*** Accs--
*** Akt1--
*** Artemis--
  *** Artemis[Ab] copptby[WB] Nbs1[Ab] is increased irt IR (2 hr)
    *** cells: HEK293T in BMS
    *** source: 15723659-Fig-6b
  *** Artemis[Ab] copptby[WB] Nbs1[Ab] is unchanged irt IR (2 hr)
    *** cells: GM5849<Atm~fmut><xAtm> in BMS
    *** source: 15723659-Fig-6b
  *** Artemis[Ab] phos[WBMS] is increased irt IR (2 hr)
    *** cells: GM5849<Atm~fmut><xAtm> in BMS
    *** comment: omission of xAtm requires more IR (10 vs 3 Gy) than WT cells
    *** source: 15723659-Fig-3c
  *** Artemis[Ab] phos[WBMS] is increased irt IR (2 hr)
    *** cells: HCT15 in BMS
    *** source: 15723659-Fig-5c
  *** Artemis[Ab] phos[WBMS] is increased irt IR (2 hr)
    *** cells: HEK293T in BMS
    *** source: 15723659-Fig-1d
  *** Artemis[Ab] phos[WBMS] is increased irt IR (2 hr)
    *** cells: HEK293T in BMS
    *** source: 15723659-Fig-5c
  *** Artemis[Ab] phos[WBMS] is increased irt IR (2 hr)
    *** cells: hFibros in BMS
    *** source: 15723659-Fig-3b
  *** Artemis[Ab] phos[WBMS] is increased irt IR (2 hr)
    *** cells: hFibros in BMS
    *** source: 15723659-Fig-5a
  *** Artemis[Ab] phos[WBMS] is increased irt IR (2 hr)
    *** cells: hFibros<Atm~fmut> in BMS
    *** comment: these cells require more IR (10 vs 3 Gy) than WT cells
    *** source: 15723659-Fig-3b
  *** Artemis[Ab] phos[WBMS] is increased irt IR (2 hr)
    *** cells: hFibros<Atm~fmut> in BMS
    *** comment: these cells require more IR (10 vs 3 Gy) than WT cells
    *** source: 15723659-Fig-5a
  *** Artemis[Ab] phos[WBMS] is increased irt IR (2 hr)
    *** cells: hFibros<Nbs1~fmut> in BMS
    *** comment: these cells require more IR (10 vs 3 Gy) than WT cells
    *** source: 15723659-Fig-5a
  *** Artemis[Ab] phos[WBMS] is increased irt IR (2 hr)
    *** cells: hFibros<Nbs1~fmut><xNbs1> in BMS
    *** comment: removal of xNbs1 causes cells to require more IR (10 vs 3 Gy) than WT cells
    *** source: 15723659-Fig-5b
  *** Artemis[Ab] phos[WBMS] is increased irt IR (2 hr)
    *** cells: hLymphoblasts in BMS
    *** source: 15723659-Fig-1c
  *** Artemis[Ab] phos[WBMS] is increased irt IR (2 hr)
    *** cells: hLymphoblasts in BMS
    *** source: 15723659-Fig-3a
  *** Artemis[Ab] phos[WBMS] is increased irt IR (2 hr)
    *** cells: hLymphoblasts<Atm~fmut> in BMS
    *** comment: these cells require more IR (10 vs 3 Gy) than WT cells
    *** source: 15723659-Fig-3a
  *** Artemis[Ab] phos[WBMS] is increased irt IR (times)
    *** cells: hLymphoblasts in BMS
    *** times: 0 30+ 60+ 120+ 240+ 480+ 1440+ hr
    *** source: 15723659-Fig-1b
  *** Artemis[Ab] phos[WBMS] is increased irt IR (times)
    *** cells: hLymphoblasts in BMS
    *** times: 0 30+ 60++ 120++ 240++ 480++ 1440+ hr
    *** source: 15723659-Fig-1a
  *** Artemis[Ab] phos[WBMS-PPase] is increased irt IR (2 hr)
    *** cells: hLymphoblasts in BMS
    *** source: 15723659-Fig-1e
  *** Artemis[Ab] phos[WBMS-PPase] is increased irt IR (2 hr)
    *** cells: M059J<Prkdc~fmut> in BMS
    *** source: 15723659-Fig-2
  *** Artemis[Ab] phos[WBMS-PPase] is increased irt IR (2 hr)
    *** cells: M059K in BMS
    *** source: 15723659-Fig-2
  *** Artemis[Ab] phos[WBMS-PPase] is unchanged irt IR (2 hr)
    *** cells: GM5849<Atm~fmut> in BMS
    *** source: 15723659-Fig-2
  *** Artemis[Ab] phos[WBMS-PPase] is unchanged irt IR (2 hr)
    *** cells: GM5849<Atm~fmut> in BMS
    *** source: 15723659-Fig-5c
  *** xArtemis[tAb] copptby[WB] Nbs1[Ab] is detectable-but unchanged irt IR (2 hr)
    *** cells: HEK293T<xArtemis> in BMS
    *** source: 15723659-Fig-6a
  *** xArtemis[tAb]IP phos[WBMS] is increased irt IR (2 hr)
    *** cells: HEK293T<xArtemis> in BMS
    *** unaffected by: xArtemis(T91A) [substitution]
    *** unaffected by: xArtemis(S538A) [substitution]
    *** unaffected by: xArtemis(S553A) [substitution]
    *** unaffected by: xArtemis(S562A) [substitution]
    *** inhibited by: xArtemis(S645A) [substitution]
    *** source: 15723659-Fig-4b
*** Atf1--
*** Atf2--
*** Atm--
  *** Atm[Ab] copptby[WB] Mdc1[Ab] is detectable-but unchanged irt IR (1 hr)
    *** cells: NotReported in BMS
    *** source: 12607005-Fig-3a
  *** Atm[Ab] copptby[WB] Nbs1[Ab] is detectable-but unchanged irt IR (1 hr)
    *** cells: NotReported in BMS
    *** source: 15758953-Fig-2c
  *** Atm[Ab] copptby[WB] Nbs1[Ab] is increased irt IR (2 hr)
    *** cells: T24 in BMS
    *** source: 10839544-Fig-2a
  *** Atm[Ab]IP IVKA(auto)[32P-ATP] is detectable-but unchanged irt IR (tnr)
    *** cells: HEK293T in BMS
    *** source: 10839544-Fig-2d
  *** xAtm[tAb] oligomerization[2TagPpt] is decreased irt DSB-Induction (24 hr)
    *** cells: GM9607<Atm~fmut><xAtm> in BMS
    *** inhibited by: xAtm(D2870A/N2875K)"KD" [substitution]
    *** inhibited by: xAtm(S1981A) [substitution]
    *** source: 17486112-Fig-1d
  *** xAtm[tAb] oligomerization[2TagPpt] is decreased irt IR (30 min)
    *** cells: HEK293T<xAtm> in BMS
    *** reversed by: xAtm(D2870A/N2875K)"KD" [substitution]
    *** reversed by: xAtm(S1981A) [substitution]
    *** source: 12556884-Fig-4c
*** Atr--
*** Atrip--
  *** Atrip[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: sublocalizes with H2ax-phos(S140)
    *** source: 16618811-Fig-3
  *** Atrip[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS<Brca1~kd> in BMS
    *** source: 16618811-Fig-S3d
  *** Atrip[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS<Mdc1~kd> in BMS
    *** comment: sublocalizes with H2ax-phos(S140)
    *** source: 16618811-Fig-S3c
  *** Atrip[Ab] locatedin(DSBs)[IHC] is unchanged irt MicroLaser (1 hr)
    *** cells: U2OS<Brca1~kd> in BMS
    *** source: 16618811-Fig-S3d
*** Bax--
*** Bax--
  *** Bax[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: IMR90 in BMS
    *** times: 0+ 12++ 24+++ 36+++ hr
    *** partially inhibited by: xTrf2 [addition]
    *** source: 15314656-Fig-2a 
  *** Bbc3-gene mRNA[RTPCR] is increased irt IR (times)
    *** cells: GM637 in BMS
