================================================================
Phosphorylation occurs at sight of DSBs but Smc1a does not bind
================================================================

  *** Smc1a[Ab] locatedin(DSBs)[IHC] is unchanged irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: does not colocalize with H2ax-phos(S140)
    *** source: 16618811-Fig-7b
  *** Smc1a[Ab] locatedin(DSBs)[IHC] is unchanged irt MicroLaser (1 hr)
    *** cells: BJ in BMS
    *** comment: does not colocalize with H2ax-phos(S140)
    *** source: 16618811-Fig-S2
  *** Smc1a[Ab] locatedin(subnuclear-bodies)[IHC] is unchanged irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: does not colocalize with H2ax-phos(S140)
    *** source: 16618811-Fig-S1a
  *** Smc1a{phos(S957)}[phosAb] locatedin(DSBs)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: colocates with H2ax-phos(S140)
    *** source: 16618811-Fig-7b
  *** Smc1a[Ab] infraction(chromatin)[WB] is detectable-but unchanged irt IR (times)
    *** cells: AT5BIVA<Atm~fmut><xAtm> in BMS
    *** times: 0+ 10+ 60+ min
    *** unaffected by: xAtm(S1981A) [substitution]
    *** source: 20026654-Fig-2d

================================
Phosphorylation on S957 and S966
================================

Atm--

  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (10 min)
    *** cells: AT1ABR<Atm~fmut><xAtm> in BMS
    *** partially reqs: xAtm [omission]
    *** partially inhibited by: xAtm(S367A) [substitution]
    *** partially inhibited by: xAtm(S1983A) [substitution]
    *** partially inhibited by: xAtm(S1981A) [substitution]
    *** source: 16858402-Fig-5b
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (times)
    *** cells: AT5BIVA<Atm~fmut><xAtm> in BMS
    *** times: 0 10+ 60++ min
    *** reqs: xAtm [omission]
    *** comment: inhibited by substituion with xAtm(S1981A) at 60 min only
    *** source: 20026654-Fig-3
  ------------------------------------------------------------------
  *** Smc1a[phosAb] phos(S957)[phosAb] is unchanged irt IR (2 hr)
    *** cells: GM9607<Atm~fmut> in BMS
    *** source: 11877376-Fig-3b
  *** Smc1a[phosAb] phos(S957)[phosAb] is unchanged irt IR (2 hr)
    *** cells: GM9607<Atm~fmut> in BMS
    *** source: 11877376-Fig-7a
  *** Smc1a[phosAb] phos(S966)[phosAb] is unchanged irt IR (2 hr)
    *** cells: GM9607<Atm~fmut> in BMS
    *** source: 11877376-Fig-3b
  *** Smc1a[phosAb] phos(S966)[phosAb] is unchanged irt IR (2 hr)
    *** cells: GM9607<Atm~fmut> in BMS
    *** source: 11877376-Fig-7a
  *** Smc1a[phosAb] phos(S957)[phosAb] is unchanged irt IR (30 min)
    *** cells: GM9607<Atm~fmut> in BMS
    *** source: 15175241-Fig-S1a
  *** Smc1a[phosAb] phos(S966)[phosAb] is unchanged irt IR (1 hr)
    *** cells: hFibros<Atm~fmut> in BMS
    *** source: 16327781-Fig-1a
  *** Smc1a[phosAb] phos(S966)[phosAb] is unchanged irt IR (tnr)
    *** cells: AT22IJET<Atm~fmut> in BMS
    *** source: 18006705-Fig-1c


Brca1--

  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (2 hr)
    *** cells: HCC1937<Brca1~fmut><xBrca1> in BMS
    *** reqs: xBrca1 [omission]
    *** unaffected by: xBrca1(S1387A) [substitution]
    *** unaffected by: xBrca1(S1423A) [substitution]
    *** source: 11877376-Fig-7b
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (2 hr)
    *** cells: HCC1937<Brca1~fmut><xBrca1> in BMS
    *** reqs: xBrca1 [omission]
    *** unaffected by: xBrca1(S1387A) [substitution]
    *** unaffected by: xBrca1(S1423A) [substitution]
    *** source: 11877376-Fig-7b
  *** Smc1a[phosAb] phos(S957)[phosAb] is unchanged irt IR (2 hr)
    *** cells: HCC1937<Brca1~fmut> in BMS
    *** source: 11877376-Fig-7a
  *** Smc1a[phosAb] phos(S966)[phosAb] is unchanged irt IR (2 hr)
    *** cells: HCC1937<Brca1~fmut> in BMS
    *** source: 11877376-Fig-7a
  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (15 min)
    *** cells: HCC1937<Brca1~fmut><xBrca1> in BMS
    *** partially reqs: xBrca1 [omission]
    *** source: 15175241-Fig-2b

not Mdc1--

  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (times)
    *** cells: NotReported in BMS
    *** times: 0 1+ 2+ hr
    *** does not req: Mdc1 [RNAi]
    *** source: 12607005-Fig-5e
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 15++ 30++ 60++ 120+ 180+ 240+ 300+ 360+ 420+ 480+ min
    *** does not req: Mdc1 [RNAi]
    *** source: 15201865-Fig-S5
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (1 hr)
    *** cells: U2OS in BMS
    *** does not req: Mdc1 [RNAi]
    *** source: 16377563-Fig-S5a
  ------------- contradiction ----------------------------------
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (times)
    *** cells: AT5BIVA<Atm~fmut><xAtm> in BMS
    *** times: 0 10+ 60+ min
    *** reqs: Mdc1 [RNAi]
    *** source: 20026654-Fig-7a


