===========================================================
Traf6 is recruited to the IL1R1 complex in response to IL1b
===========================================================

  *** Traf6[Ab] copptby[WB] IL1Rap[Ab] is increased irt IL1b (times)
    *** cells: HEK293 in BMS
    *** times: 0+ 5++ 10++ 20++ min
    *** source: 16306937-Fig-S2b
  *** Traf6[Ab] copptby[WB] IL1R1[Ab] is increased irt IL1b (times)
    *** cells: HEK293 in BMS
    *** times: 0 1+ 2+++ 5+++ 10++ 30++ 60+ 120 240 min
    *** source: 12242293-Fig-2a
  *** Traf6[Ab] copptby[WB] IL1R1[Ab] is increased irt IL1b (10 min)
    *** cells: HEK293 in BMS
    *** source: 12242293-Fig-2b
  *** Traf6[Ab] copptby[WB] IL1R1[Ab] is increased irt IL1b (10 min)
    *** cells: HEK293 in BMS
    *** source: 12242293-Fig-2c
  *** Traf6[Ab] copptby[WB] IL1R1[tAb] is increased irt IL1b (times)
    *** cells: HEK293<xTLR3> in BMS
    *** times: 0 10+ 20+ min
    *** source: 12609980-Fig-2a

  *** IL1R1[Ab] copptby[WB] Traf6[Ab] is increased irt IL1b (times)
    *** cells: HEK293 in BMS
    *** times: 0 10++ 30++ 60+ min
    *** source: 12496252-Fig-2b

======================================================
Traf6 requires Irak1 for recruitment to IL1R1 complex
======================================================

  *** Traf6[Ab] copptby[WB] IL1R1[Ab] is increased irt IL1b (10 min)
    *** cells: HEK293I1A<Irak1~null><xIrak1> in BMS
    *** reqs: xIrak1 [omission]
    *** source: 12242293-Fig-2b
  *** Traf6[Ab] copptby[WB] IL1R1[Ab] is increased irt IL1b (10 min)
    *** cells: HEK293I1A<Irak1~null><xIrak1(del(199-1522))> in BMS
    *** reqs: xIrak1(del(199-1522))"deleted-kinase-domain" [omission]
    *** source: 12242293-Fig-2c

======================================================
Traf6 and Irak1 coppt is increased in response to IL1b
======================================================

  *** Traf6[Ab] copptby[WB] Irak1[Ab] is increased irt IL1b (times)
    *** cells: HEK293 in BMS
    *** times: 0 1+ 2++ 5+++ 10+++ 30+++ 60++ 120+ 240+ min
    *** source: 12242293-Fig-2a

  *** Irak1[Ab] copptby[WB] Traf6[Ab] is increased irt IL1b (times)
    *** cells: HEK293T in BMS
    *** times: 0 3++ 10+ 30 min
    *** inhibited by: xIrak3 [addition]
    *** source: 12150927-Fig-6a
  *** Irak1[Ab] copptby[WB] xTraf6[tAb] is increased irt IL1 (5 min)
    *** cells: HEK293<xIL1R1> in BMS
    *** unaffected by: xTraf6(289-522) [substitution]
    *** source: 8837778-Fig-4a

  *** Irak1[Ab] copptby[WB] Traf6[Ab] is undetectable
    *** cells: RAW2647 in BMS
    *** source: 16831874-Fig-10c
  *** Irak1[Ab] copptby[WB] xTraf6[tAb] is detectable
    *** cells: HEK293T in BMS
    *** source: 9374458-Fig-3a
  *** xIrak1[tAb] copptby[WB] xTraf6[tAb] is detectable
    *** cells: HEK293T in BMS
    *** unaffected by: xIrak3 [addition]
    *** unaffected by: xIrak1(K206A)"KD" [substitution]
    *** source: 12150927-Fig-6c

======================================================
Traf6 and Irak4 coppt is increased in response to IL1b
implies that Irak4 is also in IL1R1 complex
======================================================

  *** Traf6[Ab] copptby[WB] Irak4[Ab] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 2+ 10++ 30 min
    *** source: 11960013-Fig-2c

======================================================
Traf6 and Irak4 coppt is increased in response to IL1b
implies that Peli1 is also in IL1R1 complex
======================================================

  *** Traf6[Ab] copptby[WB] xPeli1[tAb] is increased irt IL1b (times)
    *** cells: HEK293 in BMS
    *** times: 0 5+ 10+ 30+ 60+ 120+ 240+ min
    *** source: 12496252-Fig-2a



