=================
Kinase Activation
=================

Dusp5--

  *** Erks[Ab]IP IVKA(Elk1)(sitenr)[phosAb] is increased irt IL2 (times)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** times: 0 5+ 15+ min
    *** partially inhibited by: xDusp5 [addition]
    *** enhanced by: xDusp5(C263S)"CIA" [addition]
    *** source: 12435740-Fig-6b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (times)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** times: 0 5++ 15+ 30+ min
    *** partially inhibited by: xDusp5 [addition]
    *** enhanced by: xDusp5(C263S)"CIA" [addition]
    *** source: 12435740-Fig-6a

Shp2--

  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt IL2 (tnr)
    *** cells: NIH3T3<xIL2Ra><xIL2Rb><xIL2Rg><Jak3~null><Lck~null><xJak3> in BMLS
    *** inhibited by: xShp2(mnr)"DN" [addition]
    *** source: 9590209-Fig-5

Chemicals--

  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt IL2 (15 min)
    *** cells: hNKCs in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 10843677-Fig-1b
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt IL2 (30 min)
    *** cells: hNKCs in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 10843677-Fig-1a

No extras--

  *** Erk2[Ab]IP IVKA(MBP)[32P-ATP] is increased irt IL2 (10 min)
    *** cells: BAF3<IL2Rb~null><xIL2Ra><xIL2Rb> in BMS
    *** source: 8376945-Fig-2
  *** Erk2[Ab]IP IVKA(MBP)[32P-ATP] is increased irt IL2 (10 min)
    *** cells: BAF3<IL2Rb~null><xIL2Rb> in BMS
    *** source: 8376945-Fig-2
  *** Erk2[Ab]IP IVKA(MBP)[32P-ATP] is increased irt IL2 (times)
    *** cells: BAF3<IL2Rb~null><xIL2Ra><xIL2Rb> in BMS
    *** times: 0 5++ 10++ 15++ 20+ 30+ 60 min
    *** source: 8376945-Fig-1b
  *** Erk2[Ab]IP IVKA(MBP)[32P-ATP] is increased irt IL2 (times)
    *** cells: BAF3<IL2Rb~null><xIL2Rb> in BMS
    *** times: 0 5+++ 10+++ 15++ 20+ 30 60 min
    *** source: 8376945-Fig-1b
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt IL2 (15 min)
    *** cells: hNKCs in BMLS
    *** source: 10843677-Fig-2a
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt IL2 (times)
    *** cells: hNKCs in BMLS
    *** times: 0 5+ 15++ 30++ min
    *** source: 10843677-Fig-1a
  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is unchanged irt IL2 (15 min)
    *** cells: hPBTCs in BMLS
    *** source: 10843677-Fig-2a
  *** Erks[Ab]IP IVKA(snr)[32P-ATP] is increased irt IL2 (10 min)
    *** cells: CTLL20 in BMS "IL2-deprived"
    *** source: 7528328-Fig-1a

===================
TEY Phosphorylation
===================

Dok2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (times)
    *** cells: 32D<xIL2Rb> in BMS
    *** times: 0 10+ 30+ min
    *** partially inhibited by: xDok2 [addition]
    *** source: 9697832-Fig-6b

Dusp5--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (times)
    *** cells: hPHAblasts in BMS "IL2-PHA-deprived"
    *** times: 0 10++ 30+ min
    *** source: 12435740-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (tnr)
    *** cells: HEK293T<xIL2Rb><xJak3> in BMS
    *** bkg inhibited by: xDusp5 [addition]
    *** unaffected by: xDusp5(C263S)"CIA" [addition]
    *** source: 12435740-Fig-5d