    *** times: 0+ 30+ 60+ 120+ 240++ 600+++ min
    *** source: 16931761-Fig-S1
*** Brca1--
  *** Brca1[Ab] phos[WBMS] is increased irt IR (1 hr)
    *** cells: AT22IJET<Atm~fmut><xAtm> in BMS
    *** reqs: xAtm [omission]
    *** source: 10550055-Fig-1c
  *** Brca1[Ab] phos[WBMS] is increased irt IR (1 hr)
    *** cells: CAPAN1<Brca2~null> in BMS
    *** source: 10550055-Fig-1c
  *** Brca1[Ab] phos[WBMS] is increased irt IR (1 hr)
    *** cells: GM637 in BMS
    *** source: 10550055-Fig-1b
  *** Brca1[Ab] phos[WBMS] is increased irt IR (1 hr)
    *** cells: GM3382 in BMS
    *** source: 10550055-Fig-1b
  *** Brca1[Ab] phos[WBMS] is unchanged irt IR (1 hr)
    *** cells: GM3189<Atm~fmut> in BMS
    *** source: 10550055-Fig-1b
  *** Brca1[Ab] phos[WBMS] is unchanged irt IR (1 hr)
    *** cells: GM5849<Atm~fmut> in BMS
    *** source: 10550055-Fig-1b
*** BRDU--
  *** BRDU[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: sublocalizes with H2ax-phos(S140)
    *** source: 16618811-Fig-3
*** Cdkn1a--
*** Cdkn1a--
*** Cdkn1a--
*** Cdkn1a--
  *** Cdkn1a-gene mRNA[RTPCR] is increased irt IR (times)
    *** cells: GM637 in BMS
    *** times: 0+ 30++ 60+++ 120+++ 240++++ 600++++ min
    *** source: 16931761-Fig-S1
  *** Cdkn1a[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: GM3490 in BMS
    *** times: 0+ 30+ 60+ 120++ 180++ 240++ 360++ 600++ min
    *** source: 16931761-Fig-1a
  *** Cdkn1a[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: IMR90 in BMS
    *** times: 0+ 12++ 24+++ 36+++ hr
    *** partially inhibited by: xTrf2 [addition]
    *** source: 15314656-Fig-2a 
  *** Cdkn1a[Ab] prot-exp[WB] is unchanged irt IR (times)
    *** cells: GM2052<Atm~fmut> in BMS
    *** times: 0+ 30+ 60+ 120+ 180+ 240+ 360+ 600+ min
    *** source: 16931761-Fig-1c
  *** Cdkn2a[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: IMR90 in BMS
    *** times: 0+ 12+ 24++ 36++ hr
    *** unaffected by: xTrf2 [addition]
    *** source: 15314656-Fig-2a 
*** Chek1--
*** Chek2--
*** Cop1--
  *** Cop1-gene mRNA[RTPCR] is increased irt IR (times)
    *** cells: GM637 in BMS
    *** times: 0+ 30++ 60++ 120++ 240++ 600+++ min
    *** source: 16931761-Fig-S1
  *** xCop1[Ab] locatedin(cytoplasm)[IHC] is increased irt IR (tnr)
    *** cells: H1299<xCop1> in BMS
    *** source: 16931761-Fig-S14
  *** Cop1[Ab] prot-exp[WB] is decreased irt IR (90 min)
    *** cells: GM637 in BMS
    *** comment: dose response 0++ 1++ 2+ 5+ 10+ 20+ Gy
    *** source: 16931761-Fig-S2
  *** Cop1[Ab] prot-exp[WB] is decreased irt IR (90 min)
    *** cells: GM2052<Atm~fmut> in BMS
    *** comment: dose response 0++ 1++ 2+ 5+ 10+ 20+ Gy
    *** source: 16931761-Fig-S3
  *** Cop1[Ab] prot-exp[WB] is decreased irt IR (times)
    *** cells: GM2052<Atm~fmut> in BMS
    *** times: 0+ 30+ 60+ 120+ 180+ 240+ 360 600 min
    *** source: 16931761-Fig-1c
  *** Cop1[Ab] prot-exp[WB] is decreased irt IR (times)
    *** cells: GM3490 in BMS
    *** times: 0++ 30+ 60+ 120+ 180+ 240+ 360+ 600+ min
    *** source: 16931761-Fig-1a
  *** Cop1[Ab] prot-stability[CHX-WB] is decreased irt IR (2 hr)
    *** cells: U2OS<xCop1> in BMS
    *** reversed by: xCop1(S387A) [substitution]
    *** source: 16931761-Fig-S6
  *** Cop1[Ab] prot-stability[CHX-WB] is decreased irt IR (30 min)
    *** cells: GM3490 in BMS
    *** source: 16931761-Fig-1b
  *** xCop1[tAb] infraction(cytoplasmic)[WB] is increased irt IR (2 hr)
    *** cells: H1299<xCop1> in BMS
    *** inhibited by: xCop1(S387A) [substitution]
    *** comment: substitution with xCop1(S387D) causes increase in cyto fraction without IR
    *** source: 16931761-Fig-3a
  *** xCop1[tAb] prot-exp[WB] is decreased irt IR (2 hr)
    *** cells: U2OS<xCop1> in BMS
    *** reversed by: xCop1(S387A) [substitution]
    *** source: 16931761-Fig-1d
  *** xCop1[tAb]IP ubiq[tUbAb] is increased irt IR (2 hr)
    *** cells: H1299<xCop1> in BMS "treated with proteosome inhibitor"
    *** inhibited by: xCop1(S387A) [substitution]
    *** source: 16931761-Fig-S11
*** Creb1--
  *** xCreb1(S133A)[Ab] snaggedby[WB] rCbp(587-666)"KIX"[GST] is decreased irt IR (1 hr)
    *** cells: HEK293T<xCreb1> in BMS
    *** reversed by: rCreb1(T100A/S111A/S121A/S133A) [substitution]
    *** source: 15073328-Fig-3b
  *** xCreb1[Ab] copptby[WB] xCbp[tAb] is decreased irt IR (1 hr)
    *** cells: HEK293T<xCreb1><xCbp> in BMS
    *** reversed by: xCreb1(T100A/S111A/S121A) [substitution]
    *** source: 15073328-Fig-3d
  *** Creb1[Ab] snaggedby[WB] rCbp(587-666)"KIX"[GST] is decreased irt IR (1 hr)
    *** cells: HEK293T in BMS
    *** reversed by: Wortmannin [pretreatment]
    *** source: 15073328-Fig-3c
  *** xCreb1[Ab] snaggedby[WB] rCbp(587-666)"KIX"[GST] is decreased irt IR (1 hr)
    *** cells: HEK293T<xCreb1> in BMS
    *** reversed by: rCreb1(T100A/S111A/S121A) [substitution]
    *** source: 15073328-Fig-3a
  *** CyclinAs[Ab] locatedin(DSBs)[IHC] is unchanged irt MicroLaser (10 min)
    *** cells: U2OS<xAtr> in BMS
    *** source: 16327781-Fig-6a
  *** CyclinB1 locatedin(DSBs)[IHC] is undetectable
    *** cells: U2OS<xRnf8> in BMS "treated with MicroLaser for 30 min"
    *** comment: CyclinB1 stays in the cytoplasm
    *** source: 18001824-Fig-1c
*** E2f1--
  *** xE2f1(86-437)[tAb] prot-exp[WB] is detectable-but unchanged irt MG132 (5 hr)
    *** cells: HEK293T<xE2f1> in BMS
    *** source: 11459832-Fig-7b
  *** xE2f1[tAb] prot-exp[WB] is increased irt MG132 (5 hr)
    *** cells: HEK293T<xE2f1> in BMS
    *** unaffected by: xE2f1(S31A) [substitution]
    *** source: 11459832-Fig-7b
*** Egr1--
*** Erc1--
*** Erk5--
*** Erks--
*** Eya1--
  *** Eya1[Ab]IP phos(SQ-TQ)[phosAb] is increased irt IR (tnr)
    *** cells: HEK293T in BMS
    *** source: 19234442-Fig-3a
  *** xEya1[tAb] locatedin(subnuclear-bodies)[IHC] is increased irt IR (1 hr)
    *** cells: HEK293T<xEya1> in BMS
    *** comment: colocates with H2ax-phos(S140)
    *** source: 19234442-Fig-2d
