============================
Recruitment to Gp130 complex
============================

  *** xStat3[tAb] copptby[WB] Gp130[Ab] is increased irt IL6 (15 min)
    *** cells: HEPG2 in BMS
    *** enhanced by: xPkcd [addition]
    *** source: 12361954-Fig-4a

===========================
Phosphorylation on Tyrosine
===========================

Jak1--  ???

  *** Stat3[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (15 min)
    *** cells: U4A<Jak1~null> in BMS
    *** enhanced by: xJak1 [addition]
    *** source: 7537214-Fig-5c

not Jak2--

  *** Stat3[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (15 min)
    *** cells: GAMMA2A<Jak2~null> in BMS
    *** source: 7537214-Fig-5c
  *** Stat3[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (15 min)
    *** cells: GAMMA2A<Jak2~null><xJak2> in BMS
    *** does not req: xJak2 [omission]
    *** inhibited by: xJak2(mnr)"KD" [substitution]
    *** source: 7537214-Fig-7b

Lmo4--  ??? need location

  *** Stat3[Ab]IP Yphos[pYAb] is increased irt IL6 (times)
    *** cells: HEPG2 in BMS
    *** times: 0 30+++ 60++ 120+ 240+ min
    *** partially reqs: Lmo4 [RNAi]
    *** source: 15677447-Fig-8c

not Tyk2--

  *** Stat3[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (15 min)
    *** cells: U1D<Tyk2~null> in BMS
    *** source: 7537214-Fig-5c

Stat3(Y705)

  *** xStat3[tAb]IP Yphos[pYAb] is increased irt IL6 (10 min)
    *** cells: HEPG2 in BMS
    *** inhibited by: xStat3(Y705F) [addition]
    *** source: 8626374-Fig-2b
  *** xStat3[tAb]IP Yphos[pYAb] is increased irt IL6 (10 min)
    *** cells: HEPG2 in BMS
    *** inhibited by: xStat3(Y705F) [substitution]
    *** source: 8626374-Fig-2a
  *** Stat3[Ab]IP Yphos[pYAb] is increased irt IL6 (times)
    *** cells: M1 in BMS
    *** times: 0 15+ 60+ 360+ 1440+ min
    *** partially inhibited by: xStat3(Y705F) [addition]
    *** unaffected by: xStat1(Y701F) [addition]
    *** source: 8670868-Fig-2

No extras

  *** Stat3[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (15 min)
    *** cells: 2C4 in BMS
    *** source: 7537214-Fig-7b
  *** Stat3[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (15 min)
    *** cells: 2FTGH in BMS
    *** source: 7537214-Fig-5c
  *** Stat3[Ab]IP Yphos[pYAb] is increased irt IL6 (15 min)
    *** cells: HEPG2 in BMLS
    *** source: 8140422-Fig-2b
  *** Stat3[Ab]IP Yphos[pYAb] is increased irt IL6 (10 min)
    *** cells: BJAB in BMS
    *** source: 9133417-Fig-5a
  *** Stat3[Ab]IP Yphos[pYAb] is increased irt IL6 (10 min)
    *** cells: KAS61 in BMS "IL6 deprived for 24 hr"
    *** unaffected by: 15dPGJ2 [pretreatment]
    *** unaffected by: Troglitazone [pretreatment]
    *** unaffected by: Troglitazone + GW9662 [pretreatment]
    *** unaffected by: WY14643 [pretreatment]
    *** source: 14975242-Fig-3b

=======================
Phosphorylation on Y705
=======================

not Ins--

  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (15 min)
    *** cells: HEPG2 in BMLS
    *** unaffected by: Ins [cotreatment]
    *** source: 12456685-Fig-3d

not Rac1--

  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (15 min)
    *** cells: HEPG2 in BMS
    *** unaffected by: xRac1(T17N) [addition]
    *** source: 11335711-Fig-5a

Jak1--  ???

  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (20 min)
    *** cells: U4A<Jak1~null><xJak1> in BMS
    *** source: 15935617-Fig-3b

not Pkcd--

  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (times)
    *** cells: HEPG2 in BMS
    *** times: 0 15 30+ min
    *** unaffected by: xPkcd(1-298)"DN" [addition]
    *** source: 11335711-Fig-3e

inhibited by Ptprec--

  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (tnr)
    *** cells: M1 in BMS
    *** partially inhibited by: xPtprec [addition]
    *** unaffected by: xPtprec(D245A) [addition]
    *** source: 10859312-Fig-5a

Chemicals

  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (times)
    *** cells: HEPG2 in BMS
    *** times: 0 15++ 30+ min
    *** unaffected by: Rottlerin [pretreatment]
    *** source: 11335711-Fig-3b
  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** unaffected by: Gefitinib [cotreatment]
    *** unaffected by: BMS345541 [cotreatment]
    *** unaffected by: PD325901 [cotreatment]
    *** unaffected by: PHA818637 [cotreatment]
    *** unaffected by: ZSTK474 [cotreatment]
    *** source: 19953085-Fig-S1
  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (15 min)
    *** cells: CHANG in BMLS
    *** unaffected by: LY294002 [pretreatment]
    *** source: 19071214-Fig-5b
  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (15 min)
    *** cells: CHANG in BMLS
    *** unaffected by: SP600125 [pretreatment]
    *** source: 19071214-Fig-5d


No extras--

  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (15 min)
    *** cells: A431 in BMS
    *** source: 10446219-Fig-2b
  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (times)
    *** cells: HEPG2 in BMLS
    *** times: 0 5+ 10+ 20+ 30+ 45+ min
    *** source: 10727406-Fig-1a
  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (times)
    *** cells: HEPG2 in BMLS
    *** times: 0 15+ 30+ min
    *** source: 10727406-Fig-5c
  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (times)
    *** cells: HEPG2 in BMS
    *** times: 0 15++ 30+ 45+ 60 min
    *** source: 10446219-Fig-1d
  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (15 min)
    *** cells: CHANG in BMLS
    *** source: 19071214-Fig-3d
  *** Stat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (30 min)
    *** cells: HELA in BMLS
    *** source: 15919823-Fig-2a
  *** xStat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (30 min)
    *** cells: HELA<xStat3> in BMLS
    *** source: 15919823-Fig-2a
  *** xStat3[phosAb] phos(Y705)[phosAb] is increased irt IL6 (30 min)
    *** cells: HELA<xStat3> in BMLS
    *** unaffected by: xStat3(150-770) [substitution]
    *** unaffected by: xStat3(162-770) [substitution]
    *** source: 15919823-Fig-4c


phos on sitenr--

  *** Stat3[phosAb] phos(sitenr)[phosAb] is increased irt IL6 (20 min)
    *** cells: COLO205 in BMS
    *** source: 15120652-Fig-3a
  *** Stat3[phosAb] phos(sitenr)[phosAb] is increased irt IL6 (20 min)
    *** cells: HEPG2 in BMS
    *** source: 15120652-Fig-3a
  *** Stat3[phosAb]IP phos(sitenr)[phosAb] is increased irt IL6 (10 min)
    *** cells: KAS61 in BMS "IL6 deprived for 24 hr"
    *** unaffected by: 15dPGJ2 [pretreatment]
    *** unaffected by: Troglitazone [pretreatment]
    *** unaffected by: Troglitazone + GW9662 [pretreatment]
    *** source: 14975242-Fig-6b