Gab2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (times)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** enhanced by: xGab2 [addition]
    *** partially inhibited by: xGab2(Y614F) [substitution]
    *** times: 0 15++ 30+ 60 min
    *** source: 15170389-Fig-3a
  *** xErk1[phosAb] phos(TEY)[phosAb] is increased irt IL2 (times)
    *** cells: KIT225 in BMS "starved"
    *** times: 0 15+ 30+ 60+ min
    *** unaffected by: xGab2 [addition]
    *** unaffected by: xGab2(Y614F) [addition]
    *** unaffected by: xGab2(Y623S) [addition]
    *** source: 15356145-Fig-6a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (times)
    *** cells: KIT225<xGab2> in BMS "starved"
    *** times: 0 15+ 30+ 60+ min
    *** unaffected by: xGab2(S623A) [substitution]
    *** source: 15356145-Fig-6b

IL2Rb--

  *** Erk2[Ab] phos[WBMS] is increased irt IL2 (10 min)
    *** cells: BAF3<IL2Rb~null><xIL2Rb> in BMS
    *** reqs: xIL2Rb [omission]
    *** inhibited by: xIL2Rb(del(266-323)) [substitution]
    *** source: 8376945-Fig-3a
  *** Erks[Ab] phos[WBMS] is increased irt IL2 (10 min)
    *** cells: BAFB03<xIL2Rb(1-355)> in BMS "IL3-deprived"
    *** inhibited by: xIL2Rb(Y338F) [substitution]
    *** inhibited by: xIL2Rb((1-355)/Y338F) [substitution]
    *** partially inhibited by: xIL2Rb(1-325)"Shc1-fusion" [substitution]
    *** source: 1066828-Fig-3b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (10 min)
    *** cells: BAFB03<xIL2Rb> in BMS "IL3-deprived"
    *** inhibited by: xIL2Rb(del(266-323)) [substitution]
    *** inhibited by: xIL2Rb(del(312-383)) [substitution]
    *** source: 1066828-Fig-2a

IL2Rg--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (10 min)
    *** cells: ED40515<xIL2Rg> in BMS
    *** inhibited by: xIL2Rg(1-290)"M1" [substitution]
    *** inhibited by: xIL2Rg(1-321)"M2" [substitution]
    *** source: 10421845-Fig-3b

Shp2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (5 min)
    *** cells: MYLA2059 in BMS
    *** enhanced by: xShp2 [addition]
    *** inhibited by: Shp2(C459S)"CIA" [addition]
    *** source: 12543077-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (times)
    *** cells: MYLA2059<xShp2> in BMS
    *** times: 0 1 5++ 15+ min
    *** partially inhibited by: Shp2(C459S)"CIA" [addition]
    *** source: 12543077-Fig-2b

Socs3-- ???

  *** Erks[Ab]IP phos(TEY)[phosAb] is increased irt IL2 (30 min)
    *** cells: BAF3<IL2Rb~null><xIL2Rb> in BMS
    *** unaffected by: xSocs3 [addition]
    *** source: 11331873-Fig-3a
  *** Erks[Ab]IP phos(TEY)[phosAb] is increased irt IL2 (30 min)
    *** cells: BAF3<IL2Rb~null><xIL2Rb><xSocs3> in BMS
    *** inhibited by: xSocs3(Y204F/Y221F) [substitution]
    *** source: 11331873-Fig-4a

Chemicals--

  *** Erks[Ab] phos[WBMS] is increased irt IL2 (10 min)
    *** cells: BAFB03<xIL2Rb> in BMS "IL3-deprived"
    *** unaffected by: CNI1493 [pretreatment]
    *** source: 1066828-Fig-5
  *** Erks[Ab] phos[WBMS] is increased irt IL2 (10 min)
    *** cells: CT6 in BMS "IL2-deprived"
    *** unaffected by: CNI1493 [pretreatment]
    *** source: 1066828-Fig-5
  *** Erks[Ab] phos[WBMS] is increased irt IL2 (10 min)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** inhibited by: PD98059 [pretreatment]
    *** source: 9305919-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (10 min)
    *** cells: hThymicBlasts in BMS "IL2-deprived"
    *** inhibited by: PD98059 [pretreatment] no-bkg-control
    *** source: 12681450-Fig-4a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (10 min)
    *** cells: hThymicBlasts in BMS "IL2-deprived"
    *** partially inhibited by: LY294002 [pretreatment] no-bkg-control
    *** source: 12681450-Fig-4a
  *** Erk2[Ab] phos[WBMS] is increased irt IL2 (10 min)
    *** cells: BAF3<IL2Rb~null><xIL2Ra><xIL2Rb> in BMS
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 8376945-Fig-4b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (10 min)
    *** cells: hThymicBlasts in BMS "IL2-deprived"
    *** unaffected by: Rapamycin [pretreatment] no-bkg-control
    *** source: 12681450-Fig-4a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (10 min)
    *** cells: CT6 in BMS
    *** unaffected by: SB203580 [pretreatment]
    *** source: 9169478-Fig-4c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (10 min)
    *** cells: hThymicBlasts in BMS "IL2-deprived"
    *** partially inhibited by: Wortmannin [pretreatment] no-bkg-control
    *** source: 12681450-Fig-4a