  *** xEya1[tAb]IP IVPPaseAct(Histones)[pYAb] is detectable
    *** cells: HEK293T<xEya1> in BMS
    *** inhibited by: xEya1(D323A)"CIA" [substitution]
    *** source: 19234442-Fig-4b
*** Eya3--
  *** xEya3[tAb] copptby[WB] xEya1[tAb] is detectable-but unchanged irt IR (tnr)
    *** cells: HEK293T<xH2ax><xEya1> in BMS
    *** source: 19234442-Fig-3e
  *** xEya3[tAb] locatedin(subnuclear-bodies)[IHC] is increased irt IR (1 hr)
    *** cells: HEK293T<xEya1> in BMS
    *** comment: colocates with H2ax-phos(S140)
    *** inhibited by: xEya3(S219A) [substitution]
    *** source: 19234442-Fig-3c
  *** xEya3[tAb] locatedin(subnuclear-bodies)[IHC] is increased irt IR (1 hr)
    *** cells: HEK293T<xEya1> in BMS
    *** comment: colocates with H2ax-phos(S140)
    *** source: 19234442-Fig-2d
  *** xEya3[tAb]IP IVPPaseAct(Histones)[pYAb] is detectable
    *** cells: HEK293T<xEya1> in BMS
    *** inhibited by: xEya3(D246A)"CIA" [substitution]
    *** source: 19234442-Fig-4b
*** Fancd2--
  *** Fancd2[Ab] copptby[WB] Mdc1[Ab] is decreased irt IR (1 hr)
    *** cells: NotReported in BMS
    *** source: 12607005-Fig-3a
*** Fos--
  *** H2afz[Ab] ubiq[WBMS] is decreased irt MG132 (times)
    *** cells: U2OS in BMS "Histone enriched fraction"
    *** times: 0+ 30 60 90 120 min
    *** source: 18001824-Fig-S6b
*** H2ax--
  *** H2ax[Ab] copptby[WB] Eya1[Ab] is increased irt IR (tnr)
    *** cells: HEK293T in BMS
    *** comment: coppt H2ax is phosed on S140
    *** source: 19234442-Fig-2b
  *** H2ax[Ab] ubiq[WBMS] is decreased irt MG132 (times)
    *** cells: U2OS in BMS "Histone enriched fraction"
    *** times: 0+ 30 60 90 120 min
    *** source: 18001824-Fig-S6b
  *** rH2ax[Ab] ubiq[WBMS] is increased by (rRnf8 + rUbe2d3 + rUbe2e1 + rUbiq)
    *** cells: none
    *** inhibited by: rRnf8(C403S)"mutRING" [substitution]
    *** source: 18001824-Fig-S9c
  *** H2ax[Ab]IP Yphos[pYAb] is decreased irt IR (tnr)
    *** cells: HEK293T in BMS
    *** source: 19234442-Fig-4a
  *** H2ax[Ab]IP Yphos[pYAb] is detectable-but unchanged itao Eya1 [RNAi]
    *** cells: HEK293T in BMS
    *** source: 19234442-Fig-S5
  *** H2ax[Ab]IP Yphos[pYAb] is detectable-but unchanged itao Eya3 [RNAi]
    *** cells: HEK293T in BMS
    *** source: 19234442-Fig-S6
  *** H2ax[Ab]IP Yphos[pYAb] is increased itao Eya1 [RNAi]
    *** cells: HEK293T in BMS "treated with IR for tnr"
    *** reversed by: xEya1 [addition]
    *** source: 19234442-Fig-S7
  *** H2ax[Ab]IP Yphos[pYAb] is increased itao Eya1 [RNAi]
    *** cells: HEK293T in BMS "treated with IR for tnr"
    *** source: 19234442-Fig-4c
  *** H2ax[Ab]IP Yphos[pYAb] is increased itao Eya3 [RNAi]
    *** cells: HEK293T in BMS "treated with IR for tnr"
    *** reversed by: xEya3 [addition]
    *** source: 19234442-Fig-4d
  *** H2ax[Ab]IP Yphos[pYAb] is increased itao Eya3 [RNAi]
    *** cells: HEK293T in BMS "treated with IR for tnr"
    *** source: 19234442-Fig-4c
  *** xH2ax[tAb] copptby[WB] Apbb1[Ab] is detectable
    *** cells: HEK293T<xH2ax> in BMS "treated with 50Gy! IR for tnr"
    *** inhibited by: xH2ax(Y143F) [substitution]
    *** source: 19234442-Fig-5d
  *** xH2ax[tAb] copptby[WB] Jnk1[Ab] is detectable
    *** cells: HEK293T<xH2ax> in BMS "treated with 50Gy! IR for tnr"
    *** inhibited by: xH2ax(Y143F) [substitution]
    *** source: 19234442-Fig-5c
  *** xH2ax[tAb] copptby[WB] xEya1[tAb] is increased irt IR (tnr)
    *** cells: HEK293T<xH2ax><xEya1> in BMS
    *** inhibited by: Caffeine [pretreatment]
    *** source: 19234442-Fig-3b
  *** xH2ax[tAb] copptby[WB] xEya1[tAb] is increased irt IR (tnr)
    *** cells: HEK293T<xH2ax><xEya1> in BMS
    *** source: 19234442-Fig-2a
  *** xH2ax[tAb] copptby[WB] xEya3[tAb] is increased irt IR (tnr)
    *** cells: HEK293T<xH2ax><xEya3> in BMS
    *** inhibited by: Caffeine [pretreatment]
    *** source: 19234442-Fig-3b
  *** xH2ax[tAb] copptby[WB] xEya3[tAb] is increased irt IR (tnr)
    *** cells: HEK293T<xH2ax><xEya3> in BMS
    *** inhibited by: xEya3(S219A) [substitution]
    *** source: 19234442-Fig-3d
  *** xH2ax[tAb] copptby[WB] xEya3[tAb] is increased irt IR (tnr)
    *** cells: HEK293T<xH2ax><xEya3> in BMS
    *** source: 19234442-Fig-2a
  *** xH2ax[tAb]IP phos(S140)[phosAb] is increased irt IR (tnr)
    *** cells: HEK293T<xH2ax> in BMS
    *** partially inhibited by: xH2ax(Y143F) [substitution]
    *** source: 19234442-Fig-5a
  *** xH2ax[tAb]IP Yphos[pYAb] is decreased irt IR (tnr)
    *** cells: HEK293T<xH2ax> in BMS
    *** source: 19234442-Fig-5a
  *** xH2ax[tAb]IP Yphos[pYAb] is detectable
    *** cells: HEK293T<xH2ax> in BMS
    *** inhibited by: xH2ax(Y143F) [substitution]
    *** source: 19234442-Fig-5a
  *** H2ax{phos(S140)}[phosAb] locatedin(subnuclear-bodies)[IHC] is detectable
    *** cells: HEK293T<xTip60> in BMS "treated with IR for tnr"
    *** unaffected by: xKdm6b [addition]
    *** unaffected by: xKdm4a [addition]
    *** unaffected by: xKdm4d [addition]
    *** source: 19783983-Fig-4c
  *** H2ax{phos(S140)}[phosAb] locatedin(subnuclear-bodies)[IHC] is increased irt IR (40 min)
    *** cells: HCT116<xTip60> in BMS
    *** unaffected by: xTip60(Y47A)"CD" [substitution]
    *** source: 19783983-Fig-S3a
*** rHist2h2be--
  *** rHist2h2be[Ab] ubiq[WBMS] is unchanged by (rRnf8 + rUbe2d3 + rUbe2e1 + rUbiq)
    *** cells: none
    *** source: 18001824-Fig-S9c
*** rHist3h2a--
  *** rHist3h2a[Ab] ubiq[WBMS] is increased by (rRnf8 + rUbe2d3 + rUbe2e1 + rUbiq)
    *** cells: none
    *** inhibited by: rRnf8(C403S)"mutRING" [substitution]
    *** source: 18001824-Fig-6d
  *** rHist3h2a[Ab] ubiq[WBMS] is increased by (rRnf8 + rUbe2d3 + rUbe2e1 + rUbiq)
    *** cells: none
    *** inhibited by: rRnf8(C403S)"mutRING" [substitution]
    *** source: 18001824-Fig-S9c
  *** xHistH2A?[tAb]IP ubiq[WBMS] is increased irt IR (1 hr)
    *** cells: U2OS<xHistH2A?><xUbiq> in BMS
    *** reqs: Mdc1 [RNAi]
    *** source: 18001824-Fig-S9b
