===============
Kinase Activity
===============

Chemicals--

  *** Mek1[Ab]IP IVKA(Erk1)[32P-ATP] is increased irt IL2 (times)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** times: 0 5+ 10+ min
    *** partially inhibited by: Wortmannin [pretreatment]
    *** source: 7760801-Fig-8

===============
Phosphorylation
===============

Dusp5--

  *** Mek1[phosAb] phos(sitenr)[phosAb] is increased irt IL2 (times)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** times: 0 5+ 15+ 30+ min
    *** unaffected by: xDusp5 [addition]
    *** unaffected by: xDusp5(C263S)"CIA" [addition]
    *** source: 12435740-Fig-6a

Chemicals--

  *** Mek12s[phosAb] phos(SMANS)[phosAb] is increased irt IL2 (10 min)
    *** cells: hThymicBlasts in BMS "IL2-deprived"
    *** inhibited by: LY294002 [pretreatment] no-bkg-control
    *** source: 12681450-Fig-4a
  *** Mek12s[phosAb] phos(SMANS)[phosAb] is increased irt IL2 (10 min)
    *** cells: hThymicBlasts in BMS "IL2-deprived"
    *** inhibited by: Wortmannin [pretreatment] no-bkg-control
    *** source: 12681450-Fig-4a
  *** Mek12s[phosAb] phos(SMANS)[phosAb] is increased irt IL2 (10 min)
    *** cells: hThymicBlasts in BMS "IL2-deprived"
    *** unaffected by: Rapamycin [pretreatment] no-bkg-control
    *** source: 12681450-Fig-4a
  *** Mek12s[phosAb] phos(SMANS)[phosAb] is increased irt IL2 (10 min)
    *** cells: hThymicBlasts in BMS "IL2-deprived"
    *** unaffected by: PD98059 [pretreatment] no-bkg-control
    *** source: 12681450-Fig-4a

No extras--

  *** Mek12s[phosAb] phos(SMANS)[phosAb] is increased irt IL2 (times)
    *** cells: hThymicBlasts in BMS "IL2-deprived"
    *** times: 0 3++ 5+ 10+ min
    *** source: 12681450-Fig-2a

