81) [substitution]
    *** unaffected by: xLamtor1(1-121) [substitution]
    *** source: 19177150-Fig-5
  *** xLamtor2[XFP] locatedin(vesicles)[IHC] is detectable
    *** cells: mEFs<Lamtor1~null><xLamtor1><xLamtor2> in BMS
    *** reqs: xLamtor1 [omission]
    *** source: 19177150-Fig-5b
  *** xLamtor3[XFP] locatedin(vesicles)[IHC] is detectable
    *** cells: mEFs<Lamtor1~null><xLamtor1><xLamtor3> in BMS
    *** inhibited by: xLamtor1(1-39) [substitution]
    *** inhibited by: xLamtor1(1-81) [substitution]
    *** inhibited by: xLamtor1(1-121) [substitution]
    *** source: 19177150-Fig-5
  *** xLamtor3[XFP] locatedin(vesicles)[IHC] is detectable
    *** cells: mEFs<Lamtor1~null><xLamtor1><xLamtor3> in BMS
    *** reqs: xLamtor1 [omission]
    *** source: 19177150-Fig-5b

in perinuclear region

  *** xLamtor1[XFP] locatedin(perinuclear-region)[IHC] is detectable
    *** cells: mEFs<Lamtor1~null><xLamtor1> in BMS
    *** source: 19177150-Fig-1f


in late endosomes (Rab7s as marker)

  *** xLamtor1[XFP] colocwith[IHC] Rab7s[Ab] is detectable
    *** cells: mEFs<Lamtor1~null><xLamtor1> in BMS
    *** source: 19177150-Fig-1e
  *** xLamtor1[XFP] colocwith[IHC] xRab7a[XFP] is detectable
    *** cells: mEFs<Lamtor1~null><xLamtor1><xRab7a> in BMS
    *** source: 19177150-Fig-1d

not in early endosomes (Rab5s as marker)

  *** xLamtor1[XFP] colocwith[IHC] xRab5a[XFP] is undetectable
    *** cells: mEFs<Lamtor1~null><xLamtor1><xRab5a> in BMS
    *** source: 19177150-Fig-1d

not in recycling endosomes (Rab4s, Rab11s as marker)

  *** xLamtor1[XFP] colocwith[IHC] xRab4a[XFP] is undetectable
    *** cells: mEFs<Lamtor1~null><xLamtor1><xRab4a> in BMS
    *** source: 19177150-Fig-1d
  *** xLamtor1[XFP] colocwith[IHC] xRab11a[XFP] is undetectable
    *** cells: mEFs<Lamtor1~null><xLamtor1><xRab11a> in BMS
    *** source: 19177150-Fig-1d



=============================
Lamtor Atp6V0 coprecipitation
=============================

  *** Atp6V0c[Ab] copptby[WB] xLamtor1[tAb] is detectable
    *** cells: HEK293T<xLamtor1> in BMS
    *** source: 22053050-Fig-3b
  *** Atp6V0c[Ab] copptby[WB] xLamtor1[tAb] is detectable
    *** cells: HEK293T<xLamtor1> in BMS
    *** source: 22053050-Fig-S4b
  *** Atp6V0c[Ab] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: HEK293T<xLamtor2> in BMS
    *** source: 22053050-Fig-3b
  *** Atp6V0c[Ab] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: HEK293T<xLamtor2> in BMS
    *** source: 22053050-Fig-S4b

  *** Atp6V0d1[Ab] copptby[WB] xLamtor1[tAb] is detectable
    *** cells: HEK293T<xLamtor1> in BMS
    *** source: 22053050-Fig-3b
  *** Atp6V0d1[Ab] copptby[WB] xLamtor1[tAb] is detectable
    *** cells: HEK293T<xLamtor1> in BMS
    *** source: 22053050-Fig-S4b
  *** Atp6V0d1[Ab] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: HEK293T<xLamtor2> in BMS
    *** source: 22053050-Fig-3b
  *** Atp6V0d1[Ab] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: HEK293T<xLamtor2> in BMS
    *** source: 22053050-Fig-S4b