  *** xHistH2A?[tAb]IP ubiq[WBMS] is increased irt IR (1 hr)
    *** cells: U2OS<xHistH2A?><xUbiq> in BMS
    *** reqs: Rnf8 [RNAi]
    *** source: 18001824-Fig-6c
  *** HistH2A[Ab] copptby[WB] xRnf8(C403S)"mutRING"[tAb] is detectable
    *** cells: HEK293T<xRnf8(C403S)"mutRING"> in BMS
    *** inhibited by: xRnf8 [substitution]
    *** inhibited by: xRnf8(R42A)"mutFHA" [substitution]
    *** source: 18001824-Fig-6b
  *** HistH2A[Ab] ubiq[WBMS] is decreased irt MG132 (times)
    *** cells: U2OS in BMS "Histone enriched fraction"
    *** times: 0+ 30 60 90 120 min
    *** source: 18001824-Fig-S6b
  *** HistH2A{ubiq}[Ab] prot-exp[WB] is increased irt IR (1 hr)
    *** cells: HEK293T in BMS
    *** source: 18001824-Fig-S9e
  *** HistH2B[Ab] boundto(Dab1-gene)[ChIP] is decreased irt DSB-Induction (times)
    *** cells: GM637 in BMS
    *** times: 0++ 2++ 4+ 6 8+ 10++ 10++ hr
    *** source: 17486112-Fig-4c
  *** HistH2B[Ab] boundto(Dab1-gene)[ChIP] is decreased irt DSB-Induction (times)
    *** cells: GM9607<Atm~fmut> in BMS
    *** times: 0++ 2++ 4+ 6+ 8+ 10 12+ hr
    *** source: 17486112-Fig-4c
  *** HistH2B[Ab] boundto(Dab1-gene)[ChIP] is decreased irt DSB-Induction (times)
    *** cells: MCF7 in BMS
    *** times: 0++ 2+ 4 6 8 10++ hr
    *** reversed by: KU55933 [cotreatment]
    *** source: 17486112-Fig-4f
  *** HistH2B[Ab] boundto(Dab1-gene)[ChIP] is decreased irt DSB-Induction (times)
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** times: 0++ 2+ 4 6+ 8++ 10++ hr
    *** reqs: xNbs1 [omission]
    *** source: 17486112-Fig-4a
  *** HistH2B[Ab] ubiq[WBMS] is decreased irt MG132 (times)
    *** cells: U2OS in BMS "Histone enriched fraction"
    *** times: 0+ 30 60 90 120 min
    *** source: 18001824-Fig-S6b
  *** rHistH3?[Ab] ubiq[WBMS] is unchanged by (rRnf8 + rUbe2d3 + rUbe2e1 + rUbiq)
    *** cells: none
    *** source: 18001824-Fig-S9c
  *** HistH3[Me3Ab] methyl(K10)[Me3Ab] is detectable-but unchanged irt IR (tnr)
    *** cells: mEFs in BMS
    *** source: 19783983-Fig-4b
  *** HistH3{methyl(K10)}[Me3Ab] locatedin(subnuclear-bodies)[IHC] is detectable
    *** cells: HEK293T in BMS "treated with IR for tnr"
    *** unaffected by: xKdm6b [addition]
    *** inhibited by: xKdm4a [addition]
    *** inhibited by: xKdm4d [addition]
    *** source: 19783983-Fig-S8b
  *** HistH3{methyl(K28)}[Me3Ab] locatedin(subnuclear-bodies)[IHC] is detectable
    *** cells: HEK293T in BMS "treated with IR for tnr"
    *** inhibited by: xKdm6b [addition]
    *** unaffected by: xKdm4a [addition]
    *** unaffected by: xKdm4d [addition]
    *** source: 19783983-Fig-S8b
*** Ikk1--
*** Ikk2--
*** Ikks--
*** Irf3--
  *** Jnk1[Ab] copptby[WB] Apbb1[Ab] is detectable
    *** cells: HEK293T in BMS "treated with Etoposide for tnr"
    *** inhibited by: xH2ax(Y143F) [substitution]
    *** source: 19234442-Fig-5e
  *** Jnk1[Ab] copptby[WB] H2ax{phos(S140)}[phosAb] is increased irt IR (tnr)
    *** cells: HEK293T<xH2ax> in BMS
    *** reqs: Apbb1 [RNAi]
    *** source: 19234442-Fig-5f
  *** Jnk1[Ab] snaggedby[WB] sH2ax(128-142){phos(S140/Y143)}[biotin] is detectable
    *** cells: HEK293T in BMS "nuclear-extracts" "treated with IR for tnr"
    *** inhibited by: sH2ax(128-142){phos(S140)} [substitution]
    *** source: 19234442-Fig-5b
*** Jnks--
*** Jnks--
*** Jun--
*** Junb--
*** Ku70--
  *** Ku70[Ab] locatedin(DSBs)[IHC] is unchanged irt MicroLaser (1 hr)
    *** cells: BJ in BMS
    *** comment: does not colocalize with H2ax-phos(S140)
    *** source: 16618811-Fig-S2
  *** Ku70[Ab] locatedin(DSBs)[IHC] is unchanged irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: does not colocalize with H2ax-phos(S140)
    *** source: 16618811-Fig-7b
  *** Ku70[Ab] locatedin(subnuclear-bodies)[IHC] is unchanged irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: does not colocalize with H2ax-phos(S140)
    *** source: 16618811-Fig-S1a
*** Ku80--
*** Map4k2--
*** Map4k5--
*** Mapkapk2--
*** Mdc1--
  *** xMdc1(1-1100)[tAb]IP phos(SQ-TQ)[phosAb] is increased irt IR (30 min)
    *** cells: HEK293T<xMdc1(1-1100)> in BMS
    *** inhibited by: xMdc1(1-1100/T699A/T719A/T752A) [substitution]
    *** source: 18001824-Fig-2e
  *** Mdc1[Ab] copptby[WB] Atm[Ab] is decreased irt IR (1 hr)
    *** cells: NotReported in BMS
    *** source: 12607005-Fig-3b
  *** Mdc1[Ab] copptby[WB] Nbs1[Ab] is decreased irt IR (1 hr)
    *** cells: NotReported in BMS
    *** source: 12607005-Fig-3b
  *** Mdc1[Ab] copptby[WB] xRnf8[tAb] is detectable
    *** cells: HEK293T<xRnf8> in BMS "treated with IR for tnr"
    *** source: 18006705-Fig-3c
  *** Mdc1[Ab] copptby[WB] xRnf8[tAb] is increased irt IR (30 min)
    *** cells: U2OS<xRnf8> in BMS
    *** source: 18001824-Fig-2f
  *** Mdc1[Ab] locatedin(DSBs)[IHC] is detectable
    *** cells: U2OS in BMS "treated with MG132 for 90 min followed by MicroLaser for 30 min"
    *** comment: colocates with H2ax{phos(S140)}[phosAb]
    *** source: 18001824-Fig-3c
  *** Mdc1[Ab] snaggedby[WB] rRnf8[GST] is detectable-but unchanged irt IR (6 hr)
    *** cells: HEK293T<xMdc1> in BMS
    *** comment: inhibited by treatment of lysates with phosphatase before IP
    *** source: 18001825-Fig-3f
  *** Mdc1[Ab] snaggedby[WB] sH2ax(128-142){phos(S140)}[biotin] is detectable
    *** cells: HEK293T in BMS "nuclear-extracts" "treated with IR for tnr"
    *** inhibited by: sH2ax(128-142){phos(S140/Y143)} [substitution]
    *** source: 19234442-Fig-5b
  *** Mdc1[phosAb] phos(S329/T331)[phosAb] is detectable-but unchanged irt IR (1 hr)
    *** cells: HELA in BMS "nuclear-extract"
    *** source: 18583988-Fig-2a
*** Mdm2--
  *** Mdm2[Ab] copptby[WB] Tp53[Ab] is detectable-but unchanged irt IR (3 hr)
    *** cells: LNCAP in BMS
    *** source: 9363941-Fig-3b
  *** Mdm2[Ab] copptby[WB] Tp53[Ab] is detectable-but unchanged irt IR (3 hr)
    *** cells: RKO in BMS
    *** source: 9363941-Fig-3b
