===============
Kinase Activity
===============

  *** xLck[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL2 (times)
    *** cells: NIH3T3<xIL2Ra><xIL2Rb><xIL2Rg><Jak3~null><Lck~null><xLck(mnr)"CA"> in BMS
    *** times: 0+ 1++ 5++ min
    *** source: 10825200-Fig-3a
  *** Lck[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL2 (times)
    *** cells: hPBTCs in BMS
    *** times: 0+ 1++ 5++ 15++ min
    *** comment: the increase in WBMS is much greater than the increase in 32P
    *** source: 10825200-Fig-3c
  *** Lck[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL2 (times)
    *** cells: NK33 in BMS
    *** times: 0+ 1++ 5++ 15++ min
    *** comment: the increase in WBMS is much greater than the increase in 32P
    *** source: 10825200-Fig-3a
  *** Lck[Ab]IP IVKA(Eno1)[32P-ATP] is increased irt IL2 (times)
    *** cells: hIL2RTCs in BMS
    *** times: 0 5+ 15++ min
    *** source: 9092570-Fig-3a
  *** Lck[Ab]IP IVKA(Eno1)[32P-ATP] is increased irt IL2 (times)
    *** cells: hPBMCs in BMS
    *** times: 0+ 5++ 15++ min
    *** source: 9092570-Fig-3a
  *** Lck[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: hPBMCs<Cd5~neg><Cd14~neg><Cd20~neg> in BMS
    *** source: 7553885-Fig-5

=====
Other
=====

  *** Lck[Ab]IP Yphos[pYAb] is detectable-but unchanged irt IL2 (10 min)
    *** cells: ILTMAT in BMS
    *** source: 10899310-Fig-2e

  *** Lck[Ab] copptby[WB] Stam[Ab] is unchanged irt IL2 (10 min)
    *** cells: ILTMAT in BMS
    *** source: 9133424-Fig-4
  *** Lck[Ab] copptby[WB] Stam2[Ab] is unchanged irt IL2 (10 min)
    *** cells: ILTMAT in BMS
    *** source: 10899310-Fig-2e

  *** rIL2Rb(306-382)[GST] phos[32P-ATP] is increased by rLck
    *** cells: none
    *** unaffected by: rIL2Rb(334-365)"Aci2" [substitution]
    *** source: 10214954-Fig-3a
  *** rIL2Rb(334-365)[GST] phos[32P-ATP] is increased by rLck
    *** cells: none
    *** unaffected by: rIL2Rb((334-365)/Y338F) [substitution]
    *** partially inhibited by: rIL2Rb((334-365)/Y355F) [substitution]
    *** partially inhibited by: rIL2Rb((334-365)/Y358F) [substitution]
    *** partially inhibited by: rIL2Rb((334-365)/Y361F) [substitution]
    *** inhibited by: rIL2Rb((334-365)/Y338F/Y355F/Y358F/Y361F) [substitution] 
    *** inhibited by: rIL2Rb((334-365)/Y355F/Y358F/Y361F) [substitution] 
    *** unaffected by: rIL2Rb((334-365)/Y338F/Y358F/Y361F) [substitution] 
    *** inhibited by: rIL2Rb((334-365)/Y338F/Y355F/Y361F) [substitution] 
    *** unaffected by: rIL2Rb((334-365)/Y338F/Y358F/Y355F) [substitution] 
    *** source: 10214954-Fig-3a
  *** rIL2Rb(382-582)[GST] phos[32P-ATP] is increased by rLck
    *** cells: none
    *** unaffected by: rIL2Rb((382-582)/Y392F) [substitution]
    *** unaffected by: rIL2Rb((382-582)/Y510F) [substitution]
    *** inhibited by: rIL2Rb((382-582)/Y392F/T510F) [substitution]
    *** source: 10214954-Fig-2b
  *** rIL2Rb(240-525)[GST] phos[32P-ATP] is increased by rLck
    *** cells: none
    *** inhibited by: rIL2Rb(240-306)"Prox" [substitution]
    *** unaffected by: rIL2Rb(306-382)"Aci" [substitution]
    *** unaffected by: rIL2Rb(382-582)"Cter" [substitution]
    *** source: 10214954-Fig-2a
  *** rIL2Rg(288-369)[GST] phos[32P-ATP] is unchanged by rLck
    *** cells: none
    *** source: 10214954-Fig-2a

