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Things required for Proliferation in response to IL4
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Cbl-- ???

  *** DNA-synthesis[3H-Thymidine] is increased irt IL4 (12 hr)
    *** cells: BAF3 in BMLS
    *** enhanced by: xCbl [addition]
    *** source: 9414268-Fig-1b

Fes--

  *** DNA-synthesis[3H-Thymidine] is increased irt IL4 (48 hr)
    *** cells: BAF3 in BMLS
    *** inhibited by: xFes(K590E)"KD" [addition]
    *** source: 11160325-Fig-6b
  *** DNA-synthesis[3H-Thymidine] is increased irt IL4 (48 hr)
    *** cells: BAF3<xFes> in BMS
    *** inhibited by: xFes(K590E)"KD" [substitution]
    *** source: 11160325-Fig-6b
  *** DNA-synthesis[3H-Thymidine] is increased irt IL4 (48 hr)
    *** cells: M1241 in BMLS
    *** inhibited by: xFes(K590E)"KD" [addition]
    *** source: 11160325-Fig-6a
  *** DNA-synthesis[3H-Thymidine] is increased irt IL4 (48 hr)
    *** cells: M1241<xFes> in BMS
    *** inhibited by: xFes(K590E)"KD" [substitution]
    *** source: 11160325-Fig-6a

IL2Rg--

  *** DNA-synthesis[3H-Thymidine] is increased irt IL4 (48 hr)
    *** cells: CTLL2 in BMS
    *** unaffected by: anti-IL2Rb [cotreatment]
    *** inhibited by: anti-IL2Rg [cotreatment]
    *** inhibited by: anti-IL2Rb + anti-IL2Rg [cotreatment]
    *** source: 8266076-Fig-2a

IL4R--   Required Features

  *** DNA-synthesis[3H-Thymidine] is increased irt IL4 (28 hr)
    *** cells: 32D<xIrs1><xIL4R> in BMS "IL3-deprived"
    *** unaffected by: xIL4R(1-657) [substitution]
    *** unaffected by: xIL4R(1-557) [substitution]
    *** inhibited by: xIL4R(1-437) [substitution]
    *** source: 9670964-Fig-1c
  *** DNA-synthesis[3H-Thymidine] is increased irt IL4 (28 hr)
    *** cells: 32D<xIrs1><xIL4R> in BMS "IL3-deprived"
    *** unaffected by: xIL4R(Y713F) [substitution]
    *** inhibited by: xIL4R(Y497F) [substitution]
    *** source: 9670964-Fig-1b
  *** DNA-synthesis[3H-Thymidine] is increased irt IL4 (53 hr)
    *** cells: 32D<xIrs2><xIL4R> in BMS
    *** reqs: xIL4R [omission]
    *** enhanced by: xIL4R(Y713F) [substitution]
    *** enhanced by: xIL4R(1-711) [substitution]
    *** source: 11714803-Fig-2
  *** DNA-synthesis[3H-Thymidine] is increased irt IL4 (tnr)
    *** cells: mSpBCs in BMS
    *** unaffected by: kIL4R(Y500F) [knockin]
    *** enhanced by: anti-IgM [cotreatment]
    *** source: 14557412-Fig-3b

Irs1--

  *** DNA-synthesis[3H-Thymidine] is increased irt IL4 (48 hr)
    *** cells: 32D<xIrs1> in BMLS "IL3-deprived"
    *** reqs: xIrs1 [omission]
    *** source: 8124718-Fig-1

Stat6--

  *** DNA-synthesis[3H-Thymidine] is increased irt IL4 (48 hr)
    *** cells: mLNCs in BMS
    *** reqs: Stat6 [KO]
    *** source: 8624821-Fig-3a

Chemicals

  *** DNA-synthesis[3H-Thymidine] is increased irt IL4 (36 hr)
    *** cells: TS1<xIL2Ra><xIL2Rb> in BMS
    *** unaffected by: Bisindolylmaleimide-I [cotreatment]
    *** source: 7737351-Fig-2