  *** Mdm2[Ab] copptby[WB] Tp53[Ab] is detectable-but unchanged irt IR (times)
    *** cells: LNCAP in BMS
    *** times: 0+ 30+ 60+ 120+ 180+ 240+ min
    *** source: 9363941-Fig-1
  *** Mdm2[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: HCT116 in BMS
    *** times: 0+ 2+ 4++ 8++ hr
    *** reqs: Chek2 [KO]
    *** source: 16163388-Fig-9c
  *** Mdm2[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: IMR90 in BMS
    *** times: 0+ 12++ 24+++ 36+++ hr
    *** partially inhibited by: xTrf2 [addition]
    *** source: 15314656-Fig-2a 
  *** Mdm2[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: MCF7 in BMS
    *** times: 0 1 2 4 6++ 8++ 12+ 22 hr
    *** source: 16163388-Fig-3a
  *** Mdm2[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: MCF7 in BMS
    *** times: 0 3+ 6+ hr
    *** source: 16163388-Fig-1a
  *** Mdm2[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: U2OS in BMS
    *** times: 0 3+ 6+ hr
    *** source: 16163388-Fig-1a
  *** Mdm2[Ab] prot-exp[WB] is increased irt IR (tnr)
    *** cells: HCT116 in BMS
    *** reqs: Tp53 [KO]
    *** source: 16163388-Fig-1b
  *** Mdm2[Ab] prot-stability[CHX-WB] is unchanged irt IR (4 hr)
    *** cells: MCF7 in BMS
    *** source: 16163388-Fig-1c
*** Mdm4--
  *** xMdm4[Ab] copptby[WB] Mdm2[Ab] is detectable-but unchanged irt IR (6 hr)
    *** cells: SAOS2<Tp53~null><xMdm4> in BMS "treated with MG132"
    *** source: 16163388-Fig-2d
  *** xMdm4[Ab] phos[WBMS] is increased irt IR (6 hr)
    *** cells: SAOS2<Tp53~null><xMdm4> in BMS
    *** source: 16163388-Fig-2b
  *** Mdm4[Ab] phos[WBMS] is unchanged irt IR (6 hr)
    *** cells: MCF7 in BMS
    *** comment: normalized to Mdm4 protein
    *** comment: MS happens irt IR when Mdm2 is removed with AntiSense
    *** source: 16163388-Fig-2c
  *** xMdm4[Ab] phos[WBMS-PPase] is increased irt IR (tnr)
    *** cells: SAOS2<Tp53~null><xMdm4> in BMS
    *** source: 16163388-Fig-2a
  *** Mdm4[Ab] prot-exp[WB] is decreased irt IR (4 hr)
    *** cells: MCF7 in BMS
    *** reversed by: MG132 [addition]
    *** comment: Mdm4 upshifts irt IR + MG132
    *** source: 16163388-Fig-1d
  *** Mdm4[Ab] prot-exp[WB] is decreased irt IR (4 hr)
    *** cells: SJSA in BMS
    *** reversed by: MG132 [addition]
    *** comment: Mdm4 upshifts irt IR + MG132
    *** source: 16163388-Fig-1d
  *** Mdm4[Ab] prot-exp[WB] is decreased irt IR (times)
    *** cells: C3ABR in BMS
    *** times: 0++ 90+ 150+ 210+ min
    *** source: 15788536-Fig-1a
  *** Mdm4[Ab] prot-exp[WB] is decreased irt IR (times)
    *** cells: HCT116 in BMS
    *** times: 0++ 2+ 4 8 hr
    *** reqs: Chek2 [KO]
    *** source: 16163388-Fig-9c
  *** Mdm4[Ab] prot-exp[WB] is decreased irt IR (times)
    *** cells: L3AT<Atm~fmut> in BMS
    *** times: 0++ 90+ 150+ 210+ min
    *** comment: decrease is less than seen in C3ABR
    *** source: 15788536-Fig-1a
  *** Mdm4[Ab] prot-exp[WB] is decreased irt IR (times)
    *** cells: MCF7 in BMS
    *** times: 0++ 3+ 6+ hr
    *** source: 16163388-Fig-1a
  *** Mdm4[Ab] prot-exp[WB] is decreased irt IR (times)
    *** cells: U2OS in BMS
    *** times: 0++ 3+ 6+ hr
    *** source: 16163388-Fig-1a
  *** Mdm4[Ab] prot-exp[WB] is decreased irt IR (tnr)
    *** cells: HCT116 in BMS
    *** does not req: Tp53 [KO]
    *** source: 16163388-Fig-1b
  *** xMdm4[Ab] prot-exp[WB] is unchanged irt IR (4 hr)
    *** cells: SAOS2<Tp53~null><xMdm4> in BMS
    *** comment: Mdm4 upshifts irt IR
    *** source: 16163388-Fig-1d
  *** Mdm4[Ab] prot-stability[CHX-WB] is decreased irt IR (4 hr)
    *** cells: MCF7 in BMS
    *** source: 16163388-Fig-1c
  *** xMdm4[Ab]IP phos(S342)[phosAb] is increased irt IR (2 hr)
    *** cells: U2OS<xMdm4> in BMS
    *** inhibited by: Caffeine [addition]
    *** source: 16163388-Fig-8b
  *** Mdm4[Ab]IP phos(S342)[phosAb] is increased irt IR (4 hr)
    *** cells: HCT116 in BMS "treated with MG132"
    *** reqs: Chek2 [KO]
    *** source: 16163388-Fig-8c
  *** xMdm4[Ab]IP phos(S342)[phosAb] is increased irt IR (4 hr)
    *** cells: U2OS<xMdm4> in BMS
    *** partially inhibited by: xMdm4(S367A) [substitution]
    *** unaffected by: xMdm4(S391A) [substitution]
    *** bkg inhibited by: xMdm4(S403A) [substitution]
    *** source: 16163388-Fig-7d
  *** xMdm4[Ab]IP phos(S367)[phosAb] is increased irt IR (2 hr)
    *** cells: U2OS<xMdm4> in BMS
    *** inhibited by: Caffeine [addition]
    *** source: 16163388-Fig-8b
  *** Mdm4[Ab]IP phos(S367)[phosAb] is increased irt IR (4 hr)
    *** cells: HCT116 in BMS "treated with MG132"
    *** reqs: Chek2 [KO]
    *** source: 16163388-Fig-8c
  *** xMdm4[Ab]IP phos(S367)[phosAb] is increased irt IR (4 hr)
    *** cells: U2OS<xMdm4> in BMS
    *** unaffected by: xMdm4(S342A) [substitution]
    *** unaffected by: xMdm4(S391A) [substitution]
    *** inhibited by: xMdm4(S403A) [substitution]
    *** source: 16163388-Fig-7d
  *** Mdm4[phosAb] phos(S342)[phosAb] is increased irt IR (4 hr)
    *** cells: MCF7 in BMS "treated with MG132"
    *** source: 16163388-Fig-7a
  *** Mdm4[phosAb] phos(S367)[phosAb] is increased irt IR (4 hr)
    *** cells: MCF7 in BMS "treated with MG132"
    *** source: 16163388-Fig-7a
  *** xMdm4[tAb] prot-exp[WB] is decreased irt IR (times)
    *** cells: MCF7<xMdm4> in BMS
    *** times: 0++ 5+ 7+ hr
    *** source: 15788536-Fig-1b
*** Mekk1--
*** Mekk2--
*** Mkk3--
*** Mkk4--
*** Mkk6--
*** Mkk7--
*** Mre11--
  *** Mre11[Ab] copptby[WB] Nbs1[Ab] is detectable-but unchanged irt IR (2 hr)
    *** cells: GM5849<Atm~fmut><xAtm> in BMS
    *** source: 15723659-Fig-6b
  *** Mre11[Ab] copptby[WB] Nbs1[Ab] is detectable-but unchanged irt IR (2 hr)
    *** cells: HEK293T in BMS
    *** source: 15723659-Fig-6b
  *** Mre11[Ab] copptby[WB] Nbs1[Ab] is detectable-but unchanged irt IR (2 hr)
    *** cells: HEK293T<xArtemis> in BMS
    *** source: 15723659-Fig-6a
  *** xMre11[Ab] copptby[WB] Nbs1[Ab] is detectable-but unchanged irt IR (15 min)
    *** cells: D6809<Mre11~fmut><xMre11> in BMS