No Extras--

  *** Erk2[Ab] phos[WBMS] is increased irt IL2 (10 min)
    *** cells: BAF3<IL2Rb~null><xIL2Ra><xIL2Rb> in BMS
    *** source: 8376945-Fig-4a
  *** Erk2[Ab] phos[WBMS] is increased irt IL2 (times)
    *** cells: BAF3<IL2Rb~null><xIL2Ra><xIL2Rb> in BMS
    *** times: 0 5+ 10+ 15+ 20+ 30 60 min
    *** source: 8376945-Fig-1a
  *** Erk2[Ab] phos[WBMS] is increased irt IL2 (times)
    *** cells: BAF3<IL2Rb~null><xIL2Rb> in BMS
    *** times: 0 5+ 10+ 15+ 20 30 60 min
    *** source: 8376945-Fig-1a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (5 min)
    *** cells: hPBTCs in BMLS
    *** source: 10849428-Fig-3a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt IL2 (10 min)
    *** cells: hThymicBlasts in BMS "IL2-deprived"
    *** source: 12681450-Fig-2b
  *** Erk2[Ab] phos[WBMS] is increased irt IL2 (10 min)
    *** cells: BAF3<IL2Rb~null><xBcl2><xIL2Rb> in BMS
    *** comment: inhibited by IL3-deprivation for more than 1 days
    *** source: 8376945-Fig-3b
  *** Erk2[Ab] phos[WBMS] is increased irt IL2 (10 min)
    *** cells: BAF3<IL2Rb~null><xBcl2><xIL2Rb> in BMS
    *** comment: inhibited by IL3-deprivation for more than 3 days
    *** source: 8376945-Fig-3b

=============
Other Effects
=============

  *** Erk2[Ab] copptby[WB] Cdk2[Ab] is increased irt IL2 (times)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** times: 0 8+ 16++ 24++ 30++ hr
    *** comment: coppt directly correlates with Cdk2 prot-exp
    *** source: 10962581-Fig-1b
  *** Erk2[Ab] infraction(cytoplasmic)[WB] is unchanged irt IL2 (times)
    *** cells: KIT225 in BMS "IL2-deprived" "treated with IL2 for 28 hr"
    *** times: 0+ 10+ 20+ 26+ hr
    *** source: 10962581-Fig-1e
  *** Erk2[Ab] infraction(nuclear)[WB] is unchanged irt IL2 (times)
    *** cells: KIT225 in BMS "IL2-deprived" "treated with IL2 for 28 hr"
    *** times: 0+ 10+ 20+ 26+ hr
    *** source: 10962581-Fig-1e

==============
Contradictions
==============

  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt IL2 (15 min)
    *** cells: hPBTCs<Itgb2~pos><Cd8~pos><Cd56~neg><Cd4~neg><Cd20~neg> in BMS
    *** unaffected by: IL12 [cotreatment]
    *** source: 10201984-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt IL2 (15 min)
    *** cells: hPBTCs<Itgb2~neg><Cd8~pos><Cd56~neg><Cd4~neg><Cd20~neg> in BMS
    *** unaffected by: IL12 [cotreatment]
    *** source: 10201984-Fig-2a
