============================================
Recruitment to the IL6 receptor complex ???
============================================

Gp130--  undetectable, unchanged  this does not agree with Shp2 datums

  *** Gab1[Ab] copptby[WB] Gp130[Ab] is unchanged irt IL6 (10 min)
    *** cells: HEPG2 in BMS
    *** source: 9632795-Fig-1c

Grb2--  detectable, unchanged

  *** Gab1[Ab] copptby[WB] Grb2[Ab] is detectable-but unchanged irt IL6 (times)
    *** cells: MM1S in BMLS
    *** times: 0+ 1+ 5+ min
    *** source: 15010462-Fig-4b
  *** Gab1[Ab] copptby[WB] Grb2[Ab] is detectable-but unchanged irt IL6 (times)
    *** cells: MM1S<xHck> in BMLS
    *** times: 0+ 1+ 5+ min
    *** source: 15010462-Fig-6b
  *** Gab1[Ab] copptby[WB] Grb2[Ab] is unchanged irt IL6 (10 min)
    *** cells: HEPG2 in BMS
    *** source: 9632795-Fig-1c

Pi3k--   increased

  *** Gab1[Ab] copptby[WB] Pik3rs[Ab] is increased irt IL6 (10 min)
    *** cells: HEPG2 in BMS
    *** source: 9632795-Fig-1c
  *** Gab1[Ab]IP IVLKA(PtdIns)[32P-ATP] is increased irt IL6 (10 min)
    *** cells: HEPG2 in BMS
    *** source: 9632795-Fig-1d

Shp2--   increased

  *** Gab1[Ab] copptby[WB] Shp2[Ab] is increased irt IL6 (10 min)
    *** cells: HEPG2 in BMS
    *** source: 9632795-Fig-1c
  *** Gab1[Ab] copptby[WB] Shp2[Ab] is increased irt IL6 (times)
    *** cells: MM1S in BMLS
    *** times: 0 1+ 5+ min
    *** inhibited by: PP2 [pretreatment]
    *** source: 15010462-Fig-4a
  *** Gab1[Ab] copptby[WB] Shp2[Ab] is increased irt IL6 (times)
    *** cells: MM1S<xHck> in BMLS
    *** times: 0 1+ 5+ min
    *** inhibited by: xHck(K269E) [substitution]
    *** source: 15010462-Fig-6a

Hck--   detectable, unchanged

  *** Gab1[Ab] copptby[WB] xHck[Ab] is detectable-but unchanged irt IL6 (times)
    *** cells: MM1S in BMLS
    *** times: 0+ 1+ 5+ min
    *** unaffected by: xHck(K269E) [substitution]
    *** source: 15010462-Fig-5b
  *** Gab1[Ab] copptby[WB] Hck[Ab] is detectable-but unchanged irt IL6 (times)
    *** cells: MM1S in BMLS
    *** times: 0+ 1+ 5+ min
    *** source: 15010462-Fig-4c

===========================
Phosphorylation on Tyrosine
===========================

Hck--  requires kinase activity

  *** Gab1[Ab]IP Yphos[pYAb] is increased irt IL6 (times)
    *** cells: MM1S<xHck> in BMLS
    *** times: 0+ 1++ 5++ min
    *** bkg inhibited by: xHck(K269E) [substitution]
    *** source: 15010462-Fig-5c
  *** xGab1[tAb]IP Yphos[pYAb] is increased irt IL6 (tnr)
    *** cells: HEK293<xHck> in BMLS
    *** inhibited by: xHck(K269E) [substitution]
    *** source: 15010462-Fig-5e

Chemicals

  *** Gab1[Ab]IP Yphos[pYAb] is increased irt IL6 (times)
    *** cells: MM1S in BMLS
    *** times: 0+ 1++ 5+ min
    *** inhibited by: PP2 [pretreatment]
    *** source: 15010462-Fig-3a

No extras

  *** Gab1[Ab]IP Yphos[pYAb] is increased irt IL6 (2 min)
    *** cells: MM1S in BMLS
    *** source: 15010462-Fig-2b
  *** Gab1[Ab]IP Yphos[pYAb] is increased irt IL6 (10 min)
    *** cells: HEPG2 in BMS
    *** source: 9632795-Fig-1c
  *** Gab1[Ab]IP Yphos[pYAb] is increased irt IL6 (times)
    *** cells: HEPG2 in BMS
    *** times: 0 5+ 10+ 30+ 60 min
    *** source: 9632795-Fig-1a