    *** unaffected by: xMre11(NLS) [substitution]
    *** source: 16478990-Fig-4b
  *** Mre11[Ab] copptby[WB] Nbs1[Ab] is detectable-but unchanged irt IR (15 min)
    *** cells: GM637 in BMS
    *** source: 16478990-Fig-4b
  *** Mre11[Ab] snaggedby[WB] sH2ax(128-142){phos(S140)}[biotin] is detectable
    *** cells: HEK293T in BMS "nuclear-extracts" "treated with IR for tnr"
    *** inhibited by: sH2ax(128-142){phos(S140/Y143)} [substitution]
    *** source: 19234442-Fig-5b
*** Msk1--
*** Msk2--
*** Nbs1--
  *** Nbs1[Ab] copptby[WB] Atm[Ab] is increased irt IR (2 hr)
    *** cells: T24 in BMS
    *** source: 10839544-Fig-2a
  *** Nbs1[Ab] copptby[WB] Mdc1[Ab] is detectable-but unchanged irt IR (1 hr)
    *** cells: NotReported in BMS
    *** source: 12607005-Fig-3a
  *** xNbs1[Ab] copptby[WB] xMdc1[Ab] is detectable
    *** cells: U2OS<xNbs1><xMdc1> in BMS "treated with MicroLaser for 1 hr"
    *** inhibited by: xNbs1(R28A)"mutFHA" [substitution]
    *** source: 15201865-Fig-7f
  *** Nbs1[Ab] infraction(chromatin)[WB] is detectable-but unchanged irt IR (1 hr)
    *** cells: HELA in BMS
    *** does not req: Mdc1 [RNAi]
    *** source: 15201865-Fig-5a
  *** xNbs1[tAb] copptby[WB] xMre11[tAb] is detectable-but unchanged irt IR (tnr)
    *** cells: HEK293T<xNbs1><xMre11> in BMS
    *** source: 10766245-Fig-5a
*** Nemo--
*** Nemo--
*** Nfkb--
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IR (2 hr)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** inhibited by: xNemo(S85A) [substitution]
    *** unaffected by: xNemo(ubiq/S85A) [substitution]
    *** source: 16497931-Fig-3d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IR (2 hr)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** reqs: xNemo [omission]
    *** source: 16497931-Fig-1a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IR (times)
    *** cells: mEFs in BMS
    *** times: 0 1 3+ 5+ 7+ 9+ 12+ hr
    *** reqs: Ripk1 [KO]
    *** source: 12654725-Fig-2a
*** P38s--
*** Pak1--
*** Parp1--
*** Pin1--
*** Pin1--
*** Pirh2--
*** Pkcd--
*** Pkce--
*** Pol2--
  *** Pol2[Ab]IP Yphos[pYAb] is increased irt IR (1 hr)
    *** cells: GM2184 in BMS "nuclear-extracts"
    *** source: 9168116-Fig-4b
  *** Pol2[Ab]IP Yphos[pYAb] is unchanged irt IR (1 hr)
    *** cells: GM1526<Atm~fmut> in BMS "nuclear-extracts"
    *** source: 9168116-Fig-4b
  *** Pol2[Ab]IP Yphos[pYAb] is unchanged irt IR (1 hr)
    *** cells: GM5849<Atm~fmut><xAtm(2711-2962)> in BMS "nuclear-extracts"
    *** reqs: xAtm [omission]
    *** source: 9168116-Fig-4b
*** Prkdc--
  *** Prkdc[Ab] copptby[WB] Nbs1[Ab] is unchanged irt IR (2 hr)
    *** cells: GM5849<Atm~fmut><xAtm> in BMS
    *** source: 15723659-Fig-6b
  *** Prkdc[Ab] copptby[WB] Nbs1[Ab] is unchanged irt IR (2 hr)
    *** cells: HEK293T in BMS
    *** source: 15723659-Fig-6b
  *** Prkdc[Ab] copptby[WB] Nbs1[Ab] is unchanged irt IR (2 hr)
    *** cells: HEK293T<xArtemis> in BMS
    *** source: 15723659-Fig-6a
  *** Prkdc[Ab] locatedin(DSBs)[IHC] is unchanged irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: does not colocalize with H2ax-phos(S140)
    *** source: 16618811-Fig-7b
  *** Prkdc[Ab]IP phos(T2609)[phosAb] is increased irt IR (1 hr)
    *** cells: XRS6Y<Ku80~null><xKu80> in BMS
    *** reqs: xKu80 [omission]
    *** inhibited by: xKu80(1-718)"delC" [substitution]
    *** source: 15758953-Fig-4e
*** Rad1--
  *** xRad1[tAb] copptby[WB] xRad17[tAb] is increased irt IR (1 hr)
    *** cells: HEK293T<xRad1><xRad17> in BMS
    *** source: 11418864-Fig-5b
*** Rad17--
  *** xRad17[Ab] copptby[WB] Atm[Ab] is increased irt IR (1 hr)
    *** cells: HEK293T<xRad17> in BMS
    *** unaffected by: xRad17(S646A/S656A) [substitution]
    *** source: 11418864-Fig-4a
  *** Rad17[Ab] copptby[WB] Atm[Ab] is increased irt IR (1 hr)
    *** cells: MCF7 in BMS
    *** source: 11418864-Fig-1a
  *** xRad17[Ab] copptby[WB] Atr[Ab] is increased irt IR (1 hr)
    *** cells: HEK293T<xRad17> in BMS
    *** unaffected by: xRad17(S646A/S656A) [substitution]
    *** source: 11418864-Fig-4a
  *** Rad17[Ab] copptby[WB] Atr[Ab] is increased irt IR (1 hr)
    *** cells: MCF7 in BMS
    *** source: 11418864-Fig-1a
  *** Rad17[phosAb] phos(S646)[phosAb] is increased irt IR (1 hr)
    *** cells: BJ in BMS
    *** source: 11418864-Fig-4b
  *** Rad17[phosAb] phos(S646)[phosAb] is increased irt IR (1 hr)
    *** cells: BJ<xRad17> in BMS
    *** inhibited by: xRad17(S646A/S656A) [substitution]
    *** source: 11418864-Fig-4b
  *** Rad17[phosAb] phos(S646)[phosAb] is increased irt IR (times)
    *** cells: A549 in BMS
    *** times: 0+ 1+++ 4++ hr
    *** source: 11418864-Fig-2c
  *** Rad17[phosAb] phos(S646)[phosAb] is increased irt IR (times)
    *** cells: MCF7 in BMS
    *** times: 0+ 1++ 4+ hr
    *** source: 11418864-Fig-2c
  *** Rad17[phosAb] phos(S656)[phosAb] is increased irt IR (1 hr)
    *** cells: HELA in BMS
    *** source: 16327781-Fig-1a
  *** Rad17[phosAb] phos(S656)[phosAb] is increased irt IR (1 hr)
    *** cells: hFibros<Atr~fmut> in BMS
    *** source: 16327781-Fig-1a
  *** Rad17[phosAb] phos(S656)[phosAb] is increased irt IR (times)
    *** cells: A549 in BMS
    *** times: 0+ 1++ 4++ hr
    *** source: 11418864-Fig-2c
  *** Rad17[phosAb] phos(S656)[phosAb] is increased irt IR (times)
    *** cells: MCF7 in BMS
    *** times: 0+ 1++ 4++ hr
    *** source: 11418864-Fig-2c
  *** Rad17[phosAb] phos(S656)[phosAb] is unchanged irt IR (1 hr)
    *** cells: hFibros<Atm~fmut> in BMS
    *** source: 16327781-Fig-1a
  *** xRad17[tAb] copptby[WB] xRad1[tAb] is increased irt IR (1 hr)
    *** cells: HEK293T<xRad1><xRad17> in BMS
    *** comment: coppt Rad17 is phosed on S646 [phosAb] regardless of IR
    *** comment: coppt Rad17 is phosed on S656 [phosAb] regardless of IR
    *** source: 11418864-Fig-5c
  *** xRad17[tAb] copptby[WB] xRad1[tAb] is increased irt IR (1 hr)
    *** cells: HEK293T<xRad1><xRad17> in BMS
    *** source: 11418864-Fig-5a