Nbs1--

  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (2 hr)
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** reqs: xNbs1 [omission]
    *** unaffected by: xNbs1(S434A) [substitution]
    *** source: 11877376-Fig-7b
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (2 hr)
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** reqs: xNbs1 [omission]
    *** unaffected by: xNbs1(S434A) [substitution]
    *** source: 11877376-Fig-7b
  *** Smc1a[phosAb] phos(S957)[phosAb] is unchanged irt IR (2 hr)
    *** cells: NBS1LBI<Nbs1~fmut> in BMS
    *** source: 11877376-Fig-7a
  *** Smc1a[phosAb] phos(S966)[phosAb] is unchanged irt IR (2 hr)
    *** cells: NBS1LBI<Nbs1~fmut> in BMS
    *** source: 11877376-Fig-7a
  *** Smc1a[Ab]IP phos(S957)[phosAb] is increased irt IR (15 min)
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** reqs: xNbs1 [omission]
    *** source: 15175241-Fig-2a
  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (60 min)
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** reqs: xNbs1 [omission]
    *** inhibited by: xNbs1(1-652) [substitution]
    *** unaffected by: xNbs1(401-754) [substitution]
    *** unaffected by: xNbs1(S278A/S343A) [substitution]
    *** source: 15234984-Fig-6
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (times)
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** times: 0 15+ 30+ 60+ min
    *** partially reqs: xNbs1 [omission]
    *** inhibited by: xNbs1(1-734)"delC" [substitution]
    *** source: 15758953-Fig-3a
  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (10 min)
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** partially reqs: xNbs1 [omission]
    *** partially inhibited by: xNbs1(S343A) [substitution]
    *** source: 14695167-Fig-3b

not Rnf8--

  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (1 hr)
    *** cells: U2OS in BMS
    *** does not req: Rnf8 [RNAi]
    *** source: 18001824-Fig-S7d
  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (1 hr)
    *** cells: U2OS in BMS
    *** does not req: Rnf8 [RNAi]
    *** source: 18006705-Fig-S14
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (1 hr)
    *** cells: U2OS in BMS
    *** does not req: Rnf8 [RNAi]
    *** source: 18006705-Fig-S14

Tp53bp1--  only in the absence of Nbs1?

  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (10 min)
    *** cells: NBS1LBI<Nbs1~fmut> in BMS
    *** partially reqs: Tp53bp1 [RNAi]
    *** source: 14695167-Fig-5a
  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (30 min)
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** does not req: Tp53bp1 [RNAi]
    *** source: 14695167-Fig-5b

Smc1a features

  *** Smc1a[Ab] phos[WBMS-PPase] is increased irt IR (30 min)
    *** cells: mEFs in BMS
    *** unaffected by: Smc1a(S957A/S966A) [knockin]
    *** source: 15175241-Fig-5c
  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (30 min)
    *** cells: mEFs in BMS
    *** inhibited by: Smc1a(S957A/S966A) [knockin]
    *** source: 15175241-Fig-5b
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (30 min)
    *** cells: mEFs in BMS
    *** inhibited by: Smc1a(S957A/S966A) [knockin]
    *** source: 15175241-Fig-5b

chemicals

  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (tnr)
    *** cells: U2OS in BMS
    *** inhibited by: KU55933 [addition]
    *** source: 18006705-Fig-1c

no extras

  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (2 hr)
    *** cells: GM637 in BMS
    *** source: 11877376-Fig-3b
  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (2 hr)
    *** cells: GM637 in BMS
    *** source: 11877376-Fig-7a
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (2 hr)
    *** cells: GM637 in BMS
    *** source: 11877376-Fig-3b
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (2 hr)
    *** cells: GM637 in BMS
    *** source: 11877376-Fig-7a
  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (15 min)
    *** cells: 1070SK in BMS
    *** source: 15175241-Fig-1a
  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (30 min)
    *** cells: GM637 in BMS
    *** source: 15175241-Fig-S1a
  *** Smc1a[phosAb] phos(S957)[phosAb] is increased irt IR (60 min)
    *** cells: GM637 in BMS
    *** source: 15234984-Fig-6
  *** Smc1a[phosAb] phos(S957)[phosAb] is unchanged irt IR (60 min)
    *** cells: AT3BI<Atm~fmut> in BMS
    *** source: 15234984-Fig-6
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (1 hr)
    *** cells: HELA in BMS "nuclear-extract"
    *** source: 18583988-Fig-2a
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (1 hr)
    *** cells: HELA in BMS
    *** source: 16327781-Fig-1a
  *** Smc1a[phosAb] phos(S966)[phosAb] is increased irt IR (1 hr)
    *** cells: hFibros<Atr~fmut> in BMS
    *** source: 16327781-Fig-1a