unaffected by AminoAcids

  *** Atp6V0c[Ab] copptby[WB] xLamtor1[tAb] is detectable-but unchanged irt AminoAcids (15 min)
    *** cells: HEK293T<xLamtor1> in BMS "AminoAcid-deprived"
    *** source: 22053050-Fig-3e
  *** Atp6V0d1[Ab] copptby[WB] xLamtor1[tAb] is detectable-but unchanged irt AminoAcids (15 min)
    *** cells: HEK293T<xLamtor1> in BMS "AminoAcid-deprived"
    *** source: 22053050-Fig-3e
  *** Atp6V0c[Ab] copptby[WB] xLamtor2[tAb] is detectable-but unchanged irt AminoAcids (15 min)
    *** cells: HEK293T<xLamtor2> in BMS "AminoAcid-deprived"
    *** source: 22053050-Fig-3e
  *** Atp6V0d1[Ab] copptby[WB] xLamtor2[tAb] is detectable-but unchanged irt AminoAcids (15 min)
    *** cells: HEK293T<xLamtor2> in BMS "AminoAcid-deprived"
    *** source: 22053050-Fig-3e

=============================
Lamtor Atp6V1 coprecipitation
=============================

  *** Atp6V1a[Ab] copptby[WB] xLamtor1[tAb] is detectable
    *** cells: HEK293T<xLamtor1> in BMS
    *** source: 22053050-Fig-3c
  *** Atp6V1b2[Ab] copptby[WB] xLamtor1[tAb] is detectable
    *** cells: HEK293T<xLamtor1> in BMS
    *** source: 22053050-Fig-3c
  *** Atp6V1a[Ab] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: HEK293T<xLamtor2> in BMS
    *** source: 22053050-Fig-3c
  *** Atp6V1b2[Ab] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: HEK293T<xLamtor2> in BMS
    *** source: 22053050-Fig-3c
  *** Atp6V1d[Ab] copptby[WB] xLamtor1[tAb] is detectable
    *** cells: HEK293T<xLamtor1> in BMS
    *** source: 22053050-Fig-3c
  *** Atp6V1d[Ab] copptby[WB] xLamtor2[tAb] is detectable
    *** cells: HEK293T<xLamtor2> in BMS
    *** source: 22053050-Fig-3c

decreased by AminoAcids

  *** Atp6V1b2[Ab] copptby[WB] xLamtor1[tAb] is decreased irt AminoAcids (15 min)
    *** cells: HEK293T<xLamtor1> in BMS "AminoAcid-deprived"
    *** source: 22053050-Fig-3e
  *** Atp6V1d[Ab] copptby[WB] xLamtor1[tAb] is decreased irt AminoAcids (15 min)
    *** cells: HEK293T<xLamtor1> in BMS "AminoAcid-deprived"
    *** source: 22053050-Fig-3e
  *** Atp6V1a[Ab] copptby[WB] xLamtor2[tAb] is decreased irt AminoAcids (15 min)
    *** cells: HEK293T<xLamtor2> in BMS "AminoAcid-deprived"
    *** source: 22053050-Fig-3f
  *** Atp6V1b2[Ab] copptby[WB] xLamtor2[tAb] is decreased irt AminoAcids (15 min)
    *** cells: HEK293T<xLamtor2> in BMS "AminoAcid-deprived"
    *** source: 22053050-Fig-3e
  *** Atp6V1b2[Ab] copptby[WB] xLamtor2[tAb] is decreased irt AminoAcids (15 min)
    *** cells: HEK293T<xLamtor2> in BMS "AminoAcid-deprived"
    *** source: 22053050-Fig-3f
  *** Atp6V1d[Ab] copptby[WB] xLamtor2[tAb] is decreased irt AminoAcids (15 min)
    *** cells: HEK293T<xLamtor2> in BMS "AminoAcid-deprived"
    *** source: 22053050-Fig-3e
  *** Atp6V1d[Ab] copptby[WB] xLamtor2[tAb] is decreased irt AminoAcids (15 min)
    *** cells: HEK293T<xLamtor2> in BMS "AminoAcid-deprived"
    *** source: 22053050-Fig-3f


===================================================
Atp6V0 and ATP6V1 do not disassemble irt AminoAcids
===================================================

  *** Atp6V0c[Ab] copptby[WB] xAtp6V1b1[tAb] is detectable-but unchanged irt AminoAcids (15 min)
    *** cells: HEK293T in BMS
    *** source: 22053050-Fig-S4d
  *** Atp6V0d1[Ab] copptby[WB] xAtp6V1b1[tAb] is detectable-but unchanged irt AminoAcids (15 min)
    *** cells: HEK293T in BMS
    *** source: 22053050-Fig-S4d