  *** xRad17[tAb]IP phos(S646)[phosAb] is increased irt IR (1 hr)
    *** cells: HEK293T<xRad17> in BMS
    *** source: 11418864-Fig-2b
*** Rad50--
  *** Rad50[Ab] copptby[WB] Mdc1[Ab] is detectable-but unchanged irt IR (1 hr)
    *** cells: NotReported in BMS
    *** source: 12607005-Fig-3a
*** Rad51--
  *** Rad51[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: limited to cells expressing CyclinB1
    *** source: 16618811-Fig-4d
  *** Rad51[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: sublocalizes with H2ax-phos(S140)
    *** source: 16618811-Fig-3
  *** Rad51[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS<Mdc1~kd> in BMS
    *** comment: sublocalizes with H2ax-phos(S140)
    *** source: 16618811-Fig-S3c
  *** Rad51[Ab] locatedin(DSBs)[IHC] is unchanged irt MicroLaser (1 hr)
    *** cells: U2OS<Brca1~kd> in BMS
    *** source: 16618811-Fig-S3d
  *** Rad51[Ab] locatedin(subnuclear-bodies)[IHC] is detectable
    *** cells: MRC5 in BMS "treated with IR for 30 min"
    *** comment: does not colocalize with Mdc1
    *** source: 12607003-Fig-2c
  *** Rad51[Ab] locatedin(subnuclear-bodies)[IHC] is increased irt IR (times)
    *** cells: MCF7 in BMS
    *** times: 0 15+ 30+ 60++ 120+++ 180++++ 360++++ min
    *** comment: time measurements are percent cells with foci
    *** source: 12551934-Fig-2a
  *** Rad51[Ab] locatedin(subnuclear-bodies)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: sublocalizes with H2ax-phos(S140)
    *** source: 16618811-Fig-S1a
*** Rad52--
  *** xRad52[XFP] locatedin(DSBs)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS<xRad52> in BMS
    *** source: 16618811-Fig-9a
  *** xRad52[XFP] locatedin(subnuclear-bodies)[IHC] is increased irt IR (1 hr)
    *** cells: U2OS<xRad52> in BMS
    *** comment: subnuclear bodies are smaller than those occupied by xMdc1 xTp53bp1
    *** comment: subnuclear bodies are larger than those occupied by xAtr
    *** source: 16618811-Fig-9b
*** Rap80--
*** Rb1--
  *** Rb1[Ab] prot-exp[WB] is decreased irt IR (times)
    *** cells: IMR90 in BMS
    *** times: 0+++ 12+++ 24++ 36+ hr
    *** unaffected by: xTrf2 [addition]
    *** comment: Rb1 phos [WBMS] is decreased with prot-exp
    *** source: 15314656-Fig-2a 
*** Rela--
*** Ripk1--
*** Rnf8--
  *** Rnf8[Ab] prot-exp[WB] is detectable-but unchanged irt IR (6 hr)
    *** cells: HELA in BMS
    *** source: 18001825-Fig-S1b
  *** xRnf8[tAb] copptby[WB] Mdc1[Ab] is detectable
    *** cells: HEK293T<xRnf8> in BMS "treated with IR for tnr"
    *** inhibited by: xRnf8(R42A) [substitution]
    *** source: 18006705-Fig-3c
  *** xRnf8[tAb] copptby[WB] Mdc1[Ab] is detectable-but unchanged irt IR (tnr)
    *** cells: HEK293T<xRnf8> in BMS
    *** source: 18006705-Fig-3c
  *** xRnf8[tAb] infraction(chromatin)[WB] is detectable
    *** cells: U2OS<xRnf8> in BMS
    *** unaffected by: xRnf8(R42A)"mutFHA" [substitution]
    *** enhanced by: xRnf8(C403S)"mutRING" [substitution]
    *** source: 18001824-Fig-S9a
*** Rpa--
  *** Rpa[Ab] locatedin(DSBs)[IHC] is detectable
    *** cells: U2OS<Rnf8~kd> in BMS "treated with MicroLaser for 30 min"
    *** comment: colocates with H2ax{phos(S140)}[phosAb]
    *** source: 18001824-Fig-S7b
*** Rpa2--
  *** Rpa2[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: limited to cells expressing CyclinA
    *** source: 16618811-Fig-2b
  *** Rpa2[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS in BMS
    *** comment: sublocalizes with H2ax-phos(S140)
    *** source: 16618811-Fig-3
  *** Rpa2[Ab] locatedin(DSBs)[IHC] is increased irt MicroLaser (1 hr)
    *** cells: U2OS<Brca1~kd> in BMS
    *** source: 16618811-Fig-S3d
  *** Rpa2[Ab] locatedin(subnuclear-bodies)[IHC] is increased irt IR (1 hr)
    *** cells: hFibros<Atm~fmut><xAtm> in BMS
    *** reqs: xAtm [omission]
    *** source: 16327781-Fig-3a
  *** Rpa2[Ab] locatedin(subnuclear-bodies)[IHC] is increased irt IR (1 hr)
    *** cells: hFibros<Mre11~fmut><xMre11> in BMS
    *** reqs: xMre11 [omission]
    *** inhibited by: xMre11(mnr)"CIA" [substitution]
    *** comment: response is an increase in intensity rather than change of pattern
    *** comment: pattern is the different than that of Mre11 in the same cell
    *** source: 16327781-Fig-4b
  *** Rpa2[Ab] locatedin(subnuclear-bodies)[IHC] is increased irt IR (1 hr)
    *** cells: hFibros<Nbs1~fmut><xNbs1> in BMS
    *** reqs: xNbs1 [omission]
    *** comment: response is an increase in intensity rather than change of pattern
    *** comment: pattern is the same as the H2ax-phos(S140) in the same cell
    *** source: 16327781-Fig-3c
  *** Rpa2[Ab] locatedin(subnuclear-bodies)[IHC] is increased irt IR (1 hr)
    *** cells: U2OS in BMS
    *** unaffected by: KU55933 [pretreatment]
    *** source: 16327781-Fig-S2
*** Rrm2b--
*** Rsk2--
*** Rsk3--
*** Siah1--
*** Smc1a--
  *** Smc1a[Ab] copptby[WB] Mdc1[Ab] is detectable-but unchanged irt IR (1 hr)
    *** cells: NotReported in BMS
    *** source: 12607005-Fig-3a
  *** xSmc3[XFP] locatedin(DSBs)[IHC] is unchanged irt MicroLaser (1 hr)
    *** cells: U2OS<xSmc3> in BMS
    *** source: 16618811-Fig-9a
  *** xSmc3[XFP] locatedin(subnuclear-bodies)[IHC] is unchanged irt IR (1 hr)
    *** cells: U2OS<xSmc3> in BMS
    *** source: 16618811-Fig-9b
*** Stat3--
*** Tab1--
*** Tab2--
*** Tab2--
*** Tab2--
*** Tak1--
*** Tak1--
*** Tip60--
  *** xTip60[tAb] locatedin(subnuclear-bodies)[IHC] is increased irt IR (20 min)
    *** cells: GM5849<Atm~fmut><xAtm><xTip60> in BMS
    *** reqs: xAtm [omission]
    *** unaffected by: xAtm(mnr)"KD" [substitution]
    *** inhibited by: xAtm(V3032A/L3035A/L3045A/W3052A)"FATC1" [substitution]
    *** partially inhibited by: xAtm(V3032A/L3045A)"FATC2" [substitution]
    *** source: 16141325-Fig-5a
  *** xTip60[tAb] locatedin(subnuclear-bodies)[IHC] is increased irt IR (20 min)
    *** cells: HELA<xTip60> in BMS
    *** comment: subnuclear-bodies visualized using Atm-phos(S1981)[phosAb]
