===============
Phosphorylation
===============

Atm--

  *** Trim28[phosAb] phos(S824)[phosAb] is increased irt IR (times)
    *** cells: AT5BIVA<Atm~fmut><xAtm> in BMS
    *** times: 0 10+ 60+ min
    *** reqs: xAtm [omission]
    *** comment: inhibited by substitution with xAtm(S1981A) at 60 min only
    *** source: 20026654-Fig-3
  *** Trim28[phosAb] phos(S824)[phosAb] is unchanged irt IR (times)
    *** cells: hLymphoblasts<Atm~fmut> in BMS
    *** times: 0 30 60 120 240 360 480 1440 min
    *** source: 16862143-Fig-1c

Mdc1--  ???

  *** Trim28[phosAb] phos(S824)[phosAb] is increased irt IR (times)
    *** cells: AT5BIVA<Atm~fmut><xAtm> in BMS
    *** times: 0 10+ 60+ min
    *** comment: might req Mdc1 {RNAi] at 60 min
    *** source: 20026654-Fig-7a

  *** Trim28[phosAb] phos(S824)[phosAb] is increased irt IR (times)
    *** cells: hLymphoblasts in BMS
    *** times: 0 30++ 60++ 120++ 240++ 360 480 1440 min
    *** source: 16862143-Fig-1c

=================================
Localization to DSBs is transient
=================================

  *** Trim28[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (times)
    *** cells: U2OS in BMS
    *** times: 1+ 2+ 5++ 10+++ 15++ 60+ min
    *** comment: colocates with H2ax-phos(S140)
    *** source: 16862143-Fig-3a
  *** xTrim28[XFP] locatedin(DSBs)[IHC] is increased irt MicroLaser (times)
    *** cells: U2OS<xTrim28> in BMS
    *** times: 2+ 5+ 12 min
    *** comment: colocates with H2ax-phos(S140)
    *** source: 16862143-Fig-S6

  *** xTrim28{phos(S140)}[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (times)
    *** cells: U2OS<xTrim28> in BMS
    *** times: 2+ 5+ 12 min
    *** comment: colocates with H2ax-phos(S140) at 2-5 min
    *** comment: spreads into rest of nucleus at 8-12 min
    *** source: 16862143-Fig-S6
  *** Trim28{phos(S824)}[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (times)
    *** cells: U2OS in BMS
    *** times: 1+ 3+ 5++ 8++ 15++ 45++ 60++ min
    *** comment: colocates with H2ax-phos(S140) at 3-8 min
    *** comment: spreads into rest of nucleus at 8-90 min
    *** source: 16862143-Fig-3b
