=============
Transcription
=============

reqs Stat4--

  *** IL18R1-gene mRNA[Northern] is increased irt IL12 (4 hr)
    *** cells: mSpCs in BMS "activated with anti-Cd3 for 48 hr"
    *** reqs: Stat4 [KO]
    *** source: 11120802-Fig-4a
  *** IL18R1-gene mRNA[RTPCR] is increased irt IL12 (48 hr)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS "stimulated with anti-Cd3 and anti-Cd28 for 48 hr"
    *** reqs: Stat4 [KO]
    *** partially reqs: Ifng [KO]
    *** source: 11466347-Fig-7

inhibited by anti-Cd3 cotreatment

  *** IL18R1-gene mRNA[RTPCR] is increased irt IL12 (48 hr)
    *** cells: mSpTCs in BMS
    *** inhibited by: anti-Cd3 [cotreatment]
    *** source: 9759857-Fig-4a

No extras

  *** IL18R1-gene mRNA[RTPCR] is increased irt IL12 (times)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS "stimulated with anti-Cd3 and anti-Cd28 for 48 hr"
    *** times: 0 4 8 12+ 24++ 36++ 48+++ hr
    *** source: 11466347-Fig-6a
  *** IL18R1-gene mRNA[Northern] is increased irt IL12 (3 hr)
    *** cells: hNKCs in BMS "resting"
    *** source: 10925275-Fig-3
  *** IL18R1-gene mRNA[Northern] is increased irt IL12 (times)
    *** cells: hPBTCs in BMS "activated"
    *** times: 0 1 2+ 3++ 6++ hr
    *** source: 10925275-Fig-1
  *** IL18R1-gene mRNA[Northern] is increased irt IL12 (times)
    *** cells: NK92 in BMS
    *** times: 0 1 3+ 6++ 12++ hr
    *** source: 10925275-Fig-4
  *** IL18R1-gene mRNA[RTPCR] is increased irt IL12 (72 hr)
    *** cells: mSpBCs in BMS
    *** source: 9759857-Fig-3b
  *** IL18R1-gene mRNA[RTPCR] is increased irt IL12 (72 hr)
    *** cells: mSpTCs in BMS
    *** source: 9759857-Fig-3b
  *** IL18R1-gene mRNA[RTPCR] is increased irt IL12 (times)
    *** cells: mSpTCs in BMS
    *** times: 0 3+ 6++ 12++ 24++ 48++ 72++ hr
    *** source: 9759857-Fig-4a


==================
Surface Expression
==================

Reqs Ifng--

  *** IL18R1[Ab] surface-exp[FACS] is increased irt IL12 (48 hr)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS "stimulated with anti-Cd3 and anti-Cd28 for 48 hr"
    *** partially reqs: Ifng [KO]
    *** comment: requirement for Ifng can be reversed by Ifng cotreatment
    *** source: 11466347-Fig-5
  *** IL18R1[Ab] surface-exp[FACS] is increased irt IL12 (48 hr)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS "stimulated with anti-Cd3 and anti-Cd28 for 48 hr"
    *** partially reqs: Ifng [KO]
    *** source: 11466347-Fig-4

Reqs Stat4--

  *** IL18R1[Ab] surface-exp[FACS] is increased irt IL12 (48 hr)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS "stimulated with anti-Cd3 and anti-Cd28 for 48 hr"
    *** reqs: Stat4 [KO]
    *** source: 11466347-Fig-4
  *** IL18R1[Ab] surface-exp[FACS] is increased irt IL12 (48 hr)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS "stimulated with anti-Cd3 and anti-Cd28 for 48 hr"
    *** reqs: Stat4 [KO]
    *** source: 11466347-Fig-5

=============
Binding Sites
=============

Reqs Ifng--

  *** IL18[Ab] receptor-binding[FACS] is increased irt IL12 (48 hr)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS "stimulated with anti-Cd3 and anti-Cd28 for 48 hr"
    *** partially reqs: Ifng [KO]
    *** comment: requirement for Ifng can be reversed by Ifng cotreatment
    *** source: 11466347-Fig-5
  *** IL18[Ab] receptor-binding[FACS] is increased irt IL12 (48 hr)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS "stimulated with anti-Cd3 and anti-Cd28 for 48 hr"
    *** partially reqs: Ifng [KO]
    *** source: 11466347-Fig-3

Reqs Stat4--

  *** IL18[Ab] receptor-binding[FACS] is increased irt IL12 (48 hr)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS "stimulated with anti-Cd3 and anti-Cd28 for 48 hr"
    *** reqs: Stat4 [KO]
    *** source: 11466347-Fig-3
  *** IL18[Ab] receptor-binding[FACS] is increased irt IL12 (48 hr)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS "stimulated with anti-Cd3 and anti-Cd28 for 48 hr"
    *** reqs: Stat4 [KO]
    *** source: 11466347-Fig-5

No extras--

  *** IL18[Ab] receptor-binding[FACS] is increased irt IL12 (times)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS "stimulated with anti-Cd3 and anti-Cd28 for 48 hr"
    *** times: 0 12 24+ 36++ 48+++ hr
    *** source: 11466347-Fig-6b