    *** source: 16141325-Fig-5a
  *** xTip60[tAb] locatedin(subnuclear-bodies)[IHC] is increased irt IR (20 min)
    *** cells: HELA<xTip60> in BMS
    *** comment: subnuclear-bodies visualized using H2ax-phos(S140)[phosAb]
    *** source: 16141325-Fig-7
*** Tp53--
  *** Tp53[Ab] prot-exp[WB] is increased irt 5Fluorouracil (times)
    *** cells: WI38 in BMS
    *** times: 0+ 3++ 6++ hr
    *** partially inhibited by: Tunicamycin [cotreatment]
    *** partially inhibited by: Thapsigargin [cotreatment]
    *** source: 14744935-Fig-2c
  *** Tp53[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: HCT116 in BMS
    *** times: 0+ 2++ 4++ 8++ hr
    *** reqs: Chek2 [KO]
    *** source: 16163388-Fig-9c
  *** Tp53[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: IMR90 in BMS
    *** times: 0+ 12++ 24+++ 36+++ hr
    *** partially inhibited by: xTrf2 [addition]
    *** source: 15314656-Fig-2a 
  *** Tp53[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: MCF7 in BMS
    *** times: 0 1+++ 2+++ 4+++ 6++ 8++ 12++ 22+ hr
    *** source: 16163388-Fig-3a
  *** Tp53[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: MCF7 in BMS
    *** times: 0+ 3++ 6+ hr
    *** source: 16163388-Fig-1a
  *** Tp53[Ab] prot-exp[WB] is increased irt IR (times)
    *** cells: U2OS in BMS
    *** times: 0+ 3++ 6++ hr
    *** source: 16163388-Fig-1a
  *** Tp53[Ab] prot-stability[CHX-WB] is increased irt IR (4 hr)
    *** cells: MCF7 in BMS
    *** source: 16163388-Fig-1c
  *** Tp53[phosAb] phos(S15)[phosAb] is increased irt IR (1 hr)
    *** cells: U2OS in BMS
    *** does not req: Rnf8 [RNAi]
    *** source: 18001824-Fig-S7d
*** Tp53aip1--
*** Tp53bp1--
  *** Tp53bp1[Ab] copptby[WB] Mdc1[Ab] is detectable-but unchanged irt IR (1 hr)
    *** cells: NotReported in BMS
    *** source: 12607005-Fig-3a
  *** Tp53bp1[Ab] snaggedby[WB] sMdc1(709-724){phos(T719)}[biotin] is undetectable
    *** cells: HELA in BMS
    *** unaffected by: sMdc1(709-724)"T719" [substitution]
    *** source: 18006705-Fig-3b
  *** Tp53bp1[Ab] snaggedby[WB] sMdc1(743-757){phos(T752)}[biotin] is undetectable
    *** cells: HELA in BMS
    *** unaffected by: sMdc1(743-757)"T752" [substitution]
    *** source: 18006705-Fig-3b
*** Tp53inp1--
*** TrailR2--
  *** Trim28[Ab] locatedin(nucleus)[IHC] is detectable
    *** cells: U2OS in BMS
    *** source: 16862143-Fig-2b
  *** xTrim28[Ab] locatedin(nucleus)[IHC] is detectable
    *** cells: U2OS<Trim28~kd><xTrim28> in BMS
    *** source: 16862143-Fig-2a
*** Trrap--
*** Ubiq--
  *** xUbiq[XFP] locatedin(nucleus)[IHC] is decreased irt MG132 (times)
    *** cells: U2OS<xUbiq> in BMS
    *** times: 0+++ 30++ 60+ min
    *** source: 18001824-Fig-S6a
  *** Ubiq{conj}[Ab] locatedin(DSBs)[IHC] is detectable
    *** cells: U2OS in BMS "treated with MicroLaser for 1 hr"
    *** comment: colocates with H2ax{phos(S140)}[phosAb]
    *** does not req: Brca1 [RNAi]
    *** source: 18001824-Fig-S8a
  *** Ubiq{conj}[Ab] locatedin(DSBs)[IHC] is detectable
    *** cells: U2OS in BMS "treated with MicroLaser for 1 hr"
    *** comment: colocates with H2ax{phos(S140)}[phosAb]
    *** inhibited by: MG132 [pretreatment]
    *** source: 18001824-Fig-4b
  *** Ubiq{conj}[Ab] locatedin(DSBs)[IHC] is detectable
    *** cells: U2OS in BMS "treated with MicroLaser for 1 hr"
    *** comment: colocates with H2ax{phos(S140)}[phosAb]
    *** reqs: Mdc1 [RNAi]
    *** source: 18001824-Fig-4b
  *** Ubiq{conj}[Ab] locatedin(DSBs)[IHC] is detectable
    *** cells: U2OS in BMS "treated with MicroLaser for 1 hr"
    *** comment: colocates with H2ax{phos(S140)}[phosAb]
    *** reqs: Rnf8 [RNAi]
    *** source: 18001824-Fig-4b
  *** Ubiq{conj}[Ab] locatedin(DSBs)[IHC] is detectable
    *** cells: U2OS<Rnf8~kd><xRnf8> in BMS "treated with MicroLaser for 1 hr"
    *** comment: colocates with H2ax{phos(S140)}[phosAb]
    *** inhibited by: xRnf8(R42A)"mutFHA" [substitution]
    *** inhibited by: xRnf8(C403S)"mutRING" [substitution]
    *** source: 18001824-Fig-5c
  *** Ubiq{conj}[Ab] locatedin(nucleus)[IHC] is decreased irt MG132 (times)
    *** cells: U2OS<xUbiq> in BMS
    *** times: 0+++ 30++ 60+ min
    *** source: 18001824-Fig-S6a
  *** Ubiq{conj}[Ab] locatedin(subnuclear-bodies)[IHC] is detectable
    *** cells: U2OS<Mdc1~kd><xMdc1> in BMS "treated with IR for tnr"
    *** reqs: xMdc1 [omission]
    *** inhibited by: xMdc1(T699A/T719A/T752A/T765A) [substitution]
    *** source: 18006705-Fig-S11b
  *** Ubiq{conj}[Ab] locatedin(subnuclear-bodies)[IHC] is increased irt IR (1 hr)
    *** cells: U2OS in BMS
    *** partially reqs: Ubc13 [RNAi]
    *** source: 18006705-Fig-4b
  *** Ubiq{conj}[Ab] locatedin(subnuclear-bodies)[IHC] is increased irt IR (1 hr)
    *** cells: U2OS in BMS
    *** reqs: Rnf8 [RNAi]
    *** source: 18006705-Fig-4a
*** Xrcc4--
  *** Xrcc4[Ab] boundto(Dab1-gene)[ChIP] is increased irt DSB-Induction (times)
    *** cells: GM637 in BMS
    *** times: 0 2 4++ 6++ 8+ 10+ 12 hr
    *** source: 17486112-Fig-4c
  *** Xrcc4[Ab] boundto(Dab1-gene)[ChIP] is increased irt DSB-Induction (times)
    *** cells: GM9607<Atm~fmut> in BMS
    *** times: 0+ 2+ 4++ 6++ 8++ 10+++ 12+++ hr
    *** source: 17486112-Fig-4c
  *** Xrcc4[Ab] boundto(Dab1-gene)[ChIP] is increased irt DSB-Induction (times)
    *** cells: MCF7 in BMS
    *** times: 0 2+ 4+ 6++ 8++ 10+ hr
    *** comment: delayed by cotreatment with KU55933
    *** source: 17486112-Fig-4f
  *** Xrcc4[Ab] boundto(Dab1-gene)[ChIP] is increased irt DSB-Induction (times)
    *** cells: MCF7 in BMS "arrested in G1 by serum-depletion for 24 hr"
    *** times: 0+ 2+ 4+ 6++ 8+++ 10+ 12+ 16+ 20+ 24+ hr
    *** source: 17486112-Fig-3b
  *** Xrcc4[Ab] boundto(Dab1-gene)[ChIP] is increased irt DSB-Induction (times)
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** times: 0+ 2+ 4++ 6+ 8+ 10+ hr
    *** comment: peak occurs at 8 hr when xNbs1 is omitted
    *** source: 17486112-Fig-4a
