not Atm--

  *** Mre11[Ab] locatedin(DSBs)[IHC] is detectable
    *** cells: GM5849<Atm~fmut> in BMS "treated with MicroLaser for 8 min"
    *** source: 12792649-Fig-3b

Mdc1--

  *** Mre11[Ab] locatedin(subnuclear-bodies)[IHC] is detectable
    *** cells: mEFs in BMS "treated with IR for tnr"
    *** reqs: Mdc1 [KO]
    *** source: 18678890-Fig-4a
  *** Mre11[Ab] locatedin(subnuclear-bodies)[IHC] is detectable
    *** cells: mEFs<Mdc1~null><xMdc1> in BMS "treated with IR for tnr"
    *** inhibited by: xMdc1(del(200-420))"dSDTD" [substitution]
    *** unaffected by: xMdc1(del(698-768))"dTQXF" [substitution]
    *** source: 18678890-Fig-4b

Nbs1--  ???

  *** Mre11[Ab] locatedin(subnuclear-bodies)[IHC] is detectable
    *** cells: NBST<Nbs1~fmut><xNbs1> in BMS "treated with IR for tnr"
    *** inhibited by: xNbs1(del(24-108))"D1" [substitution]
    *** inhibited by: xNbs1(del(109-196))"D2" [substitution]
    *** partially inhibited by: xNbs1(del(361-460))"D3" [substitution]
    *** inhibited by: xNbs1(del(261-460))"D4" [substitution]
    *** inhibited by: xNbs1(del(219-460))"D5" [substitution]
    *** source: 18678890-Fig-5a

Mre11 features

  *** xMre11[Ab] locatedin(subnuclear-bodies)[IHC] is increased irt IR (1 hr)
    *** cells: hFibros<Mre11~fmut><xMre11> in BMS
    *** inhibited by: xMre11(mnr)"CIA" [substitution]
    *** source: 16327781-Fig-4b

=============
Colocalizaton
=============

  *** Mre11[Ab] locatedin(subnuclear-bodies)[IHC] is increased irt IR (times)
    *** cells: HELA in BMS
    *** times: 0 15+ 480+ min
    *** comment: colocates with Mdc1
    *** source: 12607003-Fig-2b
  *** Mre11[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: colocates with H2ax-phos(S140)
    *** source: 16618811-Fig-2a


====================
Mre11 dsDNA binding
====================

does not require Nbs1--

  *** rMre11[Ab] boundby[WB] dsDNA[biotin] is detectable
    *** cells: none
    *** comment: reaction also contains rRad50
    *** comment: binding does not req rNbs1 [omission]
    *** unaffected by: xAtm{dimer}[tAb]IP [addition]
    *** source: 15790808-Fig-2d

does not require Rad50--

  *** rMre11[Ab] boundby[WB] dsDNA[biotin] is detectable
    *** cells: none
    *** comment: reaction also contains rRad50 + rNbs1 + xAtm{dimer}[tAb]IP
    *** comment: binding does not req rNbs1 or rRad50 [omission]
    *** source: 15790808-Fig-2e

